AT306233B - Verfahren zur Herstellung neuer Cephalosporinderivate - Google Patents
Verfahren zur Herstellung neuer CephalosporinderivateInfo
- Publication number
- AT306233B AT306233B AT803370A AT803370A AT306233B AT 306233 B AT306233 B AT 306233B AT 803370 A AT803370 A AT 803370A AT 803370 A AT803370 A AT 803370A AT 306233 B AT306233 B AT 306233B
- Authority
- AT
- Austria
- Prior art keywords
- preparation
- cephalosporin derivatives
- new cephalosporin
- new
- derivatives
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title 1
- 229940124587 cephalosporin Drugs 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB38494/67A GB1241657A (en) | 1967-08-21 | 1967-08-21 | Improvements in or relating to cephalosporin compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AT306233B true AT306233B (de) | 1973-03-26 |
Family
ID=10403834
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT811468A AT303955B (de) | 1967-08-21 | 1968-08-20 | Verfahren zur Herstellung von Cephalosporinderivaten |
| AT803370A AT306233B (de) | 1967-08-21 | 1968-08-20 | Verfahren zur Herstellung neuer Cephalosporinderivate |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT811468A AT303955B (de) | 1967-08-21 | 1968-08-20 | Verfahren zur Herstellung von Cephalosporinderivaten |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US3658799A (de) |
| JP (2) | JPS5010872B1 (de) |
| AT (2) | AT303955B (de) |
| BE (1) | BE719711A (de) |
| CA (1) | CA927381A (de) |
| CH (2) | CH561726A5 (de) |
| DE (2) | DE1795184A1 (de) |
| FR (1) | FR1589109A (de) |
| GB (1) | GB1241657A (de) |
| NL (1) | NL6811829A (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE755256A (de) * | 1969-08-26 | 1971-02-25 | Glaxo Lab Ltd | |
| US3922268A (en) * | 1969-12-08 | 1975-11-25 | Lilly Co Eli | 3-Halomethyl-{66 {hu 3-Cephalosporin esters |
| DE2132883A1 (de) * | 1970-07-08 | 1972-01-13 | Ciba Geigy Ag | Cephemverbindungen |
| IL38657A (en) * | 1971-01-29 | 1979-01-31 | Glaxo Lab Ltd | Hydroxyimino-and -acyloxyimino-acylamido cephalosporins |
| GB1399086A (en) * | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
| GB1426072A (en) * | 1973-01-18 | 1976-02-25 | Beecham Group Ltd | Cephalosporins |
| GB1459212A (en) * | 1973-08-01 | 1976-12-22 | Glaxo Lab Ltd | N-deacylation of 7-acylamido-3-hydroxy-methyl cephalosporins |
| AR207327A1 (es) * | 1974-02-06 | 1976-09-30 | Lilly Co Eli | Un procedimiento para preparar acidos 3-cefem 3-sulfonatos y sus esteres |
| US3890311A (en) * | 1974-03-18 | 1975-06-17 | American Home Prod | 7-(2-(1-(phenylsulfonyl)-2-pyrrolidinylthio)acetamino)cephalosporanic acids |
| DK159154C (da) * | 1975-02-24 | 1991-02-11 | Takeda Chemical Industries Ltd | Fremgangsmaade til fremstilling af cephalosporinderivater eller salte deraf |
| US4048160A (en) * | 1976-03-22 | 1977-09-13 | Eli Lilly And Company | Process for preparation of 7-alkoxy-3-bromomethylcephems |
| US4048163A (en) * | 1976-03-22 | 1977-09-13 | Eli Lilly And Company | Process for preparation of 7-alkoxy-3-chloromethylcephems |
| US4042585A (en) * | 1976-03-22 | 1977-08-16 | Eli Lilly And Company | Process for preparation of 3-halomethylcephems |
| US4144391A (en) * | 1977-03-07 | 1979-03-13 | Eli Lilly And Company | Cephalosporin displacement reaction |
| US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
