ATE357445T1 - Darstellung von 1h-imidazo(4,5-c)chinolin-4- aminen über neue 1h-imidazo(4,5-c)chinolin-4- cyano- und 1h-imidazo(4,5-c)chinolin-4-carboxamid intermediate - Google Patents
Darstellung von 1h-imidazo(4,5-c)chinolin-4- aminen über neue 1h-imidazo(4,5-c)chinolin-4- cyano- und 1h-imidazo(4,5-c)chinolin-4-carboxamid intermediateInfo
- Publication number
- ATE357445T1 ATE357445T1 AT03771977T AT03771977T ATE357445T1 AT E357445 T1 ATE357445 T1 AT E357445T1 AT 03771977 T AT03771977 T AT 03771977T AT 03771977 T AT03771977 T AT 03771977T AT E357445 T1 ATE357445 T1 AT E357445T1
- Authority
- AT
- Austria
- Prior art keywords
- imidazo
- quinoline
- cyano
- preparation
- carboxamide intermediate
- Prior art date
Links
- UQUPJGMZYBOGDJ-UHFFFAOYSA-N 3h-imidazo[4,5-c]quinoline-4-carboxamide Chemical compound NC(=O)C1=NC2=CC=CC=C2C2=C1N=CN2 UQUPJGMZYBOGDJ-UHFFFAOYSA-N 0.000 title abstract 3
- HQBUPOAKJGJGCD-UHFFFAOYSA-N 3h-imidazo[4,5-c]quinolin-4-amine Chemical compound NC1=NC2=CC=CC=C2C2=C1N=CN2 HQBUPOAKJGJGCD-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 5
- DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- ZDKGVDBUWDUSTO-UHFFFAOYSA-N 1-(2-methylpropyl)imidazo[4,5-c]quinoline-4-carboxamide Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(C(N)=O)N=C21 ZDKGVDBUWDUSTO-UHFFFAOYSA-N 0.000 abstract 1
- ITIRVXDSMXFTPW-UHFFFAOYSA-N 1H-imidazo[4,5-c]quinoline Chemical compound C1=CC=CC2=C(NC=N3)C3=CN=C21 ITIRVXDSMXFTPW-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229960002751 imiquimod Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39859202P | 2002-07-26 | 2002-07-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE357445T1 true ATE357445T1 (de) | 2007-04-15 |
Family
ID=31188428
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03771977T ATE357445T1 (de) | 2002-07-26 | 2003-07-28 | Darstellung von 1h-imidazo(4,5-c)chinolin-4- aminen über neue 1h-imidazo(4,5-c)chinolin-4- cyano- und 1h-imidazo(4,5-c)chinolin-4-carboxamid intermediate |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US6841678B2 (de) |
| EP (1) | EP1539752B1 (de) |
| JP (1) | JP2005537287A (de) |
| KR (1) | KR20050030958A (de) |
| CN (1) | CN100372847C (de) |
| AT (1) | ATE357445T1 (de) |
| AU (1) | AU2003254221A1 (de) |
| CA (1) | CA2493158A1 (de) |
| DE (1) | DE60312701T8 (de) |
| DK (1) | DK1539752T3 (de) |
| ES (1) | ES2282691T3 (de) |
| HR (1) | HRP20050183A2 (de) |
| IL (2) | IL166307A0 (de) |
| MX (1) | MXPA05000997A (de) |
| PL (1) | PL374866A1 (de) |
| PT (1) | PT1539752E (de) |
| SI (1) | SI1539752T1 (de) |
| WO (1) | WO2004011462A1 (de) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6677347B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
| WO2003042612A2 (en) * | 2001-11-13 | 2003-05-22 | Barton John C | Touchless automatic fiber optic beverage/ice dispenser |
| JP2005538057A (ja) | 2002-06-07 | 2005-12-15 | スリーエム イノベイティブ プロパティズ カンパニー | エーテル置換イミダゾピリジン |
| PL374866A1 (en) * | 2002-07-26 | 2005-11-14 | Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag | Preparation of 1h-imidazo [4,5-c] quinolin-4-amines via novel 1h-imidazo [4,5-c] quinolin-4-cyano and 1h-imidazo [4,5-c] quinolin-4-carboxamide intermediates |
| US20040265351A1 (en) | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| WO2004096144A2 (en) * | 2003-04-28 | 2004-11-11 | 3M Innovative Properties Company | Compositions and methods for induction of opioid receptors |
| MXPA06001669A (es) * | 2003-08-12 | 2006-04-28 | 3M Innovative Properties Co | Compuestos que contienen imidazo-oxima sustituidos. |
| EP2939693A1 (de) * | 2003-08-14 | 2015-11-04 | 3M Innovative Properties Company | Lipidmodifizierte immunreaktionsmodifikatoren |
| NZ545412A (en) * | 2003-08-27 | 2008-12-24 | Coley Pharm Group Inc | Aryloxy and arylalkyleneoxy substituted imidazoquinolines |
| JP2007504269A (ja) * | 2003-09-05 | 2007-03-01 | スリーエム イノベイティブ プロパティズ カンパニー | Cd5+b細胞リンパ腫の治療方法 |
| EP1673087B1 (de) | 2003-10-03 | 2015-05-13 | 3M Innovative Properties Company | Alkoxy-substituierte imidazochinoline |
| KR101494056B1 (ko) | 2003-10-03 | 2015-02-16 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 피라졸로피리딘 및 그의 유사체 |
| US20090075980A1 (en) * | 2003-10-03 | 2009-03-19 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and Analogs Thereof |
| US7544697B2 (en) * | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
| WO2005048933A2 (en) * | 2003-11-14 | 2005-06-02 | 3M Innovative Properties Company | Oxime substituted imidazo ring compounds |
| CN1906192A (zh) | 2003-11-14 | 2007-01-31 | 3M创新有限公司 | 羟胺取代的咪唑环化合物 |
| AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| US8778963B2 (en) * | 2003-11-25 | 2014-07-15 | 3M Innovative Properties Company | Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| WO2005076783A2 (en) * | 2003-12-04 | 2005-08-25 | 3M Innovative Properties Company | Sulfone substituted imidazo ring ethers |
| JP2007517035A (ja) * | 2003-12-29 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | アリールアルケニルおよびアリールアルキニル置換されたイミダゾキノリン |
| CA2552101A1 (en) * | 2003-12-29 | 2005-07-21 | 3M Innovative Properties Company | Piperazine, [1,4]diazepane, [1,4]diazocane, and [1,5]diazocane fused imidazo ring compounds |
| EP1699788A2 (de) * | 2003-12-30 | 2006-09-13 | 3M Innovative Properties Company | Imidazochinolinyl-, imidazopyridinyl- und imidazonaphthyridinylsulfonamide |
| US8697873B2 (en) * | 2004-03-24 | 2014-04-15 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
| US20080015184A1 (en) * | 2004-06-14 | 2008-01-17 | 3M Innovative Properties Company | Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines |
| US8017779B2 (en) * | 2004-06-15 | 2011-09-13 | 3M Innovative Properties Company | Nitrogen containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
| WO2006009826A1 (en) * | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
| WO2006038923A2 (en) * | 2004-06-18 | 2006-04-13 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
| US7915281B2 (en) * | 2004-06-18 | 2011-03-29 | 3M Innovative Properties Company | Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and method |
| US8541438B2 (en) | 2004-06-18 | 2013-09-24 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| AU2005283085B2 (en) * | 2004-06-18 | 2012-06-21 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
| AU2005282523A1 (en) | 2004-09-02 | 2006-03-16 | 3M Innovative Properties Company | 2-amino 1H imidazo ring systems and methods |
| WO2006026760A2 (en) * | 2004-09-02 | 2006-03-09 | 3M Innovative Properties Company | 1-amino imidazo-containing compounds and methods |
| JP5209312B2 (ja) * | 2004-09-02 | 2013-06-12 | スリーエム イノベイティブ プロパティズ カンパニー | 1−アルコキシ1h−イミダゾ環系および方法 |
| JP2008515928A (ja) * | 2004-10-08 | 2008-05-15 | スリーエム イノベイティブ プロパティズ カンパニー | Dnaワクチンのためのアジュバント |
| JP2008523076A (ja) * | 2004-12-08 | 2008-07-03 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫調節性の組成物、合剤、および方法 |
| AU2005321912B2 (en) * | 2004-12-30 | 2012-04-05 | 3M Innovative Properties Company | Treatment for cutaneous metastases |
| JP5313502B2 (ja) | 2004-12-30 | 2013-10-09 | スリーエム イノベイティブ プロパティズ カンパニー | 置換キラル縮合[1,2]イミダゾ[4,5−c]環状化合物 |
| CA2592904C (en) | 2004-12-30 | 2015-04-07 | 3M Innovative Properties Company | Chiral fused [1,2]imidazo[4,5-c] ring compounds |
| US8436176B2 (en) * | 2004-12-30 | 2013-05-07 | Medicis Pharmaceutical Corporation | Process for preparing 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine |
| CA2592897A1 (en) * | 2004-12-30 | 2006-07-13 | Takeda Pharmaceutical Company Limited | 1-(2-methylpropyl)-1h-imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate and 1-(2-methylpropyl)-1h-imidazo[4,5-c][1,5]naphthyridin-4-amine methanesulfonate |
| JP2008530022A (ja) | 2005-02-04 | 2008-08-07 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 免疫反応調節物質を含む水性ゲル処方物 |
| CA2602083A1 (en) | 2005-02-09 | 2006-08-09 | Coley Pharmaceutical Group, Inc. | Oxime and hydroxylamine substituted thiazolo(4,5-c) ring compounds and methods |
| US20080318998A1 (en) | 2005-02-09 | 2008-12-25 | Coley Pharmaceutical Group, Inc. | Alkyloxy Substituted Thiazoloquinolines and Thiazolonaphthyridines |
| CA2597446A1 (en) * | 2005-02-11 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Substituted imidazoquinolines and imidazonaphthyridines |
| EP1846405A2 (de) | 2005-02-11 | 2007-10-24 | 3M Innovative Properties Company | Oxim- und hydroxylaminsubstituierte imidazo-4,5-c-ringverbindungen und verfahren |
| AU2006223634A1 (en) * | 2005-02-23 | 2006-09-21 | Coley Pharmaceutical Group, Inc. | Hydroxyalkyl substituted imidazoquinolines |
| AU2006216686A1 (en) * | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Method of preferentially inducing the biosynthesis of interferon |
| EP1851218A2 (de) * | 2005-02-23 | 2007-11-07 | 3M Innovative Properties Company | Hydroxyalkylsubstituierte imidazochinolinverbindungen und verfahren |
| CA2598639A1 (en) | 2005-02-23 | 2006-08-31 | Coley Pharmaceutical Group, Inc. | Hydroxyalkyl substituted imidazonaphthyridines |
| CA2602590A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases |
| CA2602683A1 (en) | 2005-04-01 | 2006-10-12 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridine-1,4-diamines and analogs thereof |
| JP2008539252A (ja) * | 2005-04-25 | 2008-11-13 | スリーエム イノベイティブ プロパティズ カンパニー | 免疫活性化組成物 |
| AU2006287270A1 (en) * | 2005-09-09 | 2007-03-15 | Coley Pharmaceutical Group, Inc. | Amide and carbamate derivatives of N-{2-[4-amino-2- (ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-1,1-dimethylethyl}methanesulfonamide and methods |
| ZA200803029B (en) * | 2005-09-09 | 2009-02-25 | Coley Pharm Group Inc | Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods |
| WO2007056112A2 (en) | 2005-11-04 | 2007-05-18 | Coley Pharmaceutical Group, Inc. | Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods |
| EP1988896A4 (de) | 2006-02-22 | 2011-07-27 | 3M Innovative Properties Co | Konjugate zur modifizierung von immunreaktionen |
| WO2007106854A2 (en) * | 2006-03-15 | 2007-09-20 | Coley Pharmaceutical Group, Inc. | Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods |
| WO2008008432A2 (en) * | 2006-07-12 | 2008-01-17 | Coley Pharmaceutical Group, Inc. | Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods |
| US8178539B2 (en) * | 2006-09-06 | 2012-05-15 | 3M Innovative Properties Company | Substituted 3,4,6,7-tetrahydro-5H-1,2a,4a,8-tetraazacyclopenta[cd]phenalenes and methods |
| US20080149123A1 (en) | 2006-12-22 | 2008-06-26 | Mckay William D | Particulate material dispensing hairbrush with combination bristles |
| LT2606047T (lt) | 2010-08-17 | 2017-04-10 | 3M Innovative Properties Company | Imuninio atsako modifikatoriaus junginio lipidizuotos kompozicijos, sudėtys ir būdai |
| CA2838023C (en) | 2011-06-03 | 2019-08-13 | 3M Innovative Properties Company | Hydrazino 1h-imidazoquinolin-4-amines and conjugates made therefrom |
| EP2717919B1 (de) | 2011-06-03 | 2016-08-03 | 3M Innovative Properties Company | Heterobifunktionale linker mit polyethylenglykolsegmenten und daraus hergestellte immunantwort-modifizierende konjugate |
| CN104725304B (zh) * | 2013-12-18 | 2017-08-18 | 上海医药工业研究院 | 一种3‑取代‑2‑氰基吡啶类化合物的制备方法 |
| EP3728255B1 (de) | 2017-12-20 | 2022-01-26 | 3M Innovative Properties Company | Amid-substituierte imidazo[4,5-c]chinolin-verbindungen mit verzweigtkettenverbindungsgruppe zur verwendung als immunreaktionsmodifikator |
| FR3113287B1 (fr) | 2020-08-07 | 2023-06-23 | Phv Pharma | Procédé industriel de synthèse de l’imiquimod à partir de la quinolèine-2,4-diol applicable à son utilisation pharmaceutique |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1271477A (en) | 1983-11-18 | 1990-07-10 | John F. Gerster | 1h-imidazo[4,5-c]quinolin-4-amines |
| ZA848968B (en) | 1983-11-18 | 1986-06-25 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinolines and 1h-imidazo(4,5-c)quinolin-4-amines |
| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| US4689388A (en) | 1985-01-24 | 1987-08-25 | Ajinomoto Co., Inc. | One pack type alicyclic epoxy resin compositions |
| US5238944A (en) | 1988-12-15 | 1993-08-24 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine |
| DK0385630T3 (da) | 1989-02-27 | 1997-05-12 | Riker Laboratories Inc | 1H-imidazo(4,5-c)quinolin-4-aminer som antivirale midler |
| US5756747A (en) | 1989-02-27 | 1998-05-26 | Riker Laboratories, Inc. | 1H-imidazo 4,5-c!quinolin-4-amines |
| US4988815A (en) | 1989-10-26 | 1991-01-29 | Riker Laboratories, Inc. | 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines |
| CA2093132C (en) | 1990-10-05 | 2002-02-26 | John F. Gerster | Process for the preparation of imidazo[4,5-c]quinolin-4-amines |
| JP2941413B2 (ja) | 1990-11-28 | 1999-08-25 | ライカー ラボラトリース インコーポレーテッド | 1H―イミダゾ[4,5―c]キノリン類の製造方法 |
| US5175296A (en) | 1991-03-01 | 1992-12-29 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-c]quinolin-4-amines and processes for their preparation |
| US5395937A (en) | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
| JP3257893B2 (ja) * | 1993-10-18 | 2002-02-18 | 三菱電機株式会社 | 位相シフトマスク、その位相シフトマスクの製造方法およびその位相シフトマスクを用いた露光方法 |
| US5741908A (en) | 1996-06-21 | 1998-04-21 | Minnesota Mining And Manufacturing Company | Process for reparing imidazoquinolinamines |
| EP1256582A1 (de) * | 2000-02-09 | 2002-11-13 | Hokuriku Seiyaku Co., Ltd. | 1h-imidazopyridin-derivate |
| GB0211649D0 (en) * | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
| PL374866A1 (en) * | 2002-07-26 | 2005-11-14 | Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag | Preparation of 1h-imidazo [4,5-c] quinolin-4-amines via novel 1h-imidazo [4,5-c] quinolin-4-cyano and 1h-imidazo [4,5-c] quinolin-4-carboxamide intermediates |
-
2003
- 2003-07-28 PL PL03374866A patent/PL374866A1/xx unknown
- 2003-07-28 CA CA002493158A patent/CA2493158A1/en not_active Abandoned
- 2003-07-28 EP EP03771977A patent/EP1539752B1/de not_active Expired - Lifetime
- 2003-07-28 HR HR20050183A patent/HRP20050183A2/xx not_active Application Discontinuation
- 2003-07-28 MX MXPA05000997A patent/MXPA05000997A/es unknown
- 2003-07-28 CN CNB038225409A patent/CN100372847C/zh not_active Expired - Fee Related
- 2003-07-28 WO PCT/US2003/023543 patent/WO2004011462A1/en not_active Ceased
- 2003-07-28 AT AT03771977T patent/ATE357445T1/de not_active IP Right Cessation
- 2003-07-28 AU AU2003254221A patent/AU2003254221A1/en not_active Abandoned
- 2003-07-28 DK DK03771977T patent/DK1539752T3/da active
- 2003-07-28 KR KR1020057001402A patent/KR20050030958A/ko not_active Ceased
- 2003-07-28 IL IL16630703A patent/IL166307A0/xx unknown
- 2003-07-28 JP JP2004524952A patent/JP2005537287A/ja active Pending
- 2003-07-28 SI SI200330819T patent/SI1539752T1/sl unknown
- 2003-07-28 DE DE60312701T patent/DE60312701T8/de not_active Expired - Fee Related
- 2003-07-28 US US10/628,927 patent/US6841678B2/en not_active Expired - Fee Related
- 2003-07-28 ES ES03771977T patent/ES2282691T3/es not_active Expired - Lifetime
- 2003-07-28 PT PT03771977T patent/PT1539752E/pt unknown
-
2004
- 2004-12-09 US US11/009,259 patent/US7166721B2/en not_active Expired - Fee Related
- 2004-12-09 US US11/008,846 patent/US7335772B2/en not_active Expired - Fee Related
-
2005
- 2005-01-16 IL IL166307A patent/IL166307A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PL374866A1 (en) | 2005-11-14 |
| JP2005537287A (ja) | 2005-12-08 |
| DE60312701T8 (de) | 2008-08-21 |
| AU2003254221A1 (en) | 2004-02-16 |
| CN1684963A (zh) | 2005-10-19 |
| IL166307A (en) | 2010-04-15 |
| EP1539752A1 (de) | 2005-06-15 |
| US20050119294A1 (en) | 2005-06-02 |
| DK1539752T3 (da) | 2007-07-16 |
| HRP20050183A2 (en) | 2005-06-30 |
| DE60312701T2 (de) | 2007-12-06 |
| CN100372847C (zh) | 2008-03-05 |
| WO2004011462A1 (en) | 2004-02-05 |
| MXPA05000997A (es) | 2005-05-16 |
| KR20050030958A (ko) | 2005-03-31 |
| SI1539752T1 (sl) | 2007-08-31 |
| IL166307A0 (en) | 2006-01-15 |
| US6841678B2 (en) | 2005-01-11 |
| EP1539752B1 (de) | 2007-03-21 |
| ES2282691T3 (es) | 2007-10-16 |
| PT1539752E (pt) | 2007-05-31 |
| DE60312701D1 (de) | 2007-05-03 |
| US7335772B2 (en) | 2008-02-26 |
| CA2493158A1 (en) | 2004-02-05 |
| US20050101627A1 (en) | 2005-05-12 |
| US7166721B2 (en) | 2007-01-23 |
| US20040063743A1 (en) | 2004-04-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60312701D1 (de) | Darstellung von 1h-imidazoä4,5-cüchinolin-4-aminen über neue 1h-imidazoä4,5-cüchinolin-4-cyano- und 1h-imidazoä4,5-cüchinolin-4-carboxamid intermediate | |
| PL374884A1 (en) | Preparation of 1h-imidazo[4,5-c]quinolin-4-amines via 1h-imidazo[4,5-c]quinolin-4-phthalimide intermediates | |
| MA29935B1 (fr) | Inhibiteurs de l'activite de akt | |
| DK1833827T3 (da) | Fremgangsmåde til fremstilling af 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amin | |
| ATE301653T1 (de) | Pyrazolopyridine | |
| GEP20084552B (en) | Tetrahydronaphthyridine derivatives useful as histamine h3 receptor ligands | |
| NO20082757L (no) | Substituerte imidazoquinoliner, imidazonaftyridiner og imidazopyridiner, sammensetninger og fremgangsmater | |
| NO20060985L (no) | Inhibitorer av Akt aktivitet | |
| ATE362932T1 (de) | Azaindolverbindungen als kinaseinhibitoren | |
| DK0912564T3 (da) | Fremgangsmåde til fremstilling af tetrahydroimidazoquinolinaminer. | |
| DE60125429D1 (de) | Zolpidem hemitartrat solvat | |
| ATE466002T1 (de) | Substituierte benzo (d) isoaxol-3-yl-amin- verbindungen als analgetika | |
| WO2007027734A3 (en) | Bicyclic and bridged nitrogen heterocycles | |
| YU51703A (sh) | Derivati benzimidazola i piridilimidazola kao veznici za gaba receptore | |
| NO20031722D0 (no) | Nye 7-azaindoler, anvendelse av de samme som fosfodiesterase- 4-inhibitorerog fremgangsmåte for fremstilling av de samme | |
| ATE384722T1 (de) | Alkoxypyridinderivate | |
| ATE297931T1 (de) | Tricyclische imidazopyridine | |
| IS8377A (is) | Arýlindenópyridín og arýlindenópyrimidín og notkun þeirra sem mótlyf A2A viðtaka adenósíns | |
| DK1879893T3 (da) | Fremgangsmåde til fremstilling af 1-substituerede 1H-imidazo[4,5-c]quinolin-4-aminforbindelser og mellemprodukter dertil | |
| ZA200704709B (en) | A process for the preparation of substantially pure 4-mino-1-isobutyl-1H-imidazo[4,5-c]-quinoline (imiquimod) | |
| ATE440605T1 (de) | Verfahren zur herstellung von camptothecin- derivaten | |
| DE602007002182D1 (de) | Verfahren zur herstellung von cgrp-antagonisten | |
| DE60320808D1 (de) | Verfahren zur herstellung von imidazo(1,2-a)pyridin-3-acetamiden | |
| DE102004015981A1 (de) | Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure | |
| WO2009006243A8 (en) | Processes for preparing bicyclic oxazine carboxaldehyde and beta-lactamase inhibitors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1539752 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |