MD20160001A2 - Utilizarea unei formulări orale pentru tratamentul bolilor cardiovasculare - Google Patents

Utilizarea unei formulări orale pentru tratamentul bolilor cardiovasculare

Info

Publication number
MD20160001A2
MD20160001A2 MDA20160001A MD20160001A MD20160001A2 MD 20160001 A2 MD20160001 A2 MD 20160001A2 MD A20160001 A MDA20160001 A MD A20160001A MD 20160001 A MD20160001 A MD 20160001A MD 20160001 A2 MD20160001 A2 MD 20160001A2
Authority
MD
Moldova
Prior art keywords
treatment
cardiovascular diseases
oral formulation
statin
acetylsalicylic acid
Prior art date
Application number
MDA20160001A
Other languages
English (en)
Russian (ru)
Other versions
MD4475C1 (ro
MD4475B1 (ro
Inventor
Sanz Pablo Martin
Hurtado Javier Urbano
Original Assignee
Ferrer Internacional, S.A.
Fundacion Centro National De Investigaciones Cardiovasculares Carlos Iii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48569993&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20160001(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ferrer Internacional, S.A., Fundacion Centro National De Investigaciones Cardiovasculares Carlos Iii filed Critical Ferrer Internacional, S.A.
Publication of MD20160001A2 publication Critical patent/MD20160001A2/ro
Publication of MD4475B1 publication Critical patent/MD4475B1/ro
Publication of MD4475C1 publication Critical patent/MD4475C1/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Prezenta invenţie se referă la o compoziţie farmaceutică, care include un inhibitor al reductazei HMG-CoA, în special o statină şi acid acetilsalicilic, într-o modalitate pentru a minimiza interacţiunea acidului acetilsalicilic cu statina, pentru utilizare în prevenirea sau tratamentul bolilor cardiovasculare.
MDA20160001A 2013-06-06 2014-06-05 Utilizare a unei formulări cu administrare orală pentru tratamentul bolilor cardiovasculare MD4475C1 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13170909.9A EP2810644A1 (en) 2013-06-06 2013-06-06 Oral formulation for the treatment of cardiovascular diseases
PCT/EP2014/061735 WO2014195421A1 (en) 2013-06-06 2014-06-05 Oral formulation for the treatment of cardiovascular diseases

Publications (3)

Publication Number Publication Date
MD20160001A2 true MD20160001A2 (ro) 2016-05-31
MD4475B1 MD4475B1 (ro) 2017-04-30
MD4475C1 MD4475C1 (ro) 2017-11-30

Family

ID=48569993

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20160001A MD4475C1 (ro) 2013-06-06 2014-06-05 Utilizare a unei formulări cu administrare orală pentru tratamentul bolilor cardiovasculare

Country Status (42)

Country Link
US (1) US10617699B2 (ro)
EP (3) EP2810644A1 (ro)
JP (1) JP6151854B2 (ro)
KR (1) KR101839665B1 (ro)
CN (2) CN104224804A (ro)
AP (1) AP2015008882A0 (ro)
AR (1) AR096350A1 (ro)
AU (1) AU2014276883B2 (ro)
BR (1) BR112015030350B1 (ro)
CA (1) CA2912350C (ro)
CL (1) CL2015003561A1 (ro)
CR (1) CR20150635A (ro)
CU (1) CU24326B1 (ro)
CY (1) CY1118766T1 (ro)
DK (1) DK2986281T3 (ro)
DO (1) DOP2015000296A (ro)
EA (1) EA028969B1 (ro)
EC (1) ECSP15050273A (ro)
ES (1) ES2620078T3 (ro)
GE (1) GEP201706743B (ro)
HK (1) HK1204562A1 (ro)
HU (1) HUE033458T2 (ro)
IL (1) IL242569B (ro)
MA (1) MA38699B1 (ro)
MD (1) MD4475C1 (ro)
MX (1) MX347801B (ro)
MY (1) MY181272A (ro)
NI (1) NI201500171A (ro)
NZ (1) NZ714707A (ro)
PE (1) PE20160051A1 (ro)
PH (1) PH12015502706B1 (ro)
PL (1) PL2986281T3 (ro)
PT (1) PT2986281T (ro)
RS (1) RS55786B1 (ro)
SA (1) SA515370243B1 (ro)
SG (1) SG11201509353QA (ro)
SI (1) SI2986281T1 (ro)
TN (1) TN2015000501A1 (ro)
TW (1) TWI630928B (ro)
UA (1) UA113806C2 (ro)
WO (1) WO2014195421A1 (ro)
ZA (1) ZA201508452B (ro)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018514523A (ja) * 2015-04-16 2018-06-07 ノバルティス アーゲー リボシクリブ錠剤
CN111135149B (zh) * 2018-11-04 2021-05-11 张家港市中医医院 一种瑞舒伐他汀钙片及其制备方法
CN110693929A (zh) * 2019-09-09 2020-01-17 安徽中医药大学 复方药物组份在治疗脑梗死恢复期中的应用
EP4299063B1 (en) * 2022-06-30 2024-05-01 Ferrer Internacional, S.A. Oral capsules comprising atorvastatin tablets showing suitable dissolution profile and bioavailability

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
WO1984002131A1 (en) 1982-11-22 1984-06-07 Sandoz Ag Analogs of mevalolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals
MY119161A (en) 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
AU732465B2 (en) * 1996-04-17 2001-04-26 Merck & Co., Inc. Combination therapy for reducing the risks associated with cardiovascular disease
US6235311B1 (en) 1998-03-18 2001-05-22 Bristol-Myers Squibb Company Pharmaceutical composition containing a combination of a statin and aspirin and method
US6197959B1 (en) 1999-04-27 2001-03-06 Hoffmann-La Roche Inc. Piperidine derivatives
US6376672B1 (en) 1999-04-27 2002-04-23 Hoffmann-La Roche Inc. Naphthalenylmethoxypiperidines as renin inhibitors
US6448323B1 (en) 1999-07-09 2002-09-10 Bpsi Holdings, Inc. Film coatings and film coating compositions based on polyvinyl alcohol
CA2397832C (en) 2000-02-10 2009-11-03 Bpsi Holdings, Inc. Acrylic enteric coating compositions
US6669955B2 (en) * 2001-08-28 2003-12-30 Longwood Pharmaceutical Research, Inc. Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US6576256B2 (en) * 2001-08-28 2003-06-10 The Brigham And Women's Hospital, Inc. Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin
US20040115265A1 (en) 2002-12-11 2004-06-17 Loutfy Benkerrour Multilayered tablet containing pravastatin and aspirin and method
WO2004080488A2 (de) 2003-03-10 2004-09-23 Bayer Healthcare Ag Kombinationspräparate von acetylsalicylsäure mit einem hmg-coa-reduktase
EP1648422A4 (en) 2003-07-28 2007-09-19 Reddys Lab Inc Dr TREATMENT AND PREVENTION OF CARDIOVASCULAR ACCIDENTS
JP4680061B2 (ja) 2003-08-20 2011-05-11 塩野義製薬株式会社 新規コーティング組成物
AU2004293178B8 (en) 2003-11-26 2009-01-08 Novartis Ag Organic compounds
CA2571447A1 (en) * 2004-06-28 2006-01-05 Howard J Smith & Associates Pty Ltd Composition and method for treatment and prevention of atherosclerosis
US20080176947A1 (en) 2005-03-11 2008-07-24 Peter Herold Heterocyclic-Substituted Alkanamides Useful as Renin Inhibitors
US20070009591A1 (en) 2005-07-07 2007-01-11 Trivedi Jay S ACE inhibitor formulation
US20070116756A1 (en) 2005-11-23 2007-05-24 Dr. Reddy's Laboratories Limited Stable pharmaceutical compositions
US7427414B2 (en) 2006-01-18 2008-09-23 Astron Research Limited Modified release oral dosage form using co-polymer of polyvinyl acetate
CN101176725A (zh) * 2006-07-14 2008-05-14 兰贝克赛实验室有限公司 辛伐他汀和阿司匹林的稳定剂型
US9095519B2 (en) * 2007-02-09 2015-08-04 Alphapharm Pty Ltd Dosage form containing two or more active pharmaceutical ingredients in different physical forms
EP2180891A4 (en) 2007-08-13 2010-12-29 Hanall Biopharma Co Ltd COMBINATION PREPARATION WITH HMG COA REDUCTASE INHIBITORS AND ASPIRIN AND METHOD FOR THE PRODUCTION THEREOF
US20090076062A1 (en) 2007-09-13 2009-03-19 Juergen Klaus Maibaum Organic Compounds
CA2720800C (en) * 2008-03-28 2013-07-30 Ferrer Internacional S.A. Capsule for the prevention of cardiovascular diseases
CN102480954B (zh) * 2009-02-11 2015-03-18 卡帝拉药物有限公司 用于动脉粥样硬化的稳定的药物组合物
AU2010242938A1 (en) * 2009-04-30 2011-11-17 Dr. Reddy's Laboratories Ltd. Fixed dose drug combination formulations
CA2777455A1 (en) 2009-11-09 2011-05-12 Novadex Pharmaceuticals Ab Novel 1,3-oxazolidine compounds and their use as renin inhibitors
KR101193493B1 (ko) * 2010-02-02 2012-10-22 한미사이언스 주식회사 소수성 첨가제가 함유된 분리막으로 코팅된 아스피린 및 ＨＭＧ?ＣｏＡ 환원효소 억제제를 포함하는 복합제제
CN102049049A (zh) * 2010-11-27 2011-05-11 王定豪 包含阿司匹林盐和他汀类药物的药物组合物

Also Published As

Publication number Publication date
HK1204562A1 (en) 2015-11-27
DOP2015000296A (es) 2016-12-30
EA201600012A1 (ru) 2016-07-29
SA515370243B1 (ar) 2016-09-19
SG11201509353QA (en) 2015-12-30
BR112015030350A2 (pt) 2017-07-25
ES2620078T3 (es) 2017-06-27
JP2016520135A (ja) 2016-07-11
SI2986281T1 (sl) 2017-07-31
CU20150173A7 (es) 2016-06-29
EP3175849A1 (en) 2017-06-07
CN113143888A (zh) 2021-07-23
AP2015008882A0 (en) 2015-11-30
TW201536357A (zh) 2015-10-01
JP6151854B2 (ja) 2017-06-21
KR20160014622A (ko) 2016-02-11
CR20150635A (es) 2016-06-10
EP2986281A1 (en) 2016-02-24
EP2986281B1 (en) 2016-12-21
CA2912350A1 (en) 2014-12-11
MD4475C1 (ro) 2017-11-30
CY1118766T1 (el) 2017-07-12
NZ714707A (en) 2019-04-26
MY181272A (en) 2020-12-21
CL2015003561A1 (es) 2016-06-10
CN104224804A (zh) 2014-12-24
ZA201508452B (en) 2017-02-22
UA113806C2 (xx) 2017-03-10
AU2014276883A1 (en) 2015-11-26
PE20160051A1 (es) 2016-01-25
RS55786B1 (sr) 2017-07-31
DK2986281T3 (en) 2017-04-03
US10617699B2 (en) 2020-04-14
PL2986281T3 (pl) 2017-06-30
CU24326B1 (es) 2018-03-13
AR096350A1 (es) 2015-12-23
ECSP15050273A (es) 2017-07-31
TWI630928B (zh) 2018-08-01
IL242569B (en) 2018-12-31
GEP201706743B (en) 2017-09-25
PH12015502706A1 (en) 2016-03-14
MA38699B1 (fr) 2017-09-29
MD4475B1 (ro) 2017-04-30
WO2014195421A1 (en) 2014-12-11
AU2014276883B2 (en) 2017-04-20
US20160106763A1 (en) 2016-04-21
HUE033458T2 (en) 2017-12-28
MX2015015753A (es) 2016-08-03
BR112015030350B1 (pt) 2022-11-29
PH12015502706B1 (en) 2016-03-14
TN2015000501A1 (en) 2017-04-06
MX347801B (es) 2017-05-15
KR101839665B1 (ko) 2018-03-16
PT2986281T (pt) 2017-03-29
MA38699A1 (fr) 2017-01-31
CA2912350C (en) 2017-04-04
EA028969B1 (ru) 2018-01-31
NI201500171A (es) 2019-05-07
EP2810644A1 (en) 2014-12-10

Similar Documents

Publication Publication Date Title
PH12017501306A1 (en) Inhibitors of histone demethylases
WO2014062720A3 (en) Methods of treating cancer
MX2012003555A (es) Composicion farmaceutica que comprende acido graso omega-3 y derivado hidroxi de una estatina y metodos para usar la misma.
UA118177C2 (uk) Композиція для лікування гіперліпідемії, яка містить похідну оксинтомодуліну
MX2022001796A (es) Metodos y composiciones para inhibir los sintomas asociados con la veisalgia.
PH12015502706B1 (en) Oral formulation for the treatment of cardiovascular diseases
MX2015013755A (es) Formulacion farmaceutica para uso en el tratamiento y/o prevencion de restenosis.
MA40590A (fr) Composition pharmaceutique et combinaison thérapeutique comprenant un inhibiteur de protéine de transfert d'ester de cholestéryle et des inhibiteurs de hmg-coa réductase
EP3085364A4 (en) Pharmaceutical combined preparation containing hmg-coa reductase inhibitor and cholesterol absorption inhibitor
MX2015007945A (es) Usos y métodos para el tratamiento de enfermedades o afecciones hepáticas.
SG10202000597UA (en) PHARMACEUTICAL COMPOSITION COMPRISING AN HMG-CoA REDUCTASE INHIBITOR AND AN ACE INHIBITOR
MX2013002503A (es) Combinacion de inhibidores de hdac con farmacos para trombocitopenia.
ES2524645B1 (es) Formulación oral para el tratamiento de enfermedades cardiovasculares
MX2012013052A (es) Asociacion de inhibidores de la xantina oxidasa y la instantina y su uso.
UA92638U (ru) Способ профилактики возникновения первичных кардиальных конечных точек у больных нестабильной стенокардией с коморбидной артериальной гипертензией
SA515360233B1 (ar) مثبطات إنزيمات هستون ديميثيلاز
UA91070U (uk) Спосіб профілактики та корекції запальних захворювань на донозологічному рівні
MX345917B (es) Composiciones analgesicas que comprenden quercetina mas ketorolaco.
UA59396U (ru) Применение композиций нестероидных противовоспалительных средств с кофеином как препаратов с антиэкссудативной активностью

Legal Events

Date Code Title Description
FG4A Patent for invention issued