| US4266049A (en) * | 1980-02-20 | 1981-05-05 | Eli Lilly And Company | Process for 3-iodomethyl cephalosporins |
| NL8005041A (nl) * | 1980-09-05 | 1982-04-01 | Gist Brocades Nv | Werkwijze voor de bereiding van thioethers, alsmede gesilyleerde thiolen voor toepassing bij deze werkwijze. |
| DE3789412T2 (de) * | 1986-10-02 | 1994-06-30 | Asahi Chemical Ind | Verfahren zur Herstellung von 3-Alkoxymethylcephalosporinen. |
| JP2612493B2 (ja) * | 1988-05-24 | 1997-05-21 | 旭化成工業株式会社 | ３―置換メチル―３―セフェム―４―カルボン酸類の製造方法 |
| US5302713A (en) * | 1992-03-31 | 1994-04-12 | Industrial Technology Research Institute | Method for the preparation of Δ3 -7-substituted amino desacetoxy cephalosporanic acid |
| GB9312853D0 (en) * | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| AT401177B (de) * | 1993-10-22 | 1996-07-25 | Biochemie Gmbh | Verfahren zur herstellung von 7-amino-3-cephem-4-carbonsäure-derivaten |
| US5591776A (en) * | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| US5922751A (en) * | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| US6025361A (en) * | 1994-12-13 | 2000-02-15 | Euro-Celtique, S.A. | Trisubstituted thioxanthines |
| EP0814809B1 (de) * | 1994-12-13 | 2003-08-13 | Euroceltique S.A. | Arylthioxanthine |
| DE69531555T2 (de) * | 1994-12-13 | 2004-06-17 | Euroceltique S.A. | Dreifachsubstituierte thioxanthine |
| US6166041A (en) * | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| US6075016A (en) * | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
| US7423168B2 (en) * | 2002-08-29 | 2008-09-09 | Mitsubishi Chemical Corporation | Method for producing allyl compound |
| WO2017153824A1 (en) | 2016-03-07 | 2017-09-14 | Dhanuka Laboratories Ltd. | A process for alkylating the hydroxymethyl group at position -3 of cephalosporins |
-
1967
- 1967-08-21 GB GB38494/67A patent/GB1241657A/en not_active Expired
-
1968
- 1968-08-13 US US752180A patent/US3658799A/en not_active Expired - Lifetime
- 1968-08-20 AT AT811468A patent/AT303955B/de not_active IP Right Cessation
- 1968-08-20 CH CH173773A patent/CH561726A5/xx not_active IP Right Cessation
- 1968-08-20 CA CA027930A patent/CA927381A/en not_active Expired
- 1968-08-20 NL NL6811829A patent/NL6811829A/xx unknown
- 1968-08-20 DE DE19681795184 patent/DE1795184A1/de active Pending
- 1968-08-20 JP JP43059104A patent/JPS5010872B1/ja active Pending
- 1968-08-20 CH CH1251468A patent/CH561222A5/xx not_active IP Right Cessation
- 1968-08-20 FR FR1589109D patent/FR1589109A/fr not_active Expired
- 1968-08-20 DE DE19681795643 patent/DE1795643A1/de active Pending
- 1968-08-20 BE BE719711A patent/BE719711A/xx unknown
- 1968-08-20 AT AT803370A patent/AT306233B/de not_active IP Right Cessation
-
1971
- 1971-04-28 JP JP46027629A patent/JPS5127679B1/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AT303955B (de) | 1972-12-27 |
| JPS5010872B1 (de) | 1975-04-24 |
| CH561726A5 (de) | 1975-05-15 |
| NL6811829A (de) | 1969-02-25 |
| DE1795184A1 (de) | 1972-03-16 |
| FR1589109A (de) | 1970-03-23 |
| BE719711A (de) | 1969-02-20 |
| JPS5127679B1 (de) | 1976-08-13 |
| DE1795643A1 (de) | 1972-11-09 |
| CA927381A (en) | 1973-05-29 |
| US3658799A (en) | 1972-04-25 |
| CH561222A5 (de) | 1975-04-30 |
| GB1241657A (en) | 1971-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |