DE602007002182D1 - Verfahren zur herstellung von cgrp-antagonisten - Google Patents
Verfahren zur herstellung von cgrp-antagonistenInfo
- Publication number
- DE602007002182D1 DE602007002182D1 DE602007002182T DE602007002182T DE602007002182D1 DE 602007002182 D1 DE602007002182 D1 DE 602007002182D1 DE 602007002182 T DE602007002182 T DE 602007002182T DE 602007002182 T DE602007002182 T DE 602007002182T DE 602007002182 D1 DE602007002182 D1 DE 602007002182D1
- Authority
- DE
- Germany
- Prior art keywords
- oxo
- preparation
- azepan
- imidazo
- difluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002360 preparation method Methods 0.000 title abstract 3
- 229940127597 CGRP antagonist Drugs 0.000 title 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 abstract 4
- CGDZXLJGHVKVIE-DNVCBOLYSA-N n-[(3r,6s)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-3h-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide Chemical compound FC1=CC=CC([C@H]2CN(CC(F)(F)F)C(=O)[C@H](NC(=O)N3CCC(CC3)N3C(NC4=NC=CC=C43)=O)CC2)=C1F CGDZXLJGHVKVIE-DNVCBOLYSA-N 0.000 abstract 2
- COZIJLDLJMKBRZ-LDYMZIIASA-N (3r,6s)-3-amino-6-(2,3-difluorophenyl)-1-(2,2,2-trifluoroethyl)azepan-2-one Chemical compound C1N(CC(F)(F)F)C(=O)[C@H](N)CC[C@H]1C1=CC=CC(F)=C1F COZIJLDLJMKBRZ-LDYMZIIASA-N 0.000 abstract 1
- OHUCGNJZMRINKX-UHFFFAOYSA-N 1-piperidin-1-ium-4-yl-3h-imidazo[4,5-b]pyridin-4-ium-2-one;dichloride Chemical compound Cl.Cl.O=C1NC2=NC=CC=C2N1C1CCNCC1 OHUCGNJZMRINKX-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79070406P | 2006-04-10 | 2006-04-10 | |
| PCT/US2007/008702 WO2007120591A1 (en) | 2006-04-10 | 2007-04-06 | Process for the preparation of cgrp antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602007002182D1 true DE602007002182D1 (de) | 2009-10-08 |
Family
ID=38477276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602007002182T Active DE602007002182D1 (de) | 2006-04-10 | 2007-04-06 | Verfahren zur herstellung von cgrp-antagonisten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7829699B2 (de) |
| EP (1) | EP2007764B1 (de) |
| JP (1) | JP2009533439A (de) |
| CN (1) | CN101421266A (de) |
| AT (1) | ATE440843T1 (de) |
| AU (1) | AU2007238895A1 (de) |
| CA (1) | CA2649159A1 (de) |
| DE (1) | DE602007002182D1 (de) |
| ES (1) | ES2330166T3 (de) |
| WO (1) | WO2007120591A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011511792A (ja) | 2008-02-05 | 2011-04-14 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｃｇｒｐ受容体アンタゴニストのプロドラッグ |
| WO2010144293A1 (en) * | 2009-06-08 | 2010-12-16 | Merck Sharp & Dohme Corp. | Synthesis of telcagepant and intermediates thereof |
| CN109400541B (zh) * | 2018-04-03 | 2022-05-17 | 淮安国瑞化工有限公司 | 通过1-氯-2-(4-氯苯基)-3-甲基-4-戊烯-2-醇制备环唑醇的方法 |
| EP4074712A1 (de) * | 2021-04-13 | 2022-10-19 | Siegfried AG | Verfahren zur synthese von 1,3-dihydro-imidazo[4,5-b]pyridin-2-on und/oder derivaten davon |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO2355B1 (en) * | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| CA2649158A1 (en) | 2006-04-10 | 2007-10-25 | Merck & Co., Inc. | Process for the preparation of pyridine heterocycle cgrp antagonist intermediate |
| AU2007238896A1 (en) | 2006-04-10 | 2007-10-25 | Merck Sharp & Dohme Corp. | CGRP antagonist salt |
| ES2328186T3 (es) | 2006-04-10 | 2009-11-10 | MERCK & CO., INC. | Procedimiento de preparacion de un intermedio de antagonista del cgrp de caprolactama. |
-
2007
- 2007-04-06 EP EP07755087A patent/EP2007764B1/de not_active Not-in-force
- 2007-04-06 US US12/226,244 patent/US7829699B2/en not_active Expired - Fee Related
- 2007-04-06 CN CNA2007800129364A patent/CN101421266A/zh active Pending
- 2007-04-06 AT AT07755087T patent/ATE440843T1/de active
- 2007-04-06 WO PCT/US2007/008702 patent/WO2007120591A1/en active Application Filing
- 2007-04-06 JP JP2009505409A patent/JP2009533439A/ja not_active Withdrawn
- 2007-04-06 ES ES07755087T patent/ES2330166T3/es active Active
- 2007-04-06 DE DE602007002182T patent/DE602007002182D1/de active Active
- 2007-04-06 AU AU2007238895A patent/AU2007238895A1/en not_active Abandoned
- 2007-04-06 CA CA002649159A patent/CA2649159A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE440843T1 (de) | 2009-09-15 |
| AU2007238895A1 (en) | 2007-10-25 |
| EP2007764A1 (de) | 2008-12-31 |
| CN101421266A (zh) | 2009-04-29 |
| US20090281306A1 (en) | 2009-11-12 |
| EP2007764B1 (de) | 2009-08-26 |
| CA2649159A1 (en) | 2007-10-25 |
| ES2330166T3 (es) | 2009-12-04 |
| US7829699B2 (en) | 2010-11-09 |
| WO2007120591A1 (en) | 2007-10-25 |
| JP2009533439A (ja) | 2009-09-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201001445A1 (ru) | ПОЛУЧЕНИЕ 6-АМИНОКАПРОНОВОЙ КИСЛОТЫ ИЗ α-КЕТОПИМЕЛИНОВОЙ КИСЛОТЫ | |
| DE60312701D1 (de) | Darstellung von 1h-imidazoä4,5-cüchinolin-4-aminen über neue 1h-imidazoä4,5-cüchinolin-4-cyano- und 1h-imidazoä4,5-cüchinolin-4-carboxamid intermediate | |
| ATE430746T1 (de) | Crf-rezeptor-antagonisten und zugehörige verfahren | |
| EA200800727A1 (ru) | Введение ингибиторов дипептидилпептидазы | |
| ATE553104T1 (de) | Substituierte 1h-benzimidazol-4-carboxamide als potente parp-hemmer | |
| WO2007120590A3 (en) | Process for the preparation of pyridine heterocycle cgrp antagonist intermediate | |
| ATE430152T1 (de) | Aryl-substituierte diazabicycloalkane als nikotinische acetylcholinagonisten | |
| EA200801757A1 (ru) | Пиперидинильные производные в качестве модуляторов активности хемокинового рецептора | |
| MX2009005461A (es) | N-oxidos de analogos de 4,5-epoxi-morfinano. | |
| DE602007012910D1 (de) | Azetidinverbindungen als orexin-rezeptor-antagonisten | |
| EP2101772A4 (de) | Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon | |
| WO2008116665A8 (en) | Substituted imidazopyridine derivatives as melanocortin-4 receptor antagonists | |
| NO20073729L (no) | Heterocykliske forbindelser som CCR2B-antagonister | |
| DK2044067T3 (da) | Fremgangsmåde til fremstilling af 3(R)-(2-hydroxy-2,2-dithien-2-ylacetoxy)-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octanbromid | |
| HK1091200A1 (en) | Arylindenopyridines and arylindenopyrimidines and their use as adenosine a2a receptor antagonists | |
| MX2008002805A (es) | Derivados de carboxamida como antagonistas del receptor muscarinico. | |
| ATE517106T1 (de) | Kondensierte spiropiperidine als modulatoren muskarinartiger rezeptoren | |
| DE602007012313D1 (de) | Als a2b-adenosinrezeptorantagonisten geeignete 5-phenyl-6-pyridin-4-yl-1,3-dihydro-2h-imidazoä4,5-büpyridin-2-onderivate | |
| DE602007002182D1 (de) | Verfahren zur herstellung von cgrp-antagonisten | |
| NO20092902L (no) | 6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]kinolinforbindelser nyttige som PDE5-inhibitorer | |
| WO2008002946A3 (en) | Method of modulating neurite outgrowth by the use of a galanin-3 receptor antagonist | |
| HRP20051005A2 (en) | Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives | |
| ATE449074T1 (de) | 2-azabicyclo 3.3.1 nonan-derivate als antagonisten des opioid-rezeptors | |
| PE20080232A1 (es) | Compuestos heterociclicos como antagonistas del receptor cgrp | |
| WO2007066201A3 (en) | Chemical compounds |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: MERCK SHARP & DOHME CORP., NEW JERSEY, N.J., US |