PT862456E - Composicoes de hialuronidase para tratar sangue hemorragico intravitreo - Google Patents

Composicoes de hialuronidase para tratar sangue hemorragico intravitreo

Info

Publication number
PT862456E
PT862456E PT96944203T PT96944203T PT862456E PT 862456 E PT862456 E PT 862456E PT 96944203 T PT96944203 T PT 96944203T PT 96944203 T PT96944203 T PT 96944203T PT 862456 E PT862456 E PT 862456E
Authority
PT
Portugal
Prior art keywords
intravitary
treating
hyaluronidase
blood
hemorrhagic blood
Prior art date
Application number
PT96944203T
Other languages
English (en)
Inventor
Hampar L Karageozian
Vicken H Karageozian
Maria C Kenney
Jose L G Flores
Gabriel A C Aragon
Anthony B Nesburn
Original Assignee
Ista Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ista Pharmaceuticals Inc filed Critical Ista Pharmaceuticals Inc
Publication of PT862456E publication Critical patent/PT862456E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT96944203T 1995-11-22 1996-11-20 Composicoes de hialuronidase para tratar sangue hemorragico intravitreo PT862456E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/561,636 US5866120A (en) 1995-11-22 1995-11-22 Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase

Publications (1)

Publication Number Publication Date
PT862456E true PT862456E (pt) 2005-11-30

Family

ID=24242789

Family Applications (1)

Application Number Title Priority Date Filing Date
PT96944203T PT862456E (pt) 1995-11-22 1996-11-20 Composicoes de hialuronidase para tratar sangue hemorragico intravitreo

Country Status (15)

Country Link
US (5) US5866120A (pt)
EP (1) EP0862456B1 (pt)
JP (1) JP2000502325A (pt)
KR (1) KR100463009B1 (pt)
CN (1) CN1207684A (pt)
AT (1) ATE298584T1 (pt)
AU (1) AU1407097A (pt)
BR (1) BR9611617A (pt)
CA (1) CA2238360C (pt)
DE (1) DE69634903T2 (pt)
DK (1) DK0862456T3 (pt)
ES (1) ES2245458T3 (pt)
MX (1) MX9804051A (pt)
PT (1) PT862456E (pt)
WO (1) WO1997018835A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
EP0983084B1 (en) * 1997-05-22 2007-01-10 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
BR9908692A (pt) 1998-03-09 2001-12-04 Ista Pharmaceuticals Inc Uso de agentes de enrijecimento corneal emortocerotologia enzimática
US7008960B1 (en) 1999-03-02 2006-03-07 Vitreo-Retinal Technologies, Inc. Agents for intravitreal administration to treat or prevent disorders of the eye
WO2000056354A2 (en) 1999-03-22 2000-09-28 Boston Innovative Optics, Inc. Methods of using agents that act on the epithelial sheet of a human eye
MXPA01011025A (es) * 1999-04-29 2002-11-07 Ista Pharmaceuticals Inc Metodos bioquimicos que eliminan las cicatrices, opacificacion y la bruma de la cornea.
