BR112012031959A2 - um processo aperfeiçoado para preparação de amisulpride - Google Patents

um processo aperfeiçoado para preparação de amisulpride

Info

Publication number
BR112012031959A2
BR112012031959A2 BR112012031959A BR112012031959A BR112012031959A2 BR 112012031959 A2 BR112012031959 A2 BR 112012031959A2 BR 112012031959 A BR112012031959 A BR 112012031959A BR 112012031959 A BR112012031959 A BR 112012031959A BR 112012031959 A2 BR112012031959 A2 BR 112012031959A2
Authority
BR
Brazil
Prior art keywords
amino
methoxy
amisulpride
preparing
ethyl
Prior art date
Application number
BR112012031959A
Other languages
English (en)
Inventor
Dinesh Jayntibhai Paghdar
Girij Pal Singh
Mahesh Ramkumar Kolekar
Purna Chandra Ray
Surya Prakash Pandurang Patil
Tushar Nandkumar Deshpande
Yuvraj Atmaram Chavan
Original Assignee
Lupin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lupin Ltd filed Critical Lupin Ltd
Publication of BR112012031959A2 publication Critical patent/BR112012031959A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/78—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C217/80—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • C07C217/82—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring
    • C07C217/84—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

um processo aperfeiçoado para preparação de amisulpride. a presente invenção está relacionada com um novo processo para a preparação de maisulpride (i) que envolve: a metilação de 4-amino-salicílico, ácido (vi) com sulfato de dimetilo e uma base, facultativamente na presença de tbab para se obter 4-amino-2 metoxi-benzoato de metilo (viii) e (ii) a oxidação de 4-amino-2-metoxi-5-etil-tio-benzólico (ix) ou de 4-amino-2-metoxi-5-etil-tio-metil benzoato de metilo (x) com o oxidante agente na presença de tungstato de sódio ou molibdato de amónio, para dar 2-metoxi-4-amino-5-etil-sulfonil-benzóico (iv) ou 2-metoxi-4-amino-5-etil-sulfonil-metil benzoato de metilo (xi), respectivamente.
BR112012031959A 2010-06-17 2011-06-09 um processo aperfeiçoado para preparação de amisulpride BR112012031959A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN648KO2010 2010-06-17
IN1365KO2010 2010-12-01
PCT/IB2011/001301 WO2011158084A1 (en) 2010-06-17 2011-06-09 An improved process for preparation of amisulpride

Publications (1)

Publication Number Publication Date
BR112012031959A2 true BR112012031959A2 (pt) 2015-09-22

Family

ID=44314997

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012031959A BR112012031959A2 (pt) 2010-06-17 2011-06-09 um processo aperfeiçoado para preparação de amisulpride

Country Status (5)

Country Link
US (1) US20130096319A1 (pt)
EP (1) EP2582665A1 (pt)
BR (1) BR112012031959A2 (pt)
MX (1) MX2012014497A (pt)
WO (1) WO2011158084A1 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102807516A (zh) * 2012-08-16 2012-12-05 四川省百草生物药业有限公司 氨磺必利的中间体及利用该中间体制备氨磺必利的方法
CN103819383A (zh) * 2012-11-19 2014-05-28 上海美迪西生物医药有限公司 一种氨磺必利的合成方法
CN103319385B (zh) * 2013-06-18 2015-07-08 苏州诚和医药化学有限公司 一种2-甲氧基-4-氨基-5-乙砜基苯甲酸的合成方法
CN103450058B (zh) * 2013-09-18 2015-10-14 广安凯特医药化工有限公司 一种氨磺必利酸的制备方法
CN103553989B (zh) * 2013-11-08 2015-03-11 苏州诚和医药化学有限公司 一种2-甲氧基-4-氨基-5-乙砜基苯甲酸甲酯的合成方法
CN104725292B (zh) * 2015-03-23 2017-07-25 湖北荆江源制药股份有限公司 一种(s)(‑)‑氨磺必利的制备方法
CN105237422A (zh) * 2015-09-06 2016-01-13 南京理工大学 一种4-氨基-5-氯-2-甲氧基苯甲酸的合成方法
SG11202005016SA (en) 2017-12-05 2020-06-29 Sunovion Pharmaceuticals Inc Nonracemic mixtures and uses thereof
WO2019113084A1 (en) 2017-12-05 2019-06-13 Sunovion Pharmaceuticals Inc. Crystal forms and production methods thereof
KR20220018004A (ko) 2019-06-04 2022-02-14 선오비온 파마슈티컬스 인코포레이티드 조절 방출 제형 및 이의 용도
CN113024432A (zh) * 2019-12-24 2021-06-25 上海科胜药物研发有限公司 一种氨磺必利药典杂质的制备方法
CN113735755B (zh) * 2021-07-28 2024-05-31 深圳市新浩瑞医药科技有限公司 一种氨磺必利的制备方法
CN114230497A (zh) * 2021-10-21 2022-03-25 广东省科学院生物与医学工程研究所 一种4-氨基-5-乙基磺酰基-2-甲氧基苯甲酸的制备方法
CN114088845B (zh) * 2021-12-06 2022-08-16 广东金城金素制药有限公司 一种测定氨磺必利口服溶液中糖精钠及苯甲酰胺类降解杂质含量的分析方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4052445A (en) * 1975-02-01 1977-10-04 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler Process for the production of alkyl sulfonic acids
FR2415099A1 (fr) 1978-01-20 1979-08-17 Ile De France Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes
US20100105755A1 (en) * 2008-09-12 2010-04-29 Auspex Pharmaceuticals, Inc. Substituted benzamide modulators of dopamine receptor

Also Published As

Publication number Publication date
MX2012014497A (es) 2013-04-03
EP2582665A1 (en) 2013-04-24
WO2011158084A1 (en) 2011-12-22
US20130096319A1 (en) 2013-04-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 4A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.