ATE372390T1 - Fluoreszenzintensitätstest für duplex- und triplex-nukleinsäurehybridisierung in lösung unter verwendung von fluoreszenzinterkalatoren - Google Patents
Fluoreszenzintensitätstest für duplex- und triplex-nukleinsäurehybridisierung in lösung unter verwendung von fluoreszenzinterkalatorenInfo
- Publication number
- ATE372390T1 ATE372390T1 AT00979887T AT00979887T ATE372390T1 AT E372390 T1 ATE372390 T1 AT E372390T1 AT 00979887 T AT00979887 T AT 00979887T AT 00979887 T AT00979887 T AT 00979887T AT E372390 T1 ATE372390 T1 AT E372390T1
- Authority
- AT
- Austria
- Prior art keywords
- hybridization
- fluorescence
- assay
- nucleic acid
- duplex
- Prior art date
Links
- 238000007899 nucleic acid hybridization Methods 0.000 title abstract 2
- 238000009396 hybridization Methods 0.000 abstract 5
- 238000003556 assay Methods 0.000 abstract 4
- 239000000523 sample Substances 0.000 abstract 3
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000000138 intercalating agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6839—Triple helix formation or other higher order conformations in hybridisation assays
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/468,679 US6403313B1 (en) | 1999-12-21 | 1999-12-21 | Fluorescent intensity assay for duplex and triplex nucleic acid hybridization solution utilizing fluorescent intercalators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE372390T1 true ATE372390T1 (de) | 2007-09-15 |
Family
ID=23860789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00979887T ATE372390T1 (de) | 1999-12-21 | 2000-12-21 | Fluoreszenzintensitätstest für duplex- und triplex-nukleinsäurehybridisierung in lösung unter verwendung von fluoreszenzinterkalatoren |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6403313B1 (de) |
| EP (1) | EP1242620B1 (de) |
| JP (1) | JP4041867B2 (de) |
| KR (1) | KR100537979B1 (de) |
| CN (1) | CN1413264A (de) |
| AT (1) | ATE372390T1 (de) |
| AU (1) | AU778892B2 (de) |
| BR (1) | BR0016614A8 (de) |
| CA (1) | CA2394752C (de) |
| DE (1) | DE60036307T2 (de) |
| ES (1) | ES2296661T3 (de) |
| HK (1) | HK1047454B (de) |
| IL (2) | IL150284A0 (de) |
| MX (1) | MXPA02006262A (de) |
| PT (1) | PT1242620E (de) |
| RU (1) | RU2273668C2 (de) |
| WO (1) | WO2001046467A2 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656692B2 (en) * | 1999-12-21 | 2003-12-02 | Ingeneus Corporation | Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes |
| US6858390B2 (en) * | 1998-12-31 | 2005-02-22 | Ingeneus Corporation | Aptamers containing sequences of nucleic acid or nucleic acid analogues bound homologously, or in novel complexes |
| US20030181412A1 (en) * | 1999-12-21 | 2003-09-25 | Ingeneus Corporation | Method for modifying transcription and/or translation in an organism for therapeutic, prophylactic and/or analytic uses |
| US7052844B2 (en) * | 1999-12-21 | 2006-05-30 | Ingeneus, Inc. | Purification of DS-DNA using heteropolymeric capture probes and a triplex, quadruplex or homologous duplex binding mechanism |
| US7309569B2 (en) | 1999-12-21 | 2007-12-18 | Ingeneus, Inc. | Parallel or antiparallel, homologous or complementary binding of nucleic acids or analogues thereof to form duplex, triplex or quadruplex complexes |
| US7220541B2 (en) | 2000-01-24 | 2007-05-22 | Ingeneus, Inc. | Homogeneous assay of biopolymer binding by means of multiple measurements under varied conditions |
| US20030170659A1 (en) * | 2000-01-24 | 2003-09-11 | Ingeneus Corporation | Electrical treatment of binding media to encourage, discourage and/or study biopolymer binding |
| KR100386606B1 (ko) * | 2001-02-03 | 2003-06-02 | 엘지전자 주식회사 | Dna 검출 방법 및 그 장치 |
| KR100434067B1 (ko) * | 2002-03-14 | 2004-06-04 | 엘지전자 주식회사 | 핵산 혼성화 검출을 위한 핵산검출장치 및 핵산 혼성화검출방법 |
