JP4860857B2 - 自己由来トロンビン - Google Patents

自己由来トロンビン Download PDF

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Publication number
JP4860857B2
JP4860857B2 JP2001501247A JP2001501247A JP4860857B2 JP 4860857 B2 JP4860857 B2 JP 4860857B2 JP 2001501247 A JP2001501247 A JP 2001501247A JP 2001501247 A JP2001501247 A JP 2001501247A JP 4860857 B2 JP4860857 B2 JP 4860857B2
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Japan
Prior art keywords
thrombin
plasma
cacl
prothrombin
solution
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Expired - Lifetime
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JP2001501247A
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English (en)
Japanese (ja)
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JP2004500026A5 (enExample
JP2004500026A (ja
Inventor
コエロ，フィリップ，エイチ．
キングスレー，フィル
ブローシュ，ジム
ゴッドセイ，ジェームス，エイチ．
ロック，ゲイル
マドセン，トリスタ，ケー．
ビー． フロスト，ソナ，
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サーモジェネシス コーポレーション
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Publication of JP2004500026A5 publication Critical patent/JP2004500026A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2001501247A 1999-06-04 2000-06-02 自己由来トロンビン Expired - Lifetime JP4860857B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/328,350 US6472162B1 (en) 1999-06-04 1999-06-04 Method for preparing thrombin for use in a biological glue
US09/328,350 1999-06-04
PCT/US2000/011865 WO2000074713A1 (en) 1999-06-04 2000-06-02 Autologous thrombin

Publications (3)

Publication Number Publication Date
JP2004500026A JP2004500026A (ja) 2004-01-08
JP2004500026A5 JP2004500026A5 (enExample) 2010-11-11
JP4860857B2 true JP4860857B2 (ja) 2012-01-25

Family

ID=23280627

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2001501247A Expired - Lifetime JP4860857B2 (ja) 1999-06-04 2000-06-02 自己由来トロンビン

Country Status (8)

Country Link
US (1) US6472162B1 (enExample)
EP (1) EP1198242B9 (enExample)
JP (1) JP4860857B2 (enExample)
AT (1) ATE395074T1 (enExample)
AU (1) AU5439400A (enExample)
DE (1) DE60038884D1 (enExample)
HK (1) HK1046241B (enExample)
WO (1) WO2000074713A1 (enExample)

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WO2000074713A1 (en) 2000-12-14
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US6472162B1 (en) 2002-10-29
EP1198242B1 (en) 2008-05-14
EP1198242A4 (en) 2004-12-29
HK1046241A1 (en) 2003-01-03
HK1046241B (en) 2009-06-05
EP1198242B9 (en) 2008-09-03
AU5439400A (en) 2000-12-28
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