ATE246194T1 - Verfahren zur herstellung von sildenafil - Google Patents
Verfahren zur herstellung von sildenafilInfo
- Publication number
- ATE246194T1 ATE246194T1 AT98123740T AT98123740T ATE246194T1 AT E246194 T1 ATE246194 T1 AT E246194T1 AT 98123740 T AT98123740 T AT 98123740T AT 98123740 T AT98123740 T AT 98123740T AT E246194 T1 ATE246194 T1 AT E246194T1
- Authority
- AT
- Austria
- Prior art keywords
- sildenafil
- producing
- producing sildenafil
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Gynecology & Obstetrics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9612514.1A GB9612514D0 (en) | 1996-06-14 | 1996-06-14 | Novel process |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE246194T1 true ATE246194T1 (de) | 2003-08-15 |
Family
ID=10795332
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98123740T ATE246194T1 (de) | 1996-06-14 | 1997-06-04 | Verfahren zur herstellung von sildenafil |
AT97303832T ATE182150T1 (de) | 1996-06-14 | 1997-06-04 | Verfahren zur herstellung sildenafil |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97303832T ATE182150T1 (de) | 1996-06-14 | 1997-06-04 | Verfahren zur herstellung sildenafil |
Country Status (48)
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060222647A1 (en) * | 1993-05-27 | 2006-10-05 | Beavo Joseph A | Methods and compositions for modulating the activity of PDE5 |
SK285991B6 (sk) * | 1997-04-25 | 2008-01-07 | Pfizer Inc. | Pyrazolopyrimidinóny, spôsob a medziprodukty na ich výrobu, ich použitie a farmaceutické a veterinárne kompozície na ich báze |
IL132993A0 (en) * | 1997-05-29 | 2001-03-19 | Mochida Pharm Co Ltd | Therapeutic agent for erection failure |
US6399618B1 (en) | 1997-07-09 | 2002-06-04 | Cardiome Pharma Corp | Compositions and methods for modulating sexual activity |
GB9722520D0 (en) | 1997-10-24 | 1997-12-24 | Pfizer Ltd | Compounds |
GB2346877B (en) | 1997-11-12 | 2001-12-05 | Bayer Ag | 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors |
DE69910368T2 (de) * | 1998-04-20 | 2004-03-25 | Pfizer Inc. | Pyrazolopyrimidinone cgmp pde5 inhibitoren zur behandlung von sexualfunktionsstörungen |
CA2235642C (en) | 1998-05-15 | 2007-11-13 | Torcan Chemical Ltd. | Processes for preparing sildenafil |
ES2220109T3 (es) * | 1998-09-04 | 2004-12-01 | Ortho-Mcneil Pharmaceutical, Inc. | 5-heterociclilpirazolo (4,3-d) pirimidin-7-onas para el tratamiento de la disfuncion erectil masculina. |
GB9822238D0 (en) * | 1998-10-12 | 1998-12-09 | Pfizer Ltd | Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof |
GB9823103D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
GB9823101D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
GB9823102D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
KR100353014B1 (ko) * | 1998-11-11 | 2002-09-18 | 동아제약 주식회사 | 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물 |
US6087362A (en) * | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
AU5204800A (en) * | 1999-06-21 | 2001-01-09 | Biochemical Pharmaceutical Factory of Zhuhai Sez, The | Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine |
CN1094492C (zh) * | 1999-06-21 | 2002-11-20 | 杭州神鹰医药化工有限公司 | 西地那非的制备方法 |
CN1077108C (zh) * | 1999-07-13 | 2002-01-02 | 成都地奥制药集团有限公司 | 用于制备药物昔多芬的前体化合物 |
