AR099566A1 - Método para producir colágeno en alta concentración para usar como material medicinal - Google Patents

Método para producir colágeno en alta concentración para usar como material medicinal

Info

Publication number
AR099566A1
AR099566A1 ARP150100553A ARP150100553A AR099566A1 AR 099566 A1 AR099566 A1 AR 099566A1 AR P150100553 A ARP150100553 A AR P150100553A AR P150100553 A ARP150100553 A AR P150100553A AR 099566 A1 AR099566 A1 AR 099566A1
Authority
AR
Argentina
Prior art keywords
collagen
mammalian tissue
solution
concentrate
stirring
Prior art date
Application number
ARP150100553A
Other languages
English (en)
Inventor
Sam Suh Dong
Ho Chang Cheong
Woo Jeong Hyeong
Chil Yoo Ji
Ken Yeo Se
Original Assignee
Sewon Cellontech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sewon Cellontech Co Ltd filed Critical Sewon Cellontech Co Ltd
Publication of AR099566A1 publication Critical patent/AR099566A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Water Supply & Treatment (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Materials For Medical Uses (AREA)
  • Cosmetics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Un método para producir colágeno en alta concentración para usar como un material medicinal, en donde el método incluye: lavar el tejido mamífero; triturar el tejido de mamífero lavado y luego depositar el tejido de mamífero en alcohol etílico; someter el tejido de mamífero a un tratamiento enzimático colocando el tejido de mamífero en ácido fosfórico, agua purificada, y pepsina, seguido por agitación y una reacción; agregar cloruro de sodio al colágeno tratado con enzima, seguido por agitación, y luego permitir que coagule el colágeno; disolver el colágeno coagulado en agua purificada, filtrar la solución de colágeno usando una membrana de filtración, eliminar materiales de bajo peso molecular incluyendo pepsina y cloruro de sodio, y materiales más pequeños que los poros de una membrana de filtración de flujo tangencial en la solución de colágeno para concentrar el colágeno usando un aparato para filtración en flujo tangencial; filtrar en esterilidad la solución de colágeno, que se concentra usando el aparato para filtración en flujo tangencial, coagular el colágeno usando un tanque de reacción de neutralización a pH entre 6,0 y 8,0, y luego eliminar la solución no coagulada para concentrar el colágeno; y concentrar el colágeno concentrado usando una centrífuga, y colocar el colágeno concentrado en un dispositivo de mezclado, seguido por agitación.
ARP150100553A 2014-11-21 2015-02-24 Método para producir colágeno en alta concentración para usar como material medicinal AR099566A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020140163800A KR101531479B1 (ko) 2014-11-21 2014-11-21 의료용 재료로 사용하기 위한 고농도 콜라겐 제조방법

Publications (1)

Publication Number Publication Date
AR099566A1 true AR099566A1 (es) 2016-08-03

Family

ID=53519806

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100553A AR099566A1 (es) 2014-11-21 2015-02-24 Método para producir colágeno en alta concentración para usar como material medicinal

Country Status (13)

Country Link
US (1) US11292827B2 (es)
EP (1) EP3222299B1 (es)
JP (1) JP6383877B2 (es)
KR (1) KR101531479B1 (es)
CN (1) CN107155305B (es)
AR (1) AR099566A1 (es)
AU (1) AU2014412124B2 (es)
BR (1) BR112017010619B1 (es)
ES (1) ES2791281T3 (es)
HU (1) HUE049757T2 (es)
PL (1) PL3222299T3 (es)
PT (1) PT3222299T (es)
WO (1) WO2016080578A1 (es)

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CN107320765A (zh) * 2016-04-29 2017-11-07 深圳兰度生物材料有限公司 一种重组纤维结构胶原蛋白海绵的制备方法
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CN109601790A (zh) * 2018-11-29 2019-04-12 东阿阿胶股份有限公司 一种胶杞红枣饮及其制备方法
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KR102196026B1 (ko) * 2020-04-06 2020-12-29 주식회사 티앤알바이오팹 동물 조직 유래 생체 소재의 제조방법, 이에 따라 제조된 동물 조직 유래 생체 소재 및 이를 이용한 3차원 프린팅 방법
WO2022073090A1 (pt) 2020-10-06 2022-04-14 Janaina De Andrea Dernowsek Ltda Método para a produção de uma composição de proteínas de matriz extracelular e produto obtido por tal método
CN113230892B (zh) * 2021-05-27 2023-11-28 广州创尔生物技术股份有限公司 一种用于超滤纯化胶原蛋白的超滤膜及纯化胶原蛋白的方法
KR20230007119A (ko) * 2021-07-05 2023-01-12 주식회사 메디카코리아 pH 적정을 이용하여 콜라겐의 수득량 또는 함량을 증진시키는 방법
CN114032623B (zh) * 2022-01-10 2022-03-29 天新福（北京）医疗器材股份有限公司 一种高产率胶原海绵的制备工艺
CN115429873A (zh) * 2022-08-03 2022-12-06 浙江珂瑞康生物医疗科技有限公司 一种天然未变性注射用胶原溶液及其制备方法

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Also Published As

Publication number Publication date
EP3222299A4 (en) 2018-07-04
ES2791281T3 (es) 2020-11-03
AU2014412124A1 (en) 2017-06-08
WO2016080578A1 (ko) 2016-05-26
AU2014412124B2 (en) 2018-09-27
BR112017010619A2 (pt) 2018-02-14
JP2017537692A (ja) 2017-12-21
HUE049757T2 (hu) 2020-10-28
BR112017010619B1 (pt) 2020-11-03
KR101531479B1 (ko) 2015-06-26
JP6383877B2 (ja) 2018-08-29
PT3222299T (pt) 2020-05-19
EP3222299B1 (en) 2020-03-25
CN107155305B (zh) 2020-11-27
PL3222299T3 (pl) 2020-11-02
US20170334969A1 (en) 2017-11-23
CN107155305A (zh) 2017-09-12
US11292827B2 (en) 2022-04-05
EP3222299A1 (en) 2017-09-27

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