GB841710A - Pharmaceutical compositions comprising ferrocene derivatives - Google Patents

Pharmaceutical compositions comprising ferrocene derivatives

Info

Publication number
GB841710A
GB841710A GB2535657A GB2535657A GB841710A GB 841710 A GB841710 A GB 841710A GB 2535657 A GB2535657 A GB 2535657A GB 2535657 A GB2535657 A GB 2535657A GB 841710 A GB841710 A GB 841710A
Authority
GB
United Kingdom
Prior art keywords
mono
butyl
test
pivalyl
neopentyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2535657A
Inventor
William Glynne Moss Jones
Thomas Leigh
Juan Luis Madinaveitia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Priority to GB2535657A priority Critical patent/GB841710A/en
Publication of GB841710A publication Critical patent/GB841710A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00—Metallocenes
    • C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic System

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Pharmaceutical compositions for oral, parenteral or external use comprise as active ingredient at least one ferrocene desivative of the formula:- <FORM:0841710/VI/1> wherein R and R 1 which may be the same or different represent hydrogen or one or more hydrocarbon radicals which may optionally be substituted by chlorine atoms, or one or more acyl radicals -CO.R 11 wherein R 11 is a hydrocarbon radical. Specified hydrocarbon radicals are straight and branched chain alkyl, cycloalkyl, cycloalkenyl, aryl and aralkyl radicals. Specified active substances are ferrocene and the following derivatives thereof; mono-ethyl, monophenyl, mono-benzyl, 1:1 1-di-n-butyl, 1:1 1-di-isobutyl, mono-neopentyl, mono-m-chlorophenyl, mono-cyclopentyl, mono-cyclopentenyl, mono-hexa-hydrobenzyl, 1:11-di-hexahydrobenzyl, 1:11 -di-test-butyl, di-test-butyl (M.Pt.61 DEG C.), tri-test-butyl (M.Pt.91 DEG C.), tetin-test-butyl (M.Pt. 198 DEG C.), tetra-tets-annyl (M.Pt.110 DEG C.), 1:1 1-di-test-anyl, 1-1 1:di-(1:1:3:3 - tetramethyl-butyl), mono-pivalyl, 1:1 1-di-pivalyl, mono-hyexahydrobenzoyl, 1:1 1-di-hexa-hydrobenzoyl, mono-benxyl, and 1-pivalyl-1 1-neopentyl ferrocenes. The 1:1 1-di-neopentyl, 1:1 1-tert-butyl, and mono-benzyl ferrocenes are stated to be particularly valuable. The compositions may be in the form of plain, coated or euteric tablets, capsules, suppositories, pastes, aqueous suspensions, emulsions, oily solutions or suspensions and in forms suitable for incorporation in animal foodstuffs e.g. a premix of the active ingredient with an inert carrier or diluent. Additional active ingredients may be present e.g. sodium ascorbate, aneurine hydrochloride, riboflavine, nicotinamide, pyridoxine, vitamin B12. Excipients and/or diluents which may be present include CaCO3, maize-starch, alginic acid, magnesium stearate, glycerol, dextrose, sucrose, flavouring, suspending, thickening and wetting agents, preservatives, vegetable or animal oils, emulsifying and dispersing agents, e.g., lecithin, soya-bean, casein, anti-oxidants e.g.,propyl-gallate, fatty acid esters, polyethylene glycols. Specifications 763,550, 819,108 and 828,965 are referred to.
GB2535657A 1957-08-12 1957-08-12 Pharmaceutical compositions comprising ferrocene derivatives Expired GB841710A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2535657A GB841710A (en) 1957-08-12 1957-08-12 Pharmaceutical compositions comprising ferrocene derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2535657A GB841710A (en) 1957-08-12 1957-08-12 Pharmaceutical compositions comprising ferrocene derivatives

Publications (1)

Publication Number Publication Date
GB841710A true GB841710A (en) 1960-07-20

Family

ID=10226343

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2535657A Expired GB841710A (en) 1957-08-12 1957-08-12 Pharmaceutical compositions comprising ferrocene derivatives

Country Status (1)

Country Link
GB (1) GB841710A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2598616A1 (en) * 1986-05-13 1987-11-20 Dgs Research Dev PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF INFLAMMATION PHENOMENA IN MAMMALS
CN113841891A (en) * 2021-09-17 2021-12-28 江苏食品药品职业技术学院 Food nutrient and preparation method thereof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2598616A1 (en) * 1986-05-13 1987-11-20 Dgs Research Dev PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF INFLAMMATION PHENOMENA IN MAMMALS
DE3715525A1 (en) * 1986-05-13 1988-02-11 Dgs Res & Dev PHARMACEUTICAL PREPARATIONS CONTAINING ANTIOXYDATIVE METAL ORGANIC COMPOUNDS FOR INFLAMMATION TREATMENT
DE3715525C2 (en) * 1986-05-13 1998-09-17 Chai Tech Corp Pharmaceutical preparations containing anti-oxidative organometallic compounds for inflammatory treatment
CN113841891A (en) * 2021-09-17 2021-12-28 江苏食品药品职业技术学院 Food nutrient and preparation method thereof

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