ATE298584T1 - Hyaluronidase zusammensetzungen zur behandlung intravitrealen hemorrhagischen blutes - Google Patents

Hyaluronidase zusammensetzungen zur behandlung intravitrealen hemorrhagischen blutes

Info

Publication number
ATE298584T1
ATE298584T1 AT96944203T AT96944203T ATE298584T1 AT E298584 T1 ATE298584 T1 AT E298584T1 AT 96944203 T AT96944203 T AT 96944203T AT 96944203 T AT96944203 T AT 96944203T AT E298584 T1 ATE298584 T1 AT E298584T1
Authority
AT
Austria
Prior art keywords
intravitreal
treatment
hyaluronidase
blood
hemorrhagic blood
Prior art date
Application number
AT96944203T
Other languages
English (en)
Inventor
Hampar L Karageozian
Vicken H Karageozian
Maria C Kenney
Jose L G Flores
Gabriel A C Aragon
Anthony B Nesburn
Original Assignee
Ista Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ista Pharmaceuticals Inc filed Critical Ista Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE298584T1 publication Critical patent/ATE298584T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/47Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016Disaccharides, e.g. lactose, lactulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT96944203T 1995-11-22 1996-11-20 Hyaluronidase zusammensetzungen zur behandlung intravitrealen hemorrhagischen blutes ATE298584T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/561,636 US5866120A (en) 1995-11-22 1995-11-22 Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
PCT/US1996/018843 WO1997018835A1 (en) 1995-11-22 1996-11-20 Enzymatic method and compositions for treating intravitreal hemorrhagic blood

Publications (1)

Publication Number Publication Date
ATE298584T1 true ATE298584T1 (de) 2005-07-15

Family

ID=24242789

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96944203T ATE298584T1 (de) 1995-11-22 1996-11-20 Hyaluronidase zusammensetzungen zur behandlung intravitrealen hemorrhagischen blutes

Country Status (15)

Country Link
US (5) US5866120A (de)
EP (1) EP0862456B1 (de)
JP (1) JP2000502325A (de)
KR (1) KR100463009B1 (de)
CN (1) CN1207684A (de)
AT (1) ATE298584T1 (de)
AU (1) AU1407097A (de)
BR (1) BR9611617A (de)
CA (1) CA2238360C (de)
DE (1) DE69634903T2 (de)
DK (1) DK0862456T3 (de)
ES (1) ES2245458T3 (de)
MX (1) MX9804051A (de)
PT (1) PT862456E (de)
WO (1) WO1997018835A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) * 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
DE69836858T2 (de) * 1997-05-22 2007-09-06 Ista Pharmaceuticals, Inc., La Jolla Verwendung von hyaluronidase zur herstellung eines augenpräparats zur glasskörperverflüssigung bei der behandlung von augenerkrankungen
AU758862B2 (en) 1998-03-09 2003-04-03 Ista Pharmaceuticals, Inc Use of corneal hardening agents in enzyme orthokeratology
US7008960B1 (en) 1999-03-02 2006-03-07 Vitreo-Retinal Technologies, Inc. Agents for intravitreal administration to treat or prevent disorders of the eye
US6335006B1 (en) 1999-03-22 2002-01-01 Boston Innovative Optics, Inc. Methods of using agents that act on the epithelial sheet of a human eye
ATE254471T1 (de) * 1999-04-29 2003-12-15 Ista Pharmaceuticals Inc Verwendung eines bestimmten hyaluronidases zur entfernung von hornhautnarbengewebe, trübung und schleier
AU4511201A (en) 1999-12-03 2001-06-12 Ista Pharmaceuticals, Inc Compositions and methods for the induction and treatment of retinal detachments
US7977385B2 (en) * 2000-03-02 2011-07-12 Numoda Biotechnologies, Inc. Agents for corneal or intrastromal administration to treat or prevent disorders of the eye
US20030199574A1 (en) * 2000-03-02 2003-10-23 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
US6902548B1 (en) * 2001-03-19 2005-06-07 Ed Schuler Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments
US6745776B2 (en) 2001-04-10 2004-06-08 David B. Soll Methods for reducing postoperative intraocular pressure
US7115408B1 (en) 2001-05-02 2006-10-03 Ista Pharmaceuticals, Inc. Method of stabilizing hyaluronidase with annexin II
JP4749667B2 (ja) * 2001-08-13 2011-08-17 ユニバーシティ オブ フロリダ リサーチ ファンデーション インコーポレーティッド 神経組織の修復を促進するための材料および方法
WO2003102160A2 (en) * 2002-06-03 2003-12-11 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase b
US20050137124A1 (en) * 2002-08-09 2005-06-23 Vitreo-Retinal Technologies, Inc. A California Corporation Agents for intravitreal administration to treat or prevent disorders of the eye
GB0228409D0 (en) * 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
MXJL02000046A (es) * 2002-12-13 2004-06-24 Jimenez Bayardo Arturo Solucion inyectable intravitrea para el tratamiento de hemorragias vitreas.
US6969514B2 (en) 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
US8012115B2 (en) 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
EP1616004A1 (de) * 2003-04-15 2006-01-18 Ista Pharmaceuticals, Inc Prozess für die isolatierung von schaf hyaluronidase
MXPA03011987A (es) 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
WO2005118799A1 (en) * 2004-04-15 2005-12-15 Ista Pharmaceuticals, Inc. Ovine hyaluronidase
WO2006056204A1 (en) * 2004-11-24 2006-06-01 Novozymes Biopolymer A/S Method of cross-linking hyaluronic acid with divinylsulfone
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
CN102266348A (zh) * 2011-08-04 2011-12-07 山西诺成制药有限公司 一种眼内冲洗液及其制备方法
SG11201500994SA (en) 2012-08-10 2015-03-30 Osio Corp D B A Yolia Health Contact lens use in the treatment of an ophthalmologic condition
US8784896B2 (en) 2012-09-17 2014-07-22 Biopep Solutions, Inc Antioxidant therapy with a whole, leech saliva extract
KR101454646B1 (ko) 2012-11-05 2014-10-27 (주)한국비엠아이 히알루로니다아제의 안정화 제제 및 이를 포함하는 액상제제
US20140212404A1 (en) * 2012-11-14 2014-07-31 Khizer Khaderi Compositions and Methods for Treating Injuries to the Visual System of a Human
TW202202168A (zh) * 2020-07-07 2022-01-16 洪啟庭 用於改善玻璃體混濁的組成物及其應用
CN113769073A (zh) * 2021-10-15 2021-12-10 杭州鑫伟低碳技术研发有限公司 一种利用生物酶治疗眼底出血的方法

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37336A (en) * 1863-01-06 Improvement in hooped skirts
FR6256M (de) * 1967-01-26 1968-08-19
US3728223A (en) 1971-10-08 1973-04-17 Amano Pharma Co Ltd Production of hyaluronidase from a strain of streptomyces
JPS5413510B2 (de) 1973-08-28 1979-05-31
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4174389A (en) * 1977-05-13 1979-11-13 Cope Louise A Ophthalmic use of collagenase
JPS6033474B2 (ja) 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼbmp−8231およびその製造法
US4490351A (en) * 1982-03-15 1984-12-25 Children's Hospital Medical Center Methods of treating disorders of an eye with liquid perfluorocarbons
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US5316926A (en) 1983-11-25 1994-05-31 Miles Inc. Method for the microbiological production of non-antigenic hyaluronic acid
GB8504025D0 (en) * 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
US4757089A (en) * 1985-06-14 1988-07-12 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
SE456245B (sv) 1986-07-09 1988-09-19 Pharmacia Ab Enzympreparation innehallande krillhyaluronidas
FR2608045B1 (fr) * 1986-12-12 1990-03-02 Chauvin Laboratoires Utilisation d'inhibiteurs de xanthine- oxydase, de piegeurs de radicaux libres oxygenes et de chelateurs du fer pour la fabrication d'une composition pharmaceutique destinee au traitement du glaucome et compositions pharmaceutiques destinees au traitement du glaucome
NO164844C (no) 1988-10-24 1990-11-21 Norsk Hydro As Fremgangsmaate ved utvinning av enzymer fra krepsdyr.
US5013714A (en) * 1988-12-15 1991-05-07 Lindstrom Richard L Viscoelastic solution
US5260059A (en) * 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
US4897349A (en) 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
US5015577A (en) 1989-08-29 1991-05-14 Board Of Regents, The University Of Texas System DNA encoding hyaluronate synthase
FR2657018A1 (fr) * 1990-01-12 1991-07-19 Merck Sharp & Dohme Composition ophtalmique fluide a base de microparticules lipidiques contenant au moins un principe actif et son procede de preparation.
ZA912770B (en) * 1990-04-16 1992-01-29 Bethesda Eye Inst Enzymatic disinsertion of vitreous body
US5300295A (en) * 1990-05-01 1994-04-05 Mediventures, Inc. Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5270051A (en) * 1991-10-15 1993-12-14 Harris Donald H Enzyme-orthokeratology
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
JP2948708B2 (ja) * 1991-11-27 1999-09-13 ニューヨーク・ブラッド・センター・インコーポレーテッド フィブロネクチン含有点眼液
US5188331A (en) * 1991-12-06 1993-02-23 Baines Gurney D Umbrella support bracket
US5758552A (en) * 1992-02-05 1998-06-02 Myers; Harry T. Tool handle safety plate
US5242961A (en) * 1992-05-28 1993-09-07 Shell Oil Company Color prevention in titanium catalyzed hydrogenated diene polymers
FI933264A (fi) * 1992-07-21 1994-01-22 Hoechst Roussel Pharma Foerfarande foer framstaellning av fysostigminkarbamatderivat fraon fysostigmin
US5593877A (en) 1993-03-11 1997-01-14 The Rockefeller University Nucleic acid and recombinant production of vespid venom hyaluronidase
US5496726A (en) 1993-04-16 1996-03-05 Lucky Limited Streptococcus zooepidemicus medium and process for preparing hyaluronic acid
US5756552A (en) 1994-10-13 1998-05-26 Wakamoto Pharmaceutical Co., Ltd. Lyophilized pharmaceutical preparations capable of providing aqueous drug composition having property of reversible thermosetting gelation
US5747027A (en) 1995-04-07 1998-05-05 The Regents Of The University Of California BH55 hyaluronidase
US6610292B2 (en) * 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US5866964A (en) 1996-01-29 1999-02-02 Emerson Electric Company Reluctance machine with auxiliary field excitations
US6123938A (en) 1996-10-17 2000-09-26 The Regents Of The University Of California Human urinary hyaluronidase
DE19726626C1 (de) 1997-06-17 1998-09-03 Pharma Dessau Gmbh Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
US5868120A (en) * 1997-06-30 1999-02-09 Siemens Canada Limited Fuel vapor management system for motor vehicles
DE69926053T2 (de) 1999-04-27 2006-04-27 Transgene S.A. Verfahren zur Herstellung von Säugetier-Zellinien
EP1185666B1 (de) 1999-06-12 2006-04-26 MERCK PATENT GmbH Hyaluronidase aus hirudinaria manillensis, isolierung, reinigung, und rekombinante herstellung

