AR102865A1 - Parejas de fusión para la producción de péptidos - Google Patents

Parejas de fusión para la producción de péptidos

Info

Publication number
AR102865A1
AR102865A1 ARP150103916A ARP150103916A AR102865A1 AR 102865 A1 AR102865 A1 AR 102865A1 AR P150103916 A ARP150103916 A AR P150103916A AR P150103916 A ARP150103916 A AR P150103916A AR 102865 A1 AR102865 A1 AR 102865A1
Authority
AR
Argentina
Prior art keywords
polypeptide
production
interest
fusion partner
peptides
Prior art date
Application number
ARP150103916A
Other languages
English (en)
Spanish (es)
Inventor
Jin Hongfan
R Bruck Torben
Chapman Adam
M Retallack Diane
Original Assignee
Pfenex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfenex Inc filed Critical Pfenex Inc
Publication of AR102865A1 publication Critical patent/AR102865A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21009—Enteropeptidase (3.4.21.9), i.e. enterokinase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
ARP150103916A 2014-12-01 2015-12-01 Parejas de fusión para la producción de péptidos AR102865A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462086119P 2014-12-01 2014-12-01

Publications (1)

Publication Number Publication Date
AR102865A1 true AR102865A1 (es) 2017-03-29

Family

ID=56092296

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150103916A AR102865A1 (es) 2014-12-01 2015-12-01 Parejas de fusión para la producción de péptidos

Country Status (16)

Country Link
US (2) US10118956B2 (enExample)
EP (1) EP3227455B1 (enExample)
JP (2) JP6817939B2 (enExample)
KR (1) KR102353262B1 (enExample)
CN (2) CN113444183B (enExample)
AR (1) AR102865A1 (enExample)
AU (1) AU2015355242B2 (enExample)
CA (1) CA2966358C (enExample)
DK (1) DK3227455T3 (enExample)
ES (1) ES2952405T3 (enExample)
MX (1) MX386884B (enExample)
NZ (1) NZ732400A (enExample)
RU (1) RU2017123283A (enExample)
SG (1) SG11201704362VA (enExample)
TW (1) TWI702289B (enExample)
WO (1) WO2016089782A1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113444183B (zh) 2014-12-01 2025-06-17 佩利肯科技控股公司 用于肽生产的融合伴侣
US10289612B2 (en) 2015-05-15 2019-05-14 Foogal Inc. Personal food inventory-based tracking
JP7784804B2 (ja) 2017-10-27 2025-12-12 フェネックス インク． 組み換えｅｒｗｉｎｉａアスパラギナーゼの製造のための方法
SG11202003614WA (en) 2017-10-27 2020-05-28 Pfenex Inc Method for production of recombinant e. coli asparaginase
WO2019143193A1 (ko) 2018-01-19 2019-07-25 주식회사 펩진 재조합 폴리펩타이드 생산용 n-말단 융합 파트너 및 이를 이용하여 재조합 폴리 펩타이드를 생산하는방법
CN108191981B (zh) * 2018-02-06 2020-11-03 美药星（南京）制药有限公司 一种利拉鲁肽中间体多肽的制备方法
KR102017540B1 (ko) * 2018-02-14 2019-09-03 주식회사 펩진 융합 폴리펩타이드를 이용하여 글루카곤 유사 펩타이드-1 또는 이의 유사체를 생산하는 방법
KR102009709B1 (ko) * 2018-02-14 2019-08-12 주식회사 펩진 융합 폴리펩타이드를 이용하여 인간 부갑상선 호르몬 1-84를 생산하는 방법
KR102017542B1 (ko) * 2018-02-14 2019-09-03 주식회사 펩진 융합 폴리펩타이드를 이용하여 글루카곤 유사 펩타이드-2 또는 이의 유사체를 생산하는 방법
CN108977423A (zh) * 2018-08-17 2018-12-11 集美大学 一种从猪肺中分离提纯血管紧张素转化酶的方法
KR102011291B1 (ko) * 2018-12-05 2019-10-21 주식회사 펩진 신규한 융합 폴리펩타이드 및 이를 이용하여 인간 부갑상선 호르몬 1-34를 생산하는 방법
MX2021006933A (es) 2018-12-13 2021-09-30 Huya Bioscience Int Llc Administración de sulcardina para el tratamiento de fibrilación auricular aguda.
CN110305223B (zh) * 2019-06-26 2022-05-13 重庆派金生物科技有限公司 重组串联融合蛋白制备目标多肽的方法
KR20210010366A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 글루카곤 유사 펩타이드-1 또는 이의 유사체 생산용 융합태그
KR20210010368A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 글루카곤 유사 펩타이드-2 또는 이의 유사체 생산용 융합태그
KR20210010367A (ko) * 2019-07-19 2021-01-27 주식회사 펩진 인간부갑상선호르몬1-34 생산용 융합태그
WO2021091304A1 (ko) * 2019-11-08 2021-05-14 한국해양과학기술원 신규한 인간 상피세포성장인자-tf 융합 단백질 및 이의 용도
CN113773400B (zh) * 2020-06-09 2023-08-18 宁波鲲鹏生物科技有限公司 一种门冬胰岛素衍生物及其应用
WO2022016118A2 (en) * 2020-07-17 2022-01-20 Cb Therapeutics, Inc. Prenyltransferase enzymes
CN113151296B (zh) * 2021-03-22 2022-09-13 云南中烟工业有限责任公司 一种烟草热激蛋白相关的基因及其应用
CN113025599B (zh) * 2021-04-02 2023-09-12 重庆科润生物医药研发有限公司 一种重组溶组织梭菌i型胶原酶及其制备方法和应用
CN112941058B (zh) * 2021-04-02 2023-12-05 重庆科润生物医药研发有限公司 一种重组溶组织梭菌ii型胶原酶及其制备方法和应用
US20230100757A1 (en) * 2021-06-10 2023-03-30 Pfenex Inc. Bacterial hosts for recombinant protein expression
WO2023012321A1 (en) * 2021-08-06 2023-02-09 Roche Diagnostics Gmbh Chimeric igg-fc-binding ligand polypeptide and uses thereof for igg affinity purification
US20240383959A1 (en) * 2021-09-09 2024-11-21 Northwestern University Cell-free methods and compositions comprising tagless therapeutic hormones
CN114350587B (zh) * 2022-01-24 2023-10-31 修实生物医药(南通)有限公司 一种基因重组串联表达利那洛肽的工程菌
CN115109766A (zh) * 2022-02-14 2022-09-27 上海理工大学 一种耐高温金属蛋白酶及其编码基因和应用
WO2024035782A1 (en) * 2022-08-10 2024-02-15 Aav Gene Therapeutics, Inc. Aav-mediated intramuscular delivery of insulin
WO2025081111A1 (en) * 2023-10-12 2025-04-17 The University Of Chicago Methods and compositions for characterizing rna-binding protein binding sites by in-situ reverse transcription-based sequencing

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4769326A (en) 1980-02-29 1988-09-06 The Regents Of The University Of California Expression linkers
US4551433A (en) 1981-05-18 1985-11-05 Genentech, Inc. Microbial hybrid promoters
US4755465A (en) 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
US5281532A (en) 1983-07-27 1994-01-25 Mycogen Corporation Pseudomas hosts transformed with bacillus endotoxin genes
US4695455A (en) 1985-01-22 1987-09-22 Mycogen Corporation Cellular encapsulation of pesticides produced by expression of heterologous genes
US4695462A (en) 1985-06-28 1987-09-22 Mycogen Corporation Cellular encapsulation of biological pesticides
GB8517071D0 (en) 1985-07-05 1985-08-14 Hoffmann La Roche Gram-positive expression control sequence
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
US5128130A (en) 1988-01-22 1992-07-07 Mycogen Corporation Hybrid Bacillus thuringiensis gene, plasmid and transformed Pseudomonas fluorescens
US5055294A (en) 1988-03-03 1991-10-08 Mycogen Corporation Chimeric bacillus thuringiensis crystal protein gene comprising hd-73 and berliner 1715 toxin genes, transformed and expressed in pseudomonas fluorescens
US5169760A (en) 1989-07-27 1992-12-08 Mycogen Corporation Method, vectors, and host cells for the control of expression of heterologous genes from lac operated promoters
US7150974B1 (en) 1991-04-05 2006-12-19 The General Hospital Corporation Parathyroid hormone receptor binding method
US7018809B1 (en) 1991-09-19 2006-03-28 Genentech, Inc. Expression of functional antibody fragments
CA2125467C (en) 1993-07-06 2001-02-06 Heinz Dobeli Process for producing hydrophobic polypeptides, proteins or peptides
US5935824A (en) 1996-01-31 1999-08-10 Technologene, Inc. Protein expression system
CA2198966C (en) 1996-03-04 2011-06-21 Yuji Suzuki Method for cleaving chimeric protein using processing enzyme
JPH1175879A (ja) * 1997-07-08 1999-03-23 Toyota Central Res & Dev Lab Inc プロテインジスルフィドイソメラーゼを含有する融合タンパク質をコードするｄｎａ
US5989868A (en) 1997-09-12 1999-11-23 The Board Of Regents Of The University Of Oklahoma Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli
DE69937272T2 (de) 1998-01-30 2008-07-10 Asubio Pharma Co., Ltd. Verfahren zur herstellung eines peptids mittels eines hilfspeptids
US6242219B1 (en) 1999-03-18 2001-06-05 Xoma (Us) Llc Methods for recombinant peptide production
WO2001098366A2 (en) 2000-06-19 2001-12-27 Dyax Corp. Enterokinase cleavage sequences and their use
JP2002262873A (ja) 2001-03-06 2002-09-17 Inst Of Physical & Chemical Res タンパク質ドメインの製造方法及びその方法により得られたドメインを用いるタンパク質の立体構造解析方法
KR100702373B1 (ko) * 2001-06-22 2007-04-02 에프. 호프만-라 로슈 아게 레트로바이러스 표면 당단백질을 함유하는 가용성 복합체
EP1417237B1 (en) 2001-07-26 2011-04-06 Advanced Protein Technologies Corp. Process for preparation of polypeptides of interest from fusion peolypeptides
DE60325611D1 (de) 2002-07-03 2009-02-12 Dow Global Technologies Inc Benzoat- und antranilatinduzierbare promotoren
US7390639B2 (en) 2002-08-09 2008-06-24 National Research Council Of Canada Staphylococcal nuclease fusion proteins for the production of recombinant peptides
US7208585B2 (en) 2002-09-18 2007-04-24 Genencor International, Inc. Protein purification
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
CA2522221A1 (en) 2003-04-18 2004-10-28 Sekisui Chemical Co., Ltd. Immunogen, composition for immunological use, and method of producing a ntibody using the same
JP2005110591A (ja) 2003-10-08 2005-04-28 Sekisui Chem Co Ltd 蛋白質の分離方法
MXPA06005634A (es) 2003-11-19 2006-08-23 Dow Global Technologies Inc Sistemas mejorados de expresion de proteinas.
PL2336153T3 (pl) 2003-11-21 2016-08-31 Pfenex Inc Udoskonalone systemy ekspresji z układem wydzielania SEC
WO2005049847A1 (en) 2003-11-24 2005-06-02 Novo Nordisk A/S Fusion proteins and methods of cleavage of such proteins
KR101183720B1 (ko) 2004-01-16 2012-09-17 다우 글로벌 테크놀로지스 엘엘씨 슈도모나스 플루오레센스에서의 포유류 단백질의 발현
WO2006078273A2 (en) 2004-04-26 2006-07-27 The United States Of America As Represented By Teh Secretary Of Health And Human Services, Nih Methods and compositions for producing recombinant proteins
EP1748071A4 (en) 2004-05-21 2009-01-07 Takara Bio Inc PROCESS FOR PRODUCTION OF POLYPEPTIDE
AU2005269527B2 (en) * 2004-07-26 2011-12-01 Pfenex Inc. Process for improved protein expression by strain engineering
ATE540981T1 (de) 2004-08-11 2012-01-15 Univ Ramot Lösliche fusionsproteine enthaltend heterologe polypeptide
JP4897792B2 (ja) 2005-04-20 2012-03-14 ビロメッド カンパニー， リミテッド 融合タンパク質の分離のための組成物および方法
JP5176114B2 (ja) 2005-06-06 2013-04-03 フェネックス インコーポレイテッド 細菌宿主細胞におけるマンニトール誘導のプロモーター系
AU2007254993A1 (en) 2006-05-30 2007-12-13 Dow Global Technologies Llc Codon optimization method
CN101495644B (zh) 2006-05-30 2012-11-07 陶氏环球技术有限责任公司 密码子优化方法
EP1873251A1 (en) 2006-06-29 2008-01-02 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Expression vector(s) for enhanced expression of a protein of interest in eukaryotic or prokaryotic host cells
KR101491867B1 (ko) 2007-01-31 2015-02-10 피페넥스 인크. 증가된 발현을 위한 박테리아 리더 서열
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2615172A1 (en) 2007-04-27 2013-07-17 Pfenex Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
MX2010001612A (es) 2007-08-09 2010-07-01 Usv Ltd Novedoso procedimiento ortogonal para la purificacion de la hormona paratiroidea humana recombinante (rhpth) (1-34).
US8809059B2 (en) * 2007-09-21 2014-08-19 Basf Plant Science Gmbh Plants with increased yield
WO2009086132A2 (en) 2007-12-20 2009-07-09 University Of Southern California Design of spacers to increase the expression of recombinant fusion proteins
EP2127678A1 (en) 2008-05-26 2009-12-02 Roche Diagnostics GmbH SlpA as a tool for recombinant protein and enzyme technology
JP2010006745A (ja) * 2008-06-27 2010-01-14 Sekisui Chem Co Ltd 融合タンパク質、融合タンパク質固定化担体、化合物のスクリーニング方法、スクリーニング用組成物、並びに、スクリーニング用キット
EP2370470B1 (en) 2008-12-04 2016-10-05 Korea Research Institute of Bioscience and Biotechnology Screening of abundantly secreted proteins and their use as fusion partners for the production of recombinant proteins
US8455218B2 (en) 2010-04-01 2013-06-04 Pfenex, Inc. Methods for G-CSF production in a Pseudomonas host cell
US8853380B2 (en) 2010-06-04 2014-10-07 Lupin Limited Modified SAK gene for the production of recombinant proteins
AR086250A1 (es) 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
CN113444183B (zh) 2014-12-01 2025-06-17 佩利肯科技控股公司 用于肽生产的融合伴侣
US20180023098A1 (en) 2015-02-13 2018-01-25 Sekisui Chemical Co., Ltd. Nucleic acid, fusion protein, recombined cell, and isoprene or cyclic terpene production method

Also Published As

Publication number Publication date
ES2952405T3 (es) 2023-10-31
JP2017536835A (ja) 2017-12-14
JP7148579B2 (ja) 2022-10-05
NZ732400A (en) 2021-07-30
US10981968B2 (en) 2021-04-20
SG11201704362VA (en) 2017-06-29
BR112017011662A2 (pt) 2018-02-27
EP3227455A4 (en) 2018-07-04
CN107532190A (zh) 2018-01-02
CA2966358C (en) 2021-12-07
RU2017123283A (ru) 2019-01-09
JP6817939B2 (ja) 2021-01-20
AU2015355242A1 (en) 2017-06-22
KR102353262B1 (ko) 2022-01-18
CN107532190B (zh) 2021-07-09
AU2015355242B2 (en) 2020-10-08
KR20170085129A (ko) 2017-07-21
JP2021003117A (ja) 2021-01-14
EP3227455A1 (en) 2017-10-11
MX2017006866A (es) 2017-11-15
HK1245336A1 (en) 2018-08-24
MX386884B (es) 2025-03-19
CA2966358A1 (en) 2016-06-09
US20190135889A1 (en) 2019-05-09
CN113444183B (zh) 2025-06-17
TWI702289B (zh) 2020-08-21
EP3227455B1 (en) 2023-07-12
US20160159877A1 (en) 2016-06-09
TW201629226A (zh) 2016-08-16
DK3227455T3 (da) 2023-08-21
US10118956B2 (en) 2018-11-06
CN113444183A (zh) 2021-09-28
WO2016089782A1 (en) 2016-06-09

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