AT8585U2 - Transdermal-pflaster zum verabreichen von fentanyl - Google Patents
Transdermal-pflaster zum verabreichen von fentanyl Download PDFInfo
- Publication number
- AT8585U2 AT8585U2 AT0034606U AT3462006U AT8585U2 AT 8585 U2 AT8585 U2 AT 8585U2 AT 0034606 U AT0034606 U AT 0034606U AT 3462006 U AT3462006 U AT 3462006U AT 8585 U2 AT8585 U2 AT 8585U2
- Authority
- AT
- Austria
- Prior art keywords
- fentanyl
- lofentanil
- remifentanil
- alfentanil
- sufentanil
- Prior art date
Links
- 229960002428 fentanyl Drugs 0.000 title abstract 4
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 title abstract 4
- IDBPHNDTYPBSNI-UHFFFAOYSA-N N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide Chemical compound C1CN(CCN2C(N(CC)N=N2)=O)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 IDBPHNDTYPBSNI-UHFFFAOYSA-N 0.000 abstract 3
- ZTVQQQVZCWLTDF-UHFFFAOYSA-N Remifentanil Chemical compound C1CN(CCC(=O)OC)CCC1(C(=O)OC)N(C(=O)CC)C1=CC=CC=C1 ZTVQQQVZCWLTDF-UHFFFAOYSA-N 0.000 abstract 3
- 229960001391 alfentanil Drugs 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 3
- 239000003814 drug Substances 0.000 abstract 3
- IMYHGORQCPYVBZ-NLFFAJNJSA-N lofentanil Chemical compound CCC(=O)N([C@@]1([C@@H](CN(CCC=2C=CC=CC=2)CC1)C)C(=O)OC)C1=CC=CC=C1 IMYHGORQCPYVBZ-NLFFAJNJSA-N 0.000 abstract 3
- 229950010274 lofentanil Drugs 0.000 abstract 3
- 229960003394 remifentanil Drugs 0.000 abstract 3
- GGCSSNBKKAUURC-UHFFFAOYSA-N sufentanil Chemical compound C1CN(CCC=2SC=CC=2)CCC1(COC)N(C(=O)CC)C1=CC=CC=C1 GGCSSNBKKAUURC-UHFFFAOYSA-N 0.000 abstract 3
- 229960004739 sufentanil Drugs 0.000 abstract 3
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 abstract 2
- 239000000853 adhesive Substances 0.000 abstract 2
- 230000001070 adhesive effect Effects 0.000 abstract 2
- 239000012528 membrane Substances 0.000 abstract 2
- 229920000058 polyacrylate Polymers 0.000 abstract 2
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 abstract 1
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 230000036407 pain Effects 0.000 abstract 1
- 229920001897 terpolymer Polymers 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Ein Transdermal-Pflaster zum Verabreichen von Fentanyl oder Alfentanil, Lofentanil, Remifentanil oder Sufentanil durch die Haut, um beim Menschen Schmerzfreiheit herbeizuführen und für mindestens drei Tage aufrechtzuerhalten, sowie dessen Verwendung zur Schmerzbekämpfung. Das Pflaster besteht aus einer Deckmembran, und einem auf der Deckmembran angeordneten Arzneistoffreservoir, wobei das Arzneistoffreservoir aus 1) einem einphasigen Polyacrylat-Klebstoff aus einem Copolymer oder Terpolymer der Komponenten ausgewählt aus der Gruppe bestehend aus 2-Ethylhexylacrylat, Methylacrylat und Hydroxyethylacrylat und 2) einem vollständig gelösten Anteil an Fentanyl oder Alfentanil, Lofentanil, Remifentanil oder Sufentanil von zwischen 0,1 mg/cm2 bis 0,75 mg/cm2 des Arzneistoffreservoirs besteht, wobei der Polyacrylat-Klebstoff kreuzvernetzt ist und eine Löslichkeit für Fentanyl oder Alfentanil, Lofentanil, Remifentanil oder Sufentanil von zwischen 1 Masse-% bis 25 Masse-% aufweist.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27683701P | 2001-03-16 | 2001-03-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
AT8585U2 true AT8585U2 (de) | 2006-10-15 |
AT8585U3 AT8585U3 (de) | 2007-02-15 |
Family
ID=23058257
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02715112T ATE364380T1 (de) | 2001-03-16 | 2002-03-15 | Transdermales pflaster zur verabreichung von fentanyl |
AT0031105U AT8273U1 (de) | 2001-03-16 | 2005-05-10 | Transdermal-pflaster zum verabreichen von fentanyl |
AT0034606U AT8585U3 (de) | 2001-03-16 | 2006-04-26 | Transdermal-pflaster zum verabreichen von fentanyl |
AT0013207U AT9258U3 (de) | 2001-03-16 | 2007-03-02 | Transdermal-pflaster zum verabreichen von fentanyl |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02715112T ATE364380T1 (de) | 2001-03-16 | 2002-03-15 | Transdermales pflaster zur verabreichung von fentanyl |
AT0031105U AT8273U1 (de) | 2001-03-16 | 2005-05-10 | Transdermal-pflaster zum verabreichen von fentanyl |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT0013207U AT9258U3 (de) | 2001-03-16 | 2007-03-02 | Transdermal-pflaster zum verabreichen von fentanyl |
Country Status (22)
Country | Link |
---|---|
US (11) | US20030026829A1 (de) |
EP (1) | EP1381352B1 (de) |
JP (7) | JP5354763B2 (de) |
KR (1) | KR100904158B1 (de) |
CN (2) | CN101524339A (de) |
AT (4) | ATE364380T1 (de) |
CA (1) | CA2440884C (de) |
CY (1) | CY1106834T1 (de) |
CZ (1) | CZ307857B6 (de) |
DE (3) | DE02715112T1 (de) |
DK (2) | DK1381352T3 (de) |
ES (1) | ES2270746T3 (de) |
FI (2) | FI6962U1 (de) |
HK (1) | HK1068545A1 (de) |
IL (3) | IL157822A0 (de) |
MX (1) | MXPA03008349A (de) |
NZ (1) | NZ528148A (de) |
PL (1) | PL363079A1 (de) |
PT (1) | PT1381352E (de) |
RU (2) | RU2708563C2 (de) |
WO (1) | WO2002074286A1 (de) |
ZA (1) | ZA200308026B (de) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
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US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
PT1381352E (pt) * | 2001-03-16 | 2007-07-27 | Alza Corp | Adesivo transdérmico para administração de fenantil |
US20030027793A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal treatment of parkinson's disease |
US20030026830A1 (en) * | 2001-05-08 | 2003-02-06 | Thomas Lauterback | Transdermal therapeutic system for parkinson's disease inducing high plasma levels of rotigotine |
DE10141650C1 (de) * | 2001-08-24 | 2002-11-28 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen |
WO2003090729A1 (en) * | 2002-04-23 | 2003-11-06 | Alza Corporation | Transdermal analgesic systems with reduced abuse potential |
GB0210397D0 (en) | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
DE10223835A1 (de) * | 2002-05-28 | 2003-12-11 | Labtec Gmbh | Pflaster, enthaltend Fentanylum |
AU2003243896B2 (en) * | 2002-05-28 | 2008-07-03 | Labtec Gesellschaft Fur Technologische Forschung Und Entwicklung Mbh | Plaster containing fentanyl |
EP1386604A1 (de) * | 2002-07-30 | 2004-02-04 | Schwarz Pharma Ag | Verbessertes transdermales Verabreichungssystem |
TWI296531B (en) | 2002-10-18 | 2008-05-11 | Hisamitsu Pharmaceutical Co | Transdermal adhesive preparations for topical administration of fentanyl |
US20040086551A1 (en) * | 2002-10-30 | 2004-05-06 | Miller Kenneth J. | Fentanyl suspension-based silicone adhesive formulations and devices for transdermal delivery of fentanyl |
CA2513402A1 (en) * | 2003-02-07 | 2004-08-19 | Walter Mueller | Transdermal therapeutic system suitable for heat application for promoting the permeation of active substances, and the use thereof |
EA009623B1 (ru) * | 2003-04-30 | 2008-02-28 | Пэдью Фарма Л.П. | Устойчивая к манипуляциям дозировочная форма для трансдермального введения |
US7182955B2 (en) * | 2003-04-30 | 2007-02-27 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
US20040219195A1 (en) * | 2003-04-30 | 2004-11-04 | 3M Innovative Properties Company | Abuse-resistant transdermal dosage form |
US8790689B2 (en) | 2003-04-30 | 2014-07-29 | Purdue Pharma L.P. | Tamper resistant transdermal dosage form |
AU2004286852A1 (en) | 2003-10-30 | 2005-05-19 | Alza Corporation | Transdermal analgesic systems having reduced abuse potential |
EP1530967B1 (de) | 2003-11-13 | 2006-05-03 | Ferring B.V. | Blisterverpackung und feste Dosierungsform enthaltend Desmopressin |
CN101005833A (zh) * | 2004-08-20 | 2007-07-25 | 3M创新有限公司 | 具有半透明保护膜的透皮药物递送装置 |
JP2008512471A (ja) * | 2004-09-08 | 2008-04-24 | ダーマトレンズ,インコーポレイティド | 疎水性生体活性物質の経皮送達 |
AU2012201164B2 (en) * | 2004-10-21 | 2014-07-24 | Durect Corporation | Transdermal delivery systems |
PL1814531T3 (pl) * | 2004-10-21 | 2010-11-30 | Durect Corp | Transdermalne systemy dostarczania |
US8252319B2 (en) * | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
GB0509276D0 (en) * | 2005-05-06 | 2005-06-15 | Univ Cranfield | Synthetic receptor |
US8632800B2 (en) | 2005-05-13 | 2014-01-21 | Alza Corporation | Multilayer drug delivery system with barrier against reservoir material flow |
TWI419717B (zh) * | 2005-06-17 | 2013-12-21 | Altea Therapeutics Corp | 滲透傳送系統及其使用方法 |
WO2007011987A2 (en) * | 2005-07-18 | 2007-01-25 | Alza Corporation | Device and method for increasing the throughput of irritation testing of transdermal formulations |
WO2007035942A2 (en) * | 2005-09-23 | 2007-03-29 | Alza Corporation | Transdermal risperidone delivery system |
EP2308480B1 (de) * | 2005-09-23 | 2014-08-13 | ALZA Corporation | Polyacrylatformulierung mit hoher Beladung von verstärkenden Substanzen für transdermale Anwendungen |
US20070104771A1 (en) * | 2005-09-23 | 2007-05-10 | Jay Audett | Transdermal galantamine delivery system |
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TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
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CN101902996B (zh) * | 2007-10-15 | 2014-11-26 | 阿尔扎公司 | 芬太尼的一天更换一次透皮施用 |
FR2924349B1 (fr) | 2007-12-03 | 2010-01-01 | Dbv Tech | Methode de desensibilitation aux allergenes |
AU2009210075B2 (en) | 2008-01-28 | 2013-10-24 | Teikoku Seiyaku Co., Ltd. | Fentanyl-containing patch for external use |
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