BR112018009782A2 - liberação de proteína baseada em bactérias - Google Patents
liberação de proteína baseada em bactériasInfo
- Publication number
- BR112018009782A2 BR112018009782A2 BR112018009782A BR112018009782A BR112018009782A2 BR 112018009782 A2 BR112018009782 A2 BR 112018009782A2 BR 112018009782 A BR112018009782 A BR 112018009782A BR 112018009782 A BR112018009782 A BR 112018009782A BR 112018009782 A2 BR112018009782 A2 BR 112018009782A2
- Authority
- BR
- Brazil
- Prior art keywords
- bacterial
- based protein
- protein release
- domains
- gram
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 230000001580 bacterial effect Effects 0.000 title abstract 2
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
a presente invenção refere-se a cepas bacterianas recombinantes gram-negativas e ao uso das mesmas para a liberação de domínios repetidos de uma proteína heteróloga ou dois ou mais domínios de diferentes proteínas heterólogas nas células eucariotas.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15195493 | 2015-11-19 | ||
| EP15195493.0 | 2015-11-19 | ||
| PCT/EP2016/078087 WO2017085235A1 (en) | 2015-11-19 | 2016-11-17 | Bacteria-based protein delivery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112018009782A2 true BR112018009782A2 (pt) | 2018-11-06 |
| BR112018009782A8 BR112018009782A8 (pt) | 2019-02-26 |
| BR112018009782B1 BR112018009782B1 (pt) | 2024-05-14 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| DK3377634T3 (da) | 2020-11-16 |
| US11702663B2 (en) | 2023-07-18 |
| US20190194670A1 (en) | 2019-06-27 |
| CN108884466A (zh) | 2018-11-23 |
| IL259050A (en) | 2018-07-31 |
| HK1256138A1 (zh) | 2019-09-13 |
| JP2019500027A (ja) | 2019-01-10 |
| CN108884466B (zh) | 2022-06-03 |
| IL259050B2 (en) | 2024-03-01 |
| ES2830251T3 (es) | 2021-06-03 |
| HRP20201792T1 (hr) | 2020-12-25 |
| SG11201803642WA (en) | 2018-06-28 |
| KR20180081798A (ko) | 2018-07-17 |
| AU2016355975B2 (en) | 2022-12-08 |
| CY1123654T1 (el) | 2022-03-24 |
| HUE051184T2 (hu) | 2021-03-01 |
| CA3005380A1 (en) | 2017-05-26 |
| EP3377634B1 (en) | 2020-08-12 |
| JP6937752B2 (ja) | 2021-09-22 |
| PT3377634T (pt) | 2020-11-16 |
| BR112018009782A8 (pt) | 2019-02-26 |
| EA039922B1 (ru) | 2022-03-28 |
| EA201890914A1 (ru) | 2018-12-28 |
| WO2017085235A1 (en) | 2017-05-26 |
| AU2016355975A1 (en) | 2018-05-10 |
| SI3377634T1 (sl) | 2021-01-29 |
| PL3377634T3 (pl) | 2021-03-08 |
| EP3377634A1 (en) | 2018-09-26 |
| ZA201803901B (en) | 2019-04-24 |
| LT3377634T (lt) | 2020-12-28 |
| IL259050B1 (en) | 2023-11-01 |
| RS61046B1 (sr) | 2020-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/11/2016, OBSERVADAS AS CONDICOES LEGAIS |