ATE146181T1 - Regioselektive synthese von 4-chlor-2- thiophencarbonsäure - Google Patents

Regioselektive synthese von 4-chlor-2- thiophencarbonsäure

Info

Publication number
ATE146181T1
ATE146181T1 AT93921527T AT93921527T ATE146181T1 AT E146181 T1 ATE146181 T1 AT E146181T1 AT 93921527 T AT93921527 T AT 93921527T AT 93921527 T AT93921527 T AT 93921527T AT E146181 T1 ATE146181 T1 AT E146181T1
Authority
AT
Austria
Prior art keywords
pct
chlorine
carboxylic acid
compound
thiophene carboxylic
Prior art date
Application number
AT93921527T
Other languages
English (en)
Inventor
Laurence E Burgess
Gary R Schulte
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE146181T1 publication Critical patent/ATE146181T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Seasonings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Catalysts (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Paper (AREA)
AT93921527T 1992-11-23 1993-09-17 Regioselektive synthese von 4-chlor-2- thiophencarbonsäure ATE146181T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US97998392A 1992-11-23 1992-11-23

Publications (1)

Publication Number Publication Date
ATE146181T1 true ATE146181T1 (de) 1996-12-15

Family

ID=25527268

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93921527T ATE146181T1 (de) 1992-11-23 1993-09-17 Regioselektive synthese von 4-chlor-2- thiophencarbonsäure

Country Status (26)

Country Link
US (1) US5648502A (de)
EP (1) EP0669924B1 (de)
JP (2) JP2706573B2 (de)
KR (1) KR950704727A (de)
CN (4) CN1036001C (de)
AT (1) ATE146181T1 (de)
AU (1) AU670454B2 (de)
BR (1) BR9307503A (de)
CA (1) CA2148616C (de)
CZ (1) CZ131695A3 (de)
DE (1) DE69306595T2 (de)
DK (1) DK0669924T3 (de)
EG (1) EG20200A (de)
ES (1) ES2095080T3 (de)
FI (1) FI935168A7 (de)
GR (1) GR3022396T3 (de)
HU (1) HUT68757A (de)
IL (2) IL107612A0 (de)
MX (1) MX9307292A (de)
MY (1) MY109037A (de)
NO (1) NO952021D0 (de)
NZ (1) NZ256279A (de)
PL (1) PL174312B1 (de)
RU (1) RU2114854C1 (de)
WO (1) WO1994012505A1 (de)
ZA (1) ZA938705B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6043379A (en) * 1997-04-04 2000-03-28 Pfizer Inc. Processes and intermediates for preparing 2-fluorothiophene derivatives
CN100413861C (zh) * 2002-12-10 2008-08-27 维勒凯姆制药股份有限公司 用于治疗或预防黄病毒感染的化合物
US7560551B2 (en) 2006-01-23 2009-07-14 Amgen Inc. Aurora kinase modulators and method of use
RU2359968C2 (ru) * 2007-01-17 2009-06-27 Институт нефтехимии и катализа РАН Способ получения метиловых эфиров 2-тиофенкарбоновой кислоты и ее производных
JP5411141B2 (ja) * 2007-09-10 2014-02-12 カルシメディカ，インク． 細胞内カルシウムを調節する化合物
ITMI20071971A1 (it) * 2007-10-10 2009-04-11 Altergon Sa Composizione farmaceutica per la somministrazione sublinguale di progesterone, e metodo per la sua preparazione
US8389567B2 (en) 2007-12-12 2013-03-05 Calcimedica, Inc. Compounds that modulate intracellular calcium
CA2734500A1 (en) 2008-08-27 2010-03-11 Calcimedica Inc. Compounds that modulate intracellular calcium
US8524763B2 (en) 2008-09-22 2013-09-03 Calcimedica, Inc. Inhibitors of store operated calcium release
US8143269B2 (en) 2008-10-03 2012-03-27 Calcimedica, Inc. Inhibitors of store operated calcium release
CN101987842A (zh) * 2009-07-31 2011-03-23 上海开拓者医药发展有限公司 一种2-甲基噻吩衍生物的制备方法
US8618307B2 (en) 2009-09-16 2013-12-31 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN103180316A (zh) 2010-08-27 2013-06-26 钙医学公司 调节细胞内钙的化合物
US9512116B2 (en) 2012-10-12 2016-12-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
CN109096245A (zh) * 2018-09-27 2018-12-28 上海雅本化学有限公司 一种5-氯噻吩-2-甲酸的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1015622A1 (ru) * 1981-07-02 1985-11-30 Всесоюзный Ордена Трудового Красного Знамени Научно-Исследовательский Химико-Фармацевтический Институт Им.Серго Орджоникидзе 2-Замещенные 3-окси-5-метил-4-тиофенуксусные кислоты,обладающие противовоспалительной и анальгетической активностью и способ их получени
US4432974A (en) * 1982-03-04 1984-02-21 E. I. Du Pont De Nemours And Company Antiinflammatory and/or analgesic 2,3-diaryl-5-silyl thiophenes
DE3534286A1 (de) * 1985-09-26 1987-04-02 Hoechst Ag Verfahren zur herstellung von halogenthiophen-2-carbonsaeuren
MX18021A (es) * 1988-10-18 1993-11-01 Pfizer Pro-farmacos de la 3-acil-2-oxindol-1-carboxamidasanti-inflamatorias
US5047554A (en) * 1989-04-18 1991-09-10 Pfizer Inc. 3-substituted-2-oxindole derivatives
FR2655655A1 (fr) * 1989-12-07 1991-06-14 Rhone Poulenc Chimie Procede de preparation de polysilthiophenediyle et polymeres obtenus a l'issue de ce procede.
PL170837B1 (pl) * 1991-10-18 1997-01-31 Monsanto Co S rod ek g r zybobó j c zy PL PL PL PL PL PL

Also Published As

Publication number Publication date
DK0669924T3 (da) 1997-06-16
JPH1081683A (ja) 1998-03-31
FI935168A0 (fi) 1993-11-22
CN1036001C (zh) 1997-10-01
ES2095080T3 (es) 1997-02-01
HUT68757A (en) 1995-07-28
CA2148616C (en) 1998-02-03
ZA938705B (en) 1995-05-22
RU2114854C1 (ru) 1998-07-10
FI935168L (fi) 1994-05-24
CN1093704A (zh) 1994-10-19
MY109037A (en) 1996-11-30
US5648502A (en) 1997-07-15
PL174312B1 (pl) 1998-07-31
NO952021L (no) 1995-05-22
DE69306595T2 (de) 1997-04-03
EP0669924A1 (de) 1995-09-06
NZ256279A (en) 1996-11-26
CN1158851A (zh) 1997-09-10
JP2795642B2 (ja) 1998-09-10
NO952021D0 (no) 1995-05-22
IL120461A0 (en) 1997-07-13
EP0669924B1 (de) 1996-12-11
WO1994012505A1 (en) 1994-06-09
FI935168A7 (fi) 1994-05-24
JPH07508761A (ja) 1995-09-28
CZ131695A3 (en) 1996-05-15
CA2148616A1 (en) 1994-06-09
BR9307503A (pt) 1999-06-29
EG20200A (en) 1997-10-30
CN1158853A (zh) 1997-09-10
GR3022396T3 (en) 1997-04-30
CN1156725A (zh) 1997-08-13
AU670454B2 (en) 1996-07-18
IL107612A0 (en) 1994-02-27
DE69306595D1 (en) 1997-01-23
JP2706573B2 (ja) 1998-01-28
MX9307292A (es) 1994-05-31
PL309048A1 (en) 1995-09-18
AU4858793A (en) 1994-06-22
KR950704727A (ko) 1995-11-20

Similar Documents

Publication Publication Date Title
NO952021D0 (no) Regioselektiv syntese av 4-klor-2-tiofenkarboksylsyre
CA2304713A1 (en) Biphenyl-5-alkanoic acid derivatives and use thereof
DE69309670D1 (de) Heterocyclische carbonsäure-derivate, die an rar rezeptoren binden können
DE69102707D1 (de) In einem DNA - Gel stabilisierte Heilwasserliposomen.
IL112432A0 (en) Fatty acid derivatives, methods for the preparation thereof and pharmaceutical compositions containing the same
DE69635057D1 (de) Verfahren zur herstellung von campothecinderivate
AU6709896A (en) Quinone compound, its production and use
EA200000389A3 (ru) Новые замещенные пиридины или пиперидины, способ их получения и содержащие их фармацевтические композиции
ATE173922T1 (de) 2-arylpropionsäure-zubereitungen und verfahren zu ihrer herstellung
DE69231314D1 (de) SYNTHESE VON HOMOCHIRALEN 2-HYDROXYSäUREN
GB0015771D0 (en) Cyclic ketones and their use in the synthesis of amino acids
ATE70842T1 (de) Bakterizide pyridobenzothiazinderivate mit langer wirkungsdauer.
DE69406451D1 (de) Verfahren zur herstellung von n-carbonylarylimine als zwischenprodukte in der synthese von therapeutisch aktiven taxol-derivaten
MY102090A (en) Compounds with antiinflammatory activity, process for preparation thereof and pharmaceutical compositions therefrom
ZA937317B (en) Process for the stereoselective preparation of a beta-phenylisoserine derivative and its use for the preparation of taxane derivatives
ATE189886T1 (de) Synthese von carbonsäurederivaten
DE69629703D1 (de) Synthese von optisch reinen verbindungen als garft-inhibitoren und deren zwischenprodukte
RU94028194A (ru) 4-ацетил-5-n-иодфенил-1-карбоксиметил-3-гидрокси-2,5-дигидропиррол-2-он, проявляющий анальгетическую активность
JPS54103845A (en) Novel cyclohexenecarboxylic acid derivative
TW334422B (en) The synthesis of novel antineoplasic and antimicrobial naphthol derivatives
ATE156822T1 (de) 3-halogen-3-hetarylcarbonsäurederivate, verfahren und zwischenprodukte zu ihrer herstellung
GB974744A (en) New 4-substituted 1,2-diaryl-3,5-dioxopyrazolidines and processes for preparing same

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee