UY25971A1 - Procedimiento de preparación de nuevos bencimidazoles, antagonistas de angiotensina ii. - Google Patents

Procedimiento de preparación de nuevos bencimidazoles, antagonistas de angiotensina ii.

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Publication number
UY25971A1
UY25971A1 UY25971A UY25971A UY25971A1 UY 25971 A1 UY25971 A1 UY 25971A1 UY 25971 A UY25971 A UY 25971A UY 25971 A UY25971 A UY 25971A UY 25971 A1 UY25971 A1 UY 25971A1
Authority
UY
Uruguay
Prior art keywords
group
signifies
alkyl
benzimidazol
angiotensin
Prior art date
Application number
UY25971A
Other languages
English (en)
Inventor
Norbert Hauel
Berthold Narr
Uwe Ries
Jacques Van Meel
Wolfgang Wienen
Michael Entzeroth
Original Assignee
Boehringer Ingelheim Pharma
Amp
Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26312447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY25971(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9722026.3A external-priority patent/GB9722026D0/en
Priority claimed from GBGB9810855.8A external-priority patent/GB9810855D0/en
Application filed by Boehringer Ingelheim Pharma, Amp, Co Kg filed Critical Boehringer Ingelheim Pharma
Publication of UY25971A1 publication Critical patent/UY25971A1/es

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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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Abstract

Procedimientos de preparación de bencimidazoles de la fórmula (I) en la que: R1 significa un átomo de flúor, cloro, bromo, un grupo alquilo, cicloalquilo, fluorometilo, difluorometilo o trifluorometilo, y R2 significa: un grupo alquilenimino o alquenilenimino de 5, 6 ó 7 miembros; un grupo bencimidazol-2-ilo ó 4,5,6,7-tetrahidro-bencimidazol-2-ilo eventualmente sustituido en posición 1 con un grupo alquilo o cicloalquilo; un grupo piridilo ó significa un grupo imidazolilo eventualmente unido en posición 1 mediante un grupo alquilo o bencilo a través de un átomo de carbono; R3 significa un grupo alquilo o cicloalquilo, y R4 significa un grupo carboxi ó 1H-tetrazolilo, y de sus sales con ácidos o bases inorgánicos u orgánicos, en particular de sus sales fisiológicamente compatibles. Dichos compuestos son antagonistas de angiotensina II, por tanto son útiles en el tratamiento de la hipertensión arterial. Ej. no limitante: ácido 4'-[[2-n-propil-4-metil-6-(1-metilbencimidazol-2-il)-bencimidazol-1-il]-metil]-bifenil-2-carboxílico.
UY25971A 1997-10-17 2000-01-17 Procedimiento de preparación de nuevos bencimidazoles, antagonistas de angiotensina ii. UY25971A1 (es)

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