DE69922362D1 - Methode zur präparation eines diafiltrierten stabilen blutproduktes - Google Patents

Methode zur präparation eines diafiltrierten stabilen blutproduktes

Info

Publication number
DE69922362D1
DE69922362D1 DE69922362T DE69922362T DE69922362D1 DE 69922362 D1 DE69922362 D1 DE 69922362D1 DE 69922362 T DE69922362 T DE 69922362T DE 69922362 T DE69922362 T DE 69922362T DE 69922362 D1 DE69922362 D1 DE 69922362D1
Authority
DE
Germany
Prior art keywords
platelets
diafiltration
paraformaldehyde
lyophilization
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69922362T
Other languages
English (en)
Other versions
DE69922362T2 (de
Inventor
Louis Summaria
Nathan Roth
Aberash Berhe
Mark Even
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Behring LLC
Original Assignee
ZLB Behring LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ZLB Behring LLC filed Critical ZLB Behring LLC
Publication of DE69922362D1 publication Critical patent/DE69922362D1/de
Application granted granted Critical
Publication of DE69922362T2 publication Critical patent/DE69922362T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0017—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3413—Diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Anesthesiology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • External Artificial Organs (AREA)
DE69922362T 1998-04-27 1999-02-26 Methode zur präparation eines diafiltrierten stabilen blutproduktes Expired - Lifetime DE69922362T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US66694 1998-04-27
US09/066,694 US6139878A (en) 1998-04-27 1998-04-27 Method for preparing a diafiltered stabilized blood product
PCT/US1999/003718 WO1999055346A1 (en) 1998-04-27 1999-02-26 Method for preparing a diafiltered stabilized blood product

Publications (2)

Publication Number Publication Date
DE69922362D1 true DE69922362D1 (de) 2005-01-05
DE69922362T2 DE69922362T2 (de) 2005-12-01

Family

ID=22071098

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69922362T Expired - Lifetime DE69922362T2 (de) 1998-04-27 1999-02-26 Methode zur präparation eines diafiltrierten stabilen blutproduktes

Country Status (10)

Country Link
US (1) US6139878A (de)
EP (1) EP1073443B1 (de)
JP (2) JP5042405B2 (de)
KR (1) KR100609262B1 (de)
AT (1) ATE283699T1 (de)
AU (1) AU760292B2 (de)
CA (1) CA2330389C (de)
DE (1) DE69922362T2 (de)
ES (1) ES2233024T3 (de)
WO (1) WO1999055346A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19964109A1 (de) * 1999-12-29 2001-07-05 Dade Behring Marburg Gmbh Gebrauchsfertiges langzeitstabiles Ristocetin Cofaktor Testreagenz
US20020131958A1 (en) * 2001-01-22 2002-09-19 John Chapman Method for purifying a biological composition
WO2003090794A1 (en) * 2002-04-26 2003-11-06 Gambro, Inc. Solution containing platelet activation inhibitors for pathogen reducing and storing blood platelets
CA2501196A1 (en) * 2002-10-10 2004-04-22 Becton, Dickinson And Company Sample collection system with caspase inhibitor
US7294455B2 (en) 2003-05-16 2007-11-13 The University Of North Carolina At Chapel Hill Fixed-dried platelets cross-linked to protein
DE102004018347A1 (de) * 2004-04-06 2005-10-27 Manfred Dr. Schmolz Wundheilungsfördende Botenstoffmischung
US20100221697A1 (en) * 2005-01-12 2010-09-02 BioVec Transfusions, LLC Composition for preserving platelets and method of using and storing the same
AU2006294654B2 (en) * 2005-09-26 2012-05-24 Lifecell Corporation Dry platelet composition
US8277837B2 (en) 2006-01-11 2012-10-02 Entegrion, Inc. Hemostatic textile
US9095818B2 (en) * 2009-06-15 2015-08-04 Biovec Transfusion, Llc Method of filtering platelets to remove antiplatelet and anticoagulant agents
US8431334B2 (en) * 2006-01-12 2013-04-30 Biovec Transfusion, Llc Method for removing antiplatelet agent and anticoagulant from a platelet composition by diafiltration
EP1902740A1 (de) * 2006-09-19 2008-03-26 Maco Pharma S.A. Blutbeutelsystem und Verfahren, um Pathogene in Blutplättchenkonzentraten mit Hilfe des Blutbeutelsystems zu neutralisieren
NZ586316A (en) 2007-12-28 2012-06-29 Baxter Int Counter-pressure filtration of proteins
EP2598660B1 (de) 2010-07-26 2017-03-15 Biomatrica, INC. Zusammensetzungen zur stabilisierung von dna, rna und proteinen in blut- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen
WO2012071135A2 (en) * 2010-11-23 2012-05-31 Biovec Transfusion, Llc Methods for removing pathogens from a platelet preparation
BR112014018970A8 (pt) * 2012-02-02 2017-07-11 Becton Dickinson Co Dispositivos de coleta de amostra com agentes de estabilização sanguínea
EP2834635A4 (de) 2012-04-03 2015-09-02 Smiths Medical Asd Inc Zusammensetzungen mit einem heparinakkumulationsmittel und verfahren dafür
EP3154338B1 (de) * 2014-06-10 2020-01-29 Biomatrica, INC. Stabilisierung von thrombozyten bei umgebungstemperatur
JP6875619B2 (ja) * 2015-02-26 2021-05-26 株式会社細胞応用技術研究所 多血小板血漿の保存方法
CN108700498B (zh) 2015-12-08 2021-07-13 生物马特里卡公司 降低红细胞沉降速率
US20190254273A1 (en) * 2016-06-08 2019-08-22 Cfgenome, Llc A chemical composition to stabilize extracellular vesicles in a blood sample and method of use thereof
CN111295094A (zh) 2017-10-09 2020-06-16 泰尔茂比司特生物技术有限公司 冻干容器及使用冻干容器的方法
EP3886879A4 (de) 2018-11-30 2022-12-07 Cellphire Inc. Thrombozyten als freisetzungsmittel
CA3121200A1 (en) 2018-11-30 2020-06-04 Cellphire, Inc. Platelets as delivery agents
JP2022525742A (ja) 2019-03-14 2022-05-19 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー 凍結乾燥用ローディングトレイ組立体及びシステム
CN114072159A (zh) 2019-05-03 2022-02-18 塞尔菲乐有限公司 用于生产血液产品的材料和方法
BR112022002892A2 (pt) 2019-08-16 2022-05-24 Cellphire Inc Trombossomos como um agente de reversão de agente antiplaqueta
US20210299179A1 (en) 2020-02-04 2021-09-30 Cellphire, Inc. Methods of treating congenital hemophilia with anti-fibrinolytic loaded platelets

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
JPS54126716A (en) * 1978-03-20 1979-10-02 Asahi Chem Ind Co Ltd Separation of platelet
JPS5762222A (en) * 1980-10-03 1982-04-15 Asahi Chem Ind Co Ltd Preparation of concentrated solution of platelet, its device and part
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
DE3245591C2 (de) * 1982-12-09 1986-11-06 Schott Glaswerke, 6500 Mainz Verfahren zur fraktionierten Auftrennung von Stoffgemischen mit Membranen
DE3444671A1 (de) * 1984-12-07 1986-06-12 Fresenius AG, 6380 Bad Homburg Haemodiafiltrationsgeraet
WO1986005410A1 (en) * 1985-03-13 1986-09-25 Baxter Travenol Laboratories, Inc. Platelet collection system
US4728430A (en) * 1986-02-10 1988-03-01 Millipore Corporation Diafiltration method
JPH01121061A (ja) * 1987-11-05 1989-05-12 Nissho Corp 血小板分離フィルター
US5213814A (en) * 1989-04-10 1993-05-25 Cryopharm Corporation Lyophilized and reconstituted blood platelet compositions
EP0642301B1 (de) * 1992-05-29 2003-03-12 The University Of North Carolina At Chapel Hill Im immobilisierten zustand getrocknete pharmazeutische verträgliche menschliche blutplättchen
US5403272A (en) * 1992-05-29 1995-04-04 Baxter International Inc. Apparatus and methods for generating leukocyte free platelet concentrate
JP3356834B2 (ja) * 1993-08-23 2002-12-16 テルモ株式会社 創傷治癒材
AU705225B2 (en) * 1995-03-23 1999-05-20 Biopure Corporation Stable polymerized hemoglobin blood substitute
US5808011A (en) * 1996-07-01 1998-09-15 Biopure Corporation Method for chromatographic removal of prions
JP4107519B2 (ja) * 1997-08-27 2008-06-25 旭化成クラレメディカル株式会社 リンス液定量装置付細胞分離セット

Also Published As

Publication number Publication date
CA2330389C (en) 2012-05-15
AU2777799A (en) 1999-11-16
ES2233024T3 (es) 2005-06-01
EP1073443A1 (de) 2001-02-07
WO1999055346A1 (en) 1999-11-04
EP1073443B1 (de) 2004-12-01
ATE283699T1 (de) 2004-12-15
KR20010071184A (ko) 2001-07-28
DE69922362T2 (de) 2005-12-01
EP1073443A4 (de) 2003-03-19
KR100609262B1 (ko) 2006-08-04
JP5042405B2 (ja) 2012-10-03
JP2002512968A (ja) 2002-05-08
US6139878A (en) 2000-10-31
AU760292B2 (en) 2003-05-08
CA2330389A1 (en) 1999-11-04
JP2012144556A (ja) 2012-08-02

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: CSL BEHRING L.L.C., KING OF PRUSSIA, PA., US