AR245450A1 - Procedimiento para preparar nuevos derivados de 4-piridona y sus sales y esteres aceptables desde el punto de vista fisiologico. - Google Patents

Procedimiento para preparar nuevos derivados de 4-piridona y sus sales y esteres aceptables desde el punto de vista fisiologico.

Info

Publication number
AR245450A1
AR245450A1 AR87308059A AR30805987A AR245450A1 AR 245450 A1 AR245450 A1 AR 245450A1 AR 87308059 A AR87308059 A AR 87308059A AR 30805987 A AR30805987 A AR 30805987A AR 245450 A1 AR245450 A1 AR 245450A1
Authority
AR
Argentina
Prior art keywords
formula
hydrogen
compounds
group
alkyl
Prior art date
Application number
AR87308059A
Other languages
English (en)
Original Assignee
Chemie Linz Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemie Linz Gmbh filed Critical Chemie Linz Gmbh
Application granted granted Critical
Publication of AR245450A1 publication Critical patent/AR245450A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE 4-PIRIDONA, DE FORMULA (I), EN LA QUE R1 ES 2,4-DIFLUOROFENILO;R2 ES HIDROGENO O S UNIDO AL N DEL CICLO A TRAVES DE UN PUENTE DE ETILENO; X ES HIDROGENO;Y ES UNA BASE DE FORMULA (IIA) O (IIB), DONDE R3 ES HIDROGENO, ALQUILO, BENCILO, FORMILO, ACETONILO O UN RESTO DE FORMULA (III), DONDE A) SE HACEN REACCIONAR COMPUESTOS DE FORMULA (IV) EN LA QUE L ES CLORO O FLUOR, Y R4 ES HIDROGENO, ALQUILO O UN COMPLEJO DE BORO DE FORMULA -B(R5R6), DONDE R5 Y R6 SON IGUALES, Y SON FLUOR O RESTOS -O(CO)ALQUILO, CON COMPUESTOS DE FORMULA (VA) O (VB) EN LAQUE R3' ES IGUAL A R3 O ES UN GRUPO PROTECTOR, Y A CONTINUACION, B) EN LOS COMPUESTOS ASI OBTENIDOS, PARA LOS QUE R4 ALQUILO O UN GRUPO -B(R6R5), SE ELIMINA EL GRUPO -B(R5R6) O EL ALQUILO MEDIANTE UN HIDROXIDO ACUOSO O UNA BASE ORGANICA, PARA OBTENER COMPUESTOS DE FORMULA (I) EN LA QUE X ES HIDROGENO; C) SE ELIMINA EL GRUPO PROTECTOR DEL AMINO, EN R3'; D) LOS COMPUESTOS OBTENIDOS, DE FORMULA (I) EN LA QUE R 3 ES HIDROGENO, EVENTUALMENTE SE METILAN, BENCILAN, FORMILAN O SE HACEN REACCIONAR CON BROMOACETONA O CON UN COMPUESTO DE FORMULA R7HAL, EN LA QUE R7 ES EL RESTO DE FORMULA (III).
AR87308059A 1986-07-04 1987-07-03 Procedimiento para preparar nuevos derivados de 4-piridona y sus sales y esteres aceptables desde el punto de vista fisiologico. AR245450A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3622509 1986-07-04

Publications (1)

Publication Number Publication Date
AR245450A1 true AR245450A1 (es) 1994-01-31

Family

ID=6304401

Family Applications (1)

Application Number Title Priority Date Filing Date
AR87308059A AR245450A1 (es) 1986-07-04 1987-07-03 Procedimiento para preparar nuevos derivados de 4-piridona y sus sales y esteres aceptables desde el punto de vista fisiologico.

Country Status (24)

Country Link
US (1) US5045549A (es)
EP (1) EP0251308B1 (es)
JP (1) JPH07103123B2 (es)
KR (1) KR880001595A (es)
AR (1) AR245450A1 (es)
AT (1) ATE58538T1 (es)
AU (1) AU608515B2 (es)
CS (1) CS277415B6 (es)
DD (1) DD262428A1 (es)
DE (1) DE3766299D1 (es)
DK (1) DK342187A (es)
ES (1) ES2018667B3 (es)
FI (1) FI88506C (es)
GR (1) GR3001097T3 (es)
HU (1) HU197907B (es)
IL (1) IL83049A (es)
MY (1) MY101261A (es)
NO (1) NO166130C (es)
NZ (1) NZ220950A (es)
PH (1) PH24239A (es)
PT (1) PT85257B (es)
SU (1) SU1551248A3 (es)
YU (1) YU45039B (es)
ZA (1) ZA874849B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN166416B (es) * 1985-09-18 1990-05-05 Pfizer
YU46451B (sh) * 1987-04-08 1993-10-20 Chinoin Gyogyszer Es Vegyeszeti Ter Mekek Gyara Rt. Postupak za dobivanje mešovitih anhidrida hinolin-karboksilne i borne kiseline
JPH02131453A (ja) * 1988-04-15 1990-05-21 Asahi Glass Co Ltd ２―クロロ―４，５―ジフルオロベンゾイルアクリル酸誘導体
JPH072679B2 (ja) * 1988-04-15 1995-01-18 旭硝子株式会社 ２―クロロ―４，５―ジフルオロ安息香酸誘導体
WO1989012055A1 (en) * 1988-06-08 1989-12-14 Kyorin Pharmaceutical Co., Ltd. Antitumor agent
JPH02298946A (ja) * 1989-05-15 1990-12-11 Johoku Seihan Center:Kk 製版・版下作製材および製版・版下作製における貼付方法
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
JPH05506033A (ja) 1990-04-18 1993-09-02 ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド 抗微生物性キノロニルラクタム類
FR2692577B1 (fr) * 1992-05-26 1996-02-02 Bouchara Sa Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
TW252107B (es) * 1993-08-27 1995-07-21 Hokuriku Pharmacetical Co Ltd
ES2092963B1 (es) * 1995-04-12 1997-12-16 Sint Quimica Sa Procedimiento para la preparacion del acido 1-ciclopropil-6-fluoro-1, 4-dihidro-7-(1s,4s)-5-metil-2,5-diazabiciclo(2.2.1) hept-2-il)-4-oxo-3-quinolincarboxilico y sus sales.
SE0003795D0 (sv) 2000-10-20 2000-10-20 Astrazeneca Ab Pharmaceutically useful compounds
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1175836A (en) * 1977-09-20 1984-10-09 Marcel Pesson Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
DE3267485D1 (en) * 1981-02-18 1986-01-02 Nippon Shinyaku Co Ltd Substituted carboxylic acid derivatives
US4499091A (en) * 1982-03-31 1985-02-12 Sterling Drug Inc. 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents
EP0090424B1 (en) * 1982-03-31 1986-05-28 Sterling Drug Inc. New quinolone compounds and preparation thereof
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
JPS6056959A (ja) * 1983-07-18 1985-04-02 アボツト　ラボラトリ−ズ キノリン抗菌性化合物
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
EP0181521A1 (en) * 1984-10-19 1986-05-21 Otsuka Pharmaceutical Co., Ltd. Antimicrobial 1-substituted Phenyl-4-oxoquinoline-3-carboxylic acid compounds
US4578473A (en) * 1985-04-15 1986-03-25 Warner-Lambert Company Process for quinoline-3-carboxylic acid antibacterial agents
IN166416B (es) * 1985-09-18 1990-05-05 Pfizer
DE3601567A1 (de) * 1986-01-21 1987-07-23 Bayer Ag 7-(azabicycloalkyl)-chinoloncarbonsaeure- und -naphthyridon-carbonsaeure-derivate
US4923879A (en) * 1987-07-31 1990-05-08 Warner-Lambert Company 1,8-Naphthyridines and their use as antibacterial agents
US4962108A (en) * 1987-07-31 1990-10-09 Warner-Lambert Company Antibacterial quinoline compounds
US4962112A (en) * 1987-08-04 1990-10-09 Abbott Laboratories 7-(2-methyl-4-aminopyrrolidinyl)naphthryidine and quinoline compounds
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
US4920120A (en) * 1988-01-25 1990-04-24 Warner-Lambert Company Antibacterial agents

Also Published As

Publication number Publication date
YU45039B (en) 1991-06-30
CS277415B6 (en) 1993-03-17
IL83049A (en) 1991-12-12
FI872897A0 (fi) 1987-07-01
GR3001097T3 (en) 1992-04-17
HUT45060A (en) 1988-05-30
DK342187A (da) 1988-01-05
FI872897A (fi) 1988-01-05
ZA874849B (en) 1988-03-30
DE3766299D1 (de) 1991-01-03
JPH07103123B2 (ja) 1995-11-08
NO872778L (no) 1988-01-05
MY101261A (en) 1991-08-17
AU608515B2 (en) 1991-04-11
FI88506B (fi) 1993-02-15
EP0251308A1 (de) 1988-01-07
JPS6322580A (ja) 1988-01-30
FI88506C (fi) 1993-05-25
EP0251308B1 (de) 1990-11-22
PH24239A (en) 1990-05-04
CS505587A3 (en) 1992-08-12
DK342187D0 (da) 1987-07-03
NO166130C (no) 1991-06-05
PT85257B (pt) 1990-03-30
SU1551248A3 (ru) 1990-03-15
HU197907B (en) 1989-06-28
NO872778D0 (no) 1987-07-02
NZ220950A (en) 1990-07-26
AU7508087A (en) 1988-01-07
PT85257A (en) 1987-08-01
ATE58538T1 (de) 1990-12-15
ES2018667B3 (es) 1991-05-01
US5045549A (en) 1991-09-03
DD262428A1 (de) 1988-11-30
NO166130B (no) 1991-02-25
IL83049A0 (en) 1987-12-31
KR880001595A (ko) 1988-04-25
YU124687A (en) 1988-12-31

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