FI945319A - Substituoidut indolit ja atsaindolit angiotensiini II:n antagonisteina - Google Patents
Substituoidut indolit ja atsaindolit angiotensiini II:n antagonisteina Download PDFInfo
- Publication number
- FI945319A FI945319A FI945319A FI945319A FI945319A FI 945319 A FI945319 A FI 945319A FI 945319 A FI945319 A FI 945319A FI 945319 A FI945319 A FI 945319A FI 945319 A FI945319 A FI 945319A
- Authority
- FI
- Finland
- Prior art keywords
- lower alkyl
- hydrogen
- angiotensin
- antagonists
- halogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88239092 | 1992-05-13 | ||
| US07/882,390 US5212195A (en) | 1992-05-13 | 1992-05-13 | Substituted indole antagonists derivatives which are angiotensin II |
| US486993 | 1993-02-04 | ||
| US08/004,869 US5380739A (en) | 1992-05-13 | 1993-02-04 | Substituted indole derivatives |
| PCT/US1993/001533 WO1993023391A1 (en) | 1992-05-13 | 1993-02-26 | Substituted indoles and azaindoles as angiotensin ii antagonists |
| US9301533 | 1993-02-26 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI945319A true FI945319A (fi) | 1994-11-11 |
| FI945319A0 FI945319A0 (fi) | 1994-11-11 |
| FI110512B FI110512B (fi) | 2003-02-14 |
Family
ID=26673598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI945319A FI110512B (fi) | 1992-05-13 | 1994-11-11 | Menetelmä angiotensiini II:n antagonisteina käyttökelpoisten substituoitujen indolien valmistamiseksi |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0640080B1 (fi) |
| JP (1) | JP3332234B2 (fi) |
| CN (1) | CN1039714C (fi) |
| AT (1) | ATE159524T1 (fi) |
| AU (1) | AU672599B2 (fi) |
| CA (1) | CA2135605A1 (fi) |
| DE (1) | DE69314786T2 (fi) |
| DK (1) | DK0640080T3 (fi) |
| ES (1) | ES2110086T3 (fi) |
| FI (1) | FI110512B (fi) |
| GR (1) | GR3025118T3 (fi) |
| HU (2) | HU221616B1 (fi) |
| IL (1) | IL104869A (fi) |
| MX (1) | MX9301088A (fi) |
| NO (1) | NO308535B1 (fi) |
| NZ (2) | NZ299146A (fi) |
| WO (1) | WO1993023391A1 (fi) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569539B2 (en) | 1996-10-30 | 2003-05-27 | Tetra Level Holdings & Finance S.A. | