ATE159765T1 - Verfahren und zusammensetzung für den nachweis von verschiedenen dns sequenzen - Google Patents

Verfahren und zusammensetzung für den nachweis von verschiedenen dns sequenzen

Info

Publication number
ATE159765T1
ATE159765T1 AT93912131T AT93912131T ATE159765T1 AT E159765 T1 ATE159765 T1 AT E159765T1 AT 93912131 T AT93912131 T AT 93912131T AT 93912131 T AT93912131 T AT 93912131T AT E159765 T1 ATE159765 T1 AT E159765T1
Authority
AT
Austria
Prior art keywords
probe
polynucleotide
target
pair
elements
Prior art date
Application number
AT93912131T
Other languages
English (en)
Inventor
Paul David Grossman
Steven Fung
Steven Michael Menchen
Sam Lee Woo
Emily Susan Winn-Deen
Original Assignee
Perkin Elmer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/866,018 external-priority patent/US5470705A/en
Application filed by Perkin Elmer Corp filed Critical Perkin Elmer Corp
Application granted granted Critical
Publication of ATE159765T1 publication Critical patent/ATE159765T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6862—Ligase chain reaction [LCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
AT93912131T 1992-04-03 1993-04-02 Verfahren und zusammensetzung für den nachweis von verschiedenen dns sequenzen ATE159765T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86264292A 1992-04-03 1992-04-03
US07/866,018 US5470705A (en) 1992-04-03 1992-04-07 Probe composition containing a binding domain and polymer chain and methods of use
US97311892A 1992-11-06 1992-11-06

Publications (1)

Publication Number Publication Date
ATE159765T1 true ATE159765T1 (de) 1997-11-15

Family

ID=27420419

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93909463T ATE173767T1 (de) 1992-04-03 1993-03-31 Proben zusammensetzung und verfahren
AT93912131T ATE159765T1 (de) 1992-04-03 1993-04-02 Verfahren und zusammensetzung für den nachweis von verschiedenen dns sequenzen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT93909463T ATE173767T1 (de) 1992-04-03 1993-03-31 Proben zusammensetzung und verfahren

Country Status (7)

Country Link
US (7) US5514543A (de)
EP (2) EP0636186B1 (de)
JP (2) JP2775346B2 (de)
AT (2) ATE173767T1 (de)
DE (2) DE69322266T2 (de)
DK (1) DK0635069T3 (de)
WO (2) WO1993020236A1 (de)

Families Citing this family (287)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040138A (en) * 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5470705A (en) * 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use
ATE173767T1 (de) * 1992-04-03 1998-12-15 Perkin Elmer Corp Proben zusammensetzung und verfahren
US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
JP3419850B2 (ja) * 1993-10-26 2003-06-23 株式会社日立製作所 核酸分別方法
US5976798A (en) * 1994-03-30 1999-11-02 Mitokor Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid
ATE174066T1 (de) * 1994-04-04 1998-12-15 Ciba Corning Diagnostics Corp Hybridisation-ligitation-verfahren zum nachweis von spezifischen dns sequenzen
US5807522A (en) * 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US7323298B1 (en) * 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US5849483A (en) * 1994-07-28 1998-12-15 Ig Laboratories, Inc. High throughput screening method for sequences or genetic alterations in nucleic acids
US5834181A (en) * 1994-07-28 1998-11-10 Genzyme Corporation High throughput screening method for sequences or genetic alterations in nucleic acids
ATE226983T1 (de) * 1994-08-19 2002-11-15 Pe Corp Ny Gekoppeltes ampflikation- und ligationverfahren
GB9417211D0 (en) * 1994-08-25 1994-10-12 Solicitor For The Affairs Of H Nucleotide sequencing method
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6280935B1 (en) 1994-10-13 2001-08-28 Lynx Therapeutics, Inc. Method of detecting the presence or absence of a plurality of target sequences using oligonucleotide tags
US5846719A (en) 1994-10-13 1998-12-08 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
US8236493B2 (en) * 1994-10-21 2012-08-07 Affymetrix, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
DE19508366C2 (de) * 1995-03-10 1998-01-29 Evotec Biosystems Gmbh Verfahren zum direkten Nachweisen weniger Nucleinsäurestränge
US5630924A (en) * 1995-04-20 1997-05-20 Perseptive Biosystems, Inc. Compositions, methods and apparatus for ultrafast electroseparation analysis
US5830655A (en) 1995-05-22 1998-11-03 Sri International Oligonucleotide sizing using cleavable primers
HUP9900910A2 (hu) * 1995-06-07 1999-07-28 Lynx Therapeutics, Inc. Oligonukleotid jelzések osztályozáshoz és azonosításhoz
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US6312893B1 (en) 1996-01-23 2001-11-06 Qiagen Genomics, Inc. Methods and compositions for determining the sequence of nucleic acid molecules
EP0880598A4 (de) * 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US6027890A (en) 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6706471B1 (en) 1996-01-24 2004-03-16 Third Wave Technologies, Inc. Detection of nucleic acid sequences by invader-directed cleavage
US6852487B1 (en) 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6020481A (en) * 1996-04-01 2000-02-01 The Perkin-Elmer Corporation Asymmetric benzoxanthene dyes
EP0912761A4 (de) 1996-05-29 2004-06-09 Cornell Res Foundation Inc Bestimmung von unterschieden in der nukleisäuresequenz mittels einer kombination von ligasebestimmung und polymerase-kettenreaktion
US6780982B2 (en) * 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
JP4000605B2 (ja) 1996-07-24 2007-10-31 株式会社日立製作所 Ｄｎａ試料調整装置及びこれを用いる電気泳動分析装置
AU3829197A (en) * 1996-09-03 1998-03-26 Pioneer Hi-Bred International, Inc. Method and apparatus for single molecule two color fluorescent detection and molecular weight and concentration determination
US6133436A (en) 1996-11-06 2000-10-17 Sequenom, Inc. Beads bound to a solid support and to nucleic acids
DE69735445T2 (de) 1996-12-10 2006-08-10 Sequenom, Inc., San Diego Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung
US6299881B1 (en) * 1997-03-24 2001-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
US20020015997A1 (en) * 1997-06-16 2002-02-07 Lafferty William Michael Capillary array-based sample screening
US20030013115A1 (en) * 1997-06-16 2003-01-16 Diversa Corporation, A Delaware Corporation Capillary array-based sample screening
US6559296B2 (en) 1997-08-29 2003-05-06 Olympus Optical Co., Ltd. DNA capillary
JP3938982B2 (ja) * 1997-08-29 2007-06-27 オリンパス株式会社 Ｄｎａキャピラリィ
US6008379A (en) 1997-10-01 1999-12-28 The Perkin-Elmer Corporation Aromatic-substituted xanthene dyes
US6583168B1 (en) 1997-11-25 2003-06-24 Applera Corporation Sulfonated diarylrhodamine dyes
US5936087A (en) 1997-11-25 1999-08-10 The Perkin-Elmer Corporation Dibenzorhodamine dyes
US6087102A (en) 1998-01-07 2000-07-11 Clontech Laboratories, Inc. Polymeric arrays and methods for their use in binding assays
US6537749B2 (en) * 1998-04-03 2003-03-25 Phylos, Inc. Addressable protein arrays
US6096875A (en) 1998-05-29 2000-08-01 The Perlein-Elmer Corporation Nucleotide compounds including a rigid linker
CA2351739A1 (en) * 1998-08-28 2000-03-09 Gryphon Sciences Polyamide chains of precise length, methods to manufacture them and their conjugates with proteins
US6238565B1 (en) * 1998-09-16 2001-05-29 Varian, Inc. Monolithic matrix for separating bio-organic molecules
US7135284B1 (en) * 1999-02-05 2006-11-14 Integrated Dna Technologies, Inc. Primer extension methods for production of high specific activity nucleic acid probes
US6635419B1 (en) 1999-02-16 2003-10-21 Applera Corporation Polynucleotide sequencing method
AU775179B2 (en) 1999-03-15 2004-07-22 Applied Biosystems, Llc Probe/mobility modifier complexes for multiplex nucleic acid detection
US7014994B1 (en) 1999-03-19 2006-03-21 Cornell Research Foundation,Inc. Coupled polymerase chain reaction-restriction-endonuclease digestion-ligase detection reaction process
US6506594B1 (en) 1999-03-19 2003-01-14 Cornell Res Foundation Inc Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US6649351B2 (en) 1999-04-30 2003-11-18 Aclara Biosciences, Inc. Methods for detecting a plurality of analytes by mass spectrometry
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
DE19924606A1 (de) * 1999-05-28 2000-11-30 Graffinity Pharm Design Gmbh Ligand-Anker-Konjugate
US20020045182A1 (en) * 1999-07-16 2002-04-18 Lynx Therapeutics, Inc. Multiplexed differential displacement for nucleic acid determinations
WO2001025481A1 (fr) * 1999-10-04 2001-04-12 Olympus Optical Co., Ltd. Procede de detection d'acide nucleique
US7332275B2 (en) 1999-10-13 2008-02-19 Sequenom, Inc. Methods for detecting methylated nucleotides
EP1136569A3 (de) 2000-03-24 2004-01-28 Bayer Corporation Nukleinsäuresonden, die hoch-hydrophile nicht-nukleosidische Gruppen mit multiplen Markern enthalten und ihre Verwendungen
JP5508654B2 (ja) 2000-04-14 2014-06-04 コーネル・リサーチ・ファンデーション・インコーポレイテッド リガーゼ検出反応を用いた核酸配列の違いの検出のための位置特定可能なアレイの設計方法
US6329801B1 (en) * 2000-04-24 2001-12-11 Volterra Semiconductor Corporation Switching regulator control system and method
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US20040067498A1 (en) * 2000-04-28 2004-04-08 Ahmed Chenna Detection of nucleic acid sequences by cleavage and separation of tag-containing structures
US20030170734A1 (en) * 2000-04-28 2003-09-11 Stephen Williams Multiplexed assays using electrophoretically separated molecular tags
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
KR20030040208A (ko) * 2000-05-08 2003-05-22 큐티엘 바이오시스템즈 엘엘씨 개선된 형광 폴리머-ｑｔｌ 바이오센싱 방법
EP1313880A2 (de) * 2000-05-30 2003-05-28 PE Corporation (NY) Methoden zur detektion gewünschter nukleinsäuren mittels kombinierter ligation und amplifizierung
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US6632606B1 (en) 2000-06-12 2003-10-14 Aclara Biosciences, Inc. Methods for single nucleotide polymorphism detection
US6958214B2 (en) 2000-07-10 2005-10-25 Sequenom, Inc. Polymorphic kinase anchor proteins and nucleic acids encoding the same
FR2812658B1 (fr) * 2000-08-01 2005-04-15 De Bruno Vandiere Procede d'analyse d'acides nucleiques
AU2001296668A1 (en) * 2000-10-05 2002-04-15 Aclara Biosciences, Inc. Multiplexed differential displacement for nucleic acid determinations
MXPA02005717A (es) * 2000-10-10 2003-10-14 Diversa Corp Analisis de alto rendimiento o a base de capilares para bioactividad o biomoleuclas.
