NO20092902L - 6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]kinolinforbindelser nyttige som PDE5-inhibitorer - Google Patents

6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]kinolinforbindelser nyttige som PDE5-inhibitorer

Info

Publication number
NO20092902L
NO20092902L NO20092902A NO20092902A NO20092902L NO 20092902 L NO20092902 L NO 20092902L NO 20092902 A NO20092902 A NO 20092902A NO 20092902 A NO20092902 A NO 20092902A NO 20092902 L NO20092902 L NO 20092902L
Authority
NO
Norway
Prior art keywords
tetrahydroindolo
benzyl
compounds useful
pde5 inhibitors
quinoline compounds
Prior art date
Application number
NO20092902A
Other languages
English (en)
Inventor
Dieter Flockerzi
Beate Schmidt
Degenhard Marx
Ulrich Kautz
Steffen Weinbrenner
Daniela Hauser
Torsten Dunkern
Thomas Stengel
Jorg Diefenbach
Johannes A M Christiaans
Wiro M P B Menge
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of NO20092902L publication Critical patent/NO20092902L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Forbindelsene med formel (I) hvori R1 til R8 og R11 har betydningene som angitt i beskrivelsen, saltene derav, N-oksidene av forbindelsene og saltene derav, og stereoisomerene av forbindelsene, saltene, N-oksidene av forbindelsene og N-oksidene av saltene derav er effektive inhibitorer av type 5-fosfodiesterase.
NO20092902A 2007-02-05 2009-08-27 6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]kinolinforbindelser nyttige som PDE5-inhibitorer NO20092902L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07101742A EP1953159A1 (en) 2007-02-05 2007-02-05 6-Benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds useful as PDE5 inhibitors
PCT/EP2008/051076 WO2008095835A1 (en) 2007-02-05 2008-01-30 6-benzyl-2,3,4,7-tetrahydro-indolo [2, 3-c] quinoline compounds useful as pde5 inhibitors

Publications (1)

Publication Number Publication Date
NO20092902L true NO20092902L (no) 2009-08-27

Family

ID=38222238

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20092902A NO20092902L (no) 2007-02-05 2009-08-27 6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]kinolinforbindelser nyttige som PDE5-inhibitorer

Country Status (18)

Country Link
US (1) US20100120730A1 (no)
EP (2) EP1953159A1 (no)
JP (1) JP2010517958A (no)
KR (1) KR20090106633A (no)
CN (1) CN101605791A (no)
AR (1) AR065157A1 (no)
AU (1) AU2008212987A1 (no)
BR (1) BRPI0808378A2 (no)
CA (1) CA2675357A1 (no)
EA (1) EA200901034A1 (no)
IL (1) IL200102A0 (no)
MA (1) MA31229B1 (no)
MX (1) MX2009007682A (no)
NO (1) NO20092902L (no)
TN (1) TN2009000267A1 (no)
TW (1) TW200902528A (no)
WO (1) WO2008095835A1 (no)
ZA (1) ZA200904440B (no)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820691B2 (en) * 2006-08-28 2010-10-26 Medipropharma, Inc. Indoloquinoline compounds as calcium channel blockers
US20090131442A1 (en) * 2007-11-16 2009-05-21 Joseph Bernstein Method of Treating Bone Pain Caused by Osteoarthritis
WO2010015587A1 (en) * 2008-08-05 2010-02-11 Nycomed Gmbh 5-benzyl-1,2,3,6-tetrahydro-4,6-diaza-cyclopenta[c]fluorene compounds and 5-benzyl-1,2,3,6-tetrahydro-4,6-diaza-cyclohepta[c]fluorene compounds
WO2010015586A2 (en) * 2008-08-05 2010-02-11 Nycomed Gmbh 2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds
WO2010015585A1 (en) * 2008-08-05 2010-02-11 Nycomed Gmbh 6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]quinoline compounds
WO2010015589A1 (en) * 2008-08-05 2010-02-11 Nycomed Gmbh Benzyl-substituted tetracyclic heterocyclic compounds as pde5 inhibitors
WO2010015588A1 (en) * 2008-08-05 2010-02-11 Nycomed Gmbh Benzyl-substituted tetracyclic heterocyclic compounds
WO2011015523A1 (en) 2009-08-03 2011-02-10 Nycomed Gmbh Benzyl-substituted tetracyclic heterocyclic compounds
WO2013109738A1 (en) 2012-01-17 2013-07-25 The Trustees Of Columbia University In The City Of New York Novel phosphodiesterase inhibitors and uses thereof
ES2776353T3 (es) 2013-07-17 2020-07-30 Univ Columbia Inhibidores de la fosfodiesterasa novedosos y usos de los mismos
WO2024173675A1 (en) 2023-02-16 2024-08-22 University Of Rochester Improving glymphatic-lymphatic efflux

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60112974T2 (de) * 2001-02-12 2006-02-16 Lilly Icos Llc, Wilmington Carbolinderivate

Also Published As

Publication number Publication date
CN101605791A (zh) 2009-12-16
ZA200904440B (en) 2010-04-28
WO2008095835A1 (en) 2008-08-14
MX2009007682A (es) 2009-07-29
EA200901034A1 (ru) 2010-02-26
US20100120730A1 (en) 2010-05-13
JP2010517958A (ja) 2010-05-27
MA31229B1 (fr) 2010-03-01
EP2109610A1 (en) 2009-10-21
AR065157A1 (es) 2009-05-20
KR20090106633A (ko) 2009-10-09
TW200902528A (en) 2009-01-16
CA2675357A1 (en) 2008-08-14
IL200102A0 (en) 2010-04-15
EP1953159A1 (en) 2008-08-06
TN2009000267A1 (en) 2010-10-18
AU2008212987A1 (en) 2008-08-14
BRPI0808378A2 (pt) 2014-07-01

Similar Documents

Publication Publication Date Title
NO20092902L (no) 6-benzyl-2,3,4,7-tetrahydro-indolo[2,3-c]kinolinforbindelser nyttige som PDE5-inhibitorer
NO20081162L (no) Imidazo [1,2-A]-pyridin med anti-celle-proliferingsaktivitet
MX2009010728A (es) Compuestos de imidazo[1,2-a]piridina como inhibidores de la tirosina-cinasa repectora.
MX2010008719A (es) Pirrolo [2,-d] piridinas y usos de las mismas como inhibidores de cinasa de tirosina.
NO20074666L (no) Imidazo(1,2-A)pyridinforbindelser som VEGF-R2-inhibitorer
EA201201663A1 (ru) Производные 2-(ариламино)-3н-имидазо[4,5-b]пиридин-6-карбоксамида и их применение в качестве ингибиторов mpges-1
MX358682B (es) Derivados de pirazolo [1,5a]pirimidina y de tieno[3,2b] pirimidina como moduladores de la cinasa asociada al receptor de la interleucina 4 (irak4).
NO20075987L (no) Bisykliske derviater som p38-kinaseinhibitorer
MX336381B (es) Boronatos como inhibidores de arginasa.
NO20070731L (no) Heterocykliske forbindelser.
NO20083427L (no) Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse
NO20072963L (no) 5-substituerte kinolin- og isokinolinderivater, fremgangsmate for deres fremstilling og deres anvendelse som betennelseshemmere
DK2124944T3 (da) Pyrazolo[3,4-b]pyridinderivater som phosphodiesteraseinhibitorer
EA201400182A1 (ru) Производные пиридин-2(1н)-она в качестве ингибиторов jak
WO2008049855A3 (en) 7-azaindole derivatives as c-met kinase inhibitors
MX2010009276A (es) Pirrolopirimidincarboxamidas.
AU2010332955A8 (en) 3,4,4A,10B-tetrahydro-1H-thiopyrano-[4, 3-c] isoquinoline derivatives
EA201491376A1 (ru) Производные 1h-пирроло[2,3-b]пиридина и их применение в качестве ингибиторов киназы
MX2010007927A (es) Derivados de 4-(pirrolo[2,3-c]piridin-3-il)pirimidin-2-ilamina.
ATE496918T1 (de) Als a2b-adenosinrezeptorantagonisten geeignete 5- phenyl-6-pyridin-4-yl-1,3-dihydro-2h-imidazoä4, - büpyridin-2-onderivate
MX337638B (es) Isoxazolo [5, 4-b] piridinas herbicidas.
WO2008104473A3 (en) Pyrazolopyriidine derivatives and their use as kinase inhibitors
MY154498A (en) Pyrazolone derivatives as pde4 inhibitors
TN2012000034A1 (en) Methylpyrrolopyrimidinecarboxamides
NO20082105L (no) Pyrazoloisokinolinderivater

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application