WO2001039765A2 (en) 1999-12-03 2001-06-07 Ista Pharmaceuticals, Inc. Compositions and methods for the induction and treatment of retinal detachments
US7977385B2 (en) * 2000-03-02 2011-07-12 Numoda Biotechnologies, Inc. Agents for corneal or intrastromal administration to treat or prevent disorders of the eye
US20030199574A1 (en) 2000-03-02 2003-10-23 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
US6902548B1 (en) * 2001-03-19 2005-06-07 Ed Schuler Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments
US6745776B2 (en) 2001-04-10 2004-06-08 David B. Soll Methods for reducing postoperative intraocular pressure
US7115408B1 (en) 2001-05-02 2006-10-03 Ista Pharmaceuticals, Inc. Method of stabilizing hyaluronidase with annexin II
BR0211888A (pt) * 2001-08-13 2004-08-24 Univ Florida Res Foudantion In Materiais e métodos para promoção de reparo de tecido nervoso
AU2003243396A1 (en) * 2002-06-03 2003-12-19 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase b
US20050137124A1 (en) * 2002-08-09 2005-06-23 Vitreo-Retinal Technologies, Inc. A California Corporation Agents for intravitreal administration to treat or prevent disorders of the eye
GB0228409D0 (en) 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
MXJL02000046A (es) * 2002-12-13 2004-06-24 Jimenez Bayardo Arturo Solucion inyectable intravitrea para el tratamiento de hemorragias vitreas.
US6969514B2 (en) 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
US8012115B2 (en) 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
AU2004230482A1 (en) * 2003-04-15 2004-10-28 Biozyme Laboratories, Ltd Process for isolating and purifing ovine hyaluronidase
MXPA03011987A (es) 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
WO2005118799A1 (en) * 2004-04-15 2005-12-15 Ista Pharmaceuticals, Inc. Ovine hyaluronidase
WO2006056204A1 (en) * 2004-11-24 2006-06-01 Novozymes Biopolymer A/S Method of cross-linking hyaluronic acid with divinylsulfone
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
CN102266348A (zh) * 2011-08-04 2011-12-07 山西诺成制药有限公司 一种眼内冲洗液及其制备方法
SG11201500994SA (en) 2012-08-10 2015-03-30 Osio Corp D B A Yolia Health Contact lens use in the treatment of an ophthalmologic condition
US8790711B2 (en) 2012-09-17 2014-07-29 Biopep Solutions, Inc. Treating diabetes with a whole, leech saliva extract
KR101454646B1 (ko) 2012-11-05 2014-10-27 (주)한국비엠아이 히알루로니다아제의 안정화 제제 및 이를 포함하는 액상제제
US20140212404A1 (en) * 2012-11-14 2014-07-31 Khizer Khaderi Compositions and Methods for Treating Injuries to the Visual System of a Human
TW202202168A (zh) * 2020-07-07 2022-01-16 洪啟庭 用於改善玻璃體混濁的組成物及其應用
CN113769073A (zh) * 2021-10-15 2021-12-10 杭州鑫伟低碳技术研发有限公司 一种利用生物酶治疗眼底出血的方法

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37336A (en) * 1863-01-06 Improvement in hooped skirts
FR6256M (pt) * 1967-01-26 1968-08-19
US3728223A (en) 1971-10-08 1973-04-17 Amano Pharma Co Ltd Production of hyaluronidase from a strain of streptomyces
JPS5413510B2 (pt) 1973-08-28 1979-05-31
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4174389A (en) * 1977-05-13 1979-11-13 Cope Louise A Ophthalmic use of collagenase
JPS6033474B2 (ja) 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法
US4490351A (en) * 1982-03-15 1984-12-25 Children's Hospital Medical Center Methods of treating disorders of an eye with liquid perfluorocarbons
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US5316926A (en) 1983-11-25 1994-05-31 Miles Inc. Method for the microbiological production of non-antigenic hyaluronic acid
GB8504025D0 (en) * 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
US4757089A (en) * 1985-06-14 1988-07-12 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
SE456245B (sv) 1986-07-09 1988-09-19 Pharmacia Ab Enzympreparation innehallande krillhyaluronidas
FR2608045B1 (fr) * 1986-12-12 1990-03-02 Chauvin Laboratoires Utilisation d'inhibiteurs de xanthine- oxydase, de piegeurs de radicaux libres oxygenes et de chelateurs du fer pour la fabrication d'une composition pharmaceutique destinee au traitement du glaucome et compositions pharmaceutiques destinees au traitement du glaucome
NO164844C (no) 1988-10-24 1990-11-21 Norsk Hydro As Fremgangsmaate ved utvinning av enzymer fra krepsdyr.
US5013714A (en) * 1988-12-15 1991-05-07 Lindstrom Richard L Viscoelastic solution
US5260059A (en) * 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
US4897349A (en) 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
US5015577A (en) 1989-08-29 1991-05-14 Board Of Regents, The University Of Texas System DNA encoding hyaluronate synthase
FR2657018A1 (fr) * 1990-01-12 1991-07-19 Merck Sharp & Dohme Composition ophtalmique fluide a base de microparticules lipidiques contenant au moins un principe actif et son procede de preparation.
ZA912770B (en) * 1990-04-16 1992-01-29 Bethesda Eye Inst Enzymatic disinsertion of vitreous body
US5300295A (en) * 1990-05-01 1994-04-05 Mediventures, Inc. Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5270051A (en) * 1991-10-15 1993-12-14 Harris Donald H Enzyme-orthokeratology
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
JP2948708B2 (ja) * 1991-11-27 1999-09-13 ニューヨーク・ブラッド・センター・インコーポレーテッド フィブロネクチン含有点眼液
US5188331A (en) * 1991-12-06 1993-02-23 Baines Gurney D Umbrella support bracket
US5758552A (en) * 1992-02-05 1998-06-02 Myers; Harry T. Tool handle safety plate
US5242961A (en) * 1992-05-28 1993-09-07 Shell Oil Company Color prevention in titanium catalyzed hydrogenated diene polymers
NZ248180A (en) * 1992-07-21 1995-02-24 Hoechst Roussel Pharma Process for the preparation of physostigmine carbamate derivatives
US5593877A (en) 1993-03-11 1997-01-14 The Rockefeller University Nucleic acid and recombinant production of vespid venom hyaluronidase
US5496726A (en) 1993-04-16 1996-03-05 Lucky Limited Streptococcus zooepidemicus medium and process for preparing hyaluronic acid
EP0782850A4 (en) 1994-10-13 1998-03-04 Wakamoto Pharma Co Ltd LYOPHILIZED PREPARATION FOR PRODUCING A REVERSIBLE THERMOGELING MEDICINAL WATER-BASED
US5747027A (en) 1995-04-07 1998-05-05 The Regents Of The University Of California BH55 hyaluronidase
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US5866964A (en) 1996-01-29 1999-02-02 Emerson Electric Company Reluctance machine with auxiliary field excitations
US6123938A (en) 1996-10-17 2000-09-26 The Regents Of The University Of California Human urinary hyaluronidase
DE19726626C1 (de) 1997-06-17 1998-09-03 Pharma Dessau Gmbh Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
US5868120A (en) * 1997-06-30 1999-02-09 Siemens Canada Limited Fuel vapor management system for motor vehicles
DE69926053T2 (de) 1999-04-27 2006-04-27 Transgene S.A. Verfahren zur Herstellung von Säugetier-Zellinien
HUP0201452A2 (en) 1999-06-12 2002-08-28 Merck Patent Gmbh Hyaluronidase from the hirudinaria manikkensis, isolation, purification and recombinant method of production

Also Published As

Publication number Publication date
US6039943A (en) 2000-03-21
KR100463009B1 (ko) 2005-02-28
US6939542B2 (en) 2005-09-06
EP0862456B1 (en) 2005-06-29
WO1997018835A1 (en) 1997-05-29
US20020071837A1 (en) 2002-06-13
MX9804051A (es) 1998-12-31
DE69634903D1 (de) 2005-08-04
DE69634903T2 (de) 2006-05-18
US5866120A (en) 1999-02-02
US6551590B2 (en) 2003-04-22
CA2238360A1 (en) 1997-05-29
US20060034822A1 (en) 2006-02-16
US20030129182A1 (en) 2003-07-10
ES2245458T3 (es) 2006-01-01
BR9611617A (pt) 1999-04-06
EP0862456A4 (en) 2003-02-12
KR19990071565A (ko) 1999-09-27
AU1407097A (en) 1997-06-11
DK0862456T3 (da) 2005-10-17
ATE298584T1 (de) 2005-07-15
CN1207684A (zh) 1999-02-10
EP0862456A1 (en) 1998-09-09
CA2238360C (en) 2009-09-01
JP2000502325A (ja) 2000-02-29

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