AT397036B - Verfahren zur entzündungsbehandlung mit antioxidativen metallorganischen verbindungen - Google Patents
Verfahren zur entzündungsbehandlung mit antioxidativen metallorganischen verbindungen Download PDFInfo
- Publication number
- AT397036B AT397036B AT0115287A AT115287A AT397036B AT 397036 B AT397036 B AT 397036B AT 0115287 A AT0115287 A AT 0115287A AT 115287 A AT115287 A AT 115287A AT 397036 B AT397036 B AT 397036B
- Authority
- AT
- Austria
- Prior art keywords
- active ingredient
- complex
- bis
- administered
- ethylenediimine
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 16
- 230000003078 antioxidant effect Effects 0.000 title claims description 3
- 150000002902 organometallic compounds Chemical class 0.000 title 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 14
- 229910017052 cobalt Inorganic materials 0.000 claims description 9
- 239000010941 cobalt Substances 0.000 claims description 9
- 230000004968 inflammatory condition Effects 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 claims description 7
- 229940125782 compound 2 Drugs 0.000 claims description 7
- 125000002524 organometallic group Chemical group 0.000 claims description 7
- 241000124008 Mammalia Species 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 206010003246 arthritis Diseases 0.000 claims description 5
- CSKRBHOAJUMOKJ-UHFFFAOYSA-N 3,4-diacetylhexane-2,5-dione Chemical compound CC(=O)C(C(C)=O)C(C(C)=O)C(C)=O CSKRBHOAJUMOKJ-UHFFFAOYSA-N 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims description 4
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims description 3
- 231100000252 nontoxic Toxicity 0.000 claims description 3
- 230000003000 nontoxic effect Effects 0.000 claims description 3
- 208000026816 acute arthritis Diseases 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 229960000905 indomethacin Drugs 0.000 claims description 2
- 230000002757 inflammatory effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000006186 oral dosage form Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 7
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 229920002261 Corn starch Polymers 0.000 claims 3
- 239000008120 corn starch Substances 0.000 claims 3
- 239000008187 granular material Substances 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical compound OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000007903 gelatin capsule Substances 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003708 ampul Substances 0.000 claims 1
- 235000013871 bee wax Nutrition 0.000 claims 1
- 239000012166 beeswax Substances 0.000 claims 1
- JAWGVVJVYSANRY-UHFFFAOYSA-N cobalt(3+) Chemical compound [Co+3] JAWGVVJVYSANRY-UHFFFAOYSA-N 0.000 claims 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 239000012153 distilled water Substances 0.000 claims 1
- 239000000576 food coloring agent Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 238000003825 pressing Methods 0.000 claims 1
- 239000000454 talc Substances 0.000 claims 1
- 229910052623 talc Inorganic materials 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 239000001301 oxygen Substances 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 108010093894 Xanthine oxidase Proteins 0.000 description 3
- 102100033220 Xanthine oxidase Human genes 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 3
- 230000002917 arthritic effect Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- -1 cobalt complex compounds Chemical class 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 102000008954 Copper amine oxidases Human genes 0.000 description 1
- 108050000918 Copper amine oxidases Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102000019197 Superoxide Dismutase Human genes 0.000 description 1
- 108010012715 Superoxide dismutase Proteins 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 230000010398 acute inflammatory response Effects 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000003683 cardiac damage Effects 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- HJHRJUZZGWUAMV-UHFFFAOYSA-N ethene;pentane-2,4-dione Chemical group C=C.CC(=O)CC(C)=O.CC(=O)CC(C)=O HJHRJUZZGWUAMV-UHFFFAOYSA-N 0.000 description 1
- 150000004687 hexahydrates Chemical class 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical group O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/06—Cobalt compounds
- C07F15/065—Cobalt compounds without a metal-carbon linkage
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86280486A | 1986-05-13 | 1986-05-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA115287A ATA115287A (de) | 1993-06-15 |
| AT397036B true AT397036B (de) | 1994-01-25 |
Family
ID=25339401
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0115287A AT397036B (de) | 1986-05-13 | 1987-05-07 | Verfahren zur entzündungsbehandlung mit antioxidativen metallorganischen verbindungen |
Country Status (7)
| Country | Link |
|---|---|
| AT (1) | AT397036B (fr) |
| CA (1) | CA1306681C (fr) |
| DE (1) | DE3715525C2 (fr) |
| FR (1) | FR2598616B1 (fr) |
| GB (2) | GB2190836B (fr) |
| IL (1) | IL82376A (fr) |
| IT (1) | IT1221920B (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5049557A (en) * | 1986-05-13 | 1991-09-17 | Chai-Tech Corporation | Metallo-organic salt compounds and pharmaceutical uses thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1158279A (en) * | 1966-05-12 | 1969-07-16 | Colgate Palmolive Co | Carbocyclic Ferrocenes |
| GB1556204A (en) * | 1975-06-18 | 1979-11-21 | Hoffmann W | Preparation for the treatment of infections diseases and of inflammations in human and veterinary medicine for which no causative microorganism can be detected |
| EP0115130A1 (fr) * | 1982-12-06 | 1984-08-08 | National Research Laboratories | Compositions pharmaceutiques pour le traitement d'inflammation ou d'arthrites |
| EP0153636A2 (fr) * | 1984-02-08 | 1985-09-04 | Petra Prof. Dr. Köpf-Maier | Sels de métallicénium et leur utilisation comme cytostatiques dans le traitement du cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB841710A (en) * | 1957-08-12 | 1960-07-20 | Ici Ltd | Pharmaceutical compositions comprising ferrocene derivatives |
-
1987
- 1987-04-30 IL IL82376A patent/IL82376A/xx not_active IP Right Cessation
- 1987-05-05 FR FR878706682A patent/FR2598616B1/fr not_active Expired - Fee Related
- 1987-05-07 AT AT0115287A patent/AT397036B/de not_active IP Right Cessation
- 1987-05-09 DE DE3715525A patent/DE3715525C2/de not_active Expired - Fee Related
- 1987-05-11 GB GB8711051A patent/GB2190836B/en not_active Expired - Lifetime
- 1987-05-12 CA CA000537099A patent/CA1306681C/fr not_active Expired - Lifetime
- 1987-05-12 IT IT20473/87A patent/IT1221920B/it active
-
1990
- 1990-02-27 GB GB909004351A patent/GB9004351D0/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1158279A (en) * | 1966-05-12 | 1969-07-16 | Colgate Palmolive Co | Carbocyclic Ferrocenes |
| GB1556204A (en) * | 1975-06-18 | 1979-11-21 | Hoffmann W | Preparation for the treatment of infections diseases and of inflammations in human and veterinary medicine for which no causative microorganism can be detected |
| EP0115130A1 (fr) * | 1982-12-06 | 1984-08-08 | National Research Laboratories | Compositions pharmaceutiques pour le traitement d'inflammation ou d'arthrites |
| EP0153636A2 (fr) * | 1984-02-08 | 1985-09-04 | Petra Prof. Dr. Köpf-Maier | Sels de métallicénium et leur utilisation comme cytostatiques dans le traitement du cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| IT8720473A0 (it) | 1987-05-12 |
| GB2190836B (en) | 1990-12-05 |
| DE3715525C2 (de) | 1998-09-17 |
| IT1221920B (it) | 1990-08-23 |
| DE3715525A1 (de) | 1988-02-11 |
| GB2190836A (en) | 1987-12-02 |
| GB9004351D0 (en) | 1990-04-25 |
| FR2598616A1 (fr) | 1987-11-20 |
| FR2598616B1 (fr) | 1991-01-18 |
| GB8711051D0 (en) | 1987-06-17 |
| CA1306681C (fr) | 1992-08-25 |
| ATA115287A (de) | 1993-06-15 |
| IL82376A (en) | 1991-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |