CY1106813T1 - Χρηση αναστολεων του συστηματος ρενινης-αγγειοτενσινης - Google Patents

Χρηση αναστολεων του συστηματος ρενινης-αγγειοτενσινης

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Publication number
CY1106813T1
CY1106813T1 CY20071101077T CY071101077T CY1106813T1 CY 1106813 T1 CY1106813 T1 CY 1106813T1 CY 20071101077 T CY20071101077 T CY 20071101077T CY 071101077 T CY071101077 T CY 071101077T CY 1106813 T1 CY1106813 T1 CY 1106813T1
Authority
CY
Cyprus
Prior art keywords
renin
angiotensin system
system inhibitors
trandolapril
inhibitor
Prior art date
Application number
CY20071101077T
Other languages
English (en)
Inventor
Hugh Edward Montgomery
John Francis Martin
Jorge Daniel Erusalimsky
Original Assignee
Ark Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26312447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1106813(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9722026.3A external-priority patent/GB9722026D0/en
Priority claimed from GBGB9810855.8A external-priority patent/GB9810855D0/en
Application filed by Ark Therapeutics Limited filed Critical Ark Therapeutics Limited
Publication of CY1106813T1 publication Critical patent/CY1106813T1/el

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Abstract

Χρησιμοποιείται αναστολέας του συστήματος ρενίνης-αγγειοτενσίνης για την παρασκευή φαρμάκου για την θεραπευτική αγωγή ή πρόληψη εγκεφαλικού επεισοδίου ή της υποτροπής του. Ο αναστολέας επιλέγεται από κιναπρίλη, καπτοπρίλη, λισινοπρίλη, περινδοπρίλη, τρανδολαπρίλη, εναλαπρίλη, μοεξιπρίλη, φοσινοπρίλη, ραμιπρίλη, σιλαζαπρίλη, ιμιδαπρίλη, σπιραπρίλη, τεμοκαπρίλη, βεναζεπρίλη, αλακεπρίλη, κεροναπρίλη, δελαπρίλη, μοβελτιπρίλη, τρανδολαπρίλη, λοσαρτάνη, βαλσαρτάνη, ιρβεσαρτάνη, κανδεσαρτάνη, επροσαρτάνη, τασοσαρτάνη και τελμισαρτάνη.
CY20071101077T 1997-10-17 2007-08-09 Χρηση αναστολεων του συστηματος ρενινης-αγγειοτενσινης CY1106813T1 (el)

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GBGB9722026.3A GB9722026D0 (en) 1997-10-17 1997-10-17 Use of compounds
GBGB9810855.8A GB9810855D0 (en) 1998-05-20 1998-05-20 Use of compounds
EP98947698A EP1023067B2 (en) 1997-10-17 1998-10-19 The use of inhibitors of the renin-angiotensin system for the treatment of hypoxia or impaired metabolic function

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CY1106813T1 true CY1106813T1 (el) 2012-05-23

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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101011390A (zh) 1999-01-26 2007-08-08 诺瓦提斯公司 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
DE60022525T2 (de) * 1999-08-30 2006-06-14 Sanofi Aventis Deutschland Ramipril zur vorbeugung von kardiovaskulären vorfällen
EA005310B1 (ru) * 2000-04-10 2004-12-30 Юити Исида Гипотензивные средства
WO2002099098A1 (en) * 2001-04-04 2002-12-12 American Diagnostica, Inc Method of preparation of stabilized thrombin-activatable fibrinolysis inhibitor (tafi) and methods of use thereof
GB0119460D0 (en) 2001-08-09 2001-10-03 Ark Therapeutics Ltd The use of inhibitors of the renin-angiotensin system
WO2003043615A2 (de) * 2001-11-23 2003-05-30 Solvay Pharmaceuticals Gmbh Hypertoniebehandlung während der akuten phase des schlaganfalls
EP1382334A1 (en) * 2002-07-11 2004-01-21 Université de Picardie Jules Verne Use of angiotensin II AT1-receptor blockers (ARB), alone or combined with thiazide or angiotensin II for the treatment of stroke
US7470519B2 (en) 2002-08-29 2008-12-30 American Diagnostica, Inc. Methods for detecting TAFIa or TAFIai
EP1600166A4 (en) * 2003-01-17 2008-02-27 Takeda Pharmaceutical SKELETAL MUSCLE PROTECTIVE AGENT
WO2005084648A1 (en) * 2004-02-27 2005-09-15 Ranbaxy Laboratories Limited Pharmaceutical compositions comprising candesartan cilexetil
ATE493973T1 (de) 2004-06-04 2011-01-15 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
WO2006009325A1 (ja) * 2004-07-23 2006-01-26 Ono Pharmaceutical Co., Ltd. メタロプロテアーゼ阻害剤
EP2374508A1 (en) * 2005-03-21 2011-10-12 Vicus Therapeutics SPE 1, LLC Combination of angiotension receptor blockers (ARB) and NSAIDs for use in ameliorating cachexia
AR068814A1 (es) * 2007-08-29 2009-12-09 Orion Corp Composicion farmaceutica que comprende levosimendan y un inhibidor de la enzima conversina de la angiotensina (ace), y uso
CA2699854A1 (en) * 2007-09-17 2009-03-26 Bioneris Ab Use of compounds comprising phosphorous for the treatment of cachexia
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
WO2012135597A2 (en) 2011-03-30 2012-10-04 The Johns Hopkins University Novel, protective, anti-inflammatory receptor and its use in preservation of mitochondrial function, wound healing and repair
KR20130074808A (ko) * 2011-12-16 2013-07-05 한올바이오파마주식회사 스타틴계 지질저하제에 의한 근육계 부작용의 치료 또는 예방을 위한 로사르탄을 포함하는 약제학적 조성물
EP2832357A1 (en) 2013-07-29 2015-02-04 Charité - Universitätsmedizin Berlin Selective AT2 receptor agonists for use in treatment of cachexia
WO2015108342A1 (ko) * 2014-01-14 2015-07-23 최원철 루테리알의 형태특성을 이용한 암 예방제 또는 항암제의 스크리닝 방법
JP2016183174A (ja) * 2016-05-12 2016-10-20 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイド塩及びそれらの使用
US11081240B2 (en) 2018-06-14 2021-08-03 Astrazeneca Uk Limited Methods for treatment of hypertension with an angiotensin II receptor blocker pharmaceutical composition
DE202023100085U1 (de) 2023-01-09 2023-02-03 Sundararajan Gothandam Eine doppelte Blockade des Renin-Angiotensin-Systems zur Verringerung der frühen Veränderungen der diabetischen Retinopathie und Nephropathie

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2655989B1 (fr) * 1989-12-20 1992-02-28 Adir Nouveaux derives d'amino-acides substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5049553A (en) * 1990-01-04 1991-09-17 E. R. Squibb & Sons, Inc. Method for preventing or treating symptoms resulting from closed head injuries employing an ace inhibitor
GB2241890A (en) 1990-03-12 1991-09-18 Squibb & Sons Inc Preventing onset of or treating protein catabolism using an ace inhibitor
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
CA2048699A1 (en) * 1990-09-04 1992-03-05 Abraham Sudilovsky Method for preventing or treating cerebro-vascular disease employing ceronapril
CA2052014A1 (en) 1990-10-19 1992-04-20 Henry Y. Pan Method for preventing diabetic complications employing a cholesterol lowering drug alone or in combination with an ace inhibitor
TW197945B (el) * 1990-11-27 1993-01-11 Hoechst Ag
FI905896A (fi) * 1990-11-29 1992-05-30 Valmet Paper Machinery Inc Formningsgapsarrangemang i en dubbelviraformare av en pappersmaskin.
GB9027199D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5591762A (en) * 1991-02-06 1997-01-07 Dr. Karl Thomae Gmbh Benzimidazoles useful as angiotensin-11 antagonists
GB9108811D0 (en) * 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole
EP0670737A4 (en) 1992-03-26 1996-05-29 Gensia Inc IN VIVO PEPTIDE THERAPY.
US5972990A (en) 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5374643A (en) 1992-09-11 1994-12-20 E. R. Squibb & Sons, Inc. Aryl urea (thiourea) and cyanoguanidine derivatives
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5824696A (en) * 1993-09-01 1998-10-20 Smithkline Beecham Corporation Medicaments
US5464854A (en) * 1993-11-11 1995-11-07 Depadova; Anathony S. Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S.
CA2140722A1 (en) * 1994-01-24 1995-07-25 Joseph A. Jakubowski Beta-carboline thromboxane synthase inhibitors
US5550118A (en) * 1994-01-31 1996-08-27 Eli Lilly And Company Polyhydronorharman synthase inhibitors
US5468757A (en) * 1994-01-31 1995-11-21 Eli Lilly And Company 6-azaindole thromboxane synthase inhibitors
DE4410997A1 (de) * 1994-03-30 1995-10-26 Isis Pharma Gmbh Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen
DE4420102A1 (de) 1994-06-09 1995-12-14 Asta Medica Ag Arzneimittelkombinationen aus alpha-Liponsäure und herz-kreislaufaktiven Substanzen
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5538991A (en) 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) * 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5645839A (en) * 1995-06-07 1997-07-08 Trustees Of Boston University Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
US5846990A (en) 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
DK0853477T3 (da) * 1995-10-06 2003-02-10 Novartis Ag AT1-receptor-antagonister til forebyggelse og behandling af postiskæmisk nyresvigt og til beskyttelse af iskæmiske nyrer
EP0868179A4 (en) * 1995-12-12 2002-01-30 Merck & Co Inc NEW USE OF LOSARTAN
US6258032B1 (en) * 1997-01-29 2001-07-10 William M. Hammesfahr Method of diagnosis and treatment and related compositions and apparatus
US6420412B2 (en) * 1996-03-29 2002-07-16 Smithkline Beecham Corporation Eprosartan dihydate and a process for its production and formulation
DE19614533A1 (de) 1996-04-12 1997-10-16 Basf Ag Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung
DE19614542A1 (de) * 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
US20040122096A1 (en) * 1996-06-03 2004-06-24 Hoechst Aktiengesellschaft Use of inhibitors of the cellular Na+/H+ exchanger (NHE) for preparing a medicament for normalizing serum lipids
DE19636046A1 (de) * 1996-09-05 1998-03-12 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten
KR20000035992A (ko) 1996-09-10 2000-06-26 메디녹스, 인크. 폴리디티오카르바메이트 함유 거대분자 및 치료 및 진단을 위한
US6008221A (en) 1996-11-06 1999-12-28 Bristol-Myers Squibb Company Method for treating Alzheimer's disease with folic acid
PL334014A1 (en) * 1996-12-18 2000-01-31 Basf Ag Heterocyclic derivatives of carboxylic acids, their preduction and application as antagonists of endothelin receptors
EP0855392A3 (de) 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US6197505B1 (en) * 1997-04-04 2001-03-06 Pyrosequencing Ab Methods for assessing cardiovascular status and compositions for use thereof
US5916910A (en) 1997-06-04 1999-06-29 Medinox, Inc. Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore
DE60022525T2 (de) * 1999-08-30 2006-06-14 Sanofi Aventis Deutschland Ramipril zur vorbeugung von kardiovaskulären vorfällen

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EP1776954A2 (en) 2007-04-25
US20140045907A1 (en) 2014-02-13
US20120178784A1 (en) 2012-07-12
CN1279606A (zh) 2001-01-10
AU9453398A (en) 1999-05-10
WO1999020260A2 (en) 1999-04-29
CA2677910A1 (en) 1999-04-29
PL340838A1 (en) 2001-02-26
DE69830069T3 (de) 2012-02-09
US20020187939A1 (en) 2002-12-12
UY25971A1 (es) 2000-12-29
CN1123342C (zh) 2003-10-08
DE69838042D1 (de) 2007-08-16
CA2677910C (en) 2011-03-15
US8003679B2 (en) 2011-08-23
JP5187991B2 (ja) 2013-04-24
HUP0003982A1 (hu) 2001-11-28
EP1023067B9 (en) 2005-08-17
US20050192326A1 (en) 2005-09-01
AP1300A (en) 2004-09-08
AP2000001796A0 (en) 2000-06-30
DK1498124T3 (da) 2007-11-05
KR100523112B1 (ko) 2005-10-19
WO1999020260A3 (en) 2000-03-09
DE69830069T2 (de) 2006-01-19
PL193215B1 (pl) 2007-01-31
US8604070B2 (en) 2013-12-10
KR20010031177A (ko) 2001-04-16
EP1559424A2 (en) 2005-08-03
ATE366110T1 (de) 2007-07-15
NO20001979D0 (no) 2000-04-14
CA2306216A1 (en) 1999-04-29
DK1023067T4 (da) 2011-12-12
KR100572080B1 (ko) 2006-04-17
ATE294579T1 (de) 2005-05-15
EP1023067B2 (en) 2011-08-24
DE69838042T2 (de) 2008-03-06
DK1023067T3 (da) 2005-09-05
US20060217429A1 (en) 2006-09-28
EP1559424A3 (en) 2009-11-11
EP1498124A3 (en) 2005-08-17
AU742506B2 (en) 2002-01-03
EP1776954A3 (en) 2009-11-11
US20090069348A1 (en) 2009-03-12
US7998953B2 (en) 2011-08-16
EP1023067B1 (en) 2005-05-04
NO20001979L (no) 2000-06-13
JP2009242426A (ja) 2009-10-22
PL197164B1 (pl) 2008-03-31
US20050192327A1 (en) 2005-09-01
HU0900792D0 (en) 2010-03-01
EP1023067A2 (en) 2000-08-02
ES2238770T5 (es) 2012-01-17
PT1498124E (pt) 2007-10-16
EP1498124B1 (en) 2007-07-04
KR20050085966A (ko) 2005-08-29
ES2287617T3 (es) 2007-12-16
US7071183B2 (en) 2006-07-04
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HUP0003982A3 (en) 2002-01-28
CA2306216C (en) 2011-06-07
PT1023067E (pt) 2005-09-30
EP1498124A2 (en) 2005-01-19
UY25972A1 (es) 2001-08-27
KR20010031179A (ko) 2001-04-16
DE69830069D1 (de) 2005-06-09
JP2003521437A (ja) 2003-07-15
NO326231B1 (no) 2008-10-20

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