US6811979B2 (en) * 2000-10-11 2004-11-02 Applera Corporation Fluorescent nucleobase conjugates having anionic linkers
CA2435894C (en) * 2001-02-02 2014-05-13 Allvivo, Inc. End group activated polymers with oligonucleotide ligands
CA2440656A1 (en) * 2001-03-09 2002-09-19 Apollo Biotechnology, Inc. Conjugate probes and optical detection of analytes
US6743905B2 (en) * 2001-04-16 2004-06-01 Applera Corporation Mobility-modified nucleobase polymers and methods of using same
EP1386002A4 (de) * 2001-04-16 2006-11-08 Applera Corp Verfahren und zusammensetzungen zur nukleotidanalyse
HUP0501021A3 (en) 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
WO2002095356A2 (en) * 2001-05-21 2002-11-28 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
AU2002344221A1 (en) * 2001-05-26 2002-12-09 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
JP2005525787A (ja) * 2001-10-24 2005-09-02 シンギュレックス・インコーポレイテッド プローブとの相互作用による遺伝子ハプロタイプの検出方法
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20030162202A1 (en) * 2001-11-09 2003-08-28 Becker Kenneth David Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
US20040067512A1 (en) * 2001-11-09 2004-04-08 Neurogenetics, Inc. Single nucleotide polymorphisms and mutations on Alpha-2-Macroglobulin
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
JP2005517900A (ja) 2001-11-21 2005-06-16 アプレラ コーポレイション デジタルアッセイ
EP1465998A2 (de) 2002-01-08 2004-10-13 Bayer HealthCare AG Herz-kreislauf-erkrankung und medikamentenwirkung voraussagende einzelnukleotid-polymorphismen
KR20040108655A (ko) * 2002-03-05 2004-12-24 아클라라 바이오사이언시스 인코퍼레이티드 막-결합된 민감제를 사용하는 복합 분석법
US20030177380A1 (en) * 2002-03-18 2003-09-18 Woods Stanley P. Devices for storing array data and methods of using the same
JP2003294742A (ja) * 2002-03-29 2003-10-15 Inst Of Physical & Chemical Res ハイブリダイゼーション用基板及びその使用方法
EP1501863A4 (de) * 2002-05-03 2007-01-24 Sequenom Inc Kinaseankerproteinmuteine, peptide davon und damit im zusammenhang stehende verfahren
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040175765A1 (en) * 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
PL374875A1 (en) * 2002-07-25 2005-11-14 Aclara Biosciences, Inc. Detecting receptor oligomerization
JP2005534686A (ja) 2002-07-31 2005-11-17 ユニバーシティ オブ サザン カリフォルニア 疾患および処置結果の予見のための多型性
US7381317B2 (en) 2002-08-12 2008-06-03 Beckman Coulter, Inc. Methods and compositions for capillary electrophoresis (CE)
AU2003275138A1 (en) 2002-09-19 2004-04-08 Applied Biosystems, Llc. Methods and compositions for detecting targets
US20040235005A1 (en) * 2002-10-23 2004-11-25 Ernest Friedlander Methods and composition for detecting targets
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
WO2004046344A2 (en) * 2002-11-19 2004-06-03 Applera Corporation Polynucleotide sequence detection assays
AU2003298672A1 (en) * 2002-11-19 2005-01-28 Singulex, Inc. Detection of target molecules through interaction with probes
CA2505687A1 (en) * 2002-11-19 2004-06-03 Applera Corporation Polynucleotide sequence detection assays and analysis
WO2005001129A2 (en) * 2003-06-06 2005-01-06 Applera Corporation Mobility cassettes
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
WO2005019419A2 (en) * 2003-07-31 2005-03-03 Singulex, Inc. Co-detection of single polypeptide and polynucleotide molecules
WO2005019470A2 (en) * 2003-08-11 2005-03-03 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US7570443B2 (en) 2003-09-19 2009-08-04 Applied Biosystems, Llc Optical camera alignment
US20050112634A1 (en) * 2003-09-19 2005-05-26 Woudenberg Timothy M. High density sequence detection methods and apparatus
CA2543830A1 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
US20050094807A1 (en) * 2003-11-04 2005-05-05 John Silzel Accuracy array assay system and method
JP2007517511A (ja) * 2004-01-10 2007-07-05 バイエル・ヘルスケア・エルエルシー ヒトチオプリンｓ−メチルトランスフェラーゼ欠損に関連するハプロタイプおよび多型
WO2005098040A2 (en) * 2004-03-24 2005-10-20 Applera Corporation Ligation and amplification reactions for determining target molecules
US20050255485A1 (en) * 2004-05-14 2005-11-17 Livak Kenneth J Detection of gene duplications
CA2572450A1 (en) 2004-05-28 2005-12-15 Ambion, Inc. Methods and compositions involving microrna
US20060003337A1 (en) * 2004-06-30 2006-01-05 John Brandis Detection of small RNAS
WO2006012361A2 (en) 2004-07-01 2006-02-02 University Of Southern California Genetic markers for predicting disease and treatment outcome
EP2302055B1 (de) 2004-11-12 2014-08-27 Asuragen, Inc. Verfahren und Zusammensetzungen, die miRNAs und miRNAa-inhibitorischen Molekülen verbunden sind
JP2008527979A (ja) * 2005-01-12 2008-07-31 アプレラ コーポレイション 核酸の選択的増幅のための組成物、方法およびキット
EP2604703B1 (de) 2005-03-14 2017-02-01 The Board of Trustees of the Leland Stanford Junior University Verfahren zur Bewertung der Haltbarkeit eines Pfropfs im Körper eines Empfängers fester Organtransplantate
US20060211030A1 (en) * 2005-03-16 2006-09-21 Sydney Brenner Methods and compositions for assay readouts on multiple analytical platforms
EP1902142B1 (de) 2005-04-14 2010-01-06 Applied Biosystems, LLC 3'-modifizierte oligonukleotide mit pseudoisocytosin-nukleobasenderivaten sowie deren anwendungen als primer oder sonden
EP1731620A1 (de) 2005-06-07 2006-12-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methode zur Diagnose von Immun-Transplantatstoleranz
US20070087360A1 (en) * 2005-06-20 2007-04-19 Boyd Victoria L Methods and compositions for detecting nucleotides
US20070014699A1 (en) * 2005-06-23 2007-01-18 Beckman Coulter, Inc, Methods and apparatus for improving the sensitivity of capillary zone electrophoresis
US20070026439A1 (en) * 2005-07-15 2007-02-01 Applera Corporation Fluid processing device and method
US20070099211A1 (en) * 2005-07-15 2007-05-03 Vissarion Aivazachvili Detection of nucleic acid amplification
EP2311995A1 (de) 2005-09-22 2011-04-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Verwendung IL-21
US20070202515A1 (en) * 2005-10-12 2007-08-30 Pathologica, Llc. Promac signature application
WO2007103814A2 (en) 2006-03-03 2007-09-13 University Of Southern California Angiogenesis pathway gene polymorphisms for therapy selection
US20070215472A1 (en) * 2006-03-15 2007-09-20 Slater Gary W Electroosmotic flow for end labelled free solution electrophoresis
US20070218494A1 (en) * 2006-03-17 2007-09-20 Gary Slater Branched polymer lables as drag-tags in free solution electrophoresis
US7759062B2 (en) * 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
EP2442108B1 (de) 2006-07-14 2016-11-16 The Regents of The University of California Krebsbiomarker und Anwendungsverfahren dafür
EP2145001A2 (de) 2006-09-19 2010-01-20 Asuragen, Inc. Von mir-15, mir-26, mir -31,mir -145, mir-147, mir-188, mir-215, mir-216 mir-331, mmu-mir-292-3p regulierte gene und stoffwechselwege als ziele für einen therapeutischen eingriff
WO2008036765A2 (en) 2006-09-19 2008-03-27 Asuragen, Inc. Micrornas differentially expressed in pancreatic diseases and uses thereof
WO2008076842A2 (en) * 2006-12-14 2008-06-26 Applied Biosystems Inc. Sequencing methods
US8114599B2 (en) 2006-12-19 2012-02-14 Northwestern University Compositions and methods for free-solution conjugate nucleic acid analysis
WO2008088860A2 (en) 2007-01-18 2008-07-24 University Of Southern California Polymorphisms in the egfr pathway as markers for cancer treatment
EP2126117A2 (de) * 2007-01-18 2009-12-02 University Of Southern California Für duale tki-therapie prädiktive genpoylmorphismen
EP2107911A4 (de) 2007-01-30 2010-09-22 Pharmacyclics Inc Verfahren zur bestimmung der krebsresistenz auf histon-deacetylasehemmer
FI20075124A0 (fi) * 2007-02-21 2007-02-21 Valtion Teknillinen Menetelmä ja testikitti nukleotidivariaatioiden toteamiseksi
EP1961825A1 (de) 2007-02-26 2008-08-27 INSERM (Institut National de la Santé et de la Recherche Medicale) Verfahren zur Vorhersage des Auftretens von Metastasen bei Brustkrebspatienten
PL2121989T5 (pl) 2007-03-13 2023-03-06 Amgen Inc. Mutacje K-RAS oraz terapia przeciwciałem anty-EGFR
AR065686A1 (es) 2007-03-13 2009-06-24 Amgen Inc Mutaciones de k- ras y b- raf y terapia con anticuerpos anti- egfr
WO2009020682A2 (en) 2007-05-08 2009-02-12 The Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
US8008010B1 (en) 2007-06-27 2011-08-30 Applied Biosystems, Llc Chimeric oligonucleotides for ligation-enhanced nucleic acid detection, methods and compositions therefor
CA2706763C (en) * 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
WO2009097424A1 (en) * 2008-01-29 2009-08-06 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Fstl-1 as a biomarker of inflammation
US8658379B2 (en) 2008-01-29 2014-02-25 University of Pittsburgh—of the Commonwealth System of Higher Education Follistatin-like protein-1 as a biomarker for sepsis
EP2113574A1 (de) 2008-04-28 2009-11-04 Biotype AG Stoffe und Verfahren für Profilierungstest auf DNA-Basis
EP2990487A1 (de) 2008-05-08 2016-03-02 Asuragen, INC. Zusammensetzungen und verfahren in zusammenhang mit der mirna-modulation von neovaskularisation oder angiogenese
US20110111417A1 (en) 2008-05-14 2011-05-12 Millennium Pharmaceuticals, Inc. Methods and kits for monitoring the effects of immunomodulators on adaptive immunity
WO2009145802A1 (en) * 2008-05-30 2009-12-03 The Trustess Of Columbia University In The City Of New York Systems and methods for integrating a single dna molecule into a molecular electronic device
US8208909B2 (en) 2008-06-02 2012-06-26 West Corporation System, apparatus and method for availing a mobile call of address information
US20110201519A1 (en) 2008-08-18 2011-08-18 Sarwal Minnie M Methods and Compositions for Determining a Graft Tolerant Phenotype in a Subject
WO2010065517A1 (en) 2008-12-01 2010-06-10 The Trustees Of Columbia University In The City Of New York Electromechanical devices and methods for fabrication of the same
DE102009010563A1 (de) 2009-02-16 2010-08-26 Matthias W. Engel Vorrichtung zum Nachweis von Analyten in Körperflüssigkeiten
WO2010123625A1 (en) 2009-04-24 2010-10-28 University Of Southern California Cd133 polymorphisms predict clinical outcome in patients with cancer
WO2011004345A1 (en) 2009-07-09 2011-01-13 Ecole Polytechnique Federale De Lausanne (Epfl) Upstream binding protein 1 polymorphisms and their use for prognosing or diagnosing arterial blood pressure
CN104293646A (zh) 2009-08-22 2015-01-21 里兰斯坦福初级大学理事会 成像并评估胚胎、卵母细胞和干细胞
AU2010301128B2 (en) 2009-09-30 2014-09-18 Quantapore, Inc. Ultrafast sequencing of biological polymers using a labeled nanopore
JP2013510564A (ja) 2009-11-13 2013-03-28 パンガエア ビオテック、ソシエダッド、リミターダ 肺癌におけるチロシンキナーゼ阻害剤に対する応答を予測するための分子バイオマーカー
WO2011068829A1 (en) 2009-12-02 2011-06-09 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers for determining an allograft tolerant phenotype
GB0922085D0 (en) 2009-12-17 2010-02-03 Cambridge Entpr Ltd Cancer diagnosis and treatment
WO2011084757A1 (en) 2009-12-21 2011-07-14 University Of Southern California Germline polymorphisms in the sparc gene associated with clinical outcome in gastric cancer
WO2011085334A1 (en) 2010-01-11 2011-07-14 University Of Southern California Cd44 polymorphisms predict clinical outcome in patients with gastric cancer
TWI518325B (zh) 2010-02-04 2016-01-21 自治醫科大學 對ａｌｋ抑制劑具有先抗性或後抗性癌症的識別、判斷和治療
EP3214174B1 (de) 2010-03-04 2019-10-16 InteRNA Technologies B.V. Mirna-molekül, das über seine quelle definiert ist, und seine diagnostischen und therapeutischen verwendungen bei mit emt assoziierten krankheiten
WO2011133538A1 (en) 2010-04-19 2011-10-27 The Procter & Gamble Company Genetic signatures and gene chips associated with administration of electrically conducted radio frequency current to skin and methods and treatments relating thereto
BR112012026871A2 (pt) 2010-04-19 2017-06-06 Procter & Gamble aplicação combinada de composição tópica e de energia para regular a condição de pele de mamíferos
EP3508854A1 (de) 2010-04-27 2019-07-10 The Regents of The University of California Krebsbiomarker und verfahren zur verwendung davon
WO2011143556A1 (en) * 2010-05-13 2011-11-17 Gen9, Inc. Methods for nucleotide sequencing and high fidelity polynucleotide synthesis
WO2011146725A1 (en) 2010-05-19 2011-11-24 Bayer Healthcare Llc Biomarkers for a multikinase inhibitor
US8586301B2 (en) 2010-06-30 2013-11-19 Stratos Genomics, Inc. Multiplexed identification of nucleic acid sequences
NZ704322A (en) 2010-07-06 2016-07-29 Interna Technologies Bv Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
WO2012019099A2 (en) 2010-08-05 2012-02-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Follistatin-like-protein-1 as a biomarker for inflammatory disorders
KR20130115250A (ko) 2010-09-15 2013-10-21 알막 다이아그노스틱스 리미티드 암에 대한 분자적 진단 테스트
WO2012051301A1 (en) 2010-10-12 2012-04-19 President And Fellows Of Harvard College Methods for identifying modulators of triglyceride metabolism, for modulating triglyceride metabolism and for identifying subjects at risk for abnormal triglyceride metabolism
CA2817882C (en) 2010-11-17 2022-08-23 Asuragen, Inc. Mirnas as biomarkers for distinguishing benign from malignant thyroid neoplasms
EP2474617A1 (de) 2011-01-11 2012-07-11 InteRNA Technologies BV MIR zur Behandlung von Neoangiogenese
US8486717B2 (en) 2011-01-18 2013-07-16 Symbolics, Llc Lateral flow assays using two dimensional features
EP2492688A1 (de) 2011-02-23 2012-08-29 Pangaea Biotech, S.A. Molekulare Biomarker zur Vorhersage der Reaktion auf die Antitumorbehandlung bei Lungenkrebs
WO2012116185A1 (en) 2011-02-23 2012-08-30 The Board Of Trustees Of The Leland Stanford Junior University Methods of detecting aneuploidy in human embryos
WO2012158238A2 (en) 2011-02-28 2012-11-22 University Of Iowa Research Foundation Anti-müllerian hormone changes in pregnancy and prediction ofadverse pregnancy outcomes and gender
EA027558B1 (ru) 2011-05-19 2017-08-31 Эйджена Байосайенс, Инк. Способ обнаружения мультиплексных нуклеиновых кислот
US10260097B2 (en) 2011-06-02 2019-04-16 Almac Diagnostics Limited Method of using a gene expression profile to determine cancer responsiveness to an anti-angiogenic agent
US9644241B2 (en) 2011-09-13 2017-05-09 Interpace Diagnostics, Llc Methods and compositions involving miR-135B for distinguishing pancreatic cancer from benign pancreatic disease
WO2013063519A1 (en) 2011-10-26 2013-05-02 Asuragen, Inc. Methods and compositions involving mirna expression levels for distinguishing pancreatic cysts
WO2013063544A1 (en) 2011-10-27 2013-05-02 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors
CN104302180B (zh) 2011-10-28 2017-05-17 米伦纽姆医药公司 对nedd8活化酶(nae)抑制剂的反应的生物标记
JP6397765B2 (ja) 2011-11-11 2018-09-26 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤に応答するバイオマーカー
WO2013071163A2 (en) 2011-11-11 2013-05-16 Millennium Pharamaceuticals, Inc. Biomarkers of response to proteasome inhibitors
WO2013087789A1 (en) 2011-12-13 2013-06-20 Glykos Finland Ltd. Antibody isoform arrays and methods thereof
WO2014007623A1 (en) 2012-07-03 2014-01-09 Interna Technologies B.V. Diagnostic portfolio and its uses
EP2875131B1 (de) 2012-07-18 2018-03-14 Siemens Healthcare Diagnostics Inc. Verfahren zur normalisierung von biologischen proben
US9874556B2 (en) 2012-07-18 2018-01-23 Symbolics, Llc Lateral flow assays using two dimensional features
EP3418395A1 (de) 2012-09-06 2018-12-26 Life Technologies Corporation Multiplex-y-str-analyse
CA2886783A1 (en) 2012-10-01 2014-04-10 Millennium Pharmaceuticals, Inc. Biomarkers and methods to predict response to inhibitors and uses thereof
WO2014055117A1 (en) 2012-10-04 2014-04-10 Asuragen, Inc. Diagnostic mirnas for differential diagnosis of incidental pancreatic cystic lesions
US10206911B2 (en) 2012-10-26 2019-02-19 Memorial Sloan-Kettering Cancer Center Androgen receptor variants and methods for making and using
US9651539B2 (en) 2012-10-28 2017-05-16 Quantapore, Inc. Reducing background fluorescence in MEMS materials by low energy ion beam treatment
RS56680B1 (sr) 2012-11-28 2018-03-30 Merck Sharp & Dohme Kompozicije i postupci za lečenje kancera
EP2925885B1 (de) 2012-12-03 2020-02-05 Almac Diagnostic Services Limited Molekular-diagnosetest für krebs
US9868992B2 (en) 2013-03-15 2018-01-16 Baylor Research Institute Tissue and blood-based miRNA biomarkers for the diagnosis, prognosis and metastasis-predictive potential in colorectal cancer
EP2970909A4 (de) 2013-03-15 2017-02-15 The University of Chicago Verfahren und zusammensetzungen in zusammenhang mit t-zell aktivität
WO2014151551A1 (en) 2013-03-15 2014-09-25 Baylor Research Institute Ulcerative colitis (uc)-associated colorectal neoplasia markers
AU2014268322B2 (en) 2013-05-24 2019-01-24 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed FRET detection
EP2805769A1 (de) 2013-05-24 2014-11-26 European Molecular Biology Laboratory Verfahren zur nanoskaligen Einzelzellenanalyse
WO2014201155A1 (en) 2013-06-11 2014-12-18 Courtagen Life Sciences, Inc. Methods and kits for treating and classifying individuals at risk of or suffering from trap1 change-of-function
KR102291045B1 (ko) 2013-08-05 2021-08-19 트위스트 바이오사이언스 코포레이션 드 노보 합성된 유전자 라이브러리
CN108051590B (zh) 2013-09-13 2020-12-11 Symbolics有限责任公司 运用二维试验和对照信号读出模式的侧向层析检测
EP3084003A4 (de) 2013-12-17 2017-07-19 Merck Sharp & Dohme Corp. Ifn-gamma-gensignaturbiomarker der tumorreaktion auf pd-1 antagonisten
GB201409479D0 (en) 2014-05-28 2014-07-09 Almac Diagnostics Ltd Molecular diagnostic test for cancer
US10328062B2 (en) 2014-04-04 2019-06-25 Amgen, Inc. Biomarkers and use of MET inhibitor for treatment of cancer
EP3194623B1 (de) 2014-08-12 2022-01-05 Wayne State University Systeme und verfahren zur erkennung von stress von stammzellen und verwendungen davon
US9885079B2 (en) 2014-10-10 2018-02-06 Quantapore, Inc. Nanopore-based polymer analysis with mutually-quenching fluorescent labels
GB201418892D0 (en) * 2014-10-23 2014-12-10 Proqr Therapeutics B V DNA editing
EP3209800B1 (de) 2014-10-24 2022-02-16 Quantapore, Inc. Effiziente optische analyse von polymeren unter verwendung von nanostrukturanordnungen
WO2016090323A1 (en) 2014-12-05 2016-06-09 Prelude, Inc. Dcis recurrence and invasive breast cancer
CA2968406A1 (en) 2014-12-09 2016-06-16 Mark D. Ayers System and methods for deriving gene signature biomarkers of response to pd-1 antagonists
