ATE253111T1 - Für den capsaicin rezeptor kodierende nukleinsäuresequenzen und dem capsaicin rezeptor ähnliche polypeptide und ihre verwendung - Google Patents
Für den capsaicin rezeptor kodierende nukleinsäuresequenzen und dem capsaicin rezeptor ähnliche polypeptide und ihre verwendungInfo
- Publication number
- ATE253111T1 ATE253111T1 AT98943332T AT98943332T ATE253111T1 AT E253111 T1 ATE253111 T1 AT E253111T1 AT 98943332 T AT98943332 T AT 98943332T AT 98943332 T AT98943332 T AT 98943332T AT E253111 T1 ATE253111 T1 AT E253111T1
- Authority
- AT
- Austria
- Prior art keywords
- capsaicin receptor
- receptor
- polypeptides
- capsaicin
- related aspects
- Prior art date
Links
- 102000011040 TRPV Cation Channels Human genes 0.000 title abstract 10
- 108010062740 TRPV Cation Channels Proteins 0.000 title abstract 10
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 150000007523 nucleic acids Chemical group 0.000 title 1
- 238000000034 method Methods 0.000 abstract 4
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical class COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 abstract 3
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 229960002504 capsaicin Drugs 0.000 abstract 1
- 235000017663 capsaicin Nutrition 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000013604 expression vector Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91546197A | 1997-08-20 | 1997-08-20 | |
| US7215198P | 1998-01-22 | 1998-01-22 | |
| PCT/US1998/017466 WO1999009140A1 (en) | 1997-08-20 | 1998-08-20 | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE253111T1 true ATE253111T1 (de) | 2003-11-15 |
Family
ID=26753050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98943332T ATE253111T1 (de) | 1997-08-20 | 1998-08-20 | Für den capsaicin rezeptor kodierende nukleinsäuresequenzen und dem capsaicin rezeptor ähnliche polypeptide und ihre verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6335180B1 (enExample) |
| EP (1) | EP1009804B1 (enExample) |
| JP (1) | JP4444493B2 (enExample) |
| AT (1) | ATE253111T1 (enExample) |
| AU (1) | AU742391B2 (enExample) |
| CA (1) | CA2298540A1 (enExample) |
| DE (1) | DE69819345T2 (enExample) |
| WO (1) | WO1999009140A1 (enExample) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6444440B1 (en) | 1997-03-07 | 2002-09-03 | Human Genome Sciences, Inc. | Vanilloid receptor-2 |
| WO1999009140A1 (en) | 1997-08-20 | 1999-02-25 | The Regents Of The University Of California | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
| JP2002503451A (ja) * | 1998-01-22 | 2002-02-05 | ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・カリフォルニア | カプサイシン受容体をコードする核酸配列 |
| WO1999037765A1 (en) * | 1998-01-27 | 1999-07-29 | Smithkline Beecham Plc | Human vanilloid receptor homologues |
| EP0943683A1 (en) | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Human vanilloid receptor homologue Vanilrep1 |
| EP0953638A1 (en) * | 1998-03-11 | 1999-11-03 | Synthelabo | Human vanilloid receptor-like cation channel |
| US6906178B2 (en) | 1998-08-11 | 2005-06-14 | Human Genome Sciences, Inc. | Vanilloid receptor-2 |
| JP2002531069A (ja) * | 1998-11-13 | 2002-09-24 | ミレニアム・フアーマシユーチカルズ・インコーポレーテツド | タンパク質のカプサイシン/バニロイド受容体ファミリーの新規メンバー及びそれらの使用 |
| US7063951B1 (en) | 1998-11-13 | 2006-06-20 | Millennium Pharmaceuticals, Inc. | Members of the capsaicin/vanilloid receptor family of proteins and uses thereof |
| GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
