BR112017002549A2 - mutações em proteínas de grupos de ferro e enxofre que aperfeiçoam a utilização de xilose - Google Patents

mutações em proteínas de grupos de ferro e enxofre que aperfeiçoam a utilização de xilose

Info

Publication number
BR112017002549A2
BR112017002549A2 BR112017002549A BR112017002549A BR112017002549A2 BR 112017002549 A2 BR112017002549 A2 BR 112017002549A2 BR 112017002549 A BR112017002549 A BR 112017002549A BR 112017002549 A BR112017002549 A BR 112017002549A BR 112017002549 A2 BR112017002549 A2 BR 112017002549A2
Authority
BR
Brazil
Prior art keywords
iron
xylose
enhance
protein group
sulfur protein
Prior art date
Application number
BR112017002549A
Other languages
English (en)
Inventor
Froehlich Allan
HENNINGSEN Brooks
M Zelle Rintze
COVALLA Sean
Original Assignee
Lallemand Hungary Liquidity Man Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lallemand Hungary Liquidity Man Llc filed Critical Lallemand Hungary Liquidity Man Llc
Publication of BR112017002549A2 publication Critical patent/BR112017002549A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C12N9/92—Glucose isomerase (5.3.1.5; 5.3.1.9; 5.3.1.18)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/06—Ethanol, i.e. non-beverage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y503/00—Intramolecular oxidoreductases (5.3)
    • C12Y503/01—Intramolecular oxidoreductases (5.3) interconverting aldoses and ketoses (5.3.1)
    • C12Y503/01005—Xylose isomerase (5.3.1.5)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

é provida uma célula hospedeira modificada que compreende (a) uma ou mais mutações em um ou mais genes endógenos que codificam uma proteína associada ao metabolismo de ferro; e (b) pelo menos um gene que codifica um polipeptídeo tendo uma atividade de isomerase de xilose, e métodos para seu uso.
BR112017002549A 2014-08-11 2015-08-11 mutações em proteínas de grupos de ferro e enxofre que aperfeiçoam a utilização de xilose BR112017002549A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462035748P 2014-08-11 2014-08-11
PCT/IB2015/056101 WO2016024215A1 (en) 2014-08-11 2015-08-11 Mutations in iron-sulfur cluster proteins that improve xylose utilization

Publications (1)

Publication Number Publication Date
BR112017002549A2 true BR112017002549A2 (pt) 2018-03-06

Family

ID=54186239

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017002549A BR112017002549A2 (pt) 2014-08-11 2015-08-11 mutações em proteínas de grupos de ferro e enxofre que aperfeiçoam a utilização de xilose

Country Status (7)

Country Link
US (3) US9920312B2 (pt)
EP (1) EP3180419A1 (pt)
CN (1) CN108064269A (pt)
BR (1) BR112017002549A2 (pt)
CA (1) CA2957707C (pt)
MX (1) MX2017001824A (pt)
WO (1) WO2016024215A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10508272B2 (en) * 2014-04-11 2019-12-17 Wisconsin Alumni Research Foundation Recombinant yeast having enhanced xylose fermentation capabilities and methods of use
US10006057B2 (en) * 2014-09-10 2018-06-26 Wisconsin Alumni Research Foundation Recombinant yeast having enhanced gamma valerolactone tolerance and methods of use
US11667680B2 (en) * 2016-03-18 2023-06-06 Lallemand Hungary Liquidity Management Llc Regulation of the RAS/cAMP/PKA signaling pathway in yeasts for obtaining a fermentation product during fermentation
WO2018073107A1 (en) * 2016-10-19 2018-04-26 Dsm Ip Assets B.V. Eukaryotic cell comprising xylose isomerase
CA3091962A1 (en) 2017-09-19 2019-03-28 Lallemand Hungary Liquidity Management Llc Acetate toxicity tolerance in recombinant microbial host cells
CN113736675B (zh) * 2020-05-29 2023-11-21 中国科学院分子植物科学卓越创新中心 一种提高酿酒酵母转化木糖能力的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2337856A1 (en) * 2008-09-29 2011-06-29 Butamax Advanced Biofuels Llc INCREASED HETEROLOGOUS Fe-S ENZYME ACTIIVTY IN YEAST
BR112012012492A2 (pt) 2009-11-24 2019-09-24 Gevo Inc métodos para aumentar atividade de diidróxi ácido desidratase para aperfeiçoar produção de combustíveis, produtos químicos e aminoácidos
WO2011079388A1 (en) * 2009-12-30 2011-07-07 Iogen Energy Corporation Modified yeast strains exhibiting enhanced fermentation of lignocellulosic hydrolysates
EP2536821B1 (en) 2010-02-17 2018-06-13 Butamax(TM) Advanced Biofuels LLC Improving activity of fe-s cluster requiring proteins
WO2012071121A1 (en) 2010-11-24 2012-05-31 Gevo, Inc. Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
WO2012097091A2 (en) 2011-01-12 2012-07-19 Verdezyne, Inc. Engineered microorganisms with enhanced fermentation activity
WO2012135591A2 (en) * 2011-03-30 2012-10-04 Amyris, Inc. Microbial isoprenoid production using a heterologous dxp pathway
BR112013025753A8 (pt) 2011-04-05 2018-06-12 Lallemand Hungary Liquidity Man Llc Métodos para aprimoramento do rendimento de produto e produção em um micro-organismo através da adição de aceptores de elétrons alternativos
WO2013003219A1 (en) 2011-06-30 2013-01-03 Codexis, Inc. Pentose fermentation by a recombinant microorganism
CN104321436A (zh) * 2011-12-30 2015-01-28 布特马斯先进生物燃料有限责任公司 醇类的发酵生产
EP2825647A4 (en) 2012-03-15 2015-10-14 Codexis Inc METHODS OF GENE REARRANGING
US9650624B2 (en) * 2012-12-28 2017-05-16 Butamax Advanced Biofuels Llc DHAD variants for butanol production
US10508272B2 (en) 2014-04-11 2019-12-17 Wisconsin Alumni Research Foundation Recombinant yeast having enhanced xylose fermentation capabilities and methods of use

Also Published As

Publication number Publication date
US9920312B2 (en) 2018-03-20
CN108064269A (zh) 2018-05-22
US20200115697A1 (en) 2020-04-16
EP3180419A1 (en) 2017-06-21
US11306304B2 (en) 2022-04-19
CA2957707C (en) 2022-05-10
CA2957707A1 (en) 2016-02-18
WO2016024215A1 (en) 2016-02-18
US20180251750A1 (en) 2018-09-06
US10465181B2 (en) 2019-11-05
MX2017001824A (es) 2017-05-23
US20160040153A1 (en) 2016-02-11

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC (HU)

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]