ATE310011T1 - Inhibitoren des interleukin-1-beta konvertierenden enzyms - Google Patents

Inhibitoren des interleukin-1-beta konvertierenden enzyms

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Publication number
ATE310011T1
ATE310011T1 AT96945237T AT96945237T ATE310011T1 AT E310011 T1 ATE310011 T1 AT E310011T1 AT 96945237 T AT96945237 T AT 96945237T AT 96945237 T AT96945237 T AT 96945237T AT E310011 T1 ATE310011 T1 AT E310011T1
Authority
AT
Austria
Prior art keywords
interleukin
compounds
inhibitors
diseases
converting enzyme
Prior art date
Application number
AT96945237T
Other languages
English (en)
Inventor
Guy W Bemis
John P Duffy
Wolf Herman Fridman
Julian M C Golec
David J Livingston
Michael D Mullican
Mark A Murcko
Robert E Zelle
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE310011T1 publication Critical patent/ATE310011T1/de

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
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    • A61P5/00Drugs for disorders of the endocrine system
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
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AT96945237T 1995-12-20 1996-12-20 Inhibitoren des interleukin-1-beta konvertierenden enzyms ATE310011T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/575,648 US5843904A (en) 1995-12-20 1995-12-20 Inhibitors of interleukin-1βconverting enzyme
PCT/US1996/020370 WO1997022618A1 (en) 1995-12-20 1996-12-20 INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME

Publications (1)

Publication Number Publication Date
ATE310011T1 true ATE310011T1 (de) 2005-12-15

Family

ID=24301162

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96945237T ATE310011T1 (de) 1995-12-20 1996-12-20 Inhibitoren des interleukin-1-beta konvertierenden enzyms

Country Status (21)

Country Link
US (2) US5843904A (de)
EP (1) EP0876395B1 (de)
JP (3) JP4009320B2 (de)
KR (1) KR20000064454A (de)
CN (2) CN1127511C (de)
AT (1) ATE310011T1 (de)
AU (1) AU722936B2 (de)
BR (1) BR9612191A (de)
CA (1) CA2240489A1 (de)
CZ (1) CZ292633B6 (de)
DE (1) DE69635458T2 (de)
HK (1) HK1016611A1 (de)
HU (1) HUP9902254A3 (de)
IL (1) IL124954A (de)
NO (1) NO982774L (de)
NZ (1) NZ326555A (de)
PL (1) PL188813B1 (de)
RU (1) RU2213096C2 (de)
TR (1) TR199801168T2 (de)
WO (1) WO1997022618A1 (de)
ZA (1) ZA9610797B (de)

Families Citing this family (49)

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WO1998011129A1 (en) * 1996-09-12 1998-03-19 Idun Pharmaceuticals, Incorporated C-TERMINAL MODIFIED (N-SUBSTITUTED)-2-INDOLYL DIPEPTIDES AS INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES
US5877197A (en) * 1996-12-16 1999-03-02 Karanewsky; Donald S. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6184244B1 (en) * 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6093742A (en) * 1997-06-27 2000-07-25 Vertex Pharmaceuticals, Inc. Inhibitors of p38
US6184210B1 (en) * 1997-10-10 2001-02-06 Cytovia, Inc. Dipeptide apoptosis inhibitors and the use thereof
US6054446A (en) * 1997-12-24 2000-04-25 Sri International Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use
DE69925268T2 (de) * 1998-03-16 2006-03-23 Cytovia, Inc., San Diego Dipeptid-Caspase-Inhibitoren und deren Verwendung
US6242422B1 (en) * 1998-10-22 2001-06-05 Idun Pharmacueticals, Inc. (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases
US7157430B2 (en) 1998-10-22 2007-01-02 Idun Pharmaceuticals, Inc. (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases
CA2360740A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
TW200404789A (en) * 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
JP2002539183A (ja) 1999-03-16 2002-11-19 サイトビア インコーポレイテッド 置換2−アミノベンズアミドカスパーゼインヒビターおよびその使用
JP2002541237A (ja) 1999-04-09 2002-12-03 サイトビア インコーポレイテッド カスパーゼインヒビターおよびその使用
JP2003506411A (ja) * 1999-08-09 2003-02-18 トリペップ アクチ ボラゲット タンパク質重合阻害剤および使用方法
WO2001016093A1 (en) 1999-08-27 2001-03-08 Cytovia, Inc. SUBSTITUTED α-HYDROXY ACID CASPASE INHIBITORS AND THE USE THEREOF
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
US6566338B1 (en) 1999-10-12 2003-05-20 Cytovia, Inc. Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death
US6525024B1 (en) 2000-04-17 2003-02-25 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
EP2241328A1 (de) 2000-05-12 2010-10-20 Immunex Corporation Interleukin-1 Inhibitoren zur Behandlung von Erkrankungen
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
US6613801B2 (en) 2000-05-30 2003-09-02 Transtech Pharma, Inc. Method for the synthesis of compounds of formula I and their uses thereof
JP2004521080A (ja) 2000-09-08 2004-07-15 メルク フロスト カナダ アンド カンパニー カスパーゼ−3阻害薬としてのγ−ケト酸ジペプチド類
PE20020500A1 (es) * 2000-09-13 2002-06-25 Vertex Pharma Derivados de piperidina, tetrahidroquinolina, tetrahidroisoquinolina como inhibidores de caspasas
HUP0303540A2 (hu) * 2000-12-20 2004-01-28 Bristol-Myers Squibb Pharma Co. Diaminok mint kemokin receptor aktivitás modulátorai, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
WO2002060859A2 (en) * 2000-12-20 2002-08-08 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
JPWO2002066063A1 (ja) * 2001-02-23 2004-06-17 星野 友昭 代謝性骨疾患治療剤
WO2002070473A2 (en) 2001-03-05 2002-09-12 Transtech Pharma, Inc. Carboxamide derivatives as therapeutic agents
AU2002245590B2 (en) 2001-03-05 2006-06-29 Transtech Pharma, Inc. Benzimidazole derivatives as therapeutic agents
EP1450837A4 (de) * 2001-08-07 2006-01-04 Immunex Corp Interleukin-1-rezeptoren bei der behandlung von krankheiten
US6593455B2 (en) * 2001-08-24 2003-07-15 Tripep Ab Tripeptide amides that block viral infectivity and methods of use thereof
WO2003024995A1 (en) * 2001-09-19 2003-03-27 Tripep Ab Molecules that block viral infectivity and methods of use thereof
EP1450901A4 (de) * 2001-12-10 2005-05-25 Bristol Myers Squibb Co (1-phenyl-2-heteroaryl)ethyl-guanidin-verbindungen als hemmer der mitochondrialen f1f0 atp hydrolase
WO2003075921A2 (en) 2002-03-05 2003-09-18 Transtech Pharma, Inc. Mono- and bicyclic azole derivatives that inhibit the interaction of ligands with rage
AU2003218028A1 (en) 2002-03-08 2003-09-22 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US7361459B2 (en) * 2002-04-22 2008-04-22 University Of Maryland, Baltimore County Antiviral inhibition of capsid proteins
US20050096319A1 (en) * 2003-02-21 2005-05-05 Balzarini Jan M.R. Identification of compounds that inhibit replication of human immunodeficiency virus
NZ541883A (en) * 2003-02-21 2008-12-24 Tripep Ab Glycinamide derivative for inhibiting HIV replication
GB0329572D0 (en) * 2003-12-20 2004-01-28 Astrazeneca Ab Amide derivatives
JP4898658B2 (ja) 2004-03-12 2012-03-21 バーテックス ファーマシューティカルズ インコーポレイテッド アスパラギン酸アセタールカスパーゼ阻害剤の製造のための方法および中間体
NZ588448A (en) * 2004-05-15 2012-01-12 Vertex Pharma Treating seizures using interleukin-1beta converting enzyme (ICE) inhibitors
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BR9612191A (pt) 1999-07-13
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US6162790A (en) 2000-12-19
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