| GB9827016D0 (en) | 1998-12-08 | 1999-02-03 | Merck Sharp & Dohme | Receptor protein |
| GB9907097D0 (en) * | 1999-03-26 | 1999-05-19 | Novartis Ag | Organic compounds |
| WO2000063415A1 (en) * | 1999-04-15 | 2000-10-26 | Ortho-Mcneil Pharmaceutical, Inc. | Dna encoding the human vanilloid receptor vr1 |
| US6421613B1 (en) * | 1999-07-09 | 2002-07-16 | Pioneer Hi-Bred International, Inc. | Data processing of the maize prolifera genetic sequence |
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| JPWO2001062915A1 (ja) * | 2000-02-25 | 2004-01-08 | 第一製薬株式会社 | 新規蛋白質及びそれをコードする遺伝子 |
| NZ524894A (en) | 2000-09-02 | 2005-03-24 | Gruenenthal Chemie | Antisense oligonucleotides against VR1 |
| DE10043674A1 (de) * | 2000-09-02 | 2002-03-21 | Gruenenthal Gmbh | Antisense Oligonukleotide |
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| US6780650B2 (en) | 2000-10-16 | 2004-08-24 | Ortho-Mcneil Pharmaceutical, Inc. | Ligand binding assays for vanilloid receptors |
| AU2002232456A1 (en) * | 2000-12-01 | 2002-06-11 | Bristol-Myers Squibb Company | Novel human nucleic acid molecules and polypeptides encoding a novel human ion channel expressed in spinal cord and brain |
| US20030171275A1 (en) * | 2000-12-20 | 2003-09-11 | Baughn Mariah R. | Transporters and ion channels |
| GB0128161D0 (en) * | 2001-11-23 | 2002-01-16 | Merck Sharp & Dohme | Receptor protein |
| DK1472225T3 (da) * | 2002-02-01 | 2010-08-09 | Euro Celtique Sa | 2-Piperazinpyridiner, som er anvendelige til behandling af smerte |
| ES2541351T3 (es) | 2002-02-25 | 2015-07-17 | Vaxiion Therapeutics, Llc | Composiciones de minicélulas y procedimientos |
| US6974818B2 (en) | 2002-03-01 | 2005-12-13 | Euro-Celtique S.A. | 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain |
| EP1497328A2 (en) * | 2002-04-16 | 2005-01-19 | Bayer HealthCare AG | Regulation of human transient receptor potential channel |
| WO2003102156A2 (en) * | 2002-05-31 | 2003-12-11 | Sloan-Kettering Institute For Cancer Research | Heterologous stimulus-gated ion channels and methods of using same |
| JP4555082B2 (ja) | 2002-08-08 | 2010-09-29 | アムジエン・インコーポレーテツド | バニロイド受容体リガンドおよびそれの治療での使用 |
| US20040096089A1 (en) * | 2002-08-16 | 2004-05-20 | David Borsook | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
| US7582635B2 (en) * | 2002-12-24 | 2009-09-01 | Purdue Pharma, L.P. | Therapeutic agents useful for treating pain |
| AU2004230915B2 (en) * | 2003-04-08 | 2008-08-07 | Algorx Pharmaceuticals, Inc. | Preparation and purification of synthetic capsaicin |
| TWI287010B (en) * | 2003-06-12 | 2007-09-21 | Euro Celtique Sa | Therapeutic agents useful for treating pain |
| US20050031717A1 (en) * | 2003-07-09 | 2005-02-10 | Desimone John A. | Salt taste modification |
| HRP20090404T1 (hr) * | 2003-07-24 | 2009-08-31 | Euro-Celtique S.A. | Spojevi piperidina i farmaceutski sastavi koji ih sadržavaju |
| DE602004021206D1 (de) * | 2003-07-24 | 2009-07-02 | Euro Celtique Sa | Zur Behandlung oder Vorbeugung von Schmerzen geeignete Heteroaryl-Tetrahydropiperidyl-Verbindungen |
| EP1867644B1 (en) | 2003-07-24 | 2009-05-20 | Euro-Celtique S.A. | Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain |
| PT1648880E (pt) * | 2003-08-01 | 2010-04-26 | Euro Celtique Sa | Agentes terapêuticos úteis para o tratamento da dor |
| PL1664041T3 (pl) * | 2003-09-22 | 2008-12-31 | Euro Celtique Sa | Przydatne do leczenia bólu związki fenylowo-karboksyamidowe |
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| US8759306B2 (en) * | 2005-05-31 | 2014-06-24 | Devgen N.V. | RNAi for the control of insects and arachnids |
| CA2655964C (en) | 2006-06-22 | 2014-10-28 | Board Of Regents Of The University Of Nebraska | Magnetically coupleable robotic devices and related methods |
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| WO2008057300A2 (en) * | 2006-10-27 | 2008-05-15 | Redpoint Bio Corporation | Trpvi antagonists and uses thereof |
| JP5372913B2 (ja) | 2007-04-27 | 2013-12-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | 疼痛治療に有効な治療薬 |
| ES2571533T3 (es) * | 2007-04-27 | 2016-05-25 | Purdue Pharma Lp | Antagonistas de TRPV1 y usos de los mismos |
| EP2170564A4 (en) | 2007-07-12 | 2015-10-07 | Univ Nebraska | ACTUATING PROCESSES AND SYSTEMS IN ROBOTIC EQUIPMENT |
| US20090076536A1 (en) | 2007-08-15 | 2009-03-19 | Board Of Regents Of The University Of Nebraska | Medical inflation, attachment, and delivery devices and related methods |
| WO2009114143A1 (en) * | 2008-03-12 | 2009-09-17 | Brown University | Treatment and prophylaxis of epilepsy and febrile seizures |
| US8759362B2 (en) * | 2008-10-24 | 2014-06-24 | Purdue Pharma L.P. | Bicycloheteroaryl compounds and their use as TRPV1 ligands |
| US8703962B2 (en) * | 2008-10-24 | 2014-04-22 | Purdue Pharma L.P. | Monocyclic compounds and their use as TRPV1 ligands |
| US8546388B2 (en) * | 2008-10-24 | 2013-10-01 | Purdue Pharma L.P. | Heterocyclic TRPV1 receptor ligands |
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| US9060781B2 (en) | 2011-06-10 | 2015-06-23 | Board Of Regents Of The University Of Nebraska | Methods, systems, and devices relating to surgical end effectors |
| ES2620528T3 (es) | 2011-06-22 | 2017-06-28 | Purdue Pharma Lp | Antagonistas de TRPV1 que incluyen un sustituyente dihidroxi y usos de los mismos |
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| EP4357083A3 (en) | 2012-05-01 | 2024-08-21 | Board of Regents of the University of Nebraska | Single site robotic device and related systems and methods |
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| US9770305B2 (en) | 2012-08-08 | 2017-09-26 | Board Of Regents Of The University Of Nebraska | Robotic surgical devices, systems, and related methods |
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| CN114027986B (zh) | 2015-08-03 | 2024-06-14 | 内布拉斯加大学董事会 | 机器人手术装置系统及相关方法 |
| CN114098975A (zh) | 2016-05-18 | 2022-03-01 | 虚拟切割有限公司 | 机器人外科装置、系统及相关方法 |
| WO2018039606A1 (en) | 2016-08-25 | 2018-03-01 | Virtual Incision Corporation | Quick-release tool coupler and related systems and methods |
| CA3035064A1 (en) | 2016-08-30 | 2018-03-08 | Board Of Regents Of The University Of Nebraska | Robotic device with compact joint design and an additional degree of freedom and related systems and methods |
| CA3036897C (en) | 2016-10-25 | 2021-11-16 | The Procter & Gamble Company | Fibrous structures |
| US10745865B2 (en) | 2016-10-25 | 2020-08-18 | The Procter & Gamble Company | Creped fibrous structures |
| CN115337111B (zh) | 2016-11-22 | 2025-04-25 | 内布拉斯加大学董事会 | 改进的粗定位装置及相关系统和方法 |
| JP7099728B2 (ja) | 2016-11-29 | 2022-07-12 | バーチャル インシジョン コーポレイション | ユーザの存在検出機能を備えたユーザコントローラ、関連システムおよび方法 |
| US10722319B2 (en) | 2016-12-14 | 2020-07-28 | Virtual Incision Corporation | Releasable attachment device for coupling to medical devices and related systems and methods |
| EP3687370B1 (en) | 2017-09-27 | 2024-11-20 | Virtual Incision Corporation | Robotic surgical devices with tracking camera technology and related systems |
| US11013564B2 (en) | 2018-01-05 | 2021-05-25 | Board Of Regents Of The University Of Nebraska | Single-arm robotic device with compact joint design and related systems and methods |
| EP3908171A4 (en) | 2019-01-07 | 2022-09-14 | Virtual Incision Corporation | Robotically assisted surgical system and related devices and methods |
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| US5074977A (en) | 1987-05-05 | 1991-12-24 | The Washington Technology Center | Digital biosensors and method of using same |
| DE68926118T2 (de) | 1988-08-18 | 1996-08-22 | Australian Membrane And Biotechnology Research Institute Ltd. Commonwealth Scientific And Industrial Research Organization, North Ryde, Neusuedwales | Verbesserungen an der empfindlichkeit und der selektivität von ionenkanalmembranbiosensoren |
| DE69030811T2 (de) | 1989-01-27 | 1997-10-02 | Au Membrane & Biotech Res Inst | Rezeptormembranen und selektive steuerung des ionenflusses durch ionophoren |
| US5491097A (en) | 1989-06-15 | 1996-02-13 | Biocircuits Corporation | Analyte detection with multilayered bioelectronic conductivity sensors |
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| WO1999009140A1 (en) | 1997-08-20 | 1999-02-25 | The Regents Of The University Of California | Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof |
| WO1999037765A1 (en) | 1998-01-27 | 1999-07-29 | Smithkline Beecham Plc | Human vanilloid receptor homologues |
| EP0943683A1 (en) | 1998-03-10 | 1999-09-22 | Smithkline Beecham Plc | Human vanilloid receptor homologue Vanilrep1 |
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| JP2002531069A (ja) | 1998-11-13 | 2002-09-24 | ミレニアム・フアーマシユーチカルズ・インコーポレーテツド | タンパク質のカプサイシン/バニロイド受容体ファミリーの新規メンバー及びそれらの使用 |
| GB9826359D0 (en) * | 1998-12-01 | 1999-01-27 | Glaxo Group Ltd | Novel receptors |
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-
1998
- 1998-08-20 WO PCT/US1998/017466 patent/WO1999009140A1/en not_active Ceased
- 1998-08-20 AU AU91156/98A patent/AU742391B2/en not_active Expired
- 1998-08-20 EP EP98943332A patent/EP1009804B1/en not_active Expired - Lifetime
- 1998-08-20 JP JP2000509807A patent/JP4444493B2/ja not_active Expired - Lifetime
- 1998-08-20 CA CA002298540A patent/CA2298540A1/en not_active Abandoned
- 1998-08-20 AT AT98943332T patent/ATE253111T1/de not_active IP Right Cessation
- 1998-08-20 DE DE69819345T patent/DE69819345T2/de not_active Expired - Lifetime
-
1999
- 1999-01-22 US US09/235,451 patent/US6335180B1/en not_active Expired - Lifetime
-
2001
- 2001-10-15 US US09/978,303 patent/US6790629B2/en not_active Expired - Lifetime
-
2004
- 2004-08-09 US US10/915,017 patent/US7097991B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US7097991B2 (en) | 2006-08-29 |
| CA2298540A1 (en) | 1999-02-25 |
| WO1999009140A1 (en) | 1999-02-25 |
| AU9115698A (en) | 1999-03-08 |
| AU742391B2 (en) | 2002-01-03 |
| EP1009804A1 (en) | 2000-06-21 |
| EP1009804B1 (en) | 2003-10-29 |
| DE69819345D1 (de) | 2003-12-04 |
| JP4444493B2 (ja) | 2010-03-31 |
| US20030049728A1 (en) | 2003-03-13 |
| DE69819345T2 (de) | 2004-07-15 |
| US6335180B1 (en) | 2002-01-01 |
| EP1009804A4 (en) | 2001-05-16 |
| US6790629B2 (en) | 2004-09-14 |
| US20050095650A1 (en) | 2005-05-05 |
| JP2001514879A (ja) | 2001-09-18 |
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