AT292193B - Verfahren zur Herstellung neuer 3,7-disubstituierter Cephalosporin-Derivate - Google Patents

Verfahren zur Herstellung neuer 3,7-disubstituierter Cephalosporin-Derivate

Info

Publication number
AT292193B
AT292193B AT1022268A AT1022268A AT292193B AT 292193 B AT292193 B AT 292193B AT 1022268 A AT1022268 A AT 1022268A AT 1022268 A AT1022268 A AT 1022268A AT 292193 B AT292193 B AT 292193B
Authority
AT
Austria
Prior art keywords
preparation
new
cephalosporin derivatives
disubstituted
disubstituted cephalosporin
Prior art date
Application number
AT1022268A
Other languages
English (en)
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6951067A external-priority patent/JPS4614736B1/ja
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of AT292193B publication Critical patent/AT292193B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47L—DOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L13/00—Implements for cleaning floors, carpets, furniture, walls, or wall coverings
    • A47L13/02—Scraping
    • A47L13/04—Scraping with steel wool

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT1022268A 1967-04-15 1968-10-18 Verfahren zur Herstellung neuer 3,7-disubstituierter Cephalosporin-Derivate AT292193B (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2397167 1967-04-15
JP6842967 1967-10-24
JP6951067A JPS4614736B1 (de) 1967-10-28 1967-10-28

Publications (1)

Publication Number Publication Date
AT292193B true AT292193B (de) 1971-08-10

Family

ID=27284465

Family Applications (1)

Application Number Title Priority Date Filing Date
AT1022268A AT292193B (de) 1967-04-15 1968-10-18 Verfahren zur Herstellung neuer 3,7-disubstituierter Cephalosporin-Derivate

Country Status (10)

Country Link
US (1) US3516997A (de)
AT (1) AT292193B (de)
CA (1) CA928292A (de)
CH (2) CH527215A (de)
DE (1) DE1795838B2 (de)
ES (3) ES352625A1 (de)
FR (1) FR7475M (de)
GB (1) GB1206305A (de)
NL (1) NL164560C (de)
SE (1) SE369908B (de)

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1953861C2 (de) * 1969-10-25 1982-12-23 Fujisawa Pharmaceutical Co., Ltd., Osaka 7-Tetrazolylacetamido-3-thiomethyl-3-cephem-4- carbonsäuren
FR2068419A1 (en) * 1969-10-27 1971-08-27 Fujisawa Pharmaceutical Co Antibacterial cephalosporin compsns
BE758587A (fr) * 1969-11-17 1971-05-06 Fujisawa Pharmaceutical Co Procede de preparation de derives d'acide 7-aminocephalosporanique et nouveaux produits ainsi obtenus
US4010264A (en) * 1970-11-06 1977-03-01 Koninklijke Nederlandsche Gist-En Spiritusfabriek N.V. 7-[3-Substituted isoxazol-5-yl]-acetamido-cephalosporanic acids and their anti-bacterial use
US3687948A (en) * 1970-11-23 1972-08-29 Bristol Myers Co 7-{8 D-(a-AMINO-a-PHENYLACETAMIDO){9 -3-(4-METHYL-1,3-OXAZOL-2-YLTHIOMETHYL-3-CEPHEM-4-CARBOXYLIC ACID AND SALTS THEREOF
US3972919A (en) * 1970-12-17 1976-08-03 Smithkline Corporation p-Hydroxymethylphenylglycine
US3867380A (en) * 1971-02-18 1975-02-18 Smithkline Corp 3-Heterocyclic thiomethylcephalosporins
US3855213A (en) * 1971-02-18 1974-12-17 Smith Kline French Lab 3-heterocyclic thiomethyl-cephalosporins
AU463529B2 (en) * 1971-01-18 1975-07-31 Bristol-Myers Company Cephalosporin derivatives and process fob the preparation thereof
IE36221B1 (en) * 1971-04-21 1976-09-15 Ciba Geigy Ag Acylamino compounds and a process for their manufacture
US3757014A (en) * 1971-05-07 1973-09-04 Bristol Myers Co Ts 1,3,4 - oxadiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid and sal7-(d-(alpha-amino-alpha-pheyle-acetamido)) - 3-(s-(5-hydroxymethyl -
US4025509A (en) * 1972-03-30 1977-05-24 Ciba-Geigy Corporation Aminopyridinium acetyl cephalosporanes
US3968226A (en) * 1972-06-14 1976-07-06 Smithkline Corporation 3-Heterocyclic thiomethylcephalosporins as antibacterial agents
US3855212A (en) * 1972-08-04 1974-12-17 Squibb & Sons Inc Cyanomethylth ioacetylcephalosporins
US3907784A (en) * 1972-09-11 1975-09-23 Lilly Co Eli 7-Halophenylthioacetamido cephalosporins
JPS49124574A (de) * 1972-09-15 1974-11-28
US4060687A (en) * 1972-11-13 1977-11-29 Merck & Co., Inc. Cephalosporins having a 3-α substituted alkyl grouping
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US4160829A (en) * 1972-12-22 1979-07-10 Gist-Brocades N.V. Antibacterial 1,2,4-oxadiazolylacetamido cephalosporins
US3898217A (en) * 1973-03-30 1975-08-05 American Home Prod 7-(1-Aminomethylcycloalkylcarboxamido)cephalosporanic
US4133882A (en) * 1973-05-11 1979-01-09 Smithkline Corporation 7-Hydroxyhalophenylacetamido-3-heterocyclicthiomethyl cephalosporins
US3884914A (en) * 1973-07-05 1975-05-20 Smithkline Corp Mandelamidocephalosporins with improved properties
US3957985A (en) * 1973-07-05 1976-05-18 Smithkline Corporation Mandelamidocephalosporins with improved properties
US4022895A (en) * 1973-08-01 1977-05-10 Smithkline Corporation Substituted phenylglycylcephalosporins
JPS5093989A (de) * 1973-10-25 1975-07-26
US4071683A (en) * 1973-10-30 1978-01-31 Bayer Aktiengesellschaft Oxoimidazolidinylthiocarbonyl derivatives of ceph-3-em-4-carboxylic acids
AR205728A1 (es) * 1973-11-14 1976-05-31 Rhone Poulenc Sa Procedimiento para preparar ((dihidro-5,6-oxa)-(di) tiino-1,4-il-2) acetamido)-7 cefalosporina y sus sales
US3943126A (en) * 1973-11-15 1976-03-09 Eli Lilly And Company Process for acylating a 7-aminocephalosporin
NZ176206A (en) * 1973-12-25 1978-03-06 Takeda Chemical Industries Ltd Cephalosporins
US4379924A (en) * 1973-12-25 1983-04-12 Takeda Chemical Industries, Ltd. Cephalosporin derivatives
US3993758A (en) * 1974-01-18 1976-11-23 Beecham Group Limited Cephalosporin compounds
US4205166A (en) * 1974-02-20 1980-05-27 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted-3-aminoalkyl-, acylaminoalkyl-, or hydroxyalkyl-substituted heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives and preparation thereof
US3929782A (en) * 1974-03-13 1975-12-30 Squibb & Sons Inc 1,2,4-Oxadiazolonylacetyl cephalosporins
US3960849A (en) * 1974-03-13 1976-06-01 E. R. Squibb & Sons, Inc. Amino-1,2,4-oxadiazolyl-3-acetyl cephalosporins
US4160086A (en) * 1974-04-27 1979-07-03 Beecham Group Limited 3-Heterocyclicthio-7-α-carboxy 2-aryl acetamido cephalosporanic acid
US4091211A (en) * 1974-05-05 1978-05-23 Hoffmann-La Roche Inc. Cephalosporins
JPS612674B2 (de) * 1974-06-20 1986-01-27 Meiji Seika Co
US3959259A (en) * 1974-07-08 1976-05-25 E. R. Squibb & Sons, Inc. 1,2,4-Oxadiazolonylacetyl penicillins
US3954745A (en) * 1974-09-12 1976-05-04 Eli Lilly And Company Process for preparing cefazolin
IE41697B1 (en) * 1974-09-27 1980-02-27 Rhone Poulenc Ind New cephalosporin derivatives their preparation and compositions containing them
US4182868A (en) * 1974-10-29 1980-01-08 Takeda Chemical Industries, Ltd. 7-Methoxycephalosporin derivatives
US4018759A (en) * 1974-12-03 1977-04-19 Smithkline Corporation 3-Heterocyclicthiomethylcephalosporins
US4286089A (en) * 1974-12-27 1981-08-25 Smithkline Corporation 7-Acyl-3-(substituted tetrazolyl thiomethyl)cephalosporins
US4093723A (en) * 1976-05-19 1978-06-06 Smithkline Corporation 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl) cephalosporins
US3979384A (en) * 1975-03-20 1976-09-07 Merck & Co., Inc. C-3 Substituted cephalosporins
US4029782A (en) * 1975-04-28 1977-06-14 Eli Lilly And Company Cefazolin suspension for parenteral administration
US4126745A (en) * 1975-04-30 1978-11-21 Sankyo Company Limited 7-Methoxycephalosporin derivatives
DE2620094A1 (de) * 1975-05-12 1976-12-02 Takeda Chemical Industries Ltd Cephalosporinverbindungen und verfahren zu ihrer herstellung
CA1088049A (en) * 1975-06-03 1980-10-21 Takashi Masugi 3-substituted-7-substituted alkanamido-3-cephem-4- carboxylic acid compounds and processes for preparation thereof
US4131672A (en) * 1975-06-09 1978-12-26 Eli Lilly And Company Method for treating methicillin resistant Staphylococcus aureus
US4049806A (en) * 1975-08-15 1977-09-20 Syntex (U.S.A.) Inc. Cephalosporin type antibacterials
US4048311A (en) * 1976-01-08 1977-09-13 Smithkline Corporation 7-Acyl-3-(sulfonic acid and sulfamoyl substituted tetrazolyl thiomethyl)cephalosporins
US4152433A (en) * 1976-03-12 1979-05-01 Fujisawa Pharmaceutical Co., Ltd. 2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and pharmaceutical compositions
US4220644A (en) * 1976-05-03 1980-09-02 Smithkline Corporation 7-Acylamino-3-(substituted tetrazolyl thiomethyl) cephalosporins
US4034092A (en) * 1976-05-03 1977-07-05 Smithkline Corporation 7-Acyl-3-(carboxyalkyl and carbamoylalkyl substituted oxadiazolylthiomethyl) cephalosporins
US4165429A (en) * 1976-06-28 1979-08-21 Yamanouchi Pharmaceutical Co., Ltd. 7α-METHOXY-CEPHALOSPORANIC ACID DERIVATIVES
FI771866A (de) * 1976-06-28 1977-12-29 Fujisawa Pharmaceutical Co
DE2655949A1 (de) * 1976-12-10 1978-06-15 Gruenenthal Gmbh Neue cephalosporin- und penicillinderivate, verfahren zu deren herstellung und diese produkte enthaltende arzneimittel
US4316037A (en) * 1977-01-21 1982-02-16 American Home Products Corporation N-Benzyl and N-substituted benzyl tetrazole-5-carboxylic acids and the preparation thereof
GB1565941A (en) * 1977-02-08 1980-04-23 Toyama Chemical Co Ltd Process for producing 7-(substituted)amino-3-substituted thiomethyl cephem carboxylic acids
US4115645A (en) * 1977-05-10 1978-09-19 Eli Lilly And Company Decolorizing process for 7-amino-3-(((2-methyl-1,3,4-thiadiazol-5-yl)thio)methyl)-3-cephem-4-carboxylic acid
US4104470A (en) * 1977-06-03 1978-08-01 Eli Lilly And Company Crystallization process for cefazolin sodium
DE2824559C2 (de) * 1977-06-10 1985-01-10 Yamanouchi Pharmaceutical Co., Ltd., Tokio / Tokyo 7α-Methoxy-7β-(4-substituierte-methylen-1,3-dithietan-2-yl)-carboxamido-3-Δ↑3↑-cephem-4-carbonsäuren, Verfahren zu deren Herstellung sowie ihre Verwendung
US4229573A (en) * 1977-06-21 1980-10-21 Asahi Kasei Kogyo Kabushiki Kaisha 7α-Methoxycephalosporin derivatives
US4148998A (en) * 1977-10-04 1979-04-10 Yeda Research And Development Co., Ltd. Pyrrole cephalosporin derivatives
IT1192287B (it) * 1977-11-14 1988-03-31 Fujisawa Pharmaceutical Co Derivati di acido cefalosporanico ad azione farmaceutica e relativo procedimento di preparazione
JPS6052711B2 (ja) * 1978-03-09 1985-11-20 旭化成株式会社 セフアロスポリン化合物の製法
US4314059A (en) * 1978-03-09 1982-02-02 Chisei Shibuya Process for preparing cephalosporin compounds
EP0004570B1 (de) * 1978-03-09 1982-04-14 Asahi Kasei Kogyo Kabushiki Kaisha Thiolester, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate und Verfahren zur Herstellung von Cephalosporinderivaten mittels dieser Thiolester
JPS6027677B2 (ja) * 1978-07-06 1985-06-29 富山化学工業株式会社 ７−置換又は非置換アミノ−３−置換チオメチルセフエムカルボン酸類の新規製造法
US4223135A (en) * 1979-03-19 1980-09-16 Bristol-Myers Company Production of cephalosporins
US4316016A (en) * 1979-03-19 1982-02-16 Bristol-Myers Company Cephalosporin intermediates
US4316017A (en) * 1979-03-19 1982-02-16 Bristol-Myers Company Cephalosporin intermediates
US4663461A (en) * 1980-08-29 1987-05-05 American Home Products Corporation Process for preparing 1-H-tetrazole-5-thiols
EP0070803A3 (de) * 1981-07-16 1984-05-02 Ciba-Geigy Ag Antibiotisch wirksame Aminotriazolyl-Cephalosporinderivate und ihre Herstellung
ES505092A0 (es) * 1981-09-01 1982-11-01 Gema Sa Procedimiento para la preparacion de un acido 7-aminocefa- losporanido-3-substituido
MA19602A1 (fr) * 1981-09-30 1983-04-01 Ciba Geigy Ag Composes d'amino-oxazolyle, procede pour leur preparation, preparations pharmaceutiques qui contiennent ces composes, et leur application
HU188874B (en) * 1983-04-19 1986-05-28 Biogal Gyogyszergyar,Hu Process for producing new 7-acylamido-3-acylaminomethyl-ceph-3-eme-4-carboxylic acid derivatives and pharmaceutically acceptable salts thereof
US4576937A (en) * 1984-02-29 1986-03-18 Smithkline Beckman Corporation 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt
KR940000112B1 (ko) * 1990-07-05 1994-01-05 주식회사 대웅제약 신규의 3-치환 세펨화합물 및 그의 제조방법
US5318781A (en) * 1993-04-06 1994-06-07 Hoffmann-La Roche Inc. Absorption enhancement of antibiotics
GB9312853D0 (en) * 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
CA2206287C (en) * 1994-12-13 2001-03-20 Mark Chasin Aryl thioxanthines
EP0799040B1 (de) * 1994-12-13 2003-08-20 Euroceltique S.A. Dreifachsubstituierte thioxanthine
US6025361A (en) * 1994-12-13 2000-02-15 Euro-Celtique, S.A. Trisubstituted thioxanthines
US5567698A (en) * 1995-02-15 1996-10-22 Bristol-Myers Squibb Company Pyridinium thiomethyl substituted chepholosporin derivatives
US6166041A (en) * 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) * 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
IT1286520B1 (it) * 1996-12-03 1998-07-15 Antibioticos Spa Procedimento per la preparazione di intermedi utili nella sintesi di cefalosporine
EP1379531A2 (de) * 2001-04-19 2004-01-14 Bioferma Murcia, S.A. Enzymatisches verfahren zur herstellung von cephalosporansäurederivaten mittels alpha-ketosäurederivaten
US7700581B2 (en) * 2007-01-31 2010-04-20 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Cephalosporin compounds comprising a C3 thio-methyl moiety substituted with N-containing heterocyclic group, and a C7 thiourea acetamido group, their preparations and uses thereof
CN104072517A (zh) * 2014-07-07 2014-10-01 江苏汉斯通药业有限公司 溴乙酰氨基头孢烷酸的生产工艺

Family Cites Families (4)

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GB1012943A (en) * 1961-05-16 1965-12-15 Glaxo Lab Ltd Improvements in or relating to antibiotics
US3365449A (en) * 1964-07-23 1968-01-23 Fujisawa Pharmaceutical Co 7-(substituted thioacylamino) cephalosporanic acid and derivatives thereof
US3239515A (en) * 1965-01-18 1966-03-08 Lilly Co Eli Dithiocarboxylated cephalosporins
US3239516A (en) * 1965-01-18 1966-03-08 Lilly Co Eli Dithiocarboxylated cephalosporins

Also Published As

Publication number Publication date
NL164560B (nl) 1980-08-15
DE1795838A1 (de) 1976-07-29
ES352625A1 (es) 1970-01-01
NL6805179A (de) 1968-10-16
GB1206305A (en) 1970-09-23
CH557381A (de) 1974-12-31
NL164560C (nl) 1981-01-15
SE369908B (de) 1974-09-23
ES367346A1 (es) 1971-05-01
US3516997A (en) 1970-06-23
ES367294A1 (es) 1971-04-01
FR7475M (de) 1969-12-01
DE1795838B2 (de) 1979-07-26
DE1770168B2 (de) 1976-04-08
CA928292A (en) 1973-06-12
CH527215A (de) 1972-08-31
DE1770168A1 (de) 1972-03-16

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ELA Expired due to lapse of time