Also Published As

Publication number Publication date
US6939542B2 (en) 2005-09-06
DE69634903T2 (de) 2006-05-18
DK0862456T3 (da) 2005-10-17
DE69634903D1 (de) 2005-08-04
AU1407097A (en) 1997-06-11
ES2245458T3 (es) 2006-01-01
KR19990071565A (ko) 1999-09-27
JP2000502325A (ja) 2000-02-29
PT862456E (pt) 2005-11-30
US20060034822A1 (en) 2006-02-16
US20030129182A1 (en) 2003-07-10
EP0862456B1 (de) 2005-06-29
WO1997018835A1 (en) 1997-05-29
CA2238360C (en) 2009-09-01
KR100463009B1 (ko) 2005-02-28
CN1207684A (zh) 1999-02-10
US6551590B2 (en) 2003-04-22
CA2238360A1 (en) 1997-05-29
EP0862456A4 (de) 2003-02-12
US20020071837A1 (en) 2002-06-13
MX9804051A (es) 1998-12-31
US6039943A (en) 2000-03-21
US5866120A (en) 1999-02-02
BR9611617A (pt) 1999-04-06
EP0862456A1 (de) 1998-09-09

Similar Documents

Publication Publication Date Title
DE69634903D1 (de) Hyaluronidase zusammensetzungen zur behandlung intravitrealen hemorrhagischen blutes
Oldberg et al. Characterization of platelet endoglycosidase degrading heparin-like polysaccharides
Huber et al. β-D-glucan hydrolase activity in Zea coleoptile cell walls
BR9815589A (pt) Composições viscosas aquosas, lìmpidas ou não, para à fabricação de cápsulas macias ou duras, e processo de fabricação de pelìcilas para tais cápsulas
EP0654077A4 (de) Methode und reagenz zur behandlung einer tierischen krankheit.
TW354756B (en) A process for the non-random cleavage of starch
AU1916899A (en) Alpha-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
EP1621082A3 (de) Verwendung von hoch-verestertem Pektin in sauren, proteinhaltigen Nahrungsmitteln
DE69032406T2 (de) Wundheilmittel enthaltend heparanase
DK0832250T3 (da) Mutant alfa-amylase
BR9808647A (pt) Inibição de ìntron anti-sentido de enzima de expressão de ramificação de amido
BR9813128A (pt) Agregado solúvel em água de derivados de insulina, derivado de insulina, preparação farmacêutica, e, processo para tratamento de diabetes mellitus
Yamamoto et al. Partial purification and properties of phleinase induced in stem base of orchardgrass after defoliation
YU47886B (sh) Postupak za dobijanje novih sojeva s. avermitilis
NO178734C (no) Fremgangsmåte for fremstilling av en ny arginin-deiminase
MX9710108A (es) Refinacion moderada de aceite de triglicerido.
UY25097A1 (es) Proceso para la produccion de heparina
MY111158A (en) Identifying microorganisms by measuring enzyme activity in the presence of enzyme activity affecting agents.
Hamai et al. Purification and characterization of hyaluronidase from Streptococcus dysgalactiae
EP1118667A4 (de) Neuartige enzym zusammensetzungen, verfahren zur und verwendung herstellung derselben
ES2004099A6 (es) Procedimiento de preparacion de polipeptidos biologicamente activos
BR9501187A (pt) Preparacão de enzima purificada,método para digerir tecido desvitalizado de mamifero e método para isolar uma preparacão de enzima substancialmente purificada de um tronco de bromelaina
ATE171698T1 (de) Herstellung von glasfaserprodukten
Pfeiler Isolation and partial characterization of a novel keratan sulfate proteoglycan from metamorphosing bonefish (Albula) larvae
AR006949A1 (es) Composicion detergente de lavanderia que comprende un agente tensioactivo, enzima lipasa y poliamina

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0862456

Country of ref document: EP