WO2012052834A3 - Multiple unit particulate system comprising metoprolol succinate - Google Patents

Multiple unit particulate system comprising metoprolol succinate Download PDF

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Publication number
WO2012052834A3
WO2012052834A3 PCT/IB2011/002516 IB2011002516W WO2012052834A3 WO 2012052834 A3 WO2012052834 A3 WO 2012052834A3 IB 2011002516 W IB2011002516 W IB 2011002516W WO 2012052834 A3 WO2012052834 A3 WO 2012052834A3
Authority
WO
WIPO (PCT)
Prior art keywords
extended release
multiple unit
release pellets
metoprolol succinate
metoprolol
Prior art date
Application number
PCT/IB2011/002516
Other languages
French (fr)
Other versions
WO2012052834A2 (en
Inventor
Sunil Deviprasad Tiwari
Vijayendrakumar Virendrakumarji Redasani
Prasad Shrikantrao Joshi
Vaibhav Narayan Sawarkar
Ankur Janak Shah
Original Assignee
Inventia Healthcare Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inventia Healthcare Private Limited filed Critical Inventia Healthcare Private Limited
Publication of WO2012052834A2 publication Critical patent/WO2012052834A2/en
Publication of WO2012052834A3 publication Critical patent/WO2012052834A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

The invention provides extended release pharmaceutical compositions comprising metoprolol or a pharmaceutically acceptable salt thereof such as metoprolol succinate wherein the composition is in the form of multiple unit extended release pellets that are compressed into tablets. The extended release pellets of the invention comprise of water soluble or water swellable inert core, the drug layer and extended release polymer layer comprising atleast one water insoluble polymer. These extended release pellets are compressed into tablets such that dissolution profile of the extended release pellets remains substantially unaffected.
PCT/IB2011/002516 2010-10-21 2011-10-19 Multiple unit particulate system comprising metoprolol succinate WO2012052834A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2921MU2010 2010-10-21
IN2921/MUM/2010 2010-10-21

Publications (2)

Publication Number Publication Date
WO2012052834A2 WO2012052834A2 (en) 2012-04-26
WO2012052834A3 true WO2012052834A3 (en) 2012-06-21

Family

ID=45975667

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2011/002516 WO2012052834A2 (en) 2010-10-21 2011-10-19 Multiple unit particulate system comprising metoprolol succinate

Country Status (1)

Country Link
WO (1) WO2012052834A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107666913B (en) 2015-03-03 2021-11-26 萨尼奥纳有限责任公司 Tesofensine, beta-receptor blocker combination formulations
CN107595795A (en) * 2017-08-30 2018-01-19 北京华素制药股份有限公司 A kind of Metoprolol succinate sustained-release tablets and preparation method thereof
WO2020144146A1 (en) 2019-01-07 2020-07-16 Saniona A/S Tesofensine for reduction of body weight in prader-willi patients
CA3176183A1 (en) 2020-04-22 2021-10-28 Jorgen Drejer Treatment of hypothalamic obesity
WO2022074681A1 (en) * 2020-10-08 2022-04-14 Harman Finochem Limited Pharmaceutical compositions with enhanced blend uniformity and content uniformity
AU2022220942A1 (en) * 2021-02-12 2023-08-24 Lyrus Life Sciences Pvt. Ltd. Extended release multiple unit pellet system composition and its process for the preparation

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050008701A1 (en) * 2003-07-11 2005-01-13 Mongkol Sriwongjanva Formulation and process for drug loaded cores
US20090208570A1 (en) * 2006-03-28 2009-08-20 Prashant Manohar Mandaogade Extended Release Dosage forms of Metoprolol
US20100255105A1 (en) * 2009-04-03 2010-10-07 Zaklady Farmaceutyczne Polpharma S.A. Extended release pharmaceutical composition comprising metoprolol succinate
US20100255093A1 (en) * 2009-03-03 2010-10-07 Xenoport, Inc. Sustained release oral dosage forms of an r-baclofen prodrug

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050008701A1 (en) * 2003-07-11 2005-01-13 Mongkol Sriwongjanva Formulation and process for drug loaded cores
US20090208570A1 (en) * 2006-03-28 2009-08-20 Prashant Manohar Mandaogade Extended Release Dosage forms of Metoprolol
US20100255093A1 (en) * 2009-03-03 2010-10-07 Xenoport, Inc. Sustained release oral dosage forms of an r-baclofen prodrug
US20100255105A1 (en) * 2009-04-03 2010-10-07 Zaklady Farmaceutyczne Polpharma S.A. Extended release pharmaceutical composition comprising metoprolol succinate

Also Published As

Publication number Publication date
WO2012052834A2 (en) 2012-04-26

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