ATE395074T1 - Autologes thrombin - Google Patents
Autologes thrombinInfo
- Publication number
- ATE395074T1 ATE395074T1 AT00939285T AT00939285T ATE395074T1 AT E395074 T1 ATE395074 T1 AT E395074T1 AT 00939285 T AT00939285 T AT 00939285T AT 00939285 T AT00939285 T AT 00939285T AT E395074 T1 ATE395074 T1 AT E395074T1
- Authority
- AT
- Austria
- Prior art keywords
- thrombin
- clotting
- component
- less
- plasma
- Prior art date
Links
- 108090000190 Thrombin Proteins 0.000 title abstract 5
- 229960004072 thrombin Drugs 0.000 title abstract 5
- 206010053567 Coagulopathies Diseases 0.000 abstract 4
- 230000035602 clotting Effects 0.000 abstract 4
- 239000000853 adhesive Substances 0.000 abstract 2
- 230000001070 adhesive effect Effects 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000283690 Bos taurus Species 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 229940030225 antihemorrhagics Drugs 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 239000002874 hemostatic agent Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000006116 polymerization reaction Methods 0.000 abstract 1
- 239000000565 sealant Substances 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6429—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21005—Thrombin (3.4.21.5)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/328,350 US6472162B1 (en) | 1999-06-04 | 1999-06-04 | Method for preparing thrombin for use in a biological glue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE395074T1 true ATE395074T1 (de) | 2008-05-15 |
Family
ID=23280627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00939285T ATE395074T1 (de) | 1999-06-04 | 2000-06-02 | Autologes thrombin |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6472162B1 (enExample) |
| EP (1) | EP1198242B9 (enExample) |
| JP (1) | JP4860857B2 (enExample) |
| AT (1) | ATE395074T1 (enExample) |
| AU (1) | AU5439400A (enExample) |
| DE (1) | DE60038884D1 (enExample) |
| HK (1) | HK1046241B (enExample) |
| WO (1) | WO2000074713A1 (enExample) |
Families Citing this family (103)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000509307A (ja) * | 1996-04-30 | 2000-07-25 | メドトロニック,インコーポレイテッド | 自己由来フィブリン密封材の製造方法 |
| WO2000062828A1 (en) | 1996-04-30 | 2000-10-26 | Medtronic, Inc. | Autologous fibrin sealant and method for making the same |
| US6942880B1 (en) | 2001-04-09 | 2005-09-13 | Medtronic, Inc. | Autologous platelet gel having beneficial geometric shapes and methods of making the same |
| ATE506929T1 (de) | 2001-06-12 | 2011-05-15 | Univ Johns Hopkins Med | Reservoirvorrichtung für die intraokulare arzneimittelabgabe |
| US6679300B1 (en) * | 2002-01-14 | 2004-01-20 | Thermogenesis Corp. | Biological adhesive loading station and method |
| US8529956B2 (en) | 2002-03-18 | 2013-09-10 | Carnell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
| US8293530B2 (en) * | 2006-10-17 | 2012-10-23 | Carnegie Mellon University | Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
| US20030175410A1 (en) * | 2002-03-18 | 2003-09-18 | Campbell Phil G. | Method and apparatus for preparing biomimetic scaffold |
| US20030205538A1 (en) | 2002-05-03 | 2003-11-06 | Randel Dorian | Methods and apparatus for isolating platelets from blood |
| US7832566B2 (en) | 2002-05-24 | 2010-11-16 | Biomet Biologics, Llc | Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles |
| US7992725B2 (en) | 2002-05-03 | 2011-08-09 | Biomet Biologics, Llc | Buoy suspension fractionation system |
| US20060278588A1 (en) | 2002-05-24 | 2006-12-14 | Woodell-May Jennifer E | Apparatus and method for separating and concentrating fluids containing multiple components |
| US7845499B2 (en) | 2002-05-24 | 2010-12-07 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| DE10392686T5 (de) | 2002-05-24 | 2005-07-07 | Biomet Mfg. Corp., Warsaw | Vorrichtung und Verfahren zum Trennen und Konzentrieren von Flüssigkeiten, welche mehrere Komponenten enthalten |
| US20040120942A1 (en) * | 2002-12-23 | 2004-06-24 | Mcginnis Daniel | Device and process for the preparation of autologous thrombin serum |
| AU2004207261B2 (en) * | 2003-01-27 | 2009-07-09 | Harvest Technologies Inc | Autologous or homologous coagulant produced from anticoagulated whole blood |
| WO2005058207A1 (en) | 2003-12-11 | 2005-06-30 | Isto Technologies, Inc. | Particulate cartilage system |
| CA2579041A1 (en) * | 2004-09-07 | 2006-03-16 | Smith & Nephew, Inc. | Methods and devices for sterile field transfer |
| US8308340B2 (en) | 2004-11-23 | 2012-11-13 | Smith & Nephew, Inc. | Composite mixer |
| PT1848473E (pt) * | 2005-02-07 | 2013-08-28 | Hanuman Llc | Dispositivo concentrador de plasma |
| US7866485B2 (en) | 2005-02-07 | 2011-01-11 | Hanuman, Llc | Apparatus and method for preparing platelet rich plasma and concentrates thereof |
| US7708152B2 (en) | 2005-02-07 | 2010-05-04 | Hanuman Llc | Method and apparatus for preparing platelet rich plasma and concentrates thereof |
| WO2006086199A1 (en) | 2005-02-07 | 2006-08-17 | Hanuman Llc | Platelet rich plasma concentrate apparatus and method |
| US7694828B2 (en) | 2005-04-27 | 2010-04-13 | Biomet Manufacturing Corp. | Method and apparatus for producing autologous clotting components |
| US20070036766A1 (en) * | 2005-08-09 | 2007-02-15 | Sherwin Kevy | Tissue graft composition comprising autologous bone marrow and purified autologous thrombin |
| WO2007025290A2 (en) | 2005-08-26 | 2007-03-01 | Isto Technologies, Inc. | Implants and methods for repair, replacement and treatment of joint disease |
| US20070119508A1 (en) * | 2005-11-29 | 2007-05-31 | West Richard L | Fluid Flow Diversion Valve and Blood Collection System Employing Same |
| US20070154510A1 (en) * | 2005-12-30 | 2007-07-05 | Wilcher Steve A | Adsorbent-Containing Hemostatic Devices |
| US20070154509A1 (en) * | 2005-12-30 | 2007-07-05 | Wilcher Steve A | Adsorbent-Containing Hemostatic Devices |
| US9096839B2 (en) * | 2006-04-26 | 2015-08-04 | Arteriocyte Medical Systems, Inc. | Compositions and methods of preparation thereof |
| US8567609B2 (en) | 2006-05-25 | 2013-10-29 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| WO2008022651A1 (en) | 2006-08-21 | 2008-02-28 | Antoine Turzi | Process and device for the preparation of platelet rich plasma for extemporaneous use and combination thereof with skin and bone cells |
| US20080063697A1 (en) * | 2006-09-08 | 2008-03-13 | Bedard Robert L | Use of Unactivated Calcium Exchanged Zeolites in Hemostatic Devices and Products |
| US8529958B2 (en) | 2006-10-17 | 2013-09-10 | Carmell Therapeutics Corporation | Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom |
| US20080145455A1 (en) * | 2006-12-13 | 2008-06-19 | Bedard Robert L | Combination of Inorganic Hemostatic Agents with Other Hemostatic Agents |
| US8163549B2 (en) | 2006-12-20 | 2012-04-24 | Zimmer Orthobiologics, Inc. | Method of obtaining viable small tissue particles and use for tissue repair |
| JP5479319B2 (ja) | 2007-04-12 | 2014-04-23 | バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー | ブイ式懸濁液分画システム |
| US20090012629A1 (en) | 2007-04-12 | 2009-01-08 | Isto Technologies, Inc. | Compositions and methods for tissue repair |
| US8328024B2 (en) | 2007-04-12 | 2012-12-11 | Hanuman, Llc | Buoy suspension fractionation system |
| US8092837B2 (en) * | 2007-04-27 | 2012-01-10 | Biomet Manufacturing Corp | Fibrin based glue with functionalized hydrophilic polymer protein binding agent |
| US20090047366A1 (en) * | 2007-08-15 | 2009-02-19 | Bedard Robert L | Inorganic Coagulation Accelerators for Individuals taking Platelet Blockers or Anticoagulants |
| US8883194B2 (en) * | 2007-11-09 | 2014-11-11 | Honeywell International, Inc. | Adsorbent-containing hemostatic devices |
| PL2259774T3 (pl) | 2008-02-27 | 2013-04-30 | Biomet Biologics Llc | Sposoby i kompozycje dla wprowadzania antagonisty receptora interleukiny-1 |
| EP2254991B1 (en) | 2008-02-29 | 2018-08-22 | Biomet Manufacturing, LLC | A system and process for separating a material |
| US8642831B2 (en) | 2008-02-29 | 2014-02-04 | Ferrosan Medical Devices A/S | Device for promotion of hemostasis and/or wound healing |
| US8795718B2 (en) * | 2008-05-22 | 2014-08-05 | Honeywell International, Inc. | Functional nano-layered hemostatic material/device |
| US8012077B2 (en) | 2008-05-23 | 2011-09-06 | Biomet Biologics, Llc | Blood separating device |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| CA3045436C (en) | 2009-01-29 | 2025-10-07 | Forsight Vision4, Inc. | ADMINISTRATION OF A MEDICATION IN THE POSTERIOR SEGMENT |
| US8187475B2 (en) | 2009-03-06 | 2012-05-29 | Biomet Biologics, Llc | Method and apparatus for producing autologous thrombin |
| US8313954B2 (en) | 2009-04-03 | 2012-11-20 | Biomet Biologics, Llc | All-in-one means of separating blood components |
| JP5442310B2 (ja) * | 2009-04-23 | 2014-03-12 | 旭化成メディカル株式会社 | トロンビン溶液の調製方法 |
| US9011800B2 (en) | 2009-07-16 | 2015-04-21 | Biomet Biologics, Llc | Method and apparatus for separating biological materials |
| GB201004072D0 (en) | 2010-03-11 | 2010-04-28 | Turzi Antoine | Process, tube and device for the preparation of wound healant composition |
| JP2013522246A (ja) | 2010-03-15 | 2013-06-13 | フェロサン メディカル デバイシーズ エイ/エス | 止血および/または創傷治癒を促進するための方法 |
| US8591391B2 (en) | 2010-04-12 | 2013-11-26 | Biomet Biologics, Llc | Method and apparatus for separating a material |
| US20120027746A1 (en) * | 2010-07-30 | 2012-02-02 | Biomet Biologics, Llc | Method for generating thrombin |
| AU2011285548B2 (en) | 2010-08-05 | 2014-02-06 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
| WO2012019136A2 (en) | 2010-08-05 | 2012-02-09 | Forsight Vision 4, Inc. | Injector apparatus and method for drug delivery |
| US9492315B2 (en) | 2010-08-05 | 2016-11-15 | Forsight Vision4, Inc. | Implantable therapeutic device |
| US20120065600A1 (en) * | 2010-09-10 | 2012-03-15 | E. I. Du Pont De Nemours And Company. | Device for dispensing microliter quantities of a material into a longitudinally extending wound site |
| AU2011329656B2 (en) | 2010-11-19 | 2017-01-05 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| US9011846B2 (en) | 2011-05-02 | 2015-04-21 | Biomet Biologics, Llc | Thrombin isolated from blood and blood fractions |
| EP4249059B1 (en) | 2011-06-28 | 2025-07-30 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
| EP2739252A4 (en) | 2011-08-05 | 2015-08-12 | Forsight Vision4 Inc | SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE |
| US8586324B2 (en) | 2011-08-15 | 2013-11-19 | Biomet Biologics, Llc | Method and apparatus to create autologous clotting serum |
| EP3903733B1 (en) | 2011-09-16 | 2025-08-27 | ForSight Vision4, Inc. | Fluid exchange apparatus |
| GB201118586D0 (en) | 2011-10-27 | 2011-12-07 | Turzi Antoine | New A-PRP medical device, manufacturing machine and process |
| WO2013116061A1 (en) | 2012-02-03 | 2013-08-08 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
| EP2822474B1 (en) | 2012-03-06 | 2018-05-02 | Ferrosan Medical Devices A/S | Pressurized container containing haemostatic paste |
| EP2977066A3 (en) | 2012-06-12 | 2016-07-27 | Ferrosan Medical Devices A/S | Dry haemostatic composition |
| US9642956B2 (en) | 2012-08-27 | 2017-05-09 | Biomet Biologics, Llc | Apparatus and method for separating and concentrating fluids containing multiple components |
| JP6018299B2 (ja) * | 2012-09-25 | 2016-11-02 | ステム セル パートナーズ,エルエルシー | 単一ドナーのトロンビン血清を調製する方法および機器 |
| US20140178343A1 (en) | 2012-12-21 | 2014-06-26 | Jian Q. Yao | Supports and methods for promoting integration of cartilage tissue explants |
| WO2014152959A1 (en) | 2013-03-14 | 2014-09-25 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
| US9895418B2 (en) | 2013-03-15 | 2018-02-20 | Biomet Biologics, Llc | Treatment of peripheral vascular disease using protein solutions |
| US10208095B2 (en) | 2013-03-15 | 2019-02-19 | Biomet Manufacturing, Llc | Methods for making cytokine compositions from tissues using non-centrifugal methods |
| US10143725B2 (en) | 2013-03-15 | 2018-12-04 | Biomet Biologics, Llc | Treatment of pain using protein solutions |
| US9950035B2 (en) | 2013-03-15 | 2018-04-24 | Biomet Biologics, Llc | Methods and non-immunogenic compositions for treating inflammatory disorders |
| US20140271589A1 (en) | 2013-03-15 | 2014-09-18 | Biomet Biologics, Llc | Treatment of collagen defects using protein solutions |
| US9526654B2 (en) | 2013-03-28 | 2016-12-27 | Forsight Vision4, Inc. | Ophthalmic implant for delivering therapeutic substances |
| WO2014202760A2 (en) | 2013-06-21 | 2014-12-24 | Ferrosan Medical Devices A/S | Vacuum expanded dry composition and syringe for retaining same |
| BR112016013322B1 (pt) | 2013-12-11 | 2020-07-21 | Ferrosan Medical Devices A/S | métodos para preparação de uma composição seca e para reconstituir uma composição seca, composição seca, uso de uma composição seca, e, kit |
| US9550028B2 (en) | 2014-05-06 | 2017-01-24 | Biomet Biologics, LLC. | Single step desiccating bead-in-syringe concentrating device |
| MX384889B (es) | 2014-07-15 | 2025-03-14 | Forsight Vision4 Inc | Dispositivo y metodo de entrega de implante ocular. |
| RU2017105844A (ru) | 2014-08-08 | 2018-09-11 | Форсайт Вижн4, Инк. | Стабильные и растворимые составы ингибиторов рецепторных тирозинкиназ и способы их получения |
| AU2015333206B2 (en) | 2014-10-13 | 2019-07-11 | Ferrosan Medical Devices A/S. | Dry composition for use in haemostasis and wound healing |
| AU2015346450B2 (en) | 2014-11-10 | 2020-01-30 | Forsight Vision4, Inc. | Expandable drug delivery devices and method of use |
| GB201421013D0 (en) | 2014-11-26 | 2015-01-07 | Turzi Antoine | New standardizations & medical devices for the preparation of platelet rich plasma (PRP) or bone marrow centrate (BMC) |
| EP3237041B1 (en) | 2014-12-24 | 2020-01-29 | Ferrosan Medical Devices A/S | Syringe for retaining and mixing first and second substances |
| US9713810B2 (en) | 2015-03-30 | 2017-07-25 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| US9757721B2 (en) | 2015-05-11 | 2017-09-12 | Biomet Biologics, Llc | Cell washing plunger using centrifugal force |
| CA2986981A1 (en) | 2015-07-03 | 2017-01-12 | Ferrosan Medical Devices A/S | Syringe for mixing two components and for retaining a vacuum in a storage condition |
| CN113069681B (zh) | 2015-11-20 | 2022-12-23 | 弗赛特影像4股份有限公司 | 制造用于缓释药物递送的治疗装置的方法 |
| EP3439591B1 (en) | 2016-04-05 | 2020-09-23 | ForSight Vision4, Inc. | Implantable ocular drug delivery devices |
| RU169564U1 (ru) * | 2016-07-01 | 2017-03-23 | Общество с ограниченной ответственностью "Центр инновационных разработок Вирави" (ООО "Вирави") | Устройство для получения свертывающихся и адгезивных белков |
| CN111295094A (zh) | 2017-10-09 | 2020-06-16 | 泰尔茂比司特生物技术有限公司 | 冻干容器及使用冻干容器的方法 |
| JP7314155B2 (ja) | 2017-11-21 | 2023-07-25 | フォーサイト・ビジョン4・インコーポレーテッド | 膨張可能ポート送達システムのための流体交換装置及びその使用方法 |
| EP3790600B1 (en) | 2018-05-09 | 2023-12-27 | Ferrosan Medical Devices A/S | Method for preparing a haemostatic composition |
| US12440835B2 (en) | 2019-01-21 | 2025-10-14 | Vias Partners, Llc | Methods, systems and apparatus for separating components of a biological sample |
| WO2020242552A1 (en) | 2019-03-14 | 2020-12-03 | Terumo Bct Biotechnologies, Llc | Multi-part lyophilization container and method of use |
| US12007382B2 (en) | 2019-10-31 | 2024-06-11 | Crown Laboratories, Inc. | Systems, methods and apparatus for separating components of a sample |