AU1888800A (en) * | 1999-09-13 | 2001-04-17 | Cipla Limited | A novel process for the synthesis of sildenafil citrate |
US6075028A (en) * | 1999-09-23 | 2000-06-13 | Graham; Richard | Method of treating Tourette's syndrome and related CNS disorders |
TWI265925B (en) * | 1999-10-11 | 2006-11-11 | Pfizer | Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them |
TR200200954T2 (tr) | 1999-10-11 | 2002-09-23 | Pfizer Inc. | Fosfodiesteraz inhibitörleri olarak 5-(2-ikame edilmiş-5-heterosiklilsülfonilpirid-3-il)- dihidropirazolo[4,3- D]pirimidin-7-onlar. |
GB0015462D0 (en) * | 2000-06-22 | 2000-08-16 | Pfizer Ltd | Novel process for the preparation of pyrazolopyrimidinones |
US6667398B2 (en) | 2000-06-22 | 2003-12-23 | Pfizer Inc | Process for the preparation of pyrazolopyrimidinones |
YU84702A (sh) * | 2000-06-22 | 2005-09-19 | Pfizer Inc. | Novi postupak za pripremanje pirazolopirimidinona |
US6730786B2 (en) * | 2000-06-22 | 2004-05-04 | Pfizer Inc | Process for the preparation of pyrazolopyrimidinones |
US6407259B1 (en) | 2000-07-28 | 2002-06-18 | Pfizer Inc. | Process for the preparation of pyrazoles |
EP1176147A1 (en) * | 2000-07-28 | 2002-01-30 | Pfizer Limited | Process for the preparation of pyrazolo[4,3-d]pyrimidin-7-ones and intermediates thereof |
EP1176142A1 (en) * | 2000-07-28 | 2002-01-30 | Pfizer Inc. | Process for the preparation of pyrazoles |
US6821978B2 (en) * | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
CN1127506C (zh) * | 2001-06-29 | 2003-11-12 | 刘宝顺 | 一种治疗阳痿的新化合物 |
CN1315835C (zh) * | 2001-08-28 | 2007-05-16 | 先灵公司 | 多环鸟嘌呤磷酸二酯酶v抑制剂 |
EP1719772A1 (en) | 2002-05-31 | 2006-11-08 | Schering Corporation | Process for preparing xanthine phosphodiesterase v inhibitors and precursors thereof |
DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
CN100374441C (zh) | 2003-06-06 | 2008-03-12 | 天津倍方科技发展有限公司 | 二氢吡咯[2,3-d]嘧啶-4-酮衍生物,其制备方法及其制药用途 |
CN100360531C (zh) * | 2003-12-18 | 2008-01-09 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物 |
DE602005004966T2 (de) | 2004-01-05 | 2009-03-12 | Teva Pharmaceutical Industries Ltd. | Prozesse zur herstellung von sildenafil-base und zitratsalz |
EP1779852A3 (en) * | 2004-01-05 | 2007-05-09 | Teva Pharmaceutical Industries Ltd. | Processes for the production of sildenafil base and citrate salt |
DE102005009240A1 (de) | 2005-03-01 | 2006-09-07 | Bayer Healthcare Ag | Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften |
CN101563348B (zh) * | 2006-12-21 | 2011-08-24 | 上海特化医药科技有限公司 | 西地那非的制备方法及其中间体 |
ES2310144B1 (es) | 2007-06-15 | 2010-01-12 | Galenicum Health, S.L. | Intermedios para la preparacion de un inhibidor de la fosfodiesterasa tipo 5. |
MX339136B (es) | 2008-12-12 | 2016-05-13 | Rhein Siegfried Sa De Cv | Composicion de liberacion pulsatil de sildenafil y proceso para prepararla. |
MX2010006227A (es) | 2010-06-07 | 2011-12-14 | World Trade Imp Exp Wtie Ag | Nuevos derivados 1,4-diazepanos, inhibidores de pde-5. |
CN102993205B (zh) * | 2012-12-27 | 2015-04-15 | 华润赛科药业有限责任公司 | 一种高收率制备高纯度西地那非游离碱的纯化方法 |
CN103044330B (zh) * | 2013-01-14 | 2018-11-13 | 常州亚邦制药有限公司 | 西地那非中间体4-氨基-1-甲基-3-正丙基吡唑-5-甲酰胺的绿色合成新工艺 |
CN105085526B (zh) * | 2014-05-15 | 2017-08-01 | 重庆圣华曦药业股份有限公司 | 一种改进的西地那非制备方法 |
CN105753870B (zh) * | 2016-04-01 | 2018-05-22 | 重庆康刻尔制药有限公司 | 一种西地那非杂质f及其制备方法和应用 |
WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
CN105837578A (zh) * | 2016-04-05 | 2016-08-10 | 重庆康刻尔制药有限公司 | 一种西地那非杂质d的合成方法 |
WO2018069316A2 (en) | 2016-10-10 | 2018-04-19 | Transgene Sa | Immunotherapeutic product and mdsc modulator combination therapy |
CN113493459B (zh) * | 2020-04-07 | 2022-12-13 | 广州白云山医药集团股份有限公司白云山制药总厂 | Pde5抑制剂化合物及其制备方法和应用 |
CN112961160A (zh) * | 2021-03-05 | 2021-06-15 | 遂成药业股份有限公司 | 一种西地那非的改良合成工艺 |
CN113754612B (zh) * | 2021-10-26 | 2023-09-26 | 山东安舜制药有限公司 | 一种西地那非中间体的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4871843A (en) * | 1983-10-18 | 1989-10-03 | Dropic-Societe Civile De Gestion De Droits De Propriete Industrielle | Cyclic benzenesulfonamides, process for their preparation and their use as active substance of pharmaceutical compositions |
GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9301192D0 (en) * | 1993-06-09 | 1993-06-09 | Trott Francis W | Flower shaped mechanised table |
SK285991B6 (sk) * | 1997-04-25 | 2008-01-07 | Pfizer Inc. | Pyrazolopyrimidinóny, spôsob a medziprodukty na ich výrobu, ich použitie a farmaceutické a veterinárne kompozície na ich báze |
US6087368A (en) * | 1998-06-08 | 2000-07-11 | Bristol-Myers Squibb Company | Quinazolinone inhibitors of cGMP phosphodiesterase |
-
1996
- 1996-06-14 GB GBGB9612514.1A patent/GB9612514D0/en active Pending
-
1997
- 1997-05-14 HN HN1997000072A patent/HN1997000072A/es unknown
- 1997-05-30 NO NO972481A patent/NO304551B1/no not_active IP Right Cessation
- 1997-06-02 AP APAP/P/1997/001009A patent/AP717A/en active
- 1997-06-04 EP EP97303832A patent/EP0812845B1/en not_active Expired - Lifetime
- 1997-06-04 ES ES98123740T patent/ES2201397T3/es not_active Expired - Lifetime
- 1997-06-04 EP EP98123740A patent/EP0916675B1/en not_active Expired - Lifetime
- 1997-06-04 ES ES97303832T patent/ES2134051T3/es not_active Expired - Lifetime
- 1997-06-04 AT AT98123740T patent/ATE246194T1/de active
- 1997-06-04 DE DE69723846T patent/DE69723846T2/de not_active Expired - Lifetime
- 1997-06-04 SI SI9730005T patent/SI0812845T1/xx not_active IP Right Cessation
- 1997-06-04 DK DK97303832T patent/DK0812845T3/da active
- 1997-06-04 AT AT97303832T patent/ATE182150T1/de active
- 1997-06-04 PT PT98123740T patent/PT916675E/pt unknown
- 1997-06-04 DE DE69700321T patent/DE69700321T2/de not_active Expired - Lifetime
- 1997-06-04 DK DK98123740T patent/DK0916675T3/da active
- 1997-06-04 SI SI9730577T patent/SI0916675T1/xx unknown
- 1997-06-05 TR TR97/00470A patent/TR199700470A2/xx unknown
- 1997-06-05 IL IL12541197A patent/IL125411A/xx not_active IP Right Cessation
- 1997-06-05 IL IL12100097A patent/IL121000A/xx not_active IP Right Cessation
- 1997-06-05 BG BG101569A patent/BG62554B1/bg unknown
- 1997-06-06 US US08/869,532 patent/US5955611A/en not_active Expired - Lifetime
- 1997-06-10 SA SA97180124A patent/SA97180124B1/ar unknown
- 1997-06-10 SK SK743-97A patent/SK283893B6/sk not_active IP Right Cessation
- 1997-06-10 SK SK1786-2001A patent/SK283896B6/sk not_active IP Right Cessation
- 1997-06-10 IN IN1548DE1997 patent/IN187350B/en unknown
- 1997-06-10 SK SK1784-2001A patent/SK283895B6/sk not_active IP Right Cessation
- 1997-06-10 SK SK1787-2001A patent/SK283897B6/sk not_active IP Right Cessation
- 1997-06-10 SK SK1783-2001A patent/SK283894B6/sk not_active IP Right Cessation
- 1997-06-10 IS IS4503A patent/IS1922B/is unknown
- 1997-06-11 TN TNTNSN97102A patent/TNSN97102A1/fr unknown
- 1997-06-11 EA EA199700061A patent/EA000102B1/ru not_active IP Right Cessation
- 1997-06-11 MA MA24655A patent/MA24205A1/fr unknown
- 1997-06-11 PE PE2001000983A patent/PE20011303A1/es not_active IP Right Cessation
- 1997-06-11 DZ DZ970097A patent/DZ2247A1/fr active
- 1997-06-11 PE PE1997000483A patent/PE1299A1/es not_active IP Right Cessation
- 1997-06-12 EG EG54097A patent/EG24123A/xx active
- 1997-06-12 AR ARP970102564A patent/AR003401A1/es unknown
- 1997-06-12 SG SG1997002037A patent/SG50024A1/en unknown
- 1997-06-12 CA CA002207694A patent/CA2207694C/en not_active Expired - Lifetime
- 1997-06-12 UA UA97062802A patent/UA27085C2/uk unknown
- 1997-06-12 CZ CZ19971811A patent/CZ290942B6/cs not_active IP Right Cessation
- 1997-06-12 ID IDP972004A patent/ID18745A/id unknown
- 1997-06-13 ZA ZA9705259A patent/ZA975259B/xx unknown
- 1997-06-13 HU HU9701048A patent/HU224497B1/hu not_active IP Right Cessation
- 1997-06-13 PL PL97320555A patent/PL189333B1/pl not_active IP Right Cessation
- 1997-06-13 MX MX9704433A patent/MX9704433A/es unknown
- 1997-06-13 JP JP9156422A patent/JP2866841B2/ja not_active Expired - Lifetime
- 1997-06-13 OA OA70024A patent/OA10426A/en unknown
- 1997-06-13 AU AU24878/97A patent/AU697684B2/en not_active Ceased
- 1997-06-13 CN CN97113261A patent/CN1106399C/zh not_active Expired - Lifetime
- 1997-06-13 CO CO97032741A patent/CO4780028A1/es unknown
- 1997-06-13 RS YUP-254/97A patent/RS49653B/sr unknown
- 1997-06-13 KR KR1019970024457A patent/KR100207352B1/ko not_active IP Right Cessation
- 1997-06-13 UY UY24585A patent/UY24585A1/es not_active IP Right Cessation
- 1997-06-13 RS YUP-2006/0484A patent/RS49924B/sr unknown
- 1997-06-13 HR HR970326A patent/HRP970326B1/xx not_active IP Right Cessation
- 1997-06-13 NZ NZ328084A patent/NZ328084A/en not_active IP Right Cessation
- 1997-06-16 BR BR9703580A patent/BR9703580A/pt not_active IP Right Cessation
- 1997-07-09 UY UY24612A patent/UY24612A1/es not_active IP Right Cessation
-
1998
- 1998-07-20 IL IL12541198A patent/IL125411A0/xx unknown
- 1998-09-25 JP JP10271067A patent/JP3058863B2/ja not_active Expired - Lifetime
- 1998-10-30 NO NO985064A patent/NO306115B1/no not_active IP Right Cessation
-
1999
- 1999-07-23 US US09/360,128 patent/US6066735A/en not_active Expired - Lifetime
- 1999-08-26 GR GR990402170T patent/GR3031087T3/el unknown
-
2000
- 2000-07-05 CN CNB001200542A patent/CN1149206C/zh not_active Expired - Lifetime
-
2001
- 2001-04-24 IN IN518DE2001 patent/IN187318B/en unknown
- 2001-04-24 IN IN520DE2001 patent/IN187320B/en unknown
- 2001-04-24 IN IN519DE2001 patent/IN187319B/en unknown
- 2001-04-24 IN IN517DE2001 patent/IN187317B/en unknown
- 2001-06-15 HK HK01104141A patent/HK1033459A1/xx not_active IP Right Cessation
-
2002
- 2002-11-25 IS IS6634A patent/IS1923B/is unknown
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