AR096350A1 - Composición farmacéutica para administración por vía oral para su uso para la prevención y/o el tratamiento de una enfermedad cardiovascular - Google Patents
Composición farmacéutica para administración por vía oral para su uso para la prevención y/o el tratamiento de una enfermedad cardiovascularInfo
- Publication number
- AR096350A1 AR096350A1 ARP140101992A ARP140101992A AR096350A1 AR 096350 A1 AR096350 A1 AR 096350A1 AR P140101992 A ARP140101992 A AR P140101992A AR P140101992 A ARP140101992 A AR P140101992A AR 096350 A1 AR096350 A1 AR 096350A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical composition
- hmg
- composition according
- coa reductase
- reductase inhibitor
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una composición farmacéutica que incluye un inhibidor de la HMG-CoA reductasa, en particular, una estatina y ácido acetilsalicílico de manera que se minimiza la interacción del ácido acetilsalicílico con la estatina, para la prevención o el tratamiento de enfermedades cardiovasculares. Reivindicación 1: Una composición farmacéutica para administración por vía oral para su uso para la prevención y/o el tratamiento de una enfermedad cardiovascular, caracterizada porque comprende: (a) un acido acetilsalicílico como primer agente activo; y (b) un inhibidor de la HMG-CoA reductasa como segundo agente activo, en la que dicho inhibidor de la HMG-CoA reductasa se selecciona de entre atorvastatina y rosuvastatina y sales de las mismas, donde (i) se proporciona en forma de dos o más unidades de dosificación recubiertas donde dicho recubrimiento comprende un polímero hidrosoluble y está sustancialmente libre de un polímero no hidrosoluble o un polímero entérico y siendo la cantidad del recubrimiento de dichas unidades (i) superior a 6 mg/cm²; presentando dichas unidades una curva de liberación no modificada; y (ii) se proporciona en forma de una o mas unidades de dosificación recubiertas; y donde dichas unidades de dosificación se seleccionan del grupo que consiste en comprimidos, partículas, gránulos, píldoras y cápsulas. Reivindicación 12: Composición farmacéutica según cualquiera de las reivindicaciones anteriores, caracterizada porque la cantidad de ácido acetilsalicílico de dicha forma de dosificación está en el intervalo de 10 a 400 mg por unidad de dosificación. Reivindicación 13: Composición farmacéutica según cualquiera de las reivindicaciones anteriores, caracterizada porque la cantidad de inhibidor de la HMG-CoA reductasa de dicha forma de dosificación está en el intervalo de 5 a 40 mg por unidad de dosificación. Reivindicación 14: Composición farmacéutica según cualquiera de las reivindicaciones anteriores, caracterizada porque el inhibidor de la HMG-CoA reductasa está en forma de dos o más unidades de dosificación. Reivindicación 15: Composición farmacéutica según cualquiera de las reivindicaciones anteriores, caracterizada porque comprende además una o más unidades de dosificación de un inhibidor del sistema renina-angiotensina como tercer agente activo. Reivindicación 16: Composición farmacéutica según la reivindicación 15, caracterizada porque el inhibidor del sistema renina-angiotensina es un inhibidor de la ACE seleccionado del grupo que consiste en ramipril, captopril, cilazapril, delapril, enalapril, fentiapril, fosinopril, indolapril, lisinopril, perindopril, pivopril, quinapril, espirapril, trandolapril y zofenopril y sales y ésteres farmacéuticamente aceptables de los mismos, o un bloqueante del receptor de angiotensina seleccionado del grupo que consiste en Iosartan, valsartán, irbesartán, candesartán, telmisartán, eprosartan, tasosartan, zolarsartán, azilsartán, olmesartán, saprisartán, forasartán, E-4177 y ZD-8731, y sales y ésteres farmacéuticamente aceptables de los mismos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13170909.9A EP2810644A1 (en) | 2013-06-06 | 2013-06-06 | Oral formulation for the treatment of cardiovascular diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR096350A1 true AR096350A1 (es) | 2015-12-23 |
Family
ID=48569993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP140101992A AR096350A1 (es) | 2013-06-06 | 2014-05-20 | Composición farmacéutica para administración por vía oral para su uso para la prevención y/o el tratamiento de una enfermedad cardiovascular |
Country Status (42)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170137101A (ko) * | 2015-04-16 | 2017-12-12 | 노파르티스 아게 | 리보시클립 정제 |
| CN111135149B (zh) * | 2018-11-04 | 2021-05-11 | 张家港市中医医院 | 一种瑞舒伐他汀钙片及其制备方法 |
| CN110693929A (zh) * | 2019-09-09 | 2020-01-17 | 安徽中医药大学 | 复方药物组份在治疗脑梗死恢复期中的应用 |
| PL4299063T3 (pl) | 2022-06-30 | 2024-06-10 | Ferrer Internacional, S.A. | Kapsułki doustne zawierające tabletki atorwastatyny wykazujące odpowiedni profil rozpuszczania i biodostępność |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4231938A (en) | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| WO1984002131A1 (en) | 1982-11-22 | 1984-06-07 | Sandoz Ag | Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| WO1997038694A1 (en) | 1996-04-17 | 1997-10-23 | Merck & Co., Inc. | Combination therapy for reducing the risks associated with cardiovascular disease |
| US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
| US6197959B1 (en) | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| US6376672B1 (en) | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
| US6448323B1 (en) | 1999-07-09 | 2002-09-10 | Bpsi Holdings, Inc. | Film coatings and film coating compositions based on polyvinyl alcohol |
| KR20030025903A (ko) | 2000-02-10 | 2003-03-29 | 비피에스아이 홀딩스, 인코포레이션. | 아크릴 장용 코팅 조성물 |
| US6576256B2 (en) * | 2001-08-28 | 2003-06-10 | The Brigham And Women's Hospital, Inc. | Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| US6669955B2 (en) * | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
| US20040115265A1 (en) | 2002-12-11 | 2004-06-17 | Loutfy Benkerrour | Multilayered tablet containing pravastatin and aspirin and method |
| WO2004080488A2 (de) | 2003-03-10 | 2004-09-23 | Bayer Healthcare Ag | Kombinationspräparate von acetylsalicylsäure mit einem hmg-coa-reduktase |
| US20050026992A1 (en) * | 2003-07-28 | 2005-02-03 | Sasmal Badal Kumar | Treatment and prevention of cardiovascular events |
| ES2395724T3 (es) | 2003-08-20 | 2013-02-14 | Shionogi & Co., Ltd. | Nueva composición de recubrimiento |
| BRPI0417017A (pt) | 2003-11-26 | 2007-02-21 | Novartis Ag | compostos orgánicos |
| US20090098201A1 (en) * | 2004-06-28 | 2009-04-16 | Bio Intellectual Property Services (Bio Ips) Llc | Composition and Method for Treatment and Prevention of Atherosclerosis |
| EP1856032A1 (en) | 2005-03-11 | 2007-11-21 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides useful as renin inhibitors |
| US20070009591A1 (en) | 2005-07-07 | 2007-01-11 | Trivedi Jay S | ACE inhibitor formulation |
| US20070116756A1 (en) | 2005-11-23 | 2007-05-24 | Dr. Reddy's Laboratories Limited | Stable pharmaceutical compositions |
| US7427414B2 (en) | 2006-01-18 | 2008-09-23 | Astron Research Limited | Modified release oral dosage form using co-polymer of polyvinyl acetate |
| CN101176725A (zh) * | 2006-07-14 | 2008-05-14 | 兰贝克赛实验室有限公司 | 辛伐他汀和阿司匹林的稳定剂型 |
| SI2120878T1 (sl) * | 2007-02-09 | 2014-12-31 | Alphapharm Pty Ltd | Dozirna oblika, ki vsebuje dve aktivni farmacevtski sestavini v različnih fizičnih oblikah |
| WO2009022821A2 (en) | 2007-08-13 | 2009-02-19 | Hanall Pharmaceutical Company. Ltd | Combination preparation comprising inhibitor of hmg-coa reductase and aspirin and method for manufacturing the same |
| US20090076062A1 (en) | 2007-09-13 | 2009-03-19 | Juergen Klaus Maibaum | Organic Compounds |
| DK2273985T3 (en) * | 2008-03-28 | 2016-04-25 | Ferrer Int | Capsule for the prevention of cardiovascular diseases |
| ES2690741T3 (es) * | 2009-02-11 | 2018-11-22 | Cadila Pharmaceuticals Ltd. | Composición farmacéutica estable para la aterosclerosis |
| AU2010242938A1 (en) * | 2009-04-30 | 2011-11-17 | Dr. Reddy's Laboratories Ltd. | Fixed dose drug combination formulations |
| JP2013510145A (ja) | 2009-11-09 | 2013-03-21 | メディヴィル・アクチエボラーグ | １，３−オキサゾリジン化合物およびレニン阻害剤としてのそれらの使用方法 |
| KR101193493B1 (ko) * | 2010-02-02 | 2012-10-22 | 한미사이언스 주식회사 | 소수성 첨가제가 함유된 분리막으로 코팅된 아스피린 및 ＨＭＧ?ＣｏＡ 환원효소 억제제를 포함하는 복합제제 |
| CN102049049A (zh) * | 2010-11-27 | 2011-05-11 | 王定豪 | 包含阿司匹林盐和他汀类药物的药物组合物 |
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2013
- 2013-06-06 EP EP13170909.9A patent/EP2810644A1/en not_active Withdrawn
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2014
- 2014-05-20 AR ARP140101992A patent/AR096350A1/es not_active Application Discontinuation
- 2014-06-04 TW TW103119340A patent/TWI630928B/zh active
- 2014-06-05 PT PT147289409T patent/PT2986281T/pt unknown
- 2014-06-05 AU AU2014276883A patent/AU2014276883B2/en active Active
- 2014-06-05 EA EA201600012A patent/EA028969B1/ru unknown
- 2014-06-05 JP JP2016517607A patent/JP6151854B2/ja active Active
- 2014-06-05 WO PCT/EP2014/061735 patent/WO2014195421A1/en active Application Filing
- 2014-06-05 BR BR112015030350-1A patent/BR112015030350B1/pt active IP Right Grant
- 2014-06-05 CA CA2912350A patent/CA2912350C/en active Active
- 2014-06-05 EP EP16204436.6A patent/EP3175849A1/en not_active Withdrawn
- 2014-06-05 PL PL14728940T patent/PL2986281T3/pl unknown
- 2014-06-05 KR KR1020157033956A patent/KR101839665B1/ko active IP Right Grant
- 2014-06-05 CU CUP2015000173A patent/CU24326B1/es unknown
- 2014-06-05 ES ES14728940.9T patent/ES2620078T3/es active Active
- 2014-06-05 SG SG11201509353QA patent/SG11201509353QA/en unknown
- 2014-06-05 TN TN2015000501A patent/TN2015000501A1/en unknown
- 2014-06-05 AP AP2015008882A patent/AP2015008882A0/xx unknown
- 2014-06-05 MD MDA20160001A patent/MD4475C1/ro active IP Right Grant
- 2014-06-05 MX MX2015015753A patent/MX347801B/es active IP Right Grant
- 2014-06-05 MY MYPI2015704409A patent/MY181272A/en unknown
- 2014-06-05 US US14/893,902 patent/US10617699B2/en active Active
- 2014-06-05 DK DK14728940.9T patent/DK2986281T3/en active
- 2014-06-05 MA MA38699A patent/MA38699B1/fr unknown
- 2014-06-05 HU HUE14728940A patent/HUE033458T2/en unknown
- 2014-06-05 EP EP14728940.9A patent/EP2986281B1/en active Active
- 2014-06-05 GE GEAP201414027A patent/GEP201706743B/en unknown
- 2014-06-05 SI SI201430175A patent/SI2986281T1/sl unknown
- 2014-06-05 PE PE2015002519A patent/PE20160051A1/es unknown
- 2014-06-05 NZ NZ714707A patent/NZ714707A/en unknown
- 2014-06-05 RS RS20170286A patent/RS55786B1/sr unknown
- 2014-06-05 UA UAA201512002A patent/UA113806C2/uk unknown
- 2014-06-06 CN CN201410249657.1A patent/CN104224804A/zh active Pending
- 2014-06-06 CN CN202110259129.4A patent/CN113143888A/zh active Pending
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2015
- 2015-05-28 HK HK15105100.9A patent/HK1204562A1/xx unknown
- 2015-11-12 IL IL242569A patent/IL242569B/en active IP Right Grant
- 2015-11-16 ZA ZA2015/08452A patent/ZA201508452B/en unknown
- 2015-12-01 EC ECIEPI201550273A patent/ECSP15050273A/es unknown
- 2015-12-03 CR CR20150635A patent/CR20150635A/es unknown
- 2015-12-04 PH PH12015502706A patent/PH12015502706A1/en unknown
- 2015-12-04 CL CL2015003561A patent/CL2015003561A1/es unknown
- 2015-12-04 NI NI201500171A patent/NI201500171A/es unknown
- 2015-12-05 SA SA515370243A patent/SA515370243B1/ar unknown
- 2015-12-08 DO DO2015000296A patent/DOP2015000296A/es unknown
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2017
- 2017-03-17 CY CY20171100340T patent/CY1118766T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |