AR221354A1 - Procedimiento para la preparacion de nuevos derivados de 2-metoxi-4-amino 5-alquilsulfonil-n-(2-pirrolidil)-metil-benzamida,sus sales de adicion con acidos farmacologicamente aceptables,sus sales de amonio cuaternarias,sus n-oxidos y sus isomeros levogiros y dextrogiros - Google Patents

Procedimiento para la preparacion de nuevos derivados de 2-metoxi-4-amino 5-alquilsulfonil-n-(2-pirrolidil)-metil-benzamida,sus sales de adicion con acidos farmacologicamente aceptables,sus sales de amonio cuaternarias,sus n-oxidos y sus isomeros levogiros y dextrogiros

Info

Publication number
AR221354A1
AR221354A1 AR275115A AR27511579A AR221354A1 AR 221354 A1 AR221354 A1 AR 221354A1 AR 275115 A AR275115 A AR 275115A AR 27511579 A AR27511579 A AR 27511579A AR 221354 A1 AR221354 A1 AR 221354A1
Authority
AR
Argentina
Prior art keywords
quaternarial
pirrolidil
levogiros
dextrogiros
alquilsulfonil
Prior art date
Application number
AR275115A
Other languages
English (en)
Spanish (es)
Original Assignee
Ile De France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ile De France filed Critical Ile De France
Application granted granted Critical
Publication of AR221354A1 publication Critical patent/AR221354A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AR275115A 1978-01-20 1979-01-10 Procedimiento para la preparacion de nuevos derivados de 2-metoxi-4-amino 5-alquilsulfonil-n-(2-pirrolidil)-metil-benzamida,sus sales de adicion con acidos farmacologicamente aceptables,sus sales de amonio cuaternarias,sus n-oxidos y sus isomeros levogiros y dextrogiros AR221354A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7801632A FR2415099A1 (fr) 1978-01-20 1978-01-20 Nouveaux derives de 4-amino-5-alkylsulfonyl ortho-anisamides, leurs procedes de preparation et leur application comme psychotropes

Publications (1)

Publication Number Publication Date
AR221354A1 true AR221354A1 (es) 1981-01-30

Family

ID=9203689

Family Applications (2)

Application Number Title Priority Date Filing Date
AR275115A AR221354A1 (es) 1978-01-20 1979-01-10 Procedimiento para la preparacion de nuevos derivados de 2-metoxi-4-amino 5-alquilsulfonil-n-(2-pirrolidil)-metil-benzamida,sus sales de adicion con acidos farmacologicamente aceptables,sus sales de amonio cuaternarias,sus n-oxidos y sus isomeros levogiros y dextrogiros
AR277738A AR220574A1 (es) 1978-01-20 1979-08-16 Procedimiento para la preparacion de nuevos derivados de 2-metoxi-4-amino-5-alquilsulfonil-n-(2-pirrolidil)-metil-benzamidas,sus sales de adicion con acidos farmacologicamente aceptables,sus sales de amonio cuaternarias,sus oxidos y sus isomeros levogiros y dextrogiros

Family Applications After (1)

Application Number Title Priority Date Filing Date
AR277738A AR220574A1 (es) 1978-01-20 1979-08-16 Procedimiento para la preparacion de nuevos derivados de 2-metoxi-4-amino-5-alquilsulfonil-n-(2-pirrolidil)-metil-benzamidas,sus sales de adicion con acidos farmacologicamente aceptables,sus sales de amonio cuaternarias,sus oxidos y sus isomeros levogiros y dextrogiros

Country Status (42)

Country Link
US (2) US4294828A (cs)
JP (1) JPS6049192B2 (cs)
AR (2) AR221354A1 (cs)
AT (1) AT377977B (cs)
AU (1) AU528561B2 (cs)
BE (1) BE872585A (cs)
BG (2) BG31496A3 (cs)
CA (1) CA1101430A (cs)
CH (1) CH637927A5 (cs)
CS (1) CS226181B2 (cs)
CY (1) CY1201A (cs)
DD (1) DD141520A5 (cs)
DE (1) DE2901181C2 (cs)
DK (1) DK158346C (cs)
EG (1) EG14045A (cs)
ES (2) ES476755A1 (cs)
FI (1) FI71126C (cs)
FR (1) FR2415099A1 (cs)
GB (2) GB2012765B (cs)
GR (1) GR64431B (cs)
HK (1) HK12184A (cs)
HU (1) HU179793B (cs)
IE (1) IE47798B1 (cs)
IL (1) IL56411A (cs)
IN (1) IN150226B (cs)
IT (1) IT1164655B (cs)
LU (1) LU80786A1 (cs)
MC (1) MC1232A1 (cs)
MX (2) MX7623E (cs)
NL (1) NL191707C (cs)
NO (1) NO151320C (cs)
NZ (1) NZ189378A (cs)
OA (1) OA06156A (cs)
PH (2) PH15725A (cs)
PL (2) PL116532B1 (cs)
PT (1) PT69068A (cs)
RO (2) RO76393A (cs)
SE (2) SE448874B (cs)
SU (1) SU820659A3 (cs)
YU (2) YU42172B (cs)
ZA (1) ZA79219B (cs)
ZM (1) ZM579A1 (cs)

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FR2440946A2 (fr) * 1978-01-20 1980-06-06 Ile De France Nouveaux benzamides heterocycliques substitues, leurs procedes de preparation et leur application comme modificateurs du comportement
ZA818221B (en) * 1980-12-12 1982-10-27 Beecham Group Plc Pharmaceutical compounds
FR2550447B1 (fr) * 1983-08-10 1986-01-17 Ile De France Application du n-(ally-2-pyrrolidinylmethyl) 2-methoxy 4-amino 5-methylsulfamoyl benzamide comme antiagregant plaquettaire
FR2574795B1 (fr) * 1984-12-18 1987-11-20 Ile De France Nouveau procede industriel de synthese du n-((1'-allyl 2'-pyrrolidinyl) methyl) 2-methoxy 4,5-azimido benzamide
FR2584401B1 (fr) * 1985-07-04 1987-11-20 Ile De France Nouveau benzamide, son procede de preparation et son application dans le domaine therapeutique
US5227388A (en) * 1989-12-26 1993-07-13 Hoechst-Roussel Pharmaceuticals Incorporated Thienobenzoxepins and naphthothiophenes
US5260319A (en) * 1989-12-26 1993-11-09 Hoechst-Roussel Pharmaceuticals Incorporated Thienobenzoxepins and naphthothiophenes
FR2678266A1 (fr) * 1991-06-28 1992-12-31 Delagrange Laboratoires Nouveaux derives de 2-hydroxy 4-amino 5-ethylsulfonyl benzamide utiles comme anxiolytiques.
FR2699533A1 (fr) * 1992-12-21 1994-06-24 Mouhtaram Mohamed Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.
FR2753376B1 (fr) * 1996-09-18 1998-10-16 Synthelabo Compositions pharmaceutiques comprenant de l'amisulpride et leurs applications therapeutiques
FR2762213B1 (fr) * 1997-04-18 1999-05-14 Synthelabo Composition pharmaceutique a retention gastrique
US6169094B1 (en) * 1998-07-14 2001-01-02 Sanofi-Synthelabo Compositions of (S) (-)-amisulpride
US20030129186A1 (en) 2001-07-25 2003-07-10 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1633400A2 (en) * 2003-05-16 2006-03-15 Pfizer Products Inc. Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines
FR2857263B1 (fr) * 2003-07-09 2005-09-09 Sanofi Synthelabo Nouvelle composition pharmaceutique solide comprenant de l'amisulpride
JP2007537232A (ja) * 2004-05-11 2007-12-20 ファイザー・プロダクツ・インク 非定型抗精神病薬と５−ｈｔ１ｂ受容体拮抗薬の組合せ
GT200600161A (es) * 2005-04-22 2007-03-14 Nuevas combinaciones terapeuticas para el tratamiento o la prevencion de los trastornos psicoticos
EP3827747A1 (en) 2005-04-28 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Pharma-informatics system
US7825156B2 (en) * 2007-02-02 2010-11-02 Copharms Method of treating bipolar depression with a benzamide derivative
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
EP2321011A1 (en) * 2008-06-25 2011-05-18 Pfizer Inc. Diaryl compounds and uses thereof
US20100105755A1 (en) * 2008-09-12 2010-04-29 Auspex Pharmaceuticals, Inc. Substituted benzamide modulators of dopamine receptor
PT3395372T (pt) 2009-02-20 2022-05-05 Enhanx Biopharm Inc Sistema de entrega de medicamentos à base de glutationa
KR101741629B1 (ko) 2009-05-06 2017-05-31 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN101898991B (zh) * 2009-05-31 2013-09-25 江苏天士力帝益药业有限公司 一种(s)(-)-氨磺必利d-(-)-酒石酸盐的合成方法
CN101628886B (zh) * 2009-08-25 2012-12-12 北京紫萌同达科技有限公司 一种2-甲氧基-4-氨基-5-乙砜基苯甲酸的合成方法
GB201004020D0 (en) 2010-03-11 2010-04-21 Acacia Pharma Ltd New therapeutic use
AU2016216578B2 (en) * 2010-03-11 2017-11-23 Acacia Pharma Limited The use of amisulpride as an anti-emetic
AU2014202535B2 (en) * 2010-03-11 2016-05-26 Acacia Pharma Limited The use of amisulpride as an anti-emetic
BR112012031959A2 (pt) 2010-06-17 2015-09-22 Lupin Ltd um processo aperfeiçoado para preparação de amisulpride
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CN103319384A (zh) * 2013-06-18 2013-09-25 苏州诚和医药化学有限公司 制备2-甲氧基-4-氨基-5-乙砜基苯甲酸的方法
CN103304453A (zh) * 2013-06-18 2013-09-18 苏州诚和医药化学有限公司 两步法合成2-甲氧基-4-氨基-5-乙砜基苯甲酸
CN103450058B (zh) * 2013-09-18 2015-10-14 广安凯特医药化工有限公司 一种氨磺必利酸的制备方法
CN104725292B (zh) * 2015-03-23 2017-07-25 湖北荆江源制药股份有限公司 一种(s)(‑)‑氨磺必利的制备方法
GB201618425D0 (en) * 2016-11-01 2016-12-14 Acacia Pharma Ltd method
US11377421B2 (en) 2016-11-28 2022-07-05 Lb Pharmaceuticals Inc. Psychotropic agents and uses thereof
CN110248655B (zh) 2016-11-28 2023-07-07 Lb制药公司 精神药剂及其用途
CN106995397B (zh) * 2016-12-12 2020-01-14 河北医科大学 R-氨磺必利药用盐、制备方法、晶型及其用途
GB201702250D0 (en) 2017-02-10 2017-03-29 Acacia Pharma Ltd Method
MX2020005517A (es) 2017-12-05 2020-11-09 Sunovion Pharmaceuticals Inc Formas cristalinas y metodos de produccion de las mismas.
CN118593482A (zh) 2017-12-05 2024-09-06 赛诺维信制药公司 非外消旋混合物及其用途
CN110790693A (zh) * 2018-08-02 2020-02-14 北京万全德众医药生物技术有限公司 一种(s)(-)-氨磺必利的制备方法
US11160758B2 (en) 2019-06-04 2021-11-02 Sunovion Pharmaceuticals Inc. Modified release formulations and uses thereof
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Publication number Priority date Publication date Assignee Title
US3342826A (en) * 1964-01-13 1967-09-19 Ile De France Heterocyclic aminoalkyl benzamides
FR2313935A1 (fr) * 1975-06-10 1977-01-07 Ile De France Nouveaux benzamides substitues, leurs derives et leur procede de preparation
US3862139A (en) * 1972-06-23 1975-01-21 Delmar Chem Heterocyclic benzamide compounds
FR2244760B1 (cs) * 1973-09-25 1980-06-27 Ile De France
FR2299862B1 (en) * 1975-02-07 1978-07-21 Soc Et Scient Et Ind Substd. N-(1-benzylpyrrolidinyl-2-alkyl)benzamides - used as antiemetics, anti-ulcer agents and CNS active
FR2294698A1 (fr) * 1974-12-18 1976-07-16 Synthelabo Nouveaux derives des methoxy-2 benzamides substitues, leurs sels, leur preparation et les medicaments qui en renferment
IE42210B1 (en) * 1974-12-18 1980-06-18 Synthelabo 2-methoxy-benzamide derivatives

Also Published As

Publication number Publication date
US4294828A (en) 1981-10-13
PH15725A (en) 1983-03-18
IE790092L (en) 1979-07-20
YU5079A (en) 1983-06-30
SE7900380L (sv) 1979-07-21
SE460968B (sv) 1989-12-11
BG31497A3 (bg) 1982-01-15
DD141520A5 (de) 1980-05-07
PL116532B1 (en) 1981-06-30
IE47798B1 (en) 1984-06-27
PL212899A1 (cs) 1980-01-14
AR220574A1 (es) 1980-11-14
NZ189378A (en) 1983-03-15
GB2012765B (en) 1982-09-08
PT69068A (fr) 1979-02-01
AU4337379A (en) 1979-07-26
FI71126C (fi) 1986-11-24
SE8603773L (sv) 1986-09-09
YU42172B (en) 1988-06-30
NO790180L (no) 1979-07-23
RO80311A (ro) 1982-12-06
DK158346B (da) 1990-05-07
CS226181B2 (en) 1984-03-19
SE448874B (sv) 1987-03-23
US4401822A (en) 1983-08-30
LU80786A1 (fr) 1979-09-07
FI71126B (fi) 1986-08-14
MC1232A1 (fr) 1979-10-26
IN150226B (cs) 1982-08-21
ZA79219B (en) 1980-01-30
IT7947706A0 (it) 1979-01-18
IL56411A (en) 1982-09-30
DE2901181A1 (de) 1979-07-26
IL56411A0 (en) 1979-03-12
GR64431B (en) 1980-03-21
GB2012765A (en) 1979-08-01
NO151320C (no) 1985-04-17
CY1201A (en) 1983-12-31
CH637927A5 (fr) 1983-08-31
ATA39879A (de) 1983-12-15
EG14045A (en) 1983-09-30
RO76393A (ro) 1981-03-30
AU528561B2 (en) 1983-05-05
NL191707B (nl) 1995-12-01
OA06156A (fr) 1981-06-30
MX5793E (es) 1984-07-19
BE872585A (fr) 1979-06-07
DK158346C (da) 1990-10-08
JPS6049192B2 (ja) 1985-10-31
FI790182A7 (fi) 1979-07-21
SE8603773D0 (sv) 1986-09-09
PH22287A (en) 1988-07-22
CA1101430A (en) 1981-05-19
SU820659A3 (ru) 1981-04-07
NL191707C (nl) 1996-04-02
HK12184A (en) 1984-02-24
GB2083458A (en) 1982-03-24
AT377977B (de) 1985-05-28
ES476755A1 (es) 1979-06-01
GB2083458B (en) 1983-03-09
MX7623E (es) 1990-03-27
DE2901181C2 (de) 1984-07-19
YU25483A (en) 1983-10-31
BG31496A3 (bg) 1982-01-15
FR2415099A1 (fr) 1979-08-17
FR2415099B1 (cs) 1981-02-20
NO151320B (no) 1984-12-10
JPS54145658A (en) 1979-11-14
PL118151B1 (en) 1981-09-30
YU41278B (en) 1986-12-31
NL7900457A (nl) 1979-07-24
ES477782A1 (es) 1979-09-16
HU179793B (en) 1982-12-28
ZM579A1 (en) 1979-12-21
DK20979A (da) 1979-07-21
IT1164655B (it) 1987-04-15

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