ATE305035T1 - Verfahren und verbindungen nützlich in der gezielten klonierung durch homologe rekombination - Google Patents
Verfahren und verbindungen nützlich in der gezielten klonierung durch homologe rekombinationInfo
- Publication number
- ATE305035T1 ATE305035T1 AT00954461T AT00954461T ATE305035T1 AT E305035 T1 ATE305035 T1 AT E305035T1 AT 00954461 T AT00954461 T AT 00954461T AT 00954461 T AT00954461 T AT 00954461T AT E305035 T1 ATE305035 T1 AT E305035T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- homologous recombination
- cloning
- compounds useful
- compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mycology (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Solid Fuels And Fuel-Associated Substances (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Detergent Compositions (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/350,830 US6355412B1 (en) | 1999-07-09 | 1999-07-09 | Methods and compositions for directed cloning and subcloning using homologous recombination |
PCT/EP2000/006533 WO2001004288A1 (en) | 1999-07-09 | 2000-07-10 | Methods and compositions for directed cloning and subcloning using homologous recombination |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE305035T1 true ATE305035T1 (de) | 2005-10-15 |
Family
ID=23378374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00954461T ATE305035T1 (de) | 1999-07-09 | 2000-07-10 | Verfahren und verbindungen nützlich in der gezielten klonierung durch homologe rekombination |
Country Status (21)
Country | Link |
---|---|
US (1) | US6355412B1 (de) |
EP (1) | EP1204740B1 (de) |
JP (2) | JP4312981B2 (de) |
KR (1) | KR100751587B1 (de) |
CN (2) | CN101492694B (de) |
AT (1) | ATE305035T1 (de) |
AU (1) | AU781379B2 (de) |
BR (1) | BR0012283A (de) |
CA (1) | CA2377938C (de) |
DE (1) | DE60022766T2 (de) |
DK (1) | DK1204740T3 (de) |
ES (1) | ES2249291T3 (de) |
HK (1) | HK1046926A1 (de) |
HU (1) | HU228977B1 (de) |
IL (1) | IL147385A0 (de) |
MX (1) | MX252928B (de) |
NZ (1) | NZ516722A (de) |
PL (1) | PL353634A1 (de) |
WO (1) | WO2001004288A1 (de) |
YU (1) | YU1502A (de) |
ZA (1) | ZA200200152B (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ520579A (en) * | 1997-10-24 | 2004-08-27 | Invitrogen Corp | Recombinational cloning using nucleic acids having recombination sites and methods for synthesizing double stranded nucleic acids |
US6355412B1 (en) * | 1999-07-09 | 2002-03-12 | The European Molecular Biology Laboratory | Methods and compositions for directed cloning and subcloning using homologous recombination |
AU8337701A (en) * | 2000-08-14 | 2002-02-25 | Us Health | Enhanced homologous recombination mediated by lambda recombination proteins |
US7198924B2 (en) | 2000-12-11 | 2007-04-03 | Invitrogen Corporation | Methods and compositions for synthesis of nucleic acid molecules using multiple recognition sites |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
US7083976B2 (en) | 2001-06-30 | 2006-08-01 | The European Molecular Biology Laboratory | Tyrosine recombinase for genetic engineering |
WO2003010322A1 (en) * | 2001-07-20 | 2003-02-06 | Youming Zhang | Improved rect or recet cloning and subcloning method |
US7338800B2 (en) * | 2002-01-16 | 2008-03-04 | Baylor College Of Medicine | In vivo gene transfer |
CA2473741C (en) * | 2002-01-18 | 2015-12-22 | Morphotek, Inc. | A method for generating engineered cells for locus specific gene regulation and analysis |
CA2482481A1 (en) * | 2002-04-16 | 2003-10-30 | Promega Corporation | Method to enhance homologous recombination |
US20040106566A1 (en) * | 2002-05-17 | 2004-06-03 | Shi-Lung Lin | RNA-splicing and processing-directed gene silencing and the relative applications thereof |
WO2004013299A2 (en) * | 2002-08-02 | 2004-02-12 | The General Hospital Corporation | Methods for the production of cells and mammals with desired genetic modifications |
US7135324B2 (en) * | 2002-09-04 | 2006-11-14 | The University Of Connecticut | Viral recombinases, related articles, and methods of use thereof |
US7563600B2 (en) * | 2002-09-12 | 2009-07-21 | Combimatrix Corporation | Microarray synthesis and assembly of gene-length polynucleotides |
EP1475437A4 (de) * | 2002-12-10 | 2005-06-01 | Kazusa Dna Res Inst Foundation | Verfahren zur effizienten rekombination eines durch cdna codierten orf und eines matrizenvektors, dabei zu verwendender trap-vektor und primer |
US20040209370A1 (en) * | 2002-12-19 | 2004-10-21 | Wonchul Suh | Method for chromosomal engineering |
WO2005017128A2 (en) * | 2003-02-26 | 2005-02-24 | University Of Massachusetts | Improved reagents for recombinogenic engineering and uses thereof |
US7521242B2 (en) * | 2003-05-09 | 2009-04-21 | The United States Of America As Represented By The Department Of Health And Human Services | Host cells deficient for mismatch repair and their use in methods for inducing homologous recombination using single-stranded nucleic acids |
WO2004106375A1 (en) | 2003-05-30 | 2004-12-09 | Merus Biopharmaceuticals B.V. I.O. | Fab library for the preparation of anti vegf and anti rabies virus fabs |
US20100069614A1 (en) | 2008-06-27 | 2010-03-18 | Merus B.V. | Antibody producing non-human mammals |
US7781190B2 (en) * | 2003-07-24 | 2010-08-24 | The University Of Hong Kong | Method for constructing and modifying large DNA molecules |
EP2484687A3 (de) | 2003-08-08 | 2012-11-14 | Life Technologies Corporation | Verfahren und Zusammensetzungen zum nahtlosen Klonieren von Nukleinsäuremolekülen |
WO2005054438A2 (en) | 2003-12-01 | 2005-06-16 | Invitrogen Corporation | Nucleic acid molecules containing recombination sites and methods of using the same |
WO2005089110A2 (en) * | 2004-02-27 | 2005-09-29 | President And Fellows Of Harvard College | Polynucleotide synthesis |
US7674621B2 (en) * | 2004-05-21 | 2010-03-09 | The United States Of America As Represented By The Department Of Health And Human Services | Plasmids and phages for homologous recombination and methods of use |
GB0423755D0 (en) * | 2004-10-26 | 2004-11-24 | Gene Bridges Gmbh | Methods for heterologus expression of secondary metabolites |
US20080051326A1 (en) * | 2004-11-12 | 2008-02-28 | Alexander Dylan C | Antiinfective Lipopeptides |
WO2006127423A2 (en) * | 2005-05-18 | 2006-11-30 | Codon Devices, Inc. | Methods of producing polynucleotide libraries using scarless ligation |
US20070004041A1 (en) * | 2005-06-30 | 2007-01-04 | Codon Devices, Inc. | Heirarchical assembly methods for genome engineering |
WO2007136834A2 (en) * | 2006-05-19 | 2007-11-29 | Codon Devices, Inc. | Combined extension and ligation for nucleic acid assembly |
WO2008027558A2 (en) | 2006-08-31 | 2008-03-06 | Codon Devices, Inc. | Iterative nucleic acid assembly using activation of vector-encoded traits |
ES2488091T3 (es) * | 2006-12-07 | 2014-08-26 | Huawei Technologies Co., Ltd. | Método y servidor de filtrado para filtrar el contenido de comunicación de un usuario itinerante |
CN101016551B (zh) * | 2007-02-01 | 2010-05-19 | 南京师范大学 | 一种在dna载体中同时引入多个dna片段的方法 |
JP5837747B2 (ja) | 2007-05-17 | 2015-12-24 | ベーリンガー インゲルハイム エルツェーファウ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 組換えタンパク質を工業規模で製造する方法 |
GB0803109D0 (en) * | 2008-02-20 | 2008-03-26 | Gene Bridges Gmbh | Method of nucleic acid recombination |
AU2009220532B2 (en) * | 2008-03-07 | 2013-10-31 | National University Corporation University Of Toyama | Homologous recombination method, cloning method, and kit |
DK3241435T3 (da) | 2009-07-08 | 2021-08-23 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
WO2011053957A2 (en) | 2009-11-02 | 2011-05-05 | Gen9, Inc. | Compositions and methods for the regulation of multiple genes of interest in a cell |
WO2011063363A2 (en) * | 2009-11-20 | 2011-05-26 | Opx Biotechnologies, Inc. | Production of an organic acid and/or related chemicals |
GB0922108D0 (en) | 2009-12-17 | 2010-02-03 | Gene Bridges Gmbh | Heterologous hosts |
WO2011080505A2 (en) | 2009-12-28 | 2011-07-07 | Bigdna Ltd | Method of growing phage for commercial use |
NZ603816A (en) | 2010-05-27 | 2014-06-27 | Pharmazell Gmbh | Novel 7alpha-hydroxysteroid dehydrogenase knockout mutants and use thereof |
GB201009732D0 (en) | 2010-06-10 | 2010-07-21 | Gene Bridges Gmbh | Direct cloning |
NZ605966A (en) | 2010-06-17 | 2015-04-24 | Kymab Ltd | Animal models and therapeutic molecules |
WO2012064975A1 (en) | 2010-11-12 | 2012-05-18 | Gen9, Inc. | Protein arrays and methods of using and making the same |
JP6118725B2 (ja) | 2010-11-12 | 2017-04-19 | ジェン9・インコーポレイテッドGen9,INC. | 核酸合成のための方法およびデバイス |
EP2689020B1 (de) | 2011-03-22 | 2018-05-16 | OPX Biotechnologies Inc. | Mikrobielle herstellung chemischer produkte und zusammensetzungen daraus sowie verfahren und systeme dafür |
EP2543720A1 (de) | 2011-07-07 | 2013-01-09 | Delphi Genetics | Genetisch modifizierte Phagen und Verwendung dafür |
JP6174019B2 (ja) | 2011-07-07 | 2017-08-02 | デルフィ ジェネティクス | 遺伝子組換えファージ及びその利用 |
US9920323B2 (en) | 2011-07-07 | 2018-03-20 | Delphi Genetics | Genetically modified phage and use thereof |
LT3594340T (lt) | 2011-08-26 | 2021-10-25 | Gen9, Inc. | Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai |
JP5813880B2 (ja) | 2011-09-19 | 2015-11-17 | カイマブ・リミテッド | ヒトへの使用に合わせて作製された抗体、可変ドメインおよび鎖 |
WO2014153188A2 (en) | 2013-03-14 | 2014-09-25 | Life Technologies Corporation | High efficiency, small volume nucleic acid synthesis |
LT2768607T (lt) | 2011-09-26 | 2021-12-27 | Thermo Fisher Scientific Geneart Gmbh | Daugiašulininė plokštelė didelio efektyvumo, mažo tūrio nukleorūgščių sintezei atlikti |
GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
US9150853B2 (en) | 2012-03-21 | 2015-10-06 | Gen9, Inc. | Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis |
CN102634534A (zh) * | 2012-03-30 | 2012-08-15 | 深圳市中联生物科技开发有限公司 | 基于同源重组的核酸分子克隆方法及相关试剂盒 |
CA2871505C (en) | 2012-04-24 | 2021-10-12 | Gen9, Inc. | Methods for sorting nucleic acids and multiplexed preparative in vitro cloning |
US20130288320A1 (en) | 2012-04-27 | 2013-10-31 | Bioamber Inc. | Methods and microorganisms for increasing the biological synthesis of difunctional alkanes |
CN102676470B (zh) * | 2012-05-29 | 2014-04-16 | 吴江近岸蛋白质科技有限公司 | 一种用于快速基因克隆的酶混合物及制备方法、包含该酶混合物的试剂盒 |
WO2013191769A1 (en) * | 2012-06-22 | 2013-12-27 | Mayo Foundation For Medical Education And Research | Genome editing |
AU2013280661A1 (en) | 2012-06-25 | 2015-01-22 | Gen9, Inc. | Methods for nucleic acid assembly and high throughput sequencing |
CA2881666A1 (en) | 2012-08-10 | 2014-02-13 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
JP6412509B2 (ja) | 2013-02-22 | 2018-10-24 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ポリペプチドの組換え生産のためのアミノ酸栄養要求性除去原核生物株の使用 |
US9447438B2 (en) | 2013-03-15 | 2016-09-20 | Cargill, Incorporated | Acetyl-coA carboxylases |
US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
US10337038B2 (en) | 2013-07-19 | 2019-07-02 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
CN105637087A (zh) * | 2013-09-18 | 2016-06-01 | 科马布有限公司 | 方法、细胞与生物体 |
JP6730199B2 (ja) | 2014-06-11 | 2020-07-29 | デューク ユニバーシティ | 合成代謝弁を用いた迅速かつ動的なフラックス制御のための組成物及び方法 |
BR112017001463A2 (pt) | 2014-07-25 | 2018-02-20 | Delphi Genetics | célula hospedeira melhorada para produzir proteínas |
EP2993228B1 (de) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Herstellung von fettsäureestern |
CN115927293A (zh) | 2014-12-09 | 2023-04-07 | 生命技术公司 | 高效小体积核酸合成 |
WO2016164586A1 (en) | 2015-04-09 | 2016-10-13 | Genomatica, Inc. | Engineered microorganisms & methods for improved crotyl alcohol production |
EP3998341A3 (de) * | 2016-04-06 | 2022-08-24 | Gene Bridges GmbH | Adenovirale vektoren |
CN106834335B (zh) * | 2017-01-11 | 2020-05-08 | 浙江科技学院 | 在酵母菌中实现高准确率基因同源克隆的方法 |
EP3577227A4 (de) | 2017-02-02 | 2020-12-30 | Cargill Inc. | Genetisch veränderte zellen, die c6-c10-fettsäurederivate produzieren |
US20200392538A1 (en) * | 2017-08-30 | 2020-12-17 | President And Fellows Of Harvard College | Iterative genome assembly |
JP7288915B2 (ja) * | 2018-10-04 | 2023-06-08 | 株式会社カネカ | 植物のゲノム編集に用いられるdna構築物 |
KR102129584B1 (ko) | 2018-11-26 | 2020-07-02 | 충북대학교 산학협력단 | 목적 유전자를 선형 벡터에 삽입하는 방법 |
JP2022530653A (ja) * | 2019-05-01 | 2022-06-30 | パクト ファーマ インコーポレイテッド | Tet2改変t細胞療法を使用するがんの治療のための組成物及び方法 |
CN110184287B (zh) * | 2019-05-24 | 2024-01-30 | 华南农业大学 | 一种制备重组病毒的方法及其应用 |
CN110218724A (zh) * | 2019-06-13 | 2019-09-10 | 山西农业大学 | 猪nr1h3基因过表达载体质粒的构建方法及其表达水平的检测 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792633A (en) * | 1992-05-21 | 1998-08-11 | Genebiomed, Inc. | Process for gene targeting and genome manipulations |
WO1998059060A1 (en) | 1997-06-23 | 1998-12-30 | The Rockefeller University | Methods of preforming homologous recombination based modification of nucleic acids in recombination deficient cells and use of the modified nucleic acid products thereof |
ATE242320T1 (de) | 1997-12-05 | 2003-06-15 | Europ Lab Molekularbiolog | Neue methode zur klonierung dns unter anwendung des e. coli rece/rect rekombinationssystems |
US6355412B1 (en) * | 1999-07-09 | 2002-03-12 | The European Molecular Biology Laboratory | Methods and compositions for directed cloning and subcloning using homologous recombination |
-
1999
- 1999-07-09 US US09/350,830 patent/US6355412B1/en not_active Expired - Lifetime
-
2000
- 2000-07-10 ES ES00954461T patent/ES2249291T3/es not_active Expired - Lifetime
- 2000-07-10 KR KR1020027000338A patent/KR100751587B1/ko active IP Right Grant
- 2000-07-10 JP JP2001509492A patent/JP4312981B2/ja not_active Expired - Fee Related
- 2000-07-10 HU HU0201963A patent/HU228977B1/hu not_active IP Right Cessation
- 2000-07-10 PL PL00353634A patent/PL353634A1/xx unknown
- 2000-07-10 CN CN2009100050851A patent/CN101492694B/zh not_active Expired - Fee Related
- 2000-07-10 CN CNB008127395A patent/CN100469877C/zh not_active Expired - Fee Related
- 2000-07-10 DE DE60022766T patent/DE60022766T2/de not_active Expired - Lifetime
- 2000-07-10 DK DK00954461T patent/DK1204740T3/da active
- 2000-07-10 YU YU1502A patent/YU1502A/sh unknown
- 2000-07-10 AU AU66911/00A patent/AU781379B2/en not_active Ceased
- 2000-07-10 MX MXPA02000233 patent/MX252928B/es active IP Right Grant
- 2000-07-10 IL IL14738500A patent/IL147385A0/xx active IP Right Grant
- 2000-07-10 NZ NZ51672200A patent/NZ516722A/en not_active IP Right Cessation
- 2000-07-10 WO PCT/EP2000/006533 patent/WO2001004288A1/en active IP Right Grant
- 2000-07-10 EP EP00954461A patent/EP1204740B1/de not_active Expired - Lifetime
- 2000-07-10 BR BR0012283-1A patent/BR0012283A/pt not_active Application Discontinuation
- 2000-07-10 CA CA2377938A patent/CA2377938C/en not_active Expired - Lifetime
- 2000-07-10 AT AT00954461T patent/ATE305035T1/de not_active IP Right Cessation
-
2002
- 2002-01-08 ZA ZA200200152A patent/ZA200200152B/en unknown
- 2002-11-14 HK HK02108259A patent/HK1046926A1/xx not_active IP Right Cessation
-
2008
- 2008-11-28 JP JP2008303506A patent/JP5067970B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
HK1046926A1 (en) | 2003-01-30 |
JP4312981B2 (ja) | 2009-08-12 |
HUP0201963A3 (en) | 2004-01-28 |
AU6691100A (en) | 2001-01-30 |
IL147385A0 (en) | 2002-08-14 |
JP5067970B2 (ja) | 2012-11-07 |
CN101492694A (zh) | 2009-07-29 |
CN1373803A (zh) | 2002-10-09 |
EP1204740B1 (de) | 2005-09-21 |
ZA200200152B (en) | 2003-01-08 |
JP2003504053A (ja) | 2003-02-04 |
CA2377938A1 (en) | 2001-01-18 |
BR0012283A (pt) | 2002-06-11 |
AU781379B2 (en) | 2005-05-19 |
MX252928B (es) | 2008-01-04 |
MXPA02000233A (es) | 2003-08-20 |
DK1204740T3 (da) | 2006-02-20 |
KR20020033726A (ko) | 2002-05-07 |
KR100751587B1 (ko) | 2007-08-28 |
YU1502A (sh) | 2005-11-28 |
NZ516722A (de) | 2003-12-19 |
HUP0201963A2 (en) | 2002-09-28 |
EP1204740A1 (de) | 2002-05-15 |
WO2001004288A1 (en) | 2001-01-18 |
CN101492694B (zh) | 2011-08-31 |
PL353634A1 (en) | 2003-12-01 |
DE60022766D1 (de) | 2006-02-02 |
HU228977B1 (hu) | 2013-07-29 |
ES2249291T3 (es) | 2006-04-01 |
CA2377938C (en) | 2018-01-09 |
DE60022766T2 (de) | 2006-07-06 |
US6355412B1 (en) | 2002-03-12 |
CN100469877C (zh) | 2009-03-18 |
JP2009106295A (ja) | 2009-05-21 |
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