ATE136297T1 - Substituierte 4-amino-3-pyridinolen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel - Google Patents

Substituierte 4-amino-3-pyridinolen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Info

Publication number
ATE136297T1
ATE136297T1 AT91116336T AT91116336T ATE136297T1 AT E136297 T1 ATE136297 T1 AT E136297T1 AT 91116336 T AT91116336 T AT 91116336T AT 91116336 T AT91116336 T AT 91116336T AT E136297 T1 ATE136297 T1 AT E136297T1
Authority
AT
Austria
Prior art keywords
loweralkyl
chem
hydrogen
pyridinoles
amino
Prior art date
Application number
AT91116336T
Other languages
German (de)
English (en)
Inventor
Gregory Michael Shutske
Kevin James Kapples
John Dick Tomer
Nicholas Joseph Hrib
John Gerard Jurcak
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of ATE136297T1 publication Critical patent/ATE136297T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Surface Treatment Of Glass (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT91116336T 1990-09-27 1991-09-25 Substituierte 4-amino-3-pyridinolen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel ATE136297T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58911390A 1990-09-27 1990-09-27

Publications (1)

Publication Number Publication Date
ATE136297T1 true ATE136297T1 (de) 1996-04-15

Family

ID=24356648

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91116336T ATE136297T1 (de) 1990-09-27 1991-09-25 Substituierte 4-amino-3-pyridinolen, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Country Status (22)

Country Link
US (3) US5821239A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0477903B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3090511B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100215357B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE136297T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU637720B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2052433C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ282002B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69118470T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0477903T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2085940T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI914504A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3019742T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUT60247A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE73874B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL99581A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO913778L (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ239935A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT99073B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TW200462B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (1) YU158591A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA917692B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6218383B1 (en) 1998-08-07 2001-04-17 Targacept, Inc. Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
FR2813891B1 (fr) * 2000-09-14 2005-01-14 Immunotech Sa Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications
DE10102791B4 (de) * 2001-01-22 2004-04-15 Ifm Electronic Gmbh Elektrischer Meßumformer
AU2002351731A1 (en) * 2001-12-14 2003-06-30 Novo Nordisk A/S Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
KR100443983B1 (ko) 2002-01-15 2004-08-09 삼성전자주식회사 냉장고
US8007826B2 (en) 2003-12-11 2011-08-30 Acorda Therapeutics, Inc. Sustained release aminopyridine composition
US8354437B2 (en) 2004-04-09 2013-01-15 Acorda Therapeutics, Inc. Method of using sustained release aminopyridine compositions
TW200640864A (en) 2005-02-17 2006-12-01 Astellas Pharma Inc Pyridyl non-aromatic nitrogenated heterocyclic-1-carboxylate ester derivative
BRPI0903914A2 (pt) * 2008-09-10 2015-07-21 Acorda Therapeutics Inc Uso de um composto, método para analisar a eficácia de uma composição de liberação prolongada, e, composição farmacêutica.
CN109662964A (zh) 2010-02-09 2019-04-23 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物
WO2014078568A1 (en) 2012-11-14 2014-05-22 The Johns Hopkins University Methods and compositions for treating schizophrenia
KR102171152B1 (ko) 2012-12-13 2020-10-29 하. 룬드벡 아크티에셀스카브 보르티옥세틴 및 도네페질을 포함하는 조성물
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam
JP6899120B2 (ja) * 2016-10-12 2021-07-07 株式会社ナノエッグ アセチルコリンエステラーゼ（ＡＣｈＥ）阻害剤

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179563A (en) * 1978-05-19 1979-12-18 Warner-Lambert Company 3-Aryloxy-substituted-aminopyridines and methods for their production
US4734275A (en) * 1983-08-19 1988-03-29 Research Corporation Anti-curare agents
DE3514073A1 (de) * 1985-04-18 1986-10-23 Hoechst Ag, 6230 Frankfurt Mehrfach substituierte pyridin-1-oxide, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
US4735958A (en) * 1986-12-22 1988-04-05 Warner-Lambert Company Trans-6-[2-[2-(substituted-phenyl)-3- (or 4-) heteroaryl-5-substituted-1H-pyrrol-1-yl]-ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one inhibitors of cholesterol biosynthesis
US4831044A (en) * 1987-10-29 1989-05-16 Ici Americas Inc. Fungicidal pyridyl cyclopropane carboxamidines
US4994473A (en) * 1987-11-17 1991-02-19 Ici Americas Inc. Pyridyl containing insecticides
EP0361489A3 (en) * 1988-09-30 1991-06-12 Chugai Seiyaku Kabushiki Kaisha Novel 3,4-diaminoquinoline and pyridine compounds
EP0369388B1 (en) * 1988-11-16 1993-05-19 Hoechst-Roussel Pharmaceuticals Incorporated Hydroxy-1,2,3,4-tetrahydroaminoacridines, a process for their preparation and their use as medicaments
US4931457B1 (en) * 1989-06-28 1993-11-16 Hoechst-Roussel Pharmaceuticals Incorporated Naphthylamino-and naphthyloxy-pyridineamin compounds useful as topical antiinflammatory agents for the treatment of skin disorders

Also Published As

Publication number Publication date
NO913778D0 (no) 1991-09-26
FI914504A0 (fi) 1991-09-25
US5866565A (en) 1999-02-02
IL99581A0 (en) 1992-08-18
TW200462B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-02-21
EP0477903A2 (en) 1992-04-01
ZA917692B (en) 1992-05-27
GR3019742T3 (en) 1996-07-31
DK0477903T3 (da) 1996-07-29
IE913389A1 (en) 1992-04-08
PT99073A (pt) 1992-08-31
IL99581A (en) 1995-07-31
ES2085940T3 (es) 1996-06-16
CA2052433C (en) 2003-04-15
NZ239935A (en) 1995-07-26
AU8475691A (en) 1992-04-02
DE69118470T2 (de) 1996-09-19
FI914504A7 (fi) 1992-03-28
AU637720B2 (en) 1993-06-03
KR100215357B1 (ko) 1999-08-16
JP3090511B2 (ja) 2000-09-25
HUT60247A (en) 1992-08-28
PT99073B (pt) 1999-02-26
CA2052433A1 (en) 1992-03-28
JPH04261157A (ja) 1992-09-17
EP0477903A3 (en) 1992-08-05
YU158591A (sh) 1994-12-28
IE73874B1 (en) 1997-07-02
US5821239A (en) 1998-10-13
CS293691A3 (en) 1992-04-15
DE69118470D1 (de) 1996-05-09
US5869480A (en) 1999-02-09
KR920006318A (ko) 1992-04-27
NO913778L (no) 1992-03-30
EP0477903B1 (en) 1996-04-03
CZ282002B6 (cs) 1997-04-16
HU913075D0 (en) 1992-01-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee