AT377977B - Verfahren zur herstellung neuer 2-(2-methoxy-4amino-5-alkylsulfonylbenzamidomethyl)-pyrrolidi e,ihrer salze, n-oxide und optischen isomeren - Google Patents

Verfahren zur herstellung neuer 2-(2-methoxy-4amino-5-alkylsulfonylbenzamidomethyl)-pyrrolidi e,ihrer salze, n-oxide und optischen isomeren

Info

Publication number
AT377977B
AT377977B AT0039879A AT39879A AT377977B AT 377977 B AT377977 B AT 377977B AT 0039879 A AT0039879 A AT 0039879A AT 39879 A AT39879 A AT 39879A AT 377977 B AT377977 B AT 377977B
Authority
AT
Austria
Prior art keywords
alkylsulfonylbenzamidomethyl
4amino
pyrrolidi
methoxy
oxides
Prior art date
Application number
AT0039879A
Other languages
German (de)
English (en)
Other versions
ATA39879A (de
Original Assignee
Ile De France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ile De France filed Critical Ile De France
Priority to AT295283A priority Critical patent/AT377978B/de
Publication of ATA39879A publication Critical patent/ATA39879A/de
Application granted granted Critical
Publication of AT377977B publication Critical patent/AT377977B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT0039879A 1978-01-20 1979-01-19 Verfahren zur herstellung neuer 2-(2-methoxy-4amino-5-alkylsulfonylbenzamidomethyl)-pyrrolidi e,ihrer salze, n-oxide und optischen isomeren AT377977B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT295283A AT377978B (de) 1978-01-20 1983-08-18 Verfahren zur herstellung neuer 2-(2-methoxy-4amino-5-alkylsulfonyl-benzamidomethyl)pyrrolidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7801632A FR2415099A1 (fr) 1978-01-20 1978-01-20 Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes

Publications (2)

Publication Number Publication Date
ATA39879A ATA39879A (de) 1983-12-15
AT377977B true AT377977B (de) 1985-05-28

Family

ID=9203689

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0039879A AT377977B (de) 1978-01-20 1979-01-19 Verfahren zur herstellung neuer 2-(2-methoxy-4amino-5-alkylsulfonylbenzamidomethyl)-pyrrolidi e,ihrer salze, n-oxide und optischen isomeren

Country Status (42)

Country Link
US (2) US4294828A (OSRAM)
JP (1) JPS6049192B2 (OSRAM)
AR (2) AR221354A1 (OSRAM)
AT (1) AT377977B (OSRAM)
AU (1) AU528561B2 (OSRAM)
BE (1) BE872585A (OSRAM)
BG (2) BG31497A3 (OSRAM)
CA (1) CA1101430A (OSRAM)
CH (1) CH637927A5 (OSRAM)
CS (1) CS226181B2 (OSRAM)
CY (1) CY1201A (OSRAM)
DD (1) DD141520A5 (OSRAM)
DE (1) DE2901181C2 (OSRAM)
DK (1) DK158346C (OSRAM)
EG (1) EG14045A (OSRAM)
ES (2) ES476755A1 (OSRAM)
FI (1) FI71126C (OSRAM)
FR (1) FR2415099A1 (OSRAM)
GB (2) GB2012765B (OSRAM)
GR (1) GR64431B (OSRAM)
HK (1) HK12184A (OSRAM)
HU (1) HU179793B (OSRAM)
IE (1) IE47798B1 (OSRAM)
IL (1) IL56411A (OSRAM)
IN (1) IN150226B (OSRAM)
IT (1) IT1164655B (OSRAM)
LU (1) LU80786A1 (OSRAM)
MC (1) MC1232A1 (OSRAM)
MX (2) MX5793E (OSRAM)
NL (1) NL191707C (OSRAM)
NO (1) NO151320C (OSRAM)
NZ (1) NZ189378A (OSRAM)
OA (1) OA06156A (OSRAM)
PH (2) PH15725A (OSRAM)
PL (2) PL118151B1 (OSRAM)
PT (1) PT69068A (OSRAM)
RO (2) RO76393A (OSRAM)
SE (2) SE448874B (OSRAM)
SU (1) SU820659A3 (OSRAM)
YU (2) YU42172B (OSRAM)
ZA (1) ZA79219B (OSRAM)
ZM (1) ZM579A1 (OSRAM)

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FR2440946A2 (fr) * 1978-01-20 1980-06-06 Ile De France Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
ZA818221B (en) * 1980-12-12 1982-10-27 Beecham Group Plc Pharmaceutical compounds
FR2550447B1 (fr) * 1983-08-10 1986-01-17 Ile De France Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
FR2574795B1 (fr) * 1984-12-18 1987-11-20 Ile De France Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide
FR2584401B1 (fr) * 1985-07-04 1987-11-20 Ile De France Nouveau benzamide, son procede de preparation et son application dans le domaine therapeutique
US5227388A (en) * 1989-12-26 1993-07-13 Hoechst-Roussel Pharmaceuticals Incorporated Thienobenzoxepins and naphthothiophenes
US5260319A (en) * 1989-12-26 1993-11-09 Hoechst-Roussel Pharmaceuticals Incorporated Thienobenzoxepins and naphthothiophenes
FR2678266A1 (fr) * 1991-06-28 1992-12-31 Delagrange Laboratoires Nouveaux derives de 2-hydroxy 4-amino 5-ethylsulfonyl benzamide utiles comme anxiolytiques.
FR2699533A1 (fr) * 1992-12-21 1994-06-24 Mouhtaram Mohamed Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.
FR2753376B1 (fr) * 1996-09-18 1998-10-16 Synthelabo Compositions pharmaceutiques comprenant de l'amisulpride et leurs applications therapeutiques
FR2762213B1 (fr) * 1997-04-18 1999-05-14 Synthelabo Composition pharmaceutique a retention gastrique
US6169094B1 (en) * 1998-07-14 2001-01-02 Sanofi-Synthelabo Compositions of (S) (-)-amisulpride
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
WO2004100992A2 (en) * 2003-05-16 2004-11-25 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
FR2857263B1 (fr) * 2003-07-09 2005-09-09 Sanofi Synthelabo Nouvelle composition pharmaceutique solide comprenant de l'amisulpride
BRPI0510942A (pt) * 2004-05-11 2007-07-17 Pfizer Prod Inc combinação de antipsicóticos atìpicos e antagonistas do receptor 5-ht1b
AU2006239900A1 (en) * 2005-04-22 2006-11-02 Wyeth Therapeutic combinations for the treatment or prevention of psychotic disorders
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
US7825156B2 (en) * 2007-02-02 2010-11-02 Copharms Method of treating bipolar depression with a benzamide derivative
WO2009156889A1 (en) * 2008-06-25 2009-12-30 Pfizer Inc. Diaryl compounds and uses thereof
US20100105755A1 (en) * 2008-09-12 2010-04-29 Auspex Pharmaceuticals, Inc. Substituted benzamide modulators of dopamine receptor
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
CA2760945A1 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
CN101898991B (zh) * 2009-05-31 2013-09-25 江苏天士力帝益药业有限公司 一种(s)(-)-氨磺必利d-(-)-酒石酸盐的合成方法
CN101628886B (zh) * 2009-08-25 2012-12-12 北京紫萌同达科技有限公司 一种2-甲氧基-4-氨基-5-乙砜基苯甲酸的合成方法
AU2014202535B2 (en) * 2010-03-11 2016-05-26 Acacia Pharma Limited The use of amisulpride as an anti-emetic
AU2016216578B2 (en) * 2010-03-11 2017-11-23 Acacia Pharma Limited The use of amisulpride as an anti-emetic
GB201004020D0 (en) 2010-03-11 2010-04-21 Acacia Pharma Ltd New therapeutic use
MX2012014497A (es) 2010-06-17 2013-04-03 Lupin Ltd Un proceso mejorado para la preparación de amilsuprida.
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN103319384A (zh) * 2013-06-18 2013-09-25 苏州诚和医药化学有限公司 制备2-甲氧基-4-氨基-5-乙砜基苯甲酸的方法
CN103304453A (zh) * 2013-06-18 2013-09-18 苏州诚和医药化学有限公司 两步法合成2-甲氧基-4-氨基-5-乙砜基苯甲酸
CN103450058B (zh) * 2013-09-18 2015-10-14 广安凯特医药化工有限公司 一种氨磺必利酸的制备方法
CN104725292B (zh) * 2015-03-23 2017-07-25 湖北荆江源制药股份有限公司 一种(s)(‑)‑氨磺必利的制备方法
GB201618425D0 (en) * 2016-11-01 2016-12-14 Acacia Pharma Ltd method
US11377421B2 (en) 2016-11-28 2022-07-05 Lb Pharmaceuticals Inc. Psychotropic agents and uses thereof
MA46901A (fr) * 2016-11-28 2019-10-02 Lb Pharmaceuticals Inc Agents psychotropes et leurs utilisations
CN106995397B (zh) * 2016-12-12 2020-01-14 河北医科大学 R-氨磺必利药用盐、制备方法、晶型及其用途
GB201702250D0 (en) 2017-02-10 2017-03-29 Acacia Pharma Ltd Method
MX2020005518A (es) 2017-12-05 2020-11-06 Sunovion Pharmaceuticals Inc Mezclas no racemicas y usos de las mismas.
WO2019113084A1 (en) 2017-12-05 2019-06-13 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
CN110790693A (zh) * 2018-08-02 2020-02-14 北京万全德众医药生物技术有限公司 一种(s)(-)-氨磺必利的制备方法
EP3980009A4 (en) 2019-06-04 2023-07-05 Sunovion Pharmaceuticals Inc. MODIFIED RELEASE FORMULATIONS AND ASSOCIATED USES
USD1047552S1 (en) * 2021-04-23 2024-10-22 Krueger International, Inc. Furniture leg with frame
CN116003304A (zh) * 2023-02-08 2023-04-25 浙江皓华制药有限公司 一种氨磺必利的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
FR2313935A1 (fr) * 1975-06-10 1977-01-07 Ile De France Nouveaux benzamides substitues, leurs derives et leur procede de preparation
US3862139A (en) * 1972-06-23 1975-01-21 Delmar Chem Heterocyclic benzamide compounds
FR2244760B1 (OSRAM) * 1973-09-25 1980-06-27 Ile De France
FR2299862B1 (en) * 1975-02-07 1978-07-21 Soc Et Scient Et Ind Substd. N-(1-benzylpyrrolidinyl-2-alkyl)benzamides - used as antiemetics, anti-ulcer agents and CNS active
FR2294698A1 (fr) * 1974-12-18 1976-07-16 Synthelabo Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment
SE412908B (sv) * 1974-12-18 1980-03-24 Synthelabo Forfarande for framstellning av terapeutiskt aktiva 2-metoxibensamider innehallande en pyrrolidin- eller en piperidinrest

Also Published As

Publication number Publication date
IL56411A0 (en) 1979-03-12
PL116532B1 (en) 1981-06-30
FR2415099B1 (OSRAM) 1981-02-20
HU179793B (en) 1982-12-28
RO80311A (ro) 1982-12-06
ZA79219B (en) 1980-01-30
SE8603773L (sv) 1986-09-09
US4401822A (en) 1983-08-30
HK12184A (en) 1984-02-24
AR220574A1 (es) 1980-11-14
DK158346B (da) 1990-05-07
SU820659A3 (ru) 1981-04-07
CA1101430A (en) 1981-05-19
US4294828A (en) 1981-10-13
CS226181B2 (en) 1984-03-19
NL7900457A (nl) 1979-07-24
FI71126C (fi) 1986-11-24
SE460968B (sv) 1989-12-11
PH22287A (en) 1988-07-22
MX5793E (es) 1984-07-19
SE8603773D0 (sv) 1986-09-09
AU4337379A (en) 1979-07-26
NL191707B (nl) 1995-12-01
NO151320C (no) 1985-04-17
NO790180L (no) 1979-07-23
IE47798B1 (en) 1984-06-27
EG14045A (en) 1983-09-30
IN150226B (OSRAM) 1982-08-21
GB2012765B (en) 1982-09-08
LU80786A1 (fr) 1979-09-07
BG31497A3 (bg) 1982-01-15
IT7947706A0 (it) 1979-01-18
RO76393A (ro) 1981-03-30
AU528561B2 (en) 1983-05-05
YU5079A (en) 1983-06-30
CY1201A (en) 1983-12-31
PH15725A (en) 1983-03-18
DK158346C (da) 1990-10-08
GB2083458A (en) 1982-03-24
JPS54145658A (en) 1979-11-14
FI71126B (fi) 1986-08-14
IT1164655B (it) 1987-04-15
ATA39879A (de) 1983-12-15
YU41278B (en) 1986-12-31
CH637927A5 (fr) 1983-08-31
FI790182A7 (fi) 1979-07-21
YU25483A (en) 1983-10-31
MX7623E (es) 1990-03-27
FR2415099A1 (fr) 1979-08-17
NZ189378A (en) 1983-03-15
DE2901181A1 (de) 1979-07-26
BE872585A (fr) 1979-06-07
DE2901181C2 (de) 1984-07-19
NO151320B (no) 1984-12-10
MC1232A1 (fr) 1979-10-26
NL191707C (nl) 1996-04-02
DK20979A (da) 1979-07-21
BG31496A3 (bg) 1982-01-15
OA06156A (fr) 1981-06-30
AR221354A1 (es) 1981-01-30
IL56411A (en) 1982-09-30
SE448874B (sv) 1987-03-23
JPS6049192B2 (ja) 1985-10-31
PL212899A1 (OSRAM) 1980-01-14
PT69068A (fr) 1979-02-01
DD141520A5 (de) 1980-05-07
GB2012765A (en) 1979-08-01
IE790092L (en) 1979-07-20
ES476755A1 (es) 1979-06-01
ES477782A1 (es) 1979-09-16
ZM579A1 (en) 1979-12-21
GR64431B (en) 1980-03-21
GB2083458B (en) 1983-03-09
PL118151B1 (en) 1981-09-30
YU42172B (en) 1988-06-30
SE7900380L (sv) 1979-07-21

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