AT373599B - Verfahren zur herstellung neuer rifamycinderivate - Google Patents

Verfahren zur herstellung neuer rifamycinderivate

Info

Publication number
AT373599B
AT373599B AT0222781A AT222781A AT373599B AT 373599 B AT373599 B AT 373599B AT 0222781 A AT0222781 A AT 0222781A AT 222781 A AT222781 A AT 222781A AT 373599 B AT373599 B AT 373599B
Authority
AT
Austria
Prior art keywords
rifamycine
derivatives
producing new
producing
new
Prior art date
Application number
AT0222781A
Other languages
German (de)
English (en)
Other versions
ATA222781A (de
Inventor
Egidio Marchi
Lauretta Montecchi
Original Assignee
Alfa Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alfa Farmaceutici Spa filed Critical Alfa Farmaceutici Spa
Publication of ATA222781A publication Critical patent/ATA222781A/de
Application granted granted Critical
Publication of AT373599B publication Critical patent/AT373599B/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT0222781A 1980-05-22 1981-05-19 Verfahren zur herstellung neuer rifamycinderivate AT373599B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT03429/80A IT1154655B (it) 1980-05-22 1980-05-22 Derivati imidazo-rifamicinici metodi per la loro preparazione e loro uso come sostanza ad azione antibatterica

Publications (2)

Publication Number Publication Date
ATA222781A ATA222781A (de) 1983-06-15
AT373599B true AT373599B (de) 1984-02-10

Family

ID=11107198

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0222781A AT373599B (de) 1980-05-22 1981-05-19 Verfahren zur herstellung neuer rifamycinderivate

Country Status (25)

