ATE387438T1 - Neue 1,2,4-triazolverbindung - Google Patents

Neue 1,2,4-triazolverbindung

Info

Publication number
ATE387438T1
ATE387438T1 AT02781876T AT02781876T ATE387438T1 AT E387438 T1 ATE387438 T1 AT E387438T1 AT 02781876 T AT02781876 T AT 02781876T AT 02781876 T AT02781876 T AT 02781876T AT E387438 T1 ATE387438 T1 AT E387438T1
Authority
AT
Austria
Prior art keywords
new
triazole compound
triazole
compound
Prior art date
Application number
AT02781876T
Other languages
English (en)
Inventor
Hiroshi Nakamura
Soichi Kaneda
Takahiro Sato
Naoki Ashizawa
Koji Matsumoto
Takashi Iwanaga
Tsutomu Inoue
Original Assignee
Fuji Yakuhin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Yakuhin Co Ltd filed Critical Fuji Yakuhin Co Ltd
Application granted granted Critical
Publication of ATE387438T1 publication Critical patent/ATE387438T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
    • C07D311/16—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT02781876T 2002-01-28 2002-12-03 Neue 1,2,4-triazolverbindung ATE387438T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002017825 2002-01-28

Publications (1)

Publication Number Publication Date
ATE387438T1 true ATE387438T1 (de) 2008-03-15

Family

ID=27653386

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02781876T ATE387438T1 (de) 2002-01-28 2002-12-03 Neue 1,2,4-triazolverbindung

Country Status (22)

Country Link
US (1) US7074816B2 (de)
EP (1) EP1471065B1 (de)
JP (1) JP3600832B2 (de)
CN (1) CN1561340B (de)
AR (1) AR042602A1 (de)
AT (1) ATE387438T1 (de)
AU (1) AU2002349754B2 (de)
BR (1) BRPI0212775B8 (de)
CA (1) CA2462132C (de)
DE (1) DE60225341T2 (de)
DK (1) DK1471065T3 (de)
ES (1) ES2300486T3 (de)
HK (1) HK1067132A1 (de)
MX (1) MXPA04004037A (de)
NO (1) NO326941B1 (de)
NZ (1) NZ531673A (de)
PL (1) PL208260B1 (de)
PT (1) PT1471065E (de)
RU (1) RU2293733C2 (de)
TW (1) TWI257926B (de)
WO (1) WO2003064410A1 (de)
ZA (1) ZA200401777B (de)

Families Citing this family (47)

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WO2005009991A1 (ja) * 2003-07-24 2005-02-03 Fujiyakuhin Co., Ltd. １，２，４−トリアゾール化合物の製造方法及びその中間体
US20060189811A1 (en) * 2004-07-23 2006-08-24 Fujiyakuhin Co., Ltd. Process for producing 1,2,4-triazole compound and intermediate therefor
JP2008545627A (ja) * 2005-05-09 2008-12-18 タツプ・フアーマシユーテイカル・プロダクツ・インコーポレイテツド 腎結石症を治療する方法
US20070167454A1 (en) * 2005-08-03 2007-07-19 Christopher Lademacher Methods for treating hypertension
KR20080066938A (ko) * 2005-10-07 2008-07-17 깃세이 야쿠힌 고교 가부시키가이샤 질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물
KR20090031744A (ko) * 2006-06-22 2009-03-27 닛뽕 케미파 가부시키가이샤 항암제 내성 극복제
JP5110536B2 (ja) * 2006-07-19 2012-12-26 学校法人日本医科大学 筋萎縮性側索硬化症治療薬
CA2669935A1 (en) * 2006-11-13 2008-05-29 Takeda Pharmaceuticals North America, Inc. Methods for preserving renal function using xanthine oxidoreductase inhibitors
US20090124623A1 (en) * 2006-11-13 2009-05-14 Christopher Lademacher Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
CN101646440A (zh) * 2007-01-19 2010-02-10 武田制药北美公司 使用黄嘌呤氧化还原酶抑制剂和抗炎剂预防痛风突发或减少痛风突发次数的方法
JO2784B1 (en) * 2007-10-18 2014-03-15 شركة جانسين فارماسوتيكا ان. في 5,3,1 - Triazole substitute derivative
BRPI0819847B1 (pt) 2007-11-27 2022-01-11 Ardea Biosciences, Inc Compostos e composições
EP2165705A1 (de) 2008-09-18 2010-03-24 Centre National de la Recherche Scientifique (CNRS) Verwendung einer Verbindung mit der Fähigkeit zur Senkung des Harnsäureniveaus zur Prävention und/oder Behandlung von Lungenentzündung und -fibrose
US20100311756A1 (en) * 2009-01-22 2010-12-09 Takeda Pharmaceuticals North America, Inc. Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
CA2812034C (en) 2010-09-10 2018-10-23 Takeda Pharmaceuticals U.S.A., Inc. Methods for concomitant treatment of theophylline and febuxostat
JP5862897B2 (ja) * 2010-11-01 2016-02-16 株式会社三和化学研究所 腎機能障害の予防又は治療に用いる医薬
PT2651915T (pt) 2010-12-17 2016-07-14 Mitsubishi Tanabe Pharma Corp Composto aricíclico contínuo
WO2012118485A1 (en) 2011-03-01 2012-09-07 Empire Technology Development Llc Temperature controlled variable reflectivity coatings
RU2476428C1 (ru) * 2011-09-01 2013-02-27 Государственное образовательное учреждение высшего профессионального образования "Южно-Российский государственный технический университет (Новочеркасский политехнический институт)" Способ получения дигидрохлорида 5-амино-3-аминометил-1,2,4-триазола
US9546155B2 (en) 2012-06-15 2017-01-17 Mitsubishi Tanabe Pharma Corporation Aromatic heterocyclic compound
CN104411700B (zh) * 2012-07-25 2016-06-15 株式会社富士药品 4-[5-(吡啶-4-基)-1h-1,2,4-三唑-3-基]吡啶-2-腈的多晶型及其制造方法
US9428488B2 (en) * 2012-07-25 2016-08-30 Fujiyakuhin Co., Ltd. Method for producing 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, and intermediate thereof
CN103724329B (zh) * 2013-12-23 2015-02-18 济南百诺医药科技开发有限公司 4-[5-(吡啶-4-基)-1h-[1,2,4]三唑-3-基]吡啶-2-甲腈的制备方法
CN104042577B (zh) * 2014-06-13 2016-08-24 安徽省逸欣铭医药科技有限公司 一种稳定的托匹司他片及其制备方法
CN105315260A (zh) * 2014-07-29 2016-02-10 北京海步医药科技股份有限公司 一种托布司他一水合物晶型及其制备方法
CN105367490B (zh) * 2014-08-18 2019-01-04 上海医药工业研究院 合成托吡司他的新中间体及其制备方法
CN105348264B (zh) * 2014-08-18 2018-01-16 上海医药工业研究院 一种托吡司他的合成方法
CN104151297B (zh) * 2014-08-27 2016-03-16 王庆本 4-[5-(吡啶-4-基)-1h-[1，2，4]三唑-3-基]吡啶-2-甲腈的制备方法
WO2016133069A1 (ja) * 2015-02-17 2016-08-25 株式会社 三和化学研究所 心不全の予防又は治療のための医薬
WO2016136727A1 (ja) 2015-02-24 2016-09-01 国立大学法人鳥取大学 認知症の予防及び／又は治療のための医薬
CN107531677A (zh) * 2015-02-25 2018-01-02 法尔玛赞公司 用于制备托匹司他及其中间体的方法
CN105693699B (zh) * 2015-03-30 2019-06-18 苏州晶云药物科技股份有限公司 托吡司他的晶型及其制备方法
CN104910068B (zh) * 2015-04-24 2017-07-14 南京医科大学 一种2‑氰基异烟酸酰肼1.5对甲苯磺酸盐的合成方法
CN106279111A (zh) * 2015-05-12 2017-01-04 北京济美堂医药研究有限公司 一种精制托吡司他的新方法
CN104961730B (zh) * 2015-06-18 2017-05-17 山东金城医药化工股份有限公司 托吡司他新晶型及其制备方法
CN105130958B (zh) * 2015-08-31 2017-10-31 济南康和医药科技有限公司 5‑(2‑氰基4‑吡啶基)‑3‑(4‑吡啶基)‑1,2,4‑三唑的制备工艺
CN105294656A (zh) * 2015-10-10 2016-02-03 大道隆达（北京）医药科技发展有限公司 一种托匹司他的制备工艺和方法
CN106336399A (zh) * 2015-11-03 2017-01-18 江苏悦兴药业有限公司 托匹司他工艺杂质的制备方法
CN105294584A (zh) * 2015-11-30 2016-02-03 中国医科大学 1-取代苯基-1h-1,2,3-三唑类化合物、制备方法及其用途
CN105399732A (zh) * 2015-12-07 2016-03-16 青岛正大海尔制药有限公司 一种托匹司他的制备方法
CN106008465A (zh) * 2016-03-16 2016-10-12 江苏悦兴药业有限公司 一种托匹司他杂质的合成方法
CN108250183A (zh) * 2016-12-29 2018-07-06 北京诚济制药有限公司 一种高纯度的托匹司他的制备方法
CN109721586B (zh) * 2017-10-27 2021-03-02 中国医科大学 一种5-苄基-3-吡啶基-1h-1,2,4-三唑类化合物及其制备方法和用途
CN107652271B (zh) * 2017-11-06 2020-06-16 上海中拓医药科技有限公司 一种托匹司他晶型i的制备方法
CN108017619B (zh) * 2017-12-06 2020-08-11 成都惟邦药业有限公司 一种托匹司他杂质及其制备方法
CN113354616B (zh) * 2020-03-05 2024-03-26 中国医学科学院药物研究所 二芳基-1,2,4-三唑类化合物及其制法和药物用途
CN114773262B (zh) * 2022-05-19 2024-05-07 兄弟科技股份有限公司 2-氰基-4-吡啶羧酸甲酯的合成方法

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Also Published As

Publication number Publication date
ES2300486T3 (es) 2008-06-16
NZ531673A (en) 2006-06-30
MXPA04004037A (es) 2004-07-23
TWI257926B (en) 2006-07-11
PT1471065E (pt) 2008-03-13
AU2002349754B2 (en) 2008-01-31
EP1471065A1 (de) 2004-10-27
ZA200401777B (en) 2005-08-31
DK1471065T3 (da) 2008-03-25
RU2293733C2 (ru) 2007-02-20
TW200302222A (en) 2003-08-01
NO326941B1 (no) 2009-03-16
CN1561340B (zh) 2012-05-23
DE60225341D1 (de) 2008-04-10
CN1561340A (zh) 2005-01-05
HK1067132A1 (de) 2005-04-01
BR0212775A (pt) 2004-10-13
NO20041075L (no) 2004-03-15
US7074816B2 (en) 2006-07-11
WO2003064410A1 (fr) 2003-08-07
CA2462132A1 (en) 2003-08-07
RU2004106554A (ru) 2005-07-27
BRPI0212775B1 (pt) 2017-06-06
EP1471065A4 (de) 2005-06-15
JP3600832B2 (ja) 2004-12-15
BRPI0212775B8 (pt) 2021-05-25
DE60225341T2 (de) 2009-04-09
PL368672A1 (en) 2005-04-04
AR042602A1 (es) 2005-06-29
EP1471065B1 (de) 2008-02-27
US20050004175A1 (en) 2005-01-06
PL208260B1 (pl) 2011-04-29
CA2462132C (en) 2010-08-10
JPWO2003064410A1 (ja) 2005-05-26

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