| JP2005289810A (ja) * | 2002-03-18 | 2005-10-20 | Sangaku Renkei Kiko Kyushu:Kk | 蛍光色素基およびインターカレート基を含有する二本鎖核酸を選択的に検出するための蛍光試薬 |
| WO2004010584A2 (en) * | 2002-07-24 | 2004-01-29 | Congruence Llc. | Code for object identification |
| EP1527333A1 (de) * | 2002-08-01 | 2005-05-04 | Sensor Technologies LLC | Vorrichtung für die fluoreszenzkorrelationsspektroskopie |
| US20040142329A1 (en) * | 2003-01-17 | 2004-07-22 | Ingeneus Corporation | Probe conjugation to increase multiplex binding motif preference |
| US20040180345A1 (en) * | 2003-03-14 | 2004-09-16 | Ingeneus Corporation | Pre-incubation method to improve signal/noise ratio of nucleic acid assays |
| GB0310270D0 (en) * | 2003-05-03 | 2003-06-11 | Univ Edinburgh | Biomolecular devices |
| EP1766061B1 (de) | 2004-05-20 | 2013-07-17 | Quest Diagnostics Investments Incorporated | Vergleichende einfachmarkierung-hybridisierung |
| AU2005286084C1 (en) * | 2004-09-24 | 2011-11-24 | Ingeneus Inc. | Genomic assay |
| EP1846760B1 (de) | 2005-01-27 | 2010-12-15 | Quest Diagnostics Investments Incorporated | Schnelle komparative genomhybridisierung |
| US8076074B2 (en) | 2005-11-29 | 2011-12-13 | Quest Diagnostics Investments Incorporated | Balanced translocation in comparative hybridization |
| RU2394915C2 (ru) * | 2006-03-24 | 2010-07-20 | Александр Борисович Четверин | Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления |
| US7807359B2 (en) | 2006-12-01 | 2010-10-05 | Quest Diagnostics Investments Incorporated | Methods of detecting TPMT mutations |
| US7507539B2 (en) | 2007-07-30 | 2009-03-24 | Quest Diagnostics Investments Incorporated | Substractive single label comparative hybridization |
| US8278047B2 (en) | 2007-10-01 | 2012-10-02 | Nabsys, Inc. | Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment |
| US8093063B2 (en) | 2007-11-29 | 2012-01-10 | Quest Diagnostics Investments Incorporated | Assay for detecting genetic abnormalities in genomic nucleic acids |
| CN102186989B (zh) | 2008-09-03 | 2021-06-29 | 纳伯塞斯2.0有限责任公司 | 用于流体通道中生物分子和其它分析物的电压感测的纵向移位纳米级电极的使用 |
| US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
| US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
| JP2012505644A (ja) * | 2008-10-15 | 2012-03-08 | エフ.ホフマン−ラ ロシュ アーゲー | オリゴヌクレオチド検出法 |
| US8039794B2 (en) | 2008-12-16 | 2011-10-18 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby |
| EP2480684A1 (de) | 2009-09-25 | 2012-08-01 | Signature Genomic Laboratories, Llc | Mehrfach (+/-)-strängige arrays und tests für den nachweis von chromosomalen anomalien im zusammenhang mit krebs und anderen erkrankungen |
| US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
| US8859201B2 (en) | 2010-11-16 | 2014-10-14 | Nabsys, Inc. | Methods for sequencing a biomolecule by detecting relative positions of hybridized probes |
| US11274341B2 (en) | 2011-02-11 | 2022-03-15 | NABsys, 2.0 LLC | Assay methods using DNA binding proteins |
| WO2013009070A2 (ko) * | 2011-07-12 | 2013-01-17 | 주식회사 파나진 | 평행 결합 구조의 이중 혼성화 pna 프로브 시스템 |
| BR112014016846B1 (pt) * | 2012-01-13 | 2020-09-29 | Koninklijke Philips N.V | Dispositivo para o controle óptico de uma reação em etapas iterativa para determinar uma sequência de um ácido nucleico por síntese e método para o controle óptico de uma reação em etapas iterativa para determinar uma sequência de um ácido nucleico por síntese |
| US8956815B2 (en) | 2012-04-18 | 2015-02-17 | Toxic Report Llc | Intercalation methods and devices |
| US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
| EP2956550B1 (de) | 2013-01-18 | 2020-04-08 | Nabsys 2.0 LLC | Verbesserte sondenanbindung |
| CN105792924A (zh) * | 2013-11-29 | 2016-07-20 | 皇家飞利浦有限公司 | 对化学反应的光学控制 |
| CN113720837B (zh) * | 2021-09-23 | 2024-01-19 | 西北大学 | 一种快速检测水体中汞离子的比色传感器 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4220450A (en) | 1978-04-05 | 1980-09-02 | Syva Company | Chemically induced fluorescence immunoassay |
| FR2558172B1 (fr) | 1984-01-16 | 1986-06-13 | Inst Nat Sante Rech Med | Sonde contenant un acide nucleique modifie et reconnaissance par des anticorps specifiques et utilisation de cette sonde et de ces anticorps specifiques pour detecter et caracteriser une sequence d'adn homologue |
| US4876187A (en) | 1985-12-05 | 1989-10-24 | Meiogenics, Inc. | Nucleic acid compositions with scissile linkage useful for detecting nucleic acid sequences |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US5874555A (en) | 1987-10-30 | 1999-02-23 | California Institute Of Technology | Triple helices and processes for making same |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| AU634990B2 (en) | 1988-08-31 | 1993-03-11 | Aprogenex, Inc. | Manual in situ hybridization assay |
| US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US5824477A (en) | 1990-09-12 | 1998-10-20 | Scientific Generics Limited | Electrochemical denaturation of double-stranded nucleic acid |
| EP0487218B1 (de) | 1990-10-31 | 1997-12-29 | Tosoh Corporation | Verfahren zum Nachweis oder Quantifizierung von Zielnukleinsäuren |
| WO1992011390A1 (en) * | 1990-12-17 | 1992-07-09 | Idexx Laboratories, Inc. | Nucleic acid sequence detection by triple helix formation |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5641625A (en) * | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
| US6048690A (en) | 1991-11-07 | 2000-04-11 | Nanogen, Inc. | Methods for electronic fluorescent perturbation for analysis and electronic perturbation catalysis for synthesis |
| US5558998A (en) * | 1992-02-25 | 1996-09-24 | The Regents Of The Univ. Of California | DNA fragment sizing and sorting by laser-induced fluorescence |
| US5332659A (en) | 1992-04-09 | 1994-07-26 | The United States Of America As Represented By The Secretary Of The Navy | Light emission-or absorbance-based binding assays for polynucleic acids |
| JPH06153997A (ja) * | 1992-11-27 | 1994-06-03 | Canon Inc | 検出信号増幅による標的核酸の検出方法 |
| US6027880A (en) | 1995-08-02 | 2000-02-22 | Affymetrix, Inc. | Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis |
| US5861124A (en) | 1993-07-15 | 1999-01-19 | Hamamatsu Photonics Kk | Method and apparatus for detecting denaturation of nucleic acid |
| CA2169837A1 (en) | 1993-08-18 | 1995-02-23 | Peter D. Duck | Compositions and methods for detecting target nucleic acid sequences utilizing adjacent sequence-enzyme molecules |
| JPH09502092A (ja) | 1993-09-02 | 1997-03-04 | リボザイム・ファーマシューティカルズ・インコーポレイテッド | 非ヌクレオチドを含有する酵素性核酸 |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| WO1995014106A2 (en) | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| US5998193A (en) | 1994-06-24 | 1999-12-07 | Gene Shears Pty., Ltd. | Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof |
| JP3189000B2 (ja) * | 1994-12-01 | 2001-07-16 | 東ソー株式会社 | 特定核酸配列の検出方法 |
| US5814516A (en) | 1995-10-13 | 1998-09-29 | Lockheed Martin Energy Systems, Inc. | Surface enhanced Raman gene probe and methods thereof |
| US5824557A (en) | 1996-04-02 | 1998-10-20 | Panvera Corporation | Method for detecting and quantitating nucleic acid impurities in biochemical preparations |
| SE506700C2 (sv) * | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| US5948897A (en) | 1996-06-14 | 1999-09-07 | Simon Fraser University | Method of binding two or more DNA double helices and products formed |
| US5912332A (en) | 1996-07-26 | 1999-06-15 | Hybridon, Inc. | Affinity-based purification of oligonucleotides using soluble multimeric oligonucleotides |
| US5691145A (en) | 1996-08-27 | 1997-11-25 | Becton, Dickinson And Company | Detection of nucleic acids using G-quartets |
| US6060242A (en) | 1997-02-27 | 2000-05-09 | Lorne Park Research, Inc. | PNA diagnostic methods |
| US5846729A (en) * | 1997-02-27 | 1998-12-08 | Lorne Park Research, Inc. | Assaying nucleotides in solution using a fluorescent intensity quenching effect |
| US6046004A (en) * | 1997-02-27 | 2000-04-04 | Lorne Park Research, Inc. | Solution hybridization of nucleic acids with antisense probes having modified backbones |
| US6251591B1 (en) | 1997-02-27 | 2001-06-26 | Lorne Park Research, Inc. | Quantitative method for detecting nucleotide concentration |
| US6312925B1 (en) * | 1997-05-08 | 2001-11-06 | Epoch Pharmaceuticals, Inc. | Methods and compositions to facilitate D-loop formation by oligonucleotides |
| US6013442A (en) * | 1997-08-05 | 2000-01-11 | Wisconsin Alumni Res Found | Direct quantitation of low copy number RNA |
| GB9725197D0 (en) * | 1997-11-29 | 1998-01-28 | Secr Defence | Detection system |
| US6017709A (en) | 1998-04-29 | 2000-01-25 | University Of Houston | DNA replication templates stabilized by guanine quartets |
| US6255050B1 (en) | 1998-05-22 | 2001-07-03 | Lorne Park Research, Inc. | Dynamic hybridization system |
| GB9812768D0 (en) * | 1998-06-13 | 1998-08-12 | Zeneca Ltd | Methods |
| GB9821989D0 (en) * | 1998-10-08 | 1998-12-02 | Hybaid Ltd | Detection of nucleic acid polymorphism |
| US6265170B1 (en) | 2000-01-24 | 2001-07-24 | Ingeneus Corporation | Homogenous assay of duplex of triplex hybridization by means of multiple measurements under varied conditions |
-
1999
- 1999-12-21 US US09/468,679 patent/US6403313B1/en not_active Expired - Lifetime
-
2000
- 2000-12-21 RU RU2002119394/13A patent/RU2273668C2/ru not_active IP Right Cessation
- 2000-12-21 IL IL15028400A patent/IL150284A0/xx active IP Right Grant
- 2000-12-21 MX MXPA02006262A patent/MXPA02006262A/es active IP Right Grant
- 2000-12-21 JP JP2001546963A patent/JP4041867B2/ja not_active Expired - Fee Related
- 2000-12-21 DE DE60036307T patent/DE60036307T2/de not_active Expired - Lifetime
- 2000-12-21 WO PCT/IB2000/001930 patent/WO2001046467A2/en not_active Ceased
- 2000-12-21 HK HK02108903.7A patent/HK1047454B/en not_active IP Right Cessation
- 2000-12-21 EP EP00979887A patent/EP1242620B1/de not_active Expired - Lifetime
- 2000-12-21 BR BRPI0016614A patent/BR0016614A8/pt not_active Application Discontinuation
- 2000-12-21 ES ES00979887T patent/ES2296661T3/es not_active Expired - Lifetime
- 2000-12-21 CA CA2394752A patent/CA2394752C/en not_active Expired - Fee Related
- 2000-12-21 AT AT00979887T patent/ATE372390T1/de not_active IP Right Cessation
- 2000-12-21 PT PT00979887T patent/PT1242620E/pt unknown
- 2000-12-21 CN CN00817639A patent/CN1413264A/zh active Pending
- 2000-12-21 AU AU17263/01A patent/AU778892B2/en not_active Ceased
-
2002
- 2002-06-18 IL IL150284A patent/IL150284A/en not_active IP Right Cessation
- 2002-06-21 KR KR20027008065A patent/KR100537979B1/ko not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001046467A3 (en) | 2002-05-30 |
| US6403313B1 (en) | 2002-06-11 |
| HK1047454A1 (en) | 2003-02-21 |
| RU2273668C2 (ru) | 2006-04-10 |
| CN1413264A (zh) | 2003-04-23 |
| EP1242620A2 (de) | 2002-09-25 |
| BR0016614A8 (pt) | 2019-01-22 |
| JP2003517841A (ja) | 2003-06-03 |
| CA2394752C (en) | 2012-09-25 |
| IL150284A0 (en) | 2002-12-01 |
| AU1726301A (en) | 2001-07-03 |
| JP4041867B2 (ja) | 2008-02-06 |
| KR100537979B1 (en) | 2005-12-21 |
| RU2002119394A (ru) | 2004-01-27 |
| BR0016614A (pt) | 2003-01-07 |
| EP1242620B1 (de) | 2007-09-05 |
| HK1047454B (en) | 2008-07-25 |
| AU778892B2 (en) | 2004-12-23 |
| MXPA02006262A (es) | 2004-09-06 |
| DE60036307T2 (de) | 2008-05-29 |
| DE60036307D1 (de) | 2007-10-18 |
| WO2001046467A2 (en) | 2001-06-28 |
| IL150284A (en) | 2008-03-20 |
| KR20020079757A (ko) | 2002-10-19 |
| ES2296661T3 (es) | 2008-05-01 |
| PT1242620E (pt) | 2007-12-13 |
| CA2394752A1 (en) | 2001-06-28 |
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