ATE20733T1 - Roentgenkontrastmittel. - Google Patents

Roentgenkontrastmittel.

Info

Publication number
ATE20733T1
ATE20733T1 AT83306766T AT83306766T ATE20733T1 AT E20733 T1 ATE20733 T1 AT E20733T1 AT 83306766 T AT83306766 T AT 83306766T AT 83306766 T AT83306766 T AT 83306766T AT E20733 T1 ATE20733 T1 AT E20733T1
Authority
AT
Austria
Prior art keywords
ch2ch
group
contrast agent
ray contrast
ch2oh
Prior art date
Application number
AT83306766T
Other languages
German (de)
English (en)
Inventor
Per-Egil Hansen
Hugo Holtermann
Knut Wille
Original Assignee
Nyegaard & Co As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nyegaard & Co As filed Critical Nyegaard & Co As
Application granted granted Critical
Publication of ATE20733T1 publication Critical patent/ATE20733T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Medicinal Preparation (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT83306766T 1982-11-08 1983-11-07 Roentgenkontrastmittel. ATE20733T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8231796 1982-11-08
EP83306766A EP0108638B1 (en) 1982-11-08 1983-11-07 X-ray contrast agents

Publications (1)

Publication Number Publication Date
ATE20733T1 true ATE20733T1 (de) 1986-08-15

Family

ID=10534110

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83306766T ATE20733T1 (de) 1982-11-08 1983-11-07 Roentgenkontrastmittel.

Country Status (10)

Country Link
US (1) US5349085A (env)
EP (1) EP0108638B1 (env)
JP (1) JPS59104352A (env)
AT (1) ATE20733T1 (env)
DE (1) DE3364536D1 (env)
DK (1) DK160868C (env)
HK (1) HK46791A (env)
LU (1) LU88639I2 (env)
NL (1) NL950010I1 (env)
NO (2) NO161368C (env)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
GB8919929D0 (en) 1989-09-04 1989-10-18 Nycomed As Compositions
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
WO1994022810A1 (es) * 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9720969D0 (en) 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
AU2002245169A1 (en) 2000-11-10 2002-07-08 Wm. Marsh Rice University Fullerene (c60)-based x-ray contrast agent for diagnostic imaging
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
SI1836239T1 (sl) 2005-01-13 2009-04-30 Cinv Ag Kompozitni materiali, ki vsebujejo ogljikove nanodelce
WO2007073202A1 (en) 2005-12-19 2007-06-28 Ge Healthcare As Purification process of iodixanol
US8124806B2 (en) 2006-02-15 2012-02-28 Ge Healthcare As Contrast agents
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
CN103951586B (zh) * 2007-07-12 2015-05-27 通用电气医疗集团股份有限公司 造影剂
JP2011500533A (ja) 2007-10-12 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
CN101820924A (zh) 2007-10-12 2010-09-01 通用电气医疗集团股份有限公司 造影剂
US20100221192A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
US20100209356A1 (en) 2007-10-12 2010-08-19 Duncan George Wynn Contrast agents
EP2245004A2 (en) * 2008-02-27 2010-11-03 GE Healthcare AS Contrast agents
WO2009106552A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
EP2385845A1 (en) 2009-01-09 2011-11-16 Ge Healthcare As Contrast media compositions
US8969619B2 (en) 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US8962886B2 (en) 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US7999134B2 (en) * 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US7696381B1 (en) 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
DK2493511T3 (da) * 2009-10-29 2013-11-25 Ge Healthcare As Diagnostisk sammensætning omfattende plasmakationer som har en forbedret sikkerhedsprofil
KR101699226B1 (ko) * 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
JP2013531685A (ja) 2010-07-12 2013-08-08 ジーイー・ヘルスケア・アクスイェ・セルスカプ 低造影剤濃度及び／又は低放射線量でのｘ線イメージング
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102816125B (zh) * 2011-06-08 2014-03-26 浙江司太立制药股份有限公司 一种造影剂
MX2014008517A (es) 2012-01-11 2014-08-21 Ge Healthcare As Medio de contraste de formacion de imagenes de rayos x con concentracion baja de yodo y proceso para formacion de imagenes de rayos x.
CN110003038A (zh) 2012-09-27 2019-07-12 通用电气医疗集团股份有限公司 Ioforminol的中间体化合物的制备
PT2917174T (pt) 2012-11-12 2018-11-14 Ge Healthcare As Preparação de intermediários de agentes de contraste de raios-x
WO2016079330A1 (en) 2014-11-21 2016-05-26 Technical University Of Denmark Gel formulations for local drug release
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
KR102358040B1 (ko) 2016-05-20 2022-01-28 테크니칼 유니버시티 오브 덴마크 촉진가능한 마커 조성물
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
WO2020249801A1 (en) 2019-06-12 2020-12-17 Technical University Of Denmark Dissacharide formulations for controlled drug release
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (env) * 1966-12-13 1972-04-04 Pharmacia Ab
SE315975B (env) * 1967-12-28 1969-10-13 Pharmacia Ab
US3763227A (en) * 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
US3804892A (en) * 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
SE315974B (env) * 1967-12-28 1969-10-13 Pharmacia Ab
DE2031724C3 (de) * 1969-06-27 1979-06-28 Nyegaard & Co. A/S., Oslo N-substituierte Trijodbenz- bzw. Jodmethansulfon-am'ide, Verfahren zu deren Herstellung und radiologische Zusammensetzungen
NL7102816A (env) * 1970-03-12 1971-09-14
DD104193A5 (env) * 1972-12-22 1974-03-05
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
FR2511871A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus

Also Published As

Publication number Publication date
EP0108638B1 (en) 1986-07-16
NO161368B (no) 1989-05-02
JPS6355509B2 (env) 1988-11-02
EP0108638A1 (en) 1984-05-16
NL950010I2 (nl) 1997-02-03
DK160868C (da) 1991-10-14
DK160868B (da) 1991-04-29
NL950010I1 (nl) 1997-02-03
HK46791A (en) 1991-06-21
LU88639I2 (fr) 1996-02-01
NO1994015I1 (no) 1994-09-05
NO834056L (no) 1984-05-09
DK508283A (da) 1984-05-09
NO161368C (no) 1989-08-09
DE3364536D1 (en) 1986-08-21
DK508283D0 (da) 1983-11-07
JPS59104352A (ja) 1984-06-16
US5349085A (en) 1994-09-20

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