| USD1033637S1 (en) | 2022-01-24 | 2024-07-02 | Forsight Vision4, Inc. | Fluid exchange device |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE25913C (de) | A. ZDARIL in Prag, Graben 6 neu | Apparat zur Behandlung der Zähne bei Wurzelhautentzündungen | ||
| US713017A (en) | 1901-03-08 | 1902-11-04 | Walter H Pumphrey | Syringe. |
| US1614532A (en) | 1921-02-26 | 1927-01-18 | Joseph Reed Littell | Means for applying liquid medicaments under pressure action |
| US2533004A (en) | 1943-10-27 | 1950-12-05 | John D Ferry | Fibrin clots and methods for preparing the same |
| CH259254A (de) | 1945-12-28 | 1949-01-15 | Szent Gyorgyi Albert Dr | Verfahren zur Herstellung von Thrombin aus Blut. |
| US2747936A (en) | 1953-11-17 | 1956-05-29 | Spraying Systems Co | Whirl spray nozzle |
| US3223083A (en) | 1960-09-09 | 1965-12-14 | President And Directors Of Geo | Method for adhesively securing together skin and other soft tissue and bone |
| US3179107A (en) | 1962-11-21 | 1965-04-20 | Becton Dickinson Co | Hypodermic unit with an improved mounting for a replaceable needle assembly |
| US3269389A (en) | 1963-03-11 | 1966-08-30 | Bernard L Meurer | Compartmental dispensing container for nose and throat preparations |
| US3236457A (en) | 1963-08-21 | 1966-02-22 | John R Kennedy | Composite spray container assembly |
| US3467096A (en) | 1966-04-12 | 1969-09-16 | Ferrell S Horn | Multiple hypodermic syringe arrangement |
| US3416737A (en) | 1967-04-05 | 1968-12-17 | Risdon Mfg Co | Mechanical break-up spray button |
| US3945574A (en) | 1972-07-24 | 1976-03-23 | Polnauer Frederick F | Dual orifice spray nozzle using two swirl chambers |
| US3828980A (en) | 1972-11-06 | 1974-08-13 | Chem Dev Corp | Dispenser for precisely metered dispensing of viscous fluids |
| US3942725A (en) | 1975-01-03 | 1976-03-09 | Green Edward | Sprayhead for swirling spray |
| AT341649B (de) | 1975-08-07 | 1978-02-27 | Immuno Ag | Injektionsspritze |
| US4040420A (en) | 1976-04-22 | 1977-08-09 | General Dynamics | Packaging and dispensing kit |
| US4109653A (en) | 1977-02-22 | 1978-08-29 | George Kozam | Successive delivery multiple barrel syringe |
| US4265233A (en) | 1978-04-12 | 1981-05-05 | Unitika Ltd. | Material for wound healing |
| AT359652B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| US4374830A (en) | 1979-10-04 | 1983-02-22 | Research Corp. | Platelet aggregating material from equine arterial tissue |
| AT366916B (de) | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| US4363319A (en) | 1980-06-30 | 1982-12-14 | Applied Medical Devices, Inc. | Ready-to-use bandage incorporating a coagulant composition and method of preparing same |
| DE3105624A1 (de) | 1981-02-16 | 1982-09-02 | Hormon-Chemie München GmbH, 8000 München | Material zum abdichten und heilen von wunden |
| ATE20824T1 (de) | 1981-06-25 | 1986-08-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundheilung. |
| ATE13810T1 (de) | 1981-06-25 | 1985-07-15 | Serapharm Gmbh & Co Kg | Angereichertes plasmaderivat zur unterstuetzung von wundverschluss und wundabdeckung. |
| US4442655A (en) | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
| AT379311B (de) | 1984-03-29 | 1985-12-27 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| JPS6144825A (ja) | 1984-08-09 | 1986-03-04 | Unitika Ltd | 止血剤 |
| US4627879A (en) | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
| EP0189900B1 (en) | 1985-01-29 | 1989-04-05 | Fuji Photo Film Co., Ltd. | Duplex pipette |
| AT382783B (de) | 1985-06-20 | 1987-04-10 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| US4696812A (en) | 1985-10-28 | 1987-09-29 | Warner-Lambert Company | Thrombin preparations |
| DE3614515A1 (de) | 1986-04-29 | 1987-11-05 | Pfeiffer Erich Gmbh & Co Kg | Austragvorrichtung fuer medien |
| FR2602089B1 (fr) | 1986-07-23 | 1988-10-21 | Radiotechnique Compelec | Court-circuit escamotable et utilisation de ce court-circuit dans un tube photoelectrique |