Country Link
US (1) US4341785A (en, 2012)
JP (1) JPS5711987A (en, 2012)
AR (1) AR226212A1 (en, 2012)
AT (1) AT373599B (en, 2012)
AU (1) AU537093B2 (en, 2012)
BE (1) BE888895A (en, 2012)
CA (1) CA1142518A (en, 2012)
CH (1) CH648037A5 (en, 2012)
DE (1) DE3120460A1 (en, 2012)
DK (1) DK157876C (en, 2012)
EG (1) EG14891A (en, 2012)
ES (1) ES502906A0 (en, 2012)
FI (1) FI69467C (en, 2012)
FR (1) FR2482967A1 (en, 2012)
GB (1) GB2079270B (en, 2012)
GR (1) GR75640B (en, 2012)
IE (1) IE51204B1 (en, 2012)
IT (1) IT1154655B (en, 2012)
LU (1) LU83376A1 (en, 2012)
NL (1) NL187022C (en, 2012)
NO (1) NO155622C (en, 2012)
PH (2) PH17207A (en, 2012)
PT (1) PT73064B (en, 2012)
SE (1) SE453089B (en, 2012)
ZA (1) ZA813430B (en, 2012)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
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IT1199374B (it) 1984-05-15 1988-12-30 Alfa Farmaceutici Spa Processo per la preparazione di pirido-imidazo-rifamicine
IT1264494B1 (it) * 1993-03-23 1996-09-24 Alfa Wassermann Spa Uso di rifaximin e di formulazioni che la contengono nel trattamento delle dispepsie gastriche originate da helicobacter
US6861053B1 (en) * 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US5981522A (en) * 1995-09-01 1999-11-09 Kaneka Corporation Treatment of disease caused by infection of Helicobacter
EP0861660B9 (en) * 1997-02-28 2006-06-28 Kaneka Corporation Curative medicine for disease caused by infection of Helicobacter
US7122525B2 (en) * 2001-11-21 2006-10-17 Activbiotics, Inc. Targeted therapeutics and uses thereof
WO2003051299A2 (en) * 2001-12-13 2003-06-26 Activbiotics, Inc. Sulfhydryl rifamycins and uses thereof
ATE552824T1 (de) * 2002-11-05 2012-04-15 Fadim S R L Kontrollierte und kontinuierliche verabreichung von rifaximin
US7820652B2 (en) * 2003-09-24 2010-10-26 Activbiotics Pharma, Llc Regimen for the administration of rifamycin-class antibiotics
ITMI20032144A1 (it) * 2003-11-07 2005-05-08 Alfa Wassermann Spa Forme polimorfe di rifaximina, processi per ottenerle e
US7906542B2 (en) * 2004-11-04 2011-03-15 Alfa Wassermann, S.P.A. Pharmaceutical compositions comprising polymorphic forms α, β, and γ of rifaximin
US20080262024A1 (en) * 2003-11-07 2008-10-23 Giuseppe Claudio Viscomi Rifaximin compositions and method of use
US7902206B2 (en) * 2003-11-07 2011-03-08 Alfa Wassermann, S.P.A. Polymorphic forms α, β and γ of rifaximin
US7923553B2 (en) * 2003-11-07 2011-04-12 Alfa Wassermann, S.P.A. Processes for the production of polymorphic forms of rifaximin
US7256187B2 (en) * 2004-03-10 2007-08-14 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime derivatives effective against drug-resistant microbes
US7265107B2 (en) * 2004-03-10 2007-09-04 Cumbre Pharmaceuticals Inc. Rifamycin C-11 oxime cyclo derivatives effective against drug-resistant microbes
US7202246B2 (en) * 2004-06-09 2007-04-10 Cumbre Pharmaceuticals Inc. Spiro-rifamycin derivatives targeting RNA polymerase
US20060210483A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Non-systemic antibiotic formulations and related method of use and treatment of upper respiratory infections
US20060210492A1 (en) * 2005-03-02 2006-09-21 Kodsi Robert E Use of rifaximin for treatment and prevention of periodontal conditions
US8003118B2 (en) * 2005-03-02 2011-08-23 Kodsi Robert E Use of rifaximin for the prevention of aspiration pneumonia and/or sepsis
EP1698630B1 (en) 2005-03-03 2014-09-03 ALFA WASSERMANN S.p.A. New polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
ITBO20050123A1 (it) * 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
KR101327635B1 (ko) 2005-08-11 2013-11-12 타간타 테라퓨틱스 인크. 포스폰산화 리파마이신, 및 그의 뼈 및 관절 감염의 저지및 치료 용도
MX2008011305A (es) 2006-03-09 2009-02-10 Salix Pharmaceuticals Inc Preparacion anti-disfunsion rectal con rifaximina.
EP2054066B1 (en) 2006-08-02 2015-04-15 Salix Pharmaceuticals, Inc. Methods for treatment of radiation enteritis
ITMI20061692A1 (it) 2006-09-05 2008-03-06 Alfa Wassermann Spa Uso di polioli per ottenere forme polimorfe stabili di rifaximina
CA2663776C (en) * 2006-09-22 2016-01-26 Cipla Limited Rifaximin in an amorphous form
US20080161337A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Chronic Prostatitis
US20080159987A1 (en) * 2007-01-03 2008-07-03 Leonard Weinstock Use of Rifaximin for the Treatment of Restless Legs Syndrome
ITMI20071241A1 (it) * 2007-06-20 2008-12-21 Solmag S P A Processo per la preparazione di rifaximina amorfa e rifaximina amorfa cosi' ottenuta
AU2008273699A1 (en) 2007-07-06 2009-01-15 Lupin Limited Pharmaceutical compositions of rifaximin
EP2837378A1 (en) 2007-07-06 2015-02-18 Lupin Limited Pharmaceutical compositions of rifaximin
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
WO2009108730A2 (en) 2008-02-25 2009-09-03 Salix Pharmaceuticals, Ltd. Forms of rifaximin and uses thereof
US8486956B2 (en) 2008-02-25 2013-07-16 Salix Pharmaceuticals, Ltd Forms of rifaximin and uses thereof
EP3563850A1 (en) 2008-02-26 2019-11-06 Salix Pharmaceuticals, Ltd. Methods for treating bowel diseases
US11779571B2 (en) 2008-02-26 2023-10-10 Salix Pharmaceuticals, Inc. Methods for treating irritable bowel syndrome (IBS)
CA2723752A1 (en) 2008-05-07 2009-11-12 Salix Pharmaceuticals, Ltd. Methods of treating bowel disease by administering a bowel cleanser and an antibiotic
EP2324041A4 (en) 2008-08-13 2012-06-13 Targanta Therapeutics Corp PHOSPHONIZED RIFAMYCINS AND ITS APPLICATION FOR THE PREVENTION AND TREATMENT OF BONE AND JOINT INFECTIONS
EP2327407B1 (en) 2008-09-26 2014-07-09 ASKA Pharmaceutical Co., Ltd. Prophylactic and/or therapeutic agent for functional gastrointestinal disorders
US12285414B2 (en) 2008-10-02 2025-04-29 Salix Pharmaceuticals, Inc. Methods of treating hepatic encephalopathy
LT3628319T (lt) 2008-10-02 2024-03-25 Salix Pharmaceuticals, Inc. Hepatinės encefalopatijos gydymas rifaksiminu
WO2010067072A1 (en) 2008-12-10 2010-06-17 Cipla Limited Rifaximin complexes
IT1397617B1 (it) * 2009-04-20 2013-01-18 Alfa Wassermann Spa Nuovi derivati della rifamicina
RU2540513C2 (ru) 2009-06-02 2015-02-10 Саликс Фармасьютикалз, Лтд. Способы лечения печеночной энцефалопатии
CN102596250A (zh) 2009-09-13 2012-07-18 萨利克斯药品有限公司 治疗肠易激综合征(ibs)的方法
KR20190000931A (ko) 2009-10-27 2019-01-03 루핀 리미티드 리팍시민의 고형 분산물
NZ600362A (en) 2009-11-23 2014-08-29 Cipla Ltd Topical foam composition
US8952159B2 (en) 2009-12-28 2015-02-10 Silvio Massimo Lavagna Method for the production of amorphous rifaximin
AU2011218129A1 (en) 2010-02-18 2012-08-23 Board Of Regents Of The University Of Texas System Methods for treating infection
IT1398550B1 (it) 2010-03-05 2013-03-01 Alfa Wassermann Spa Formulazioni comprendenti rifaximina utili per ottenere un effetto prolungato nel tempo
JP6092629B2 (ja) 2010-03-10 2017-03-08 ルピン・リミテッドLupin Limited リファキシミン使用準備済懸濁液
EP3750526A1 (en) 2010-07-12 2020-12-16 Salix Pharmaceuticals, Inc. Formulations of rifaximin and uses thereof
WO2012035544A2 (en) 2010-09-13 2012-03-22 Sequent Scientific Ltd. A novel polymorphic form of rifaximin and process for its preparation
PH12013501643A1 (en) 2011-02-11 2019-10-11 Salix Pharmaceuticals Ltd Forms of rifaximin and uses thereof
EP2705042A1 (en) 2011-05-02 2014-03-12 Ranbaxy Laboratories Limited Rifaximin dimethylformamide solvate
ITMI20110890A1 (it) * 2011-05-19 2012-11-20 A M S A Anonima Materie Sint & Affini S P A Polimorfo di rifaximina e processo per la sua preparazione
ITBO20110461A1 (it) 2011-07-29 2013-01-30 Alfa Wassermann Spa Composizioni farmaceutiche comprendenti rifaximina, processi per la loro preparazione e loro uso nel trattamento di infezioni vaginali.
RU2496475C2 (ru) 2011-10-26 2013-10-27 Александр Васильевич Иващенко Фармацевтическая композиция и набор для лечения бактериальных инфекций
PL2773205T3 (pl) 2011-11-02 2024-09-02 Salix Pharmaceuticals, Inc. Ryfaksymina w leczeniu ustępującej biegunki z przewagą zespołu jelita drażliwego
JP2015509105A (ja) * 2012-01-25 2015-03-26 サリックス ファーマスーティカルズ,リミテッド リファキシミン誘導体及びその使用
ITBO20120368A1 (it) 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
US9849090B2 (en) 2012-12-12 2017-12-26 Sun Pharmaceutical Industries Limited Pharmaceutical compositions of rifaximin
JP2016516988A (ja) 2013-03-15 2016-06-09 アルファ ワッセルマン ソシエタ ペル アチオニAlfa Wassermann S.P.A. 膣感染症を診断するための方法
US20160038468A1 (en) 2013-03-15 2016-02-11 Alfa Wassermann S.P.A. Rifaximin for use in the treating of vaginal infections
PL2983647T3 (pl) 2013-04-12 2021-01-25 Alfasigma S.P.A. Podawanie nlpz oraz związane z tym składniki, sposoby i układy
US9018225B1 (en) 2013-07-26 2015-04-28 Novel Laboratories Rifaximin crystalline forms and methods of preparation thereof
ES2621557T3 (es) 2014-03-31 2017-07-04 Euticals S.P.A. Mezcla polimórfica de rifaximina y su uso para la preparación de formulaciones sólidas
CA2946101A1 (en) * 2014-04-19 2015-10-22 Granules India Limited An improved process for the preparation of rifamycin derivatives
JP6693946B2 (ja) 2014-05-04 2020-05-13 サリックス ファーマスーティカルズ,インコーポレーテッド Ibs微生物叢及びその使用
KR102362719B1 (ko) 2014-05-12 2022-02-14 알파시그마 에스.피.에이. 리팍시민의 신규한 용매화 결정 형태, 생산물, 조성물 및 이의 용도
EP2982764A1 (en) 2014-08-05 2016-02-10 ALFA WASSERMANN S.p.A. Identification of vaginal bacteria
US9988398B2 (en) 2016-06-07 2018-06-05 Cadila Healthcare Limited Crystalline form of rifaximin and process for its preparation
KR20230023043A (ko) 2016-09-30 2023-02-16 샐릭스 파마슈티컬스 인코포레이티드 리팍시민의 고체 분산물 형태
ES2868180T3 (es) 2017-06-26 2021-10-21 Biofer Spa Derivados de pirido-imidazo rifamicina como agentes antibacterianos
IT201700091912A1 (it) * 2017-08-08 2019-02-08 Biofer Spa Nuove pirido-imidazo rifamicine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE273377C (en, 2012) *
AT273377B (de) * 1967-03-01 1969-08-11 Lepetit Spa Verfahren zur Herstellung von neuen Rifamycinen
AT344898B (de) * 1975-06-13 1978-08-10 Archifar Ind Chim Trentino Verfahren zur herstellung neuer rifamycin-verbindungen
DK345977A (da) * 1976-09-30 1978-03-31 Archifar Ind Chim Trentino G rifamycinforbindelser og fremgangsmaade til deres fremstillin
CH629212A5 (it) * 1976-10-18 1982-04-15 Erba Farmitalia Procedimento per la preparazione di composti di rifamicina.
CH633014A5 (en) * 1978-06-09 1982-11-15 Erba Farmitalia Rifamycin compounds

Also Published As

Publication number Publication date
ES8203388A1 (es) 1982-04-01
ZA813430B (en) 1982-06-30
PH18704A (en) 1985-09-05
NO811731L (no) 1981-11-23
DE3120460A1 (de) 1982-03-11
IE811139L (en) 1981-11-22
US4341785A (en) 1982-07-27
GR75640B (en, 2012) 1984-08-02
GB2079270A (en) 1982-01-20
NL187022B (nl) 1990-12-03
FR2482967A1 (fr) 1981-11-27
IT8003429A0 (it) 1980-05-22
FI811565L (fi) 1981-11-23
AU7065581A (en) 1981-11-26
NL187022C (nl) 1991-05-01
DK157876C (da) 1990-07-30
ES502906A0 (es) 1982-04-01
FI69467C (fi) 1986-02-10
IE51204B1 (en) 1986-10-29
LU83376A1 (fr) 1981-09-11
PH17207A (en) 1984-06-19
JPS5711987A (en) 1982-01-21
NO155622B (no) 1987-01-19
DK157876B (da) 1990-02-26
BE888895A (fr) 1981-09-16
JPS6123192B2 (en, 2012) 1986-06-04
FI69467B (fi) 1985-10-31
EG14891A (en) 1985-12-31
CA1142518A (en) 1983-03-08
FR2482967B1 (en, 2012) 1985-03-29
SE8103216L (sv) 1981-11-23
NO155622C (no) 1987-04-29
PT73064A (en) 1981-06-01
AU537093B2 (en) 1984-06-07
PT73064B (en) 1982-07-05
CH648037A5 (de) 1985-02-28
SE453089B (sv) 1988-01-11
GB2079270B (en) 1984-01-18
DE3120460C2 (en, 2012) 1990-12-13
NL8102290A (nl) 1981-12-16
AR226212A1 (es) 1982-06-15
ATA222781A (de) 1983-06-15
DK224781A (da) 1981-11-23
IT1154655B (it) 1987-01-21

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Legal Events

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ELA Expired due to lapse of time