TW200716588A - A process for preparing dibenzoxepin derivative - Google Patents

A process for preparing dibenzoxepin derivative

Info

Publication number
TW200716588A
TW200716588A TW095119299A TW95119299A TW200716588A TW 200716588 A TW200716588 A TW 200716588A TW 095119299 A TW095119299 A TW 095119299A TW 95119299 A TW95119299 A TW 95119299A TW 200716588 A TW200716588 A TW 200716588A
Authority
TW
Taiwan
Prior art keywords
formula
compound
preparing
atom etc
iii
Prior art date
Application number
TW095119299A
Other languages
Chinese (zh)
Inventor
Koichiro Nishimura
Masahiko Kinugawa
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Publication of TW200716588A publication Critical patent/TW200716588A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/75—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of acids with a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/753—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring of polycyclic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/12—[b,e]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

The present invention provides a process for preparing a 11-alkylidene dibenz[b,e]oxepin derivative or the salt thereof of the formula (V), which comprises step (1) halogenizing a compound of the formula (I) to obtain a compound of the formula (II), step (2) coupling a compound of the formula (II) with an alkyne compound of the formula (III) to obtain a compound of the formula (3), and step (iii) subjecting a compound of the formula (IV) to molecular endocyclic reaction. (wherein, R1 represents a hydrogen atom etc., R2 represents a lower alkyl group etc., X1 represents a chlorine atom etc., X2 represents a chlorine atom etc., n represents an integer of 0~4).
TW095119299A 2005-06-02 2006-06-01 A process for preparing dibenzoxepin derivative TW200716588A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005162240 2005-06-02

Publications (1)

Publication Number Publication Date
TW200716588A true TW200716588A (en) 2007-05-01

Family

ID=37481708

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095119299A TW200716588A (en) 2005-06-02 2006-06-01 A process for preparing dibenzoxepin derivative

Country Status (5)

Country Link
JP (1) JP5099830B2 (en)
KR (1) KR101001129B1 (en)
CN (1) CN101151256B (en)
TW (1) TW200716588A (en)
WO (1) WO2006129781A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5139104B2 (en) * 2007-02-16 2013-02-06 住友化学株式会社 Method for producing dibenzooxepin compound
ES2344242B1 (en) * 2007-02-16 2011-06-06 Sumitomo Chemical Company, Limited METHOD FOR THE PRODUCTION OF A DIBENZOXEPINE COMPOUND.
WO2011033532A1 (en) 2009-09-17 2011-03-24 Indoco Remedies Limited Process for preparation of olopatadine hydrochloride

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282365A (en) * 1978-11-24 1981-08-04 Merck & Co., Inc. Dibenz[b,e]oxepin compounds
JPS5821679A (en) * 1981-07-31 1983-02-08 メルク　エンド　カムパニー　インコーポレーテツド Dibenz(b,e)oxepine compound
AU1624801A (en) * 1999-11-19 2001-05-30 Corvas International, Inc. Plasminogen activator inhibitor antagonists related applications
PT1477472E (en) * 2002-02-21 2009-03-17 Asahi Kasei Pharma Corp Substituted phenylalkanoic acid derivative and use thereof

Also Published As

Publication number Publication date
KR20080011652A (en) 2008-02-05
CN101151256B (en) 2011-02-09
WO2006129781A1 (en) 2006-12-07
KR101001129B1 (en) 2010-12-14
CN101151256A (en) 2008-03-26
JP5099830B2 (en) 2012-12-19
JPWO2006129781A1 (en) 2009-01-08

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