CY1123654T1 - Αποδεσμευση πρωτεϊνης me βαση βακτηρια - Google Patents

Αποδεσμευση πρωτεϊνης me βαση βακτηρια

Info

Publication number
CY1123654T1
CY1123654T1 CY20201101044T CY201101044T CY1123654T1 CY 1123654 T1 CY1123654 T1 CY 1123654T1 CY 20201101044 T CY20201101044 T CY 20201101044T CY 201101044 T CY201101044 T CY 201101044T CY 1123654 T1 CY1123654 T1 CY 1123654T1
Authority
CY
Cyprus
Prior art keywords
bacteria
based protein
protein release
release
domains
Prior art date
Application number
CY20201101044T
Other languages
English (en)
Inventor
Simon ITTIG
Marlise AMSTUTZ
Christoph Kasper
Original Assignee
Universität Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universität Basel filed Critical Universität Basel
Publication of CY1123654T1 publication Critical patent/CY1123654T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Η παρούσα εφεύρεση αναφέρεται σε ανασυνδυασμένα αρνητικά κατά Gram βακτηριακά στελέχη και στη χρήση αυτών για την αποδέσμευση επαναλαμβανόμενων επικρατειών ετερόλογης πρωτεΐνης ή δύο ή περισσότερων επικρατειών διαφορετικών ετερόλογων πρωτεϊνών σε ευκαρυωτικά κύτταρα.
CY20201101044T 2015-11-19 2020-11-05 Αποδεσμευση πρωτεϊνης me βαση βακτηρια CY1123654T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15195493 2015-11-19
PCT/EP2016/078087 WO2017085235A1 (en) 2015-11-19 2016-11-17 Bacteria-based protein delivery

Publications (1)

Publication Number Publication Date
CY1123654T1 true CY1123654T1 (el) 2022-03-24

Family

ID=54697465

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20201101044T CY1123654T1 (el) 2015-11-19 2020-11-05 Αποδεσμευση πρωτεϊνης me βαση βακτηρια

Country Status (24)

Country Link
US (1) US11702663B2 (el)
EP (1) EP3377634B1 (el)
JP (1) JP6937752B2 (el)
KR (1) KR20180081798A (el)
CN (1) CN108884466B (el)
AU (1) AU2016355975B2 (el)
BR (1) BR112018009782A8 (el)
CA (1) CA3005380A1 (el)
CY (1) CY1123654T1 (el)
DK (1) DK3377634T3 (el)
EA (1) EA039922B1 (el)
ES (1) ES2830251T3 (el)
HK (1) HK1256138A1 (el)
HR (1) HRP20201792T1 (el)
HU (1) HUE051184T2 (el)
IL (1) IL259050B2 (el)
LT (1) LT3377634T (el)
PL (1) PL3377634T3 (el)
PT (1) PT3377634T (el)
RS (1) RS61046B1 (el)
SG (1) SG11201803642WA (el)
SI (1) SI3377634T1 (el)
WO (1) WO2017085235A1 (el)
ZA (1) ZA201803901B (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014071182A1 (en) 2012-11-01 2014-05-08 Massachusetts Institute Of Technology Directed evolution of synthetic gene cluster
BR112016027196B1 (pt) * 2014-05-21 2023-05-02 Universität Basel Vetor e cepa bacteriana gram-negativa recombinante
RU2769873C2 (ru) 2015-07-13 2022-04-07 Пивот Байо, Инк. Способы и композиции для улучшения признаков растений
CA3003563A1 (en) 2015-11-19 2017-05-26 Universitat Basel Virulence attenuated bacteria for treatment of malignant solid tumors
US11518789B2 (en) 2016-12-20 2022-12-06 Universitaet Basel Virulence attenuated bacteria based protein delivery
CN114480463A (zh) * 2020-10-26 2022-05-13 南京吉芮康生物科技研究院有限公司 一种减毒沙门氏菌分泌表达rbd结构域蛋白的新型冠状病毒疫苗抗原递呈系统及其应用
AU2021370840A1 (en) * 2020-10-27 2023-06-22 T3 Pharmaceuticals Ag Bacteria based protein delivery
PE20240636A1 (es) * 2021-03-25 2024-03-27 T3 Pharmaceuticals Ag Combinaciones farmaceuticas para el tratamiento del cancer
CN117362451B (zh) * 2023-12-04 2024-03-08 北京质肽生物医药科技有限公司 一种包含tev蛋白酶的融合蛋白、制备方法及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965381A (en) 1998-03-06 1999-10-12 Ludwig Institute For Cancer Research Delivery of proteins into eukaryotic cells with recombinant yersinia
US6596509B1 (en) * 1998-07-10 2003-07-22 Cornell Research Foundation, Inc. Recombinant constructs and systems for secretion of proteins via type III secretion systems
US20020160502A1 (en) 2000-09-26 2002-10-31 Roger Williams Hospital Recombinant BCG vaccines for the prevention and treatment of cancer
AU2002312778A1 (en) * 2001-03-26 2002-10-08 Universite Catholique De Louvain Type iii bacterial strains for use in medicine
FR2862312B1 (fr) * 2003-11-13 2006-02-17 Univ Grenoble 1 Outil de transfert et de production de proteines mettant en oeuvre le systeme de secretion de type iii de pseudomonas
EP1661912A1 (en) * 2004-11-29 2006-05-31 Xigen S.A. Fusion protein comprising a BH3-domain of a BH3-only protein
WO2007044406A2 (en) 2005-10-04 2007-04-19 Ludwig Institute For Cancer Research Methods for stimulating an immune response using bacterial antigen delivery system
WO2008019183A2 (en) * 2006-05-18 2008-02-14 The Regents Of The University Of California Biopolymer and protein production using type iii secretion systems of gram negative bacteria
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
JP5670875B2 (ja) 2008-03-17 2015-02-18 ウニベルジテーツクリニクム ミュンスター カーゴ分子の送達ビヒクルおよび炎症反応を免疫調節するための生物学的治療剤としてのＹｏｐＭ
EP3049526B1 (en) * 2013-09-24 2021-02-24 Medicenna Therapeutics, Inc. Interleukin-4 receptor-binding fusion proteins and uses thereof
US10143743B2 (en) * 2013-11-18 2018-12-04 Yale University Non-replicating bacterial nanoparticle delivery system and methods of use
BR112016027196B1 (pt) * 2014-05-21 2023-05-02 Universität Basel Vetor e cepa bacteriana gram-negativa recombinante
CA3003563A1 (en) 2015-11-19 2017-05-26 Universitat Basel Virulence attenuated bacteria for treatment of malignant solid tumors
US11518789B2 (en) 2016-12-20 2022-12-06 Universitaet Basel Virulence attenuated bacteria based protein delivery

Also Published As

Publication number Publication date
HUE051184T2 (hu) 2021-03-01
HRP20201792T1 (hr) 2020-12-25
CA3005380A1 (en) 2017-05-26
IL259050A (en) 2018-07-31
EA039922B1 (ru) 2022-03-28
EP3377634A1 (en) 2018-09-26
ZA201803901B (en) 2019-04-24
SG11201803642WA (en) 2018-06-28
CN108884466B (zh) 2022-06-03
HK1256138A1 (zh) 2019-09-13
KR20180081798A (ko) 2018-07-17
US20190194670A1 (en) 2019-06-27
JP2019500027A (ja) 2019-01-10
EA201890914A1 (ru) 2018-12-28
RS61046B1 (sr) 2020-12-31
BR112018009782A2 (pt) 2018-11-06
CN108884466A (zh) 2018-11-23
AU2016355975B2 (en) 2022-12-08
US11702663B2 (en) 2023-07-18
SI3377634T1 (sl) 2021-01-29
AU2016355975A1 (en) 2018-05-10
ES2830251T3 (es) 2021-06-03
EP3377634B1 (en) 2020-08-12
PT3377634T (pt) 2020-11-16
IL259050B2 (en) 2024-03-01
WO2017085235A1 (en) 2017-05-26
LT3377634T (lt) 2020-12-28
JP6937752B2 (ja) 2021-09-22
IL259050B1 (en) 2023-11-01
BR112018009782A8 (pt) 2019-02-26
DK3377634T3 (da) 2020-11-16
PL3377634T3 (pl) 2021-03-08

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