BR112018009782A8 - liberação de proteína baseada em bactérias - Google Patents

liberação de proteína baseada em bactérias

Info

Publication number
BR112018009782A8
BR112018009782A8 BR112018009782A BR112018009782A BR112018009782A8 BR 112018009782 A8 BR112018009782 A8 BR 112018009782A8 BR 112018009782 A BR112018009782 A BR 112018009782A BR 112018009782 A BR112018009782 A BR 112018009782A BR 112018009782 A8 BR112018009782 A8 BR 112018009782A8
Authority
BR
Brazil
Prior art keywords
bacterial
based protein
protein release
domains
gram
Prior art date
Application number
BR112018009782A
Other languages
English (en)
Other versions
BR112018009782A2 (pt
Inventor
Kasper Christoph
Amstutz Marlise
Ittig Simon
Original Assignee
Univ Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Basel filed Critical Univ Basel
Publication of BR112018009782A2 publication Critical patent/BR112018009782A2/pt
Publication of BR112018009782A8 publication Critical patent/BR112018009782A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

a presente invenção refere-se a cepas bacterianas recombinantes gram-negativas e ao uso das mesmas para a liberação de domínios repetidos de uma proteína heteróloga ou dois ou mais domínios de diferentes proteínas heterólogas nas células eucariotas.
BR112018009782A 2015-11-19 2016-11-17 liberação de proteína baseada em bactérias BR112018009782A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15195493 2015-11-19
PCT/EP2016/078087 WO2017085235A1 (en) 2015-11-19 2016-11-17 Bacteria-based protein delivery

Publications (2)

Publication Number Publication Date
BR112018009782A2 BR112018009782A2 (pt) 2018-11-06
BR112018009782A8 true BR112018009782A8 (pt) 2019-02-26

Family

ID=54697465

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018009782A BR112018009782A8 (pt) 2015-11-19 2016-11-17 liberação de proteína baseada em bactérias

Country Status (24)

Country Link
US (1) US11702663B2 (pt)
EP (1) EP3377634B1 (pt)
JP (1) JP6937752B2 (pt)
KR (1) KR20180081798A (pt)
CN (1) CN108884466B (pt)
AU (1) AU2016355975B2 (pt)
BR (1) BR112018009782A8 (pt)
CA (1) CA3005380A1 (pt)
CY (1) CY1123654T1 (pt)
DK (1) DK3377634T3 (pt)
EA (1) EA039922B1 (pt)
ES (1) ES2830251T3 (pt)
HK (1) HK1256138A1 (pt)
HR (1) HRP20201792T1 (pt)
HU (1) HUE051184T2 (pt)
IL (1) IL259050B2 (pt)
LT (1) LT3377634T (pt)
PL (1) PL3377634T3 (pt)
PT (1) PT3377634T (pt)
RS (1) RS61046B1 (pt)
SG (1) SG11201803642WA (pt)
SI (1) SI3377634T1 (pt)
WO (1) WO2017085235A1 (pt)
ZA (1) ZA201803901B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014071182A1 (en) 2012-11-01 2014-05-08 Massachusetts Institute Of Technology Directed evolution of synthetic gene cluster
CN115960919A (zh) * 2014-05-21 2023-04-14 巴塞尔大学 基于细菌的蛋白质递送
RU2769873C2 (ru) 2015-07-13 2022-04-07 Пивот Байо, Инк. Способы и композиции для улучшения признаков растений
AU2016358257B2 (en) 2015-11-19 2023-08-17 Universitat Basel Virulence attenuated bacteria for treatment of malignant solid tumors
PT3559022T (pt) 2016-12-20 2021-08-19 Univ Basel Distribuição de proteínas baseada em bactérias com virulência atenuada
CN111587287A (zh) 2017-10-25 2020-08-25 皮沃特生物股份有限公司 用于改良固氮的工程微生物的方法和组合物
WO2022087856A1 (zh) * 2020-10-26 2022-05-05 南京吉芮康生物科技研究院有限公司 一种减毒沙门氏菌分泌表达rbd结构域蛋白的新型冠状病毒疫苗抗原递呈系统及其应用
KR20230098197A (ko) * 2020-10-27 2023-07-03 티3 파마슈티컬스 아게 세균 기반한 단백질 전달
CN117440829A (zh) * 2021-03-25 2024-01-23 T3制药股份公司 用于治疗癌症的药物组合
CN117362451B (zh) * 2023-12-04 2024-03-08 北京质肽生物医药科技有限公司 一种包含tev蛋白酶的融合蛋白、制备方法及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965381A (en) * 1998-03-06 1999-10-12 Ludwig Institute For Cancer Research Delivery of proteins into eukaryotic cells with recombinant yersinia
WO2000002996A2 (en) * 1998-07-10 2000-01-20 Cornell Research Foundation, Inc. Recombinant constructs and systems for secretion of proteins via type iii secretion systems
WO2002026819A2 (en) 2000-09-26 2002-04-04 Roger Williams Hospital Recombinant bcg vaccines for the prevention and treatment of cancer
WO2002077249A2 (en) * 2001-03-26 2002-10-03 Universite Catholique De Louvain Type iii bacterial strains for use in medicine
FR2862312B1 (fr) * 2003-11-13 2006-02-17 Univ Grenoble 1 Outil de transfert et de production de proteines mettant en oeuvre le systeme de secretion de type iii de pseudomonas
EP1661912A1 (en) * 2004-11-29 2006-05-31 Xigen S.A. Fusion protein comprising a BH3-domain of a BH3-only protein
JP2009510169A (ja) 2005-10-04 2009-03-12 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ 細菌抗原送達系を用いた免疫応答を刺激するための方法
WO2008019183A2 (en) * 2006-05-18 2008-02-14 The Regents Of The University Of California Biopolymer and protein production using type iii secretion systems of gram negative bacteria
TW200819540A (en) 2006-07-11 2008-05-01 Genelux Corp Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
AU2009226972B2 (en) 2008-03-17 2014-05-29 Gerhard Heusipp YopM as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
CN113563478A (zh) * 2013-09-24 2021-10-29 梅迪塞纳医疗股份有限公司 白介素-4受体结合融合蛋白及其应用
US10143743B2 (en) * 2013-11-18 2018-12-04 Yale University Non-replicating bacterial nanoparticle delivery system and methods of use
CN115960919A (zh) * 2014-05-21 2023-04-14 巴塞尔大学 基于细菌的蛋白质递送
AU2016358257B2 (en) 2015-11-19 2023-08-17 Universitat Basel Virulence attenuated bacteria for treatment of malignant solid tumors
PT3559022T (pt) 2016-12-20 2021-08-19 Univ Basel Distribuição de proteínas baseada em bactérias com virulência atenuada

Also Published As

Publication number Publication date
EP3377634B1 (en) 2020-08-12
LT3377634T (lt) 2020-12-28
HK1256138A1 (zh) 2019-09-13
CN108884466B (zh) 2022-06-03
US20190194670A1 (en) 2019-06-27
EP3377634A1 (en) 2018-09-26
AU2016355975B2 (en) 2022-12-08
CA3005380A1 (en) 2017-05-26
BR112018009782A2 (pt) 2018-11-06
ES2830251T3 (es) 2021-06-03
DK3377634T3 (da) 2020-11-16
SG11201803642WA (en) 2018-06-28
SI3377634T1 (sl) 2021-01-29
IL259050B2 (en) 2024-03-01
US11702663B2 (en) 2023-07-18
AU2016355975A1 (en) 2018-05-10
HRP20201792T1 (hr) 2020-12-25
PT3377634T (pt) 2020-11-16
EA201890914A1 (ru) 2018-12-28
JP6937752B2 (ja) 2021-09-22
ZA201803901B (en) 2019-04-24
IL259050A (en) 2018-07-31
CY1123654T1 (el) 2022-03-24
HUE051184T2 (hu) 2021-03-01
JP2019500027A (ja) 2019-01-10
WO2017085235A1 (en) 2017-05-26
RS61046B1 (sr) 2020-12-31
EA039922B1 (ru) 2022-03-28
KR20180081798A (ko) 2018-07-17
PL3377634T3 (pl) 2021-03-08
IL259050B1 (en) 2023-11-01
CN108884466A (zh) 2018-11-23

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Legal Events

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/11/2016, OBSERVADAS AS CONDICOES LEGAIS