CA2975855A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Compositions and methods for synthetic gene assembly
CA2975852A1 (en) 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
EP3839510A3 (de) 2015-04-17 2021-08-25 Merck Sharp & Dohme Corp. Blutbasierte biomarker der tumorempfindlichkeit gegen pd-1-antagonisten
WO2016172377A1 (en) 2015-04-21 2016-10-27 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
CN107406882B (zh) 2015-04-24 2022-03-01 基纳生物技术有限公司 用于次要等位基因和多态性的鉴定和定量的多重化方法
WO2016172579A1 (en) 2015-04-24 2016-10-27 Agena Bioscience, Inc, Multiplex methods for detection and quantification of minor variants
GB201512869D0 (en) 2015-07-21 2015-09-02 Almac Diagnostics Ltd Gene signature for minute therapies
KR20180050411A (ko) 2015-09-18 2018-05-14 트위스트 바이오사이언스 코포레이션 올리고핵산 변이체 라이브러리 및 그의 합성
CN113604546A (zh) 2015-09-22 2021-11-05 特韦斯特生物科学公司 用于核酸合成的柔性基底
WO2017095958A1 (en) 2015-12-01 2017-06-08 Twist Bioscience Corporation Functionalized surfaces and preparation thereof
CN109073654A (zh) 2016-04-20 2018-12-21 苏州爱尔迪思生物科技有限公司 用于预测早产的方法和组合物
CN109196362A (zh) 2016-05-17 2019-01-11 苏州爱尔迪思生物科技有限公司 用于提供子痫前期评估的方法和组合物
EP3482196B1 (de) 2016-07-05 2022-02-23 Quantapore, Inc. Optisch basierte nanoporensequenzierung
WO2018038772A1 (en) 2016-08-22 2018-03-01 Twist Bioscience Corporation De novo synthesized nucleic acid libraries
KR102217487B1 (ko) 2016-09-21 2021-02-23 트위스트 바이오사이언스 코포레이션 핵산 기반 데이터 저장
EA201991262A1 (ru) 2016-12-16 2020-04-07 Твист Байосайенс Корпорейшн Библиотеки вариантов иммунологического синапса и их синтез
CA3054303A1 (en) 2017-02-22 2018-08-30 Twist Bioscience Corporation Nucleic acid based data storage
CA3056388A1 (en) 2017-03-15 2018-09-20 Twist Bioscience Corporation Variant libraries of the immunological synapse and synthesis thereof
WO2018186930A1 (en) * 2017-04-06 2018-10-11 MyOmicsDx, Inc Method and kit for constructing nucleic acid library
WO2018186947A1 (en) * 2017-04-06 2018-10-11 MyOmicsDx, Inc Method and kit for targeted enrichment of nucleic acids
CA3057157A1 (en) 2017-04-28 2018-11-01 Merck Sharp & Dohme Corp. Biomarkers for cancer therapeutics
KR20240013290A (ko) 2017-06-12 2024-01-30 트위스트 바이오사이언스 코포레이션 심리스 핵산 어셈블리를 위한 방법
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
GB2581620A (en) 2017-09-11 2020-08-26 Twist Bioscience Corp GPCR binding proteins and synthesis thereof
CN111565834B (zh) 2017-10-20 2022-08-26 特韦斯特生物科学公司 用于多核苷酸合成的加热的纳米孔
CA3079524A1 (en) 2017-11-03 2019-05-09 Interna Technologies B.V. Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation
WO2019109016A1 (en) 2017-12-01 2019-06-06 Millennium Pharmaceuticals, Inc. Biomarkers and methods for treatment with nae inhibitors
EP3735459A4 (de) 2018-01-04 2021-10-06 Twist Bioscience Corporation Digitale informationsspeicherung auf dna-basis
US11957695B2 (en) 2018-04-26 2024-04-16 The Broad Institute, Inc. Methods and compositions targeting glucocorticoid signaling for modulating immune responses
WO2019213660A2 (en) 2018-05-04 2019-11-07 The Broad Institute, Inc. Compositions and methods for modulating cgrp signaling to regulate innate lymphoid cell inflammatory responses
CA3100739A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
WO2020036926A1 (en) 2018-08-17 2020-02-20 Cellecta, Inc. Multiplex preparation of barcoded gene specific dna fragments
CA3112792A1 (en) 2018-09-14 2020-03-19 Prelude Corporation Method of selection for treatment of subjects at risk of invasive breast cancer
US20220401460A1 (en) 2018-10-10 2022-12-22 Dana-Farber Cancer Institute, Inc. Modulating resistance to bcl-2 inhibitors
EP3930753A4 (de) 2019-02-26 2023-03-29 Twist Bioscience Corporation Variante nukleinsäurebibliotheken für glp1-rezeptor
KR20210144698A (ko) 2019-02-26 2021-11-30 트위스트 바이오사이언스 코포레이션 항체 최적화를 위한 변이 핵산 라이브러리
AU2020228047A1 (en) 2019-02-27 2021-09-30 Madera Therapeutics, LLC Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
WO2020186101A1 (en) 2019-03-12 2020-09-17 The Broad Institute, Inc. Detection means, compositions and methods for modulating synovial sarcoma cells
US20220143148A1 (en) 2019-03-14 2022-05-12 The Broad Institute, Inc. Compositions and methods for modulating cgrp signaling to regulate intestinal innate lymphoid cells
US20220142948A1 (en) 2019-03-18 2022-05-12 The Broad Institute, Inc. Compositions and methods for modulating metabolic regulators of t cell pathogenicity
US20220152148A1 (en) 2019-03-18 2022-05-19 The Broad Institute, Inc. Modulation of type 2 immunity by targeting clec-2 signaling
WO2020210521A2 (en) 2019-04-12 2020-10-15 The Regents Of The University Of California Compositions and methods for increasing muscle mass and oxidative metabolism
CN114729342A (zh) 2019-06-21 2022-07-08 特韦斯特生物科学公司 基于条形码的核酸序列装配
WO2021030627A1 (en) 2019-08-13 2021-02-18 The General Hospital Corporation Methods for predicting outcomes of checkpoint inhibition and treatment thereof
CN110470760A (zh) * 2019-08-16 2019-11-19 谱尼测试集团吉林有限公司 塑料制品中聚乳酸含量的检测方法
US11793787B2 (en) 2019-10-07 2023-10-24 The Broad Institute, Inc. Methods and compositions for enhancing anti-tumor immunity by targeting steroidogenesis
US11844800B2 (en) 2019-10-30 2023-12-19 Massachusetts Institute Of Technology Methods and compositions for predicting and preventing relapse of acute lymphoblastic leukemia
US20230044602A1 (en) 2019-12-20 2023-02-09 EDWARD Via COLLEGE OF OSTEOPATHIC MEDICINE Cancer signatures, methods of generating cancer signatures, and uses thereof
WO2022192419A2 (en) 2021-03-09 2022-09-15 Massachusetts Institute Of Technology Methods of treating inflammatory bowel disease (ibd) with anti- tnf-blockade
WO2023158732A1 (en) 2022-02-16 2023-08-24 Dana-Farber Cancer Institute, Inc. Methods for decreasing pathologic alpha-synuclein using agents that modulate fndc5 or biologically active fragments thereof
WO2024028794A1 (en) 2022-08-02 2024-02-08 Temple Therapeutics BV Methods for treating endometrial and ovarian hyperproliferative disorders

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687732A (en) * 1983-06-10 1987-08-18 Yale University Visualization polymers and their application to diagnostic medicine
US5171534A (en) * 1984-01-16 1992-12-15 California Institute Of Technology Automated DNA sequencing technique
US4883750A (en) * 1984-12-13 1989-11-28 Applied Biosystems, Inc. Detection of specific sequences in nucleic acids
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5011769A (en) * 1985-12-05 1991-04-30 Meiogenics U.S. Limited Partnership Methods for detecting nucleic acid sequences
US5093232A (en) * 1985-12-11 1992-03-03 Chiron Corporation Nucleic acid probes
US4855225A (en) 1986-02-07 1989-08-08 Applied Biosystems, Inc. Method of detecting electrophoretically separated oligonucleotides
US4925785A (en) * 1986-03-07 1990-05-15 Biotechnica Diagnostics, Inc. Nucleic acid hybridization assays
US5525465A (en) * 1987-10-28 1996-06-11 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates and methods of production and applications of the same
US4879214A (en) * 1988-11-15 1989-11-07 E. I. Du Pont De Nemours And Company Differentiation of nucleic acid segments on the basis of nucleotide differences
US5061361A (en) * 1989-03-06 1991-10-29 Hewlett-Packard Company Capillary zone electrophoresis cell system
US5108568A (en) * 1989-07-07 1992-04-28 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Controlled method of reducing electrophoretic mobility of macromolecules, particles or cells
EP0442177B1 (de) * 1990-02-13 1994-03-30 Bio-Rad Laboratories, Inc. Elektrophoretische Trennung in einem gelfreien Medium mittels gelösten Polymeren
DE69133629D1 (de) * 1990-05-03 2010-04-15 Cornell Res Foundation Inc nssystem zur Bestimmung von genetischen Krankheiten
US5096557A (en) * 1990-07-11 1992-03-17 Genetype A.G. Internal standard for electrophoretic separations
US5677440A (en) * 1990-07-16 1997-10-14 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates
WO1992008728A1 (en) * 1990-11-08 1992-05-29 Hybridon, Inc. Incorporation of multiple reporter groups on synthetic oligonucleotides
ATE173767T1 (de) 1992-04-03 1998-12-15 Perkin Elmer Corp Proben zusammensetzung und verfahren
US5470705A (en) 1992-04-03 1995-11-28 Applied Biosystems, Inc. Probe composition containing a binding domain and polymer chain and methods of use

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ATE173767T1 (de) 1998-12-15
US20050112608A1 (en) 2005-05-26
US5989871A (en) 1999-11-23
EP0635069A1 (de) 1995-01-25
DE69314946T2 (de) 1998-04-02
JPH07505529A (ja) 1995-06-22
EP0636186A1 (de) 1995-02-01
US6759202B2 (en) 2004-07-06
US5624800A (en) 1997-04-29
US20030073108A1 (en) 2003-04-17
DE69322266D1 (de) 1999-01-07
JPH08504082A (ja) 1996-05-07
EP0635069B1 (de) 1997-10-29
WO1993020239A1 (en) 1993-10-14
US5777096A (en) 1998-07-07
JP2775346B2 (ja) 1998-07-16
WO1993020236A1 (en) 1993-10-14
US5580732A (en) 1996-12-03
JP2701092B2 (ja) 1998-01-21
DE69322266T2 (de) 1999-06-02
EP0636186B1 (de) 1998-11-25
US5514543A (en) 1996-05-07
DE69314946D1 (de) 1997-12-04
DK0635069T3 (da) 1998-07-20
US7115376B2 (en) 2006-10-03

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