| US4714457A (en) | 1986-09-15 | 1987-12-22 | Robert Alterbaum | Method and apparatus for use in preparation of fibrinogen from a patient's blood |
| DK475386D0 (da) | 1986-10-03 | 1986-10-03 | Weis Fogh Ulla Sivertsen | Fremgangsmaade og apparat til fremstilling af biologiske stoffer |
| US5352664A (en) | 1986-10-31 | 1994-10-04 | Board Of Regents, The University Of Texas System | Thrombin derived polypeptides; compositions and methods for use |
| US4767416A (en) | 1986-12-01 | 1988-08-30 | Johnson & Johnson Patient Care, Inc. | Spray nozzle for syringe |
| US4965203A (en) | 1987-01-28 | 1990-10-23 | Warner-Lambert Company | Purified thrombin preparations |
| JPS63243032A (ja) | 1987-03-27 | 1988-10-07 | Green Cross Corp:The | トロンビンの加熱処理方法 |
| JPS6440433A (en) | 1987-08-05 | 1989-02-10 | Green Cross Corp | Aqueous liquid composition of thrombin |
| US4752466A (en) | 1987-08-31 | 1988-06-21 | Johnson & Johnson Products, Inc. | Thrombin aerosol |
| US4842581A (en) | 1987-09-11 | 1989-06-27 | Davis Richard C | Medical lavage apparatus |
| US4978336A (en) | 1987-09-29 | 1990-12-18 | Hemaedics, Inc. | Biological syringe system |
| DE3734923C1 (de) | 1987-10-15 | 1989-01-26 | Biotest Pharma Gmbh | Verfahren zur Herstellung einer sterilen Plasmaproteinloesung,die Fibrinogen und den Gerinnungsfaktor XIII enthaelt |
| SU1527261A1 (ru) | 1988-03-21 | 1989-12-07 | Институт Химической И Биологической Физики Ан Эсср | Способ получени тромбина |
| US5290552A (en) | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| AT397203B (de) | 1988-05-31 | 1994-02-25 | Immuno Ag | Gewebeklebstoff |
| US4874368A (en) | 1988-07-25 | 1989-10-17 | Micromedics, Inc. | Fibrin glue delivery system |
| US4902281A (en) | 1988-08-16 | 1990-02-20 | Corus Medical Corporation | Fibrinogen dispensing kit |
| US5165928A (en) | 1988-11-14 | 1992-11-24 | Cornell Research Foundation, Inc. | Biological control of phytophthora by gliocladium |
| FR2639958B1 (fr) | 1988-12-06 | 1992-08-21 | Lille Transfusion Sanguine | Support biologique pour cultures cellulaires constitue de proteines plasmatiques coagulees par la thrombine, son utilisation pour la culture des keratinocytes, leur recuperation et leur transport a des fins d'utilisation therapeutique |
| DE3843126C3 (de) | 1988-12-22 | 1994-10-06 | Octapharma Ag | Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates |
| US5226877A (en) | 1989-06-23 | 1993-07-13 | Epstein Gordon H | Method and apparatus for preparing fibrinogen adhesive from whole blood |
| US5138034A (en) * | 1989-07-12 | 1992-08-11 | The Green Cross Corporation | Method of fractionating plasma proteins |
| US5116315A (en) | 1989-10-03 | 1992-05-26 | Hemaedics, Inc. | Biological syringe system |
| US5104375A (en) | 1989-10-16 | 1992-04-14 | Johnson & Johnson Medical, Inc. | Locking holder for a pair of syringes and method of use |
| US4979942A (en) | 1989-10-16 | 1990-12-25 | Johnson & Johnson Medical, Inc. | Two component syringe delivery system |
| US5037390A (en) | 1989-12-28 | 1991-08-06 | Kenneth Raines | System and method for mixing parenteral nutrition solutions |
| US5219328A (en) | 1990-01-03 | 1993-06-15 | Cryolife, Inc. | Fibrin sealant delivery method |
| US5318524A (en) | 1990-01-03 | 1994-06-07 | Cryolife, Inc. | Fibrin sealant delivery kit |
| US5646265A (en) | 1990-01-11 | 1997-07-08 | Isis Pharmceuticals, Inc. | Process for the preparation of 2'-O-alkyl purine phosphoramidites |
| US5185001A (en) | 1990-01-18 | 1993-02-09 | The Research Foundation Of State University Of New York | Method of preparing autologous plasma fibrin and application apparatus therefor |
| IE73210B1 (en) | 1990-01-24 | 1997-05-07 | Warner Lambert Co | Process for the production of thrombin and high purity thrombin preparation thereby obtained |
| EP0443724B1 (en) | 1990-02-20 | 1999-03-17 | Baxter International Inc. | Viral-safe purified human thrombin |
| DK119490D0 (da) | 1990-05-14 | 1990-05-14 | Unes As | Apparat til fremstilling af et koncentrat af koagulationsfaktorer, saasom fibrinogen, fra en blodportion |
| JP3134079B2 (ja) * | 1990-06-08 | 2001-02-13 | サントル レジョナル ド トランスヒュジオン サンギーヌ ド リル | トロンビンにより凝固した血漿蛋白質により構成された角化細胞培養物のための生物学的支持体、並びに角化細胞培養物を調製し、回収し、治療目的のために移送することにおいて上記支持体を用いる方法 |
| US5089415A (en) | 1990-09-17 | 1992-02-18 | International Technidyne Corp. | Method for clotting heparized blood by the addition of protamine, thrombin and snake venom |
| DE69122376D1 (de) | 1991-03-28 | 1996-10-31 | Warner Lambert Co | Hochreine Thrombinzubereitung |
| US5460945A (en) | 1991-05-30 | 1995-10-24 | Center For Blood Research, Inc. | Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response |
| US5232024A (en) | 1991-05-30 | 1993-08-03 | Eli Williams | Slide-valve manifold |
| FR2679251B1 (fr) * | 1991-07-18 | 1993-11-12 | Nord Assoc Essor Transfusion San | Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique. |
| EP0534178B1 (en) | 1991-09-27 | 2001-04-18 | Omrix Biopharmaceuticals S.A. | Improved tissue glue prepared by using cryoprecipitate |
| US5368563A (en) | 1991-12-18 | 1994-11-29 | Micromedics, Inc. | Sprayer assembly for physiologic glue |
| AT396937B (de) | 1992-04-06 | 1993-12-27 | Immuno Ag | Verfahren zur aktivierung von blutgerinnungsfaktoren |
| DK83092D0 (da) | 1992-06-24 | 1992-06-24 | Unes As | Fremgangsmaade til udvinding af thrombin |
| US5344039A (en) | 1992-09-08 | 1994-09-06 | Yoshihiko Taniyama | Storage container |
| US5443959A (en) | 1992-09-09 | 1995-08-22 | Tokuyama Corporation | Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof |
| CN1091315A (zh) | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| US5290259A (en) | 1993-02-18 | 1994-03-01 | Ultradent Products, Inc. | Double syringe delivery system |
| US5330974A (en) | 1993-03-01 | 1994-07-19 | Fibratek, Inc. | Therapeutic fibrinogen compositions |
| US5795780A (en) * | 1993-06-23 | 1998-08-18 | Bristol-Myers Squibb Company | Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes |
| US5328462A (en) | 1993-09-03 | 1994-07-12 | Ultradent Products, Inc. | Methods and apparatus for mixing and dispensing multi-part compositions |
| US5578459A (en) | 1993-11-24 | 1996-11-26 | Abbott Laboratories | Method and apparatus for collecting a cell sample from a liquid specimen |
| US5411885A (en) | 1993-12-17 | 1995-05-02 | New York Blood Center, Inc. | Methods for tissue embedding and tissue culturing |
| ATE241340T1 (de) | 1994-02-17 | 2003-06-15 | New York Blood Ct Inc | Biologische bioadhäsive präparate, die fibrinkleber und liposomen enthalten, verfahren für ihre herstellung und verwendung |
| US5474540A (en) | 1994-03-25 | 1995-12-12 | Micromedics, Inc. | Fluid separation control attachment for physiologic glue applicator |
| US5506127A (en) | 1994-09-21 | 1996-04-09 | Proba; Zbigniew | Therapeutic grade thrombin produced by chromatography |
| US5585007A (en) * | 1994-12-07 | 1996-12-17 | Plasmaseal Corporation | Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant |
| US5575779A (en) | 1994-12-30 | 1996-11-19 | Namic U.S.A. Corporation | Liquid regulator and method of use |
| US5614204A (en) | 1995-01-23 | 1997-03-25 | The Regents Of The University Of California | Angiographic vascular occlusion agents and a method for hemostatic occlusion |
| US5510102A (en) | 1995-01-23 | 1996-04-23 | The Regents Of The University Of California | Plasma and polymer containing surgical hemostatic adhesives |
| US5643192A (en) | 1995-04-06 | 1997-07-01 | Hamilton Civic Hospitals Research Development, Inc. | Autologous fibrin glue and methods for its preparation and use |
| JP3944267B2 (ja) * | 1996-08-09 | 2007-07-11 | 財団法人化学及血清療法研究所 | プロトロンビンの活性化方法および該方法に基づくトロンビンの製造方法 |
| CA2295247C (en) * | 1997-06-18 | 2009-05-26 | Cohesion Technologies, Inc. | Compositions containing thrombin and microfibrillar collagen |
| AU2900599A (en) | 1998-03-10 | 1999-09-27 | Baxter International Inc. | Thrombin preparation and products and fibrin sealant methods employing same |
| US6274090B1 (en) * | 1998-08-05 | 2001-08-14 | Thermogenesis Corp. | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby |
| US6060461A (en) * | 1999-02-08 | 2000-05-09 | Drake; James Franklin | Topically applied clotting material |
-
1999
- 1999-06-04 US US09/328,350 patent/US6472162B1/en not_active Expired - Lifetime
-
2000
- 2000-06-02 JP JP2001501247A patent/JP4860857B2/ja not_active Expired - Lifetime
- 2000-06-02 AT AT00939285T patent/ATE395074T1/de not_active IP Right Cessation
- 2000-06-02 WO PCT/US2000/011865 patent/WO2000074713A1/en not_active Ceased
- 2000-06-02 DE DE60038884T patent/DE60038884D1/de not_active Expired - Lifetime
- 2000-06-02 EP EP00939285A patent/EP1198242B9/en not_active Expired - Lifetime
- 2000-06-02 HK HK02107715.7A patent/HK1046241B/en not_active IP Right Cessation
- 2000-06-02 AU AU54394/00A patent/AU5439400A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1198242B9 (en) | 2008-09-03 |
| EP1198242A4 (en) | 2004-12-29 |
| DE60038884D1 (en) | 2008-06-26 |
| JP4860857B2 (ja) | 2012-01-25 |
| HK1046241A1 (en) | 2003-01-03 |
| HK1046241B (en) | 2009-06-05 |
| US6472162B1 (en) | 2002-10-29 |
| JP2004500026A (ja) | 2004-01-08 |
| WO2000074713A1 (en) | 2000-12-14 |
| AU5439400A (en) | 2000-12-28 |
| EP1198242A1 (en) | 2002-04-24 |
| EP1198242B1 (en) | 2008-05-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE395074T1 (de) | Autologes thrombin | |
| AU5459199A (en) | Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby | |
| Mazzucco et al. | Platelet‐rich plasma and platelet gel preparation using Plateltex® | |
| Hartman et al. | Autologous whole plasma fibrin gel: intraoperative procurement | |
| RU2130946C1 (ru) | Способ получения биологического клея, изготовленного из концентрированных коагулирующих факторов посредством "высаливания" | |
| DK1294414T3 (da) | Præparat og fremgangsmåde til heling og regenerering af brusk og andre væv | |
| Valbonesi | Fibrin glues of human origin | |
| DE69922362D1 (de) | Methode zur präparation eines diafiltrierten stabilen blutproduktes | |
| Valbonesi et al. | The role of autologous fibrin-platelet glue in plastic surgery: a preliminary report | |
| Lee et al. | Haemophilia and advanced fibrin sealant technologies | |
| Burnouf et al. | Blood‐derived biomaterials: fibrin sealant, platelet gel and platelet fibrin glue | |
| AU2024205654A1 (en) | Viral infections- treatment with convalescent plasma/serum | |
| JPH02129224A (ja) | フィブリンの製造法 | |
| Burnouf et al. | Viral safety of human platelet lysate for cell therapy and regenerative medicine: moving forward, yes, but without forgetting the past | |
| Dahlstrøm et al. | The use of autologous fibrin adhesive in skin transplantation | |
| NO316155B1 (no) | Forbedret vevslim fremstilt ved anvendelse av kryopresipitat, fremgangsmåtefor fremstilling derav, samt anvendelse av en mengde avproteaseinhibitor | |
| ATE300310T1 (de) | Verfahren zur steigerung von hematopoietischen zellen | |
| Chou et al. | Current methods to manufacture human platelet lysates for cell therapy and tissue engineering: possible trends in product safety and standardization | |
| Burnouf | Platelet gels | |
| Adant et al. | Skin grafting with fibrin glue in burns | |
| Galois et al. | Autologous bone marrow graft and treatment of delayed and non-unions of long bones: technical aspects | |
| Burnouf-Radosevich et al. | Biological and Rheological Properties of a Virally Inactivated Fibrin Glue (Biocol®): Comparison to an Autologous Fibrin Glue | |
| Kale et al. | Role of platelet rich plasma gel in tissue regeneration-A review. | |
| Trowbridge | Fibrin Glue and Platelet Gel | |
| Adant et al. | Skin grafting with fibrin glue in burns |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |