BR9611617A - Método e composições enzimáticas para o tratamento de sangue hemorrágico intravitreal - Google Patents

Método e composições enzimáticas para o tratamento de sangue hemorrágico intravitreal

Info

Publication number
BR9611617A
BR9611617A BR9611617A BR9611617A BR9611617A BR 9611617 A BR9611617 A BR 9611617A BR 9611617 A BR9611617 A BR 9611617A BR 9611617 A BR9611617 A BR 9611617A BR 9611617 A BR9611617 A BR 9611617A
Authority
BR
Brazil
Prior art keywords
intravitreal
compositions
treatment
blood
enzymatic method
Prior art date
Application number
BR9611617A
Other languages
English (en)
Inventor
Hampar L Karageozian
Vicken H Karageozian
Maria C Kenney
Jose L G Flores
Gabriel A C Aragon
Anthony B Nesburn
Original Assignee
Advanced Corneal Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Advanced Corneal Systems Inc filed Critical Advanced Corneal Systems Inc
Publication of BR9611617A publication Critical patent/BR9611617A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
BR9611617A 1995-11-22 1996-11-20 Método e composições enzimáticas para o tratamento de sangue hemorrágico intravitreal BR9611617A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/561,636 US5866120A (en) 1995-11-22 1995-11-22 Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
PCT/US1996/018843 WO1997018835A1 (en) 1995-11-22 1996-11-20 Enzymatic method and compositions for treating intravitreal hemorrhagic blood

Publications (1)

Publication Number Publication Date
BR9611617A true BR9611617A (pt) 1999-04-06

Family

ID=24242789

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9611617A BR9611617A (pt) 1995-11-22 1996-11-20 Método e composições enzimáticas para o tratamento de sangue hemorrágico intravitreal

Country Status (15)

Country Link
US (5) US5866120A (pt)
EP (1) EP0862456B1 (pt)
JP (1) JP2000502325A (pt)
KR (1) KR100463009B1 (pt)
CN (1) CN1207684A (pt)
AT (1) ATE298584T1 (pt)
AU (1) AU1407097A (pt)
BR (1) BR9611617A (pt)
CA (1) CA2238360C (pt)
DE (1) DE69634903T2 (pt)
DK (1) DK0862456T3 (pt)
ES (1) ES2245458T3 (pt)
MX (1) MX9804051A (pt)
PT (1) PT862456E (pt)
WO (1) WO1997018835A1 (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5866120A (en) 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
CN1257430A (zh) * 1997-05-22 2000-06-21 先进角膜系统公司 透明质酸酶在制备用于治疗眼科疾病中液化玻璃体液的眼用制剂中的应用
EP1061873B1 (en) * 1998-03-09 2005-11-02 Ista Pharmaceuticals, Inc Use of glyceraldehyde as corneal hardening agents
US7008960B1 (en) 1999-03-02 2006-03-07 Vitreo-Retinal Technologies, Inc. Agents for intravitreal administration to treat or prevent disorders of the eye
US6335006B1 (en) 1999-03-22 2002-01-01 Boston Innovative Optics, Inc. Methods of using agents that act on the epithelial sheet of a human eye
ES2209877T3 (es) * 1999-04-29 2004-07-01 Ista Pharmaceuticals, Inc Uso de una hialuronidasa determinada para eliminar las cicatrices, las opacidades y las nubeculas corneales.
WO2001039765A2 (en) 1999-12-03 2001-06-07 Ista Pharmaceuticals, Inc. Compositions and methods for the induction and treatment of retinal detachments
US20030199574A1 (en) 2000-03-02 2003-10-23 Vitreo-Retinal Technologies, Inc. Treatment of ophthalmic disorders using urea and urea derivatives
US7977385B2 (en) * 2000-03-02 2011-07-12 Numoda Biotechnologies, Inc. Agents for corneal or intrastromal administration to treat or prevent disorders of the eye
US7141607B1 (en) 2000-03-10 2006-11-28 Insite Vision Incorporated Methods and compositions for treating and inhibiting retinal neovascularization
US6902548B1 (en) * 2001-03-19 2005-06-07 Ed Schuler Use of Streptomyces hyalurolyticus enzyme in ophthalmic treatments
US6745776B2 (en) 2001-04-10 2004-06-08 David B. Soll Methods for reducing postoperative intraocular pressure
US7115408B1 (en) 2001-05-02 2006-10-03 Ista Pharmaceuticals, Inc. Method of stabilizing hyaluronidase with annexin II
ES2378227T3 (es) 2001-08-13 2012-04-10 University Of Florida Research Foundation, Inc. Materiales y métodos para favorecer la reparación del tejido nervioso
US6962699B2 (en) * 2002-06-03 2005-11-08 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from chondroitinase B
US20050137124A1 (en) * 2002-08-09 2005-06-23 Vitreo-Retinal Technologies, Inc. A California Corporation Agents for intravitreal administration to treat or prevent disorders of the eye
GB0228409D0 (en) 2002-12-06 2003-01-08 Thromb X Nv Pharmacological vitreolysis
MXJL02000046A (es) * 2002-12-13 2004-06-24 Jimenez Bayardo Arturo Solucion inyectable intravitrea para el tratamiento de hemorragias vitreas.
US6969514B2 (en) 2003-02-05 2005-11-29 Soll David B Method for treating elevated intraocular pressure, including glaucoma
US8012115B2 (en) 2003-02-18 2011-09-06 S.K. Pharmaceuticals, Inc. Optic nerve implants
CA2522544A1 (en) * 2003-04-15 2004-10-28 Ista Pharmaceuticals, Inc. Process for isolating and purifing ovine hyaluronidase
MXPA03011987A (es) 2003-12-19 2005-06-23 Osio Sancho Alberto Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal.
WO2005118799A1 (en) * 2004-04-15 2005-12-15 Ista Pharmaceuticals, Inc. Ovine hyaluronidase
PL1817347T3 (pl) * 2004-11-24 2017-10-31 Albumedix As Sposób sieciowania kwasu hialuronowego za pomocą diwinylosulfonu
US20090286289A1 (en) * 2008-03-10 2009-11-19 Pang Danny Z Production of Hyaluronate Unsaturated Disaccharides and its Application
CN102266348A (zh) * 2011-08-04 2011-12-07 山西诺成制药有限公司 一种眼内冲洗液及其制备方法
KR102184340B1 (ko) 2012-08-10 2020-12-01 오시오 코포레이션 디/비/에이 율리아 헬스 안과적 상태 치료시의 컨택트 렌즈 사용
US8784896B2 (en) 2012-09-17 2014-07-22 Biopep Solutions, Inc Antioxidant therapy with a whole, leech saliva extract
KR101454646B1 (ko) 2012-11-05 2014-10-27 (주)한국비엠아이 히알루로니다아제의 안정화 제제 및 이를 포함하는 액상제제
US20140212404A1 (en) * 2012-11-14 2014-07-31 Khizer Khaderi Compositions and Methods for Treating Injuries to the Visual System of a Human
TW202202168A (zh) * 2020-07-07 2022-01-16 洪啟庭 用於改善玻璃體混濁的組成物及其應用
CN113769073A (zh) * 2021-10-15 2021-12-10 杭州鑫伟低碳技术研发有限公司 一种利用生物酶治疗眼底出血的方法

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37336A (en) * 1863-01-06 Improvement in hooped skirts
FR6256M (pt) * 1967-01-26 1968-08-19
US3728223A (en) 1971-10-08 1973-04-17 Amano Pharma Co Ltd Production of hyaluronidase from a strain of streptomyces
JPS5413510B2 (pt) 1973-08-28 1979-05-31
US4141973A (en) * 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4174389A (en) * 1977-05-13 1979-11-13 Cope Louise A Ophthalmic use of collagenase
JPS6033474B2 (ja) 1978-05-11 1985-08-02 藤沢薬品工業株式会社 新規なヒアルロニダ−ゼｂｍｐ−８２３１およびその製造法
US4490351A (en) * 1982-03-15 1984-12-25 Children's Hospital Medical Center Methods of treating disorders of an eye with liquid perfluorocarbons
US5166331A (en) * 1983-10-10 1992-11-24 Fidia, S.P.A. Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
US4474751A (en) * 1983-05-16 1984-10-02 Merck & Co., Inc. Ophthalmic drug delivery system utilizing thermosetting gels
US5316926A (en) 1983-11-25 1994-05-31 Miles Inc. Method for the microbiological production of non-antigenic hyaluronic acid
GB8504025D0 (en) * 1985-02-16 1985-03-20 Biopharm Ltd Hyaluronidase
US4757089A (en) * 1985-06-14 1988-07-12 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
FR2588189B1 (fr) * 1985-10-03 1988-12-02 Merck Sharp & Dohme Composition pharmaceutique de type a transition de phase liquide-gel
SE456245B (sv) 1986-07-09 1988-09-19 Pharmacia Ab Enzympreparation innehallande krillhyaluronidas
FR2608045B1 (fr) * 1986-12-12 1990-03-02 Chauvin Laboratoires Utilisation d'inhibiteurs de xanthine- oxydase, de piegeurs de radicaux libres oxygenes et de chelateurs du fer pour la fabrication d'une composition pharmaceutique destinee au traitement du glaucome et compositions pharmaceutiques destinees au traitement du glaucome
NO164844C (no) 1988-10-24 1990-11-21 Norsk Hydro As Fremgangsmaate ved utvinning av enzymer fra krepsdyr.
US5013714A (en) * 1988-12-15 1991-05-07 Lindstrom Richard L Viscoelastic solution
US5260059A (en) * 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
US4897349A (en) 1989-04-28 1990-01-30 Medchem Products, Inc. Biosynthesis of hyaluronic acid
US5015577A (en) 1989-08-29 1991-05-14 Board Of Regents, The University Of Texas System DNA encoding hyaluronate synthase
FR2657018A1 (fr) * 1990-01-12 1991-07-19 Merck Sharp & Dohme Composition ophtalmique fluide a base de microparticules lipidiques contenant au moins un principe actif et son procede de preparation.
ZA912770B (en) * 1990-04-16 1992-01-29 Bethesda Eye Inst Enzymatic disinsertion of vitreous body
US5300295A (en) * 1990-05-01 1994-04-05 Mediventures, Inc. Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH
US5252318A (en) * 1990-06-15 1993-10-12 Allergan, Inc. Reversible gelation compositions and methods of use
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5270051A (en) * 1991-10-15 1993-12-14 Harris Donald H Enzyme-orthokeratology
US5318780A (en) * 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
JP2948708B2 (ja) * 1991-11-27 1999-09-13 ニューヨーク・ブラッド・センター・インコーポレーテッド フィブロネクチン含有点眼液
US5188331A (en) * 1991-12-06 1993-02-23 Baines Gurney D Umbrella support bracket
US5758552A (en) * 1992-02-05 1998-06-02 Myers; Harry T. Tool handle safety plate
US5242961A (en) * 1992-05-28 1993-09-07 Shell Oil Company Color prevention in titanium catalyzed hydrogenated diene polymers
NZ248180A (en) * 1992-07-21 1995-02-24 Hoechst Roussel Pharma Process for the preparation of physostigmine carbamate derivatives
US5593877A (en) 1993-03-11 1997-01-14 The Rockefeller University Nucleic acid and recombinant production of vespid venom hyaluronidase
US5496726A (en) 1993-04-16 1996-03-05 Lucky Limited Streptococcus zooepidemicus medium and process for preparing hyaluronic acid
EP0782850A4 (en) 1994-10-13 1998-03-04 Wakamoto Pharma Co Ltd LYOPHILIZED PREPARATION FOR PRODUCING A REVERSIBLE THERMOGELING MEDICINAL WATER-BASED
US5747027A (en) 1995-04-07 1998-05-05 The Regents Of The University Of California BH55 hyaluronidase
US5866120A (en) * 1995-11-22 1999-02-02 Advanced Corneal Systems, Inc. Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase
US6610292B2 (en) * 1995-11-22 2003-08-26 Ista Pharmaceuticals, Inc. Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders
US5866964A (en) 1996-01-29 1999-02-02 Emerson Electric Company Reluctance machine with auxiliary field excitations
US6123938A (en) 1996-10-17 2000-09-26 The Regents Of The University Of California Human urinary hyaluronidase
DE19726626C1 (de) 1997-06-17 1998-09-03 Pharma Dessau Gmbh Verfahren zur Herstellung eines eine Hyaluronidase enthaltenden Präparats
US5868120A (en) * 1997-06-30 1999-02-09 Siemens Canada Limited Fuel vapor management system for motor vehicles
DK1048725T3 (da) 1999-04-27 2005-08-22 Transgene Sa Fremgangsmåde til fremstilling af pattedyrcellelinjer
HUP0201452A2 (en) 1999-06-12 2002-08-28 Merck Patent Gmbh Hyaluronidase from the hirudinaria manikkensis, isolation, purification and recombinant method of production

Also Published As

Publication number Publication date
KR100463009B1 (ko) 2005-02-28
ATE298584T1 (de) 2005-07-15
AU1407097A (en) 1997-06-11
US20020071837A1 (en) 2002-06-13
CN1207684A (zh) 1999-02-10
CA2238360C (en) 2009-09-01
US6039943A (en) 2000-03-21
ES2245458T3 (es) 2006-01-01
MX9804051A (es) 1998-12-31
EP0862456B1 (en) 2005-06-29
US5866120A (en) 1999-02-02
US20030129182A1 (en) 2003-07-10
US6939542B2 (en) 2005-09-06
DE69634903T2 (de) 2006-05-18
CA2238360A1 (en) 1997-05-29
KR19990071565A (ko) 1999-09-27
WO1997018835A1 (en) 1997-05-29
US6551590B2 (en) 2003-04-22
DE69634903D1 (de) 2005-08-04
DK0862456T3 (da) 2005-10-17
EP0862456A1 (en) 1998-09-09
PT862456E (pt) 2005-11-30
US20060034822A1 (en) 2006-02-16
JP2000502325A (ja) 2000-02-29
EP0862456A4 (en) 2003-02-12

Similar Documents

Publication Publication Date Title
BR9611617A (pt) Método e composições enzimáticas para o tratamento de sangue hemorrágico intravitreal
DK0832250T3 (da) Mutant alfa-amylase
Huber et al. β-D-glucan hydrolase activity in Zea coleoptile cell walls
BR9609791A (pt) Processo para estabilizar proteínas em um meio ácido com um pectina de elevado teor em éster
Klein et al. Partial purification and characterization of a heparan sulfate specific endoglucuronidase
BRPI0410520B8 (pt) produção de proteínas de fusão de glucocerebrosidase (gcd) glicosilada em cultura de plantas
EP0654077A4 (en) PROCESS AND REAGENT FOR THE TREATMENT OF DISEASES IN ANIMALS.
TW354756B (en) A process for the non-random cleavage of starch
NZ337701A (en) Process for processing sucrose into glucose and fructose
AU1916899A (en) Alpha-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same
BR9813128A (pt) Agregado solúvel em água de derivados de insulina, derivado de insulina, preparação farmacêutica, e, processo para tratamento de diabetes mellitus
Yamamoto et al. Partial purification and properties of phleinase induced in stem base of orchardgrass after defoliation
Bishop et al. Effects of hyaluronan lyase, hyaluronidase, and chondroitin ABC lyase on mammalian vitreous gel
DK0697461T3 (da) Rekombinant termostabilt enzym, som frigør trehalose fra ikke-reducerende saccharid
Takagaki et al. Isolation and characterization of a chondroitin sulfate-degrading endo-beta-glucuronidase from rabbit liver.
Shiomi et al. Purification and properties of sucrose: sucrose 1F-β-D-fructosyltransferase in onion seeds
Hamai et al. Purification and characterization of hyaluronidase from Streptococcus dysgalactiae
UY25097A1 (es) Proceso para la produccion de heparina
EP1118667A4 (en) NOVEL ENZYME COMPOSITIONS, PROCESS FOR PRODUCING SUCH COMPOSITIONS, AND USE THEREOF
IL114637A0 (en) Recombinant thermostable enzyne which forms non-reducing saccharide from reducing amylaceous saccharide and its preparation
MY111158A (en) Identifying microorganisms by measuring enzyme activity in the presence of enzyme activity affecting agents.
Lomako et al. The substrate specificity of isoamylase and the preparation of apo-glycogenin
Pfeiler Isolation and partial characterization of a novel keratan sulfate proteoglycan from metamorphosing bonefish (Albula) larvae
GB9424331D0 (en) Manufacture of vitreous fibre products
WO1994029452A3 (en) Enzymatic rna molecules and their application in the treatment of fibrosis and fibrous tissue disease

Legal Events

Date Code Title Description
TC Change of name
EG Technical examination (opinion): publication of technical examination (opinion)
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1882 DE 30/01/2007.