BR9612191A - Inibidores de enzima conversora de interleuciana-1beta - Google Patents
Inibidores de enzima conversora de interleuciana-1betaInfo
- Publication number
- BR9612191A BR9612191A BR9612191A BR9612191A BR9612191A BR 9612191 A BR9612191 A BR 9612191A BR 9612191 A BR9612191 A BR 9612191A BR 9612191 A BR9612191 A BR 9612191A BR 9612191 A BR9612191 A BR 9612191A
- Authority
- BR
- Brazil
- Prior art keywords
- interleukin
- compounds
- converting enzyme
- diseases
- relates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Rheumatology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/575,648 US5843904A (en) | 1995-12-20 | 1995-12-20 | Inhibitors of interleukin-1βconverting enzyme |
PCT/US1996/020370 WO1997022618A1 (en) | 1995-12-20 | 1996-12-20 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9612191A true BR9612191A (pt) | 1999-07-13 |
Family
ID=24301162
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9612191A BR9612191A (pt) | 1995-12-20 | 1996-12-20 | Inibidores de enzima conversora de interleuciana-1beta |
Country Status (21)
Country | Link |
---|---|
US (2) | US5843904A (pt) |
EP (1) | EP0876395B1 (pt) |
JP (3) | JP4009320B2 (pt) |
KR (1) | KR20000064454A (pt) |
CN (2) | CN1500781A (pt) |
AT (1) | ATE310011T1 (pt) |
AU (1) | AU722936B2 (pt) |
BR (1) | BR9612191A (pt) |
CA (1) | CA2240489A1 (pt) |
CZ (1) | CZ292633B6 (pt) |
DE (1) | DE69635458T2 (pt) |
HK (1) | HK1016611A1 (pt) |
HU (1) | HUP9902254A3 (pt) |
IL (1) | IL124954A (pt) |
NO (1) | NO982774L (pt) |
NZ (1) | NZ326555A (pt) |
PL (1) | PL188813B1 (pt) |
RU (1) | RU2213096C2 (pt) |
TR (1) | TR199801168T2 (pt) |
WO (1) | WO1997022618A1 (pt) |
ZA (1) | ZA9610797B (pt) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843904A (en) * | 1995-12-20 | 1998-12-01 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1βconverting enzyme |
EP0920444B1 (en) * | 1996-09-12 | 2002-12-18 | Idun Pharmaceuticals, Inc. | C-TERMINAL MODIFIED (N-SUBSTITUTED)-2-INDOLYL DIPEPTIDES AS INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES |
US5869519A (en) * | 1996-12-16 | 1999-02-09 | Idun Pharmaceuticals, Inc. | C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6184244B1 (en) * | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US5877197A (en) * | 1996-12-16 | 1999-03-02 | Karanewsky; Donald S. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
US6184210B1 (en) * | 1997-10-10 | 2001-02-06 | Cytovia, Inc. | Dipeptide apoptosis inhibitors and the use thereof |
US6054446A (en) * | 1997-12-24 | 2000-04-25 | Sri International | Anti-estrogenic steroids, and associated pharmaceutical compositions and methods of use |
WO1999047154A1 (en) * | 1998-03-16 | 1999-09-23 | Cytovia, Inc. | Dipeptide caspase inhibitors and the use thereof |
US7157430B2 (en) | 1998-10-22 | 2007-01-02 | Idun Pharmaceuticals, Inc. | (Substituted)acyl dipeptidyl inhibitors of the ICE/CED-3 family of cysteine proteases |
US6242422B1 (en) * | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
CA2360740A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
TW200404789A (en) * | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
DE60030097T2 (de) | 1999-03-16 | 2007-03-08 | Cytovia, Inc., San Diego | Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung |
EP1177168B1 (en) | 1999-04-09 | 2007-05-30 | Cytovia, Inc. | Caspase inhibitors and the use thereof |
MXPA02001349A (es) * | 1999-08-09 | 2002-07-22 | Tripep Ab | Inhibidores de la polimerizacion de proteinas y metodos de uso. |
KR20020033777A (ko) | 1999-08-27 | 2002-05-07 | 추후보정 | 치환된 α-히드록시 산 카스파제 억제제 및 이의 용도 |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6566338B1 (en) | 1999-10-12 | 2003-05-20 | Cytovia, Inc. | Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death |
US6525024B1 (en) | 2000-04-17 | 2003-02-25 | Idun Pharmaceuticals, Inc. | Inhibitors of the ICE/ced-3 family of cysteine proteases |
EP1712239A3 (en) * | 2000-05-12 | 2007-08-22 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
US6613801B2 (en) * | 2000-05-30 | 2003-09-02 | Transtech Pharma, Inc. | Method for the synthesis of compounds of formula I and their uses thereof |
JP2004521080A (ja) | 2000-09-08 | 2004-07-15 | メルク フロスト カナダ アンド カンパニー | カスパーゼ−3阻害薬としてのγ−ケト酸ジペプチド類 |
JP2004509120A (ja) * | 2000-09-13 | 2004-03-25 | バーテックス ファーマシューティカルズ インコーポレイテッド | カスパーゼ阻害剤およびそれらの用途 |
JP2005506949A (ja) * | 2000-12-20 | 2005-03-10 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | ケモカイン受容体の調節剤としてのジアミン |
EP1343751A2 (en) * | 2000-12-20 | 2003-09-17 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US20050074434A1 (en) * | 2001-02-23 | 2005-04-07 | Tomoaki Hoshino | Remedies for metabolic bone diseases |
WO2002070473A2 (en) | 2001-03-05 | 2002-09-12 | Transtech Pharma, Inc. | Carboxamide derivatives as therapeutic agents |
WO2002069965A1 (en) | 2001-03-05 | 2002-09-12 | Transtech Pharma, Inc. | Benzimidazole derivatives as therapeutic agents |
EP1450837A4 (en) * | 2001-08-07 | 2006-01-04 | Immunex Corp | INTERLEUKIN-1 RECEPTORS IN THE TREATMENT OF DISEASES |
US6593455B2 (en) * | 2001-08-24 | 2003-07-15 | Tripep Ab | Tripeptide amides that block viral infectivity and methods of use thereof |
WO2003024995A1 (en) * | 2001-09-19 | 2003-03-27 | Tripep Ab | Molecules that block viral infectivity and methods of use thereof |
WO2003050261A2 (en) * | 2001-12-10 | 2003-06-19 | Bristol-Myers Squibb Company | (1-phenyl-2-heteroaryl)ethyl-guanidine compounds as inhibitors of mitochondrial f1f0 atp hydrolase |
CN100525763C (zh) | 2002-03-05 | 2009-08-12 | 特兰斯泰克制药公司 | 抑制配体与高级糖化终产物受体相互作用的单和双环吡咯衍生物 |
US7087604B2 (en) | 2002-03-08 | 2006-08-08 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
KR100960909B1 (ko) * | 2002-04-22 | 2010-06-04 | 유니버시티 오브 메릴랜드, 볼티모어 카운티 | 캡시드 단백질의 항바이러스 억제 |
US20050096319A1 (en) * | 2003-02-21 | 2005-05-05 | Balzarini Jan M.R. | Identification of compounds that inhibit replication of human immunodeficiency virus |
JP2006518373A (ja) * | 2003-02-21 | 2006-08-10 | トリペップ アクチ ボラゲット | Hiv複製を抑制するためのグリシンアミド誘導体 |
GB0329572D0 (en) * | 2003-12-20 | 2004-01-28 | Astrazeneca Ab | Amide derivatives |
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1995
- 1995-12-20 US US08/575,648 patent/US5843904A/en not_active Expired - Lifetime
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1996
- 1996-12-20 IL IL12495496A patent/IL124954A/xx not_active IP Right Cessation
- 1996-12-20 BR BR9612191A patent/BR9612191A/pt not_active Application Discontinuation
- 1996-12-20 NZ NZ326555A patent/NZ326555A/xx unknown
- 1996-12-20 CZ CZ19981905A patent/CZ292633B6/cs not_active IP Right Cessation
- 1996-12-20 CN CNA031589928A patent/CN1500781A/zh active Pending
- 1996-12-20 KR KR1019980704611A patent/KR20000064454A/ko not_active Application Discontinuation
- 1996-12-20 TR TR1998/01168T patent/TR199801168T2/xx unknown
- 1996-12-20 EP EP96945237A patent/EP0876395B1/en not_active Expired - Lifetime
- 1996-12-20 JP JP52300897A patent/JP4009320B2/ja not_active Expired - Fee Related
- 1996-12-20 ZA ZA9610797A patent/ZA9610797B/xx unknown
- 1996-12-20 DE DE69635458T patent/DE69635458T2/de not_active Expired - Lifetime
- 1996-12-20 RU RU98113932/04K patent/RU2213096C2/ru not_active IP Right Cessation
- 1996-12-20 AT AT96945237T patent/ATE310011T1/de not_active IP Right Cessation
- 1996-12-20 PL PL96327333A patent/PL188813B1/pl not_active IP Right Cessation
- 1996-12-20 CN CN96199733A patent/CN1127511C/zh not_active Expired - Fee Related
- 1996-12-20 CA CA002240489A patent/CA2240489A1/en not_active Abandoned
- 1996-12-20 WO PCT/US1996/020370 patent/WO1997022618A1/en active IP Right Grant
- 1996-12-20 HU HU9902254A patent/HUP9902254A3/hu unknown
- 1996-12-20 AU AU14658/97A patent/AU722936B2/en not_active Ceased
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1998
- 1998-02-17 US US09/024,537 patent/US6162790A/en not_active Expired - Lifetime
- 1998-06-16 NO NO982774A patent/NO982774L/no not_active Application Discontinuation
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1999
- 1999-04-09 HK HK99101441A patent/HK1016611A1/xx not_active IP Right Cessation
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2003
- 2003-12-05 JP JP2003408331A patent/JP2004143182A/ja not_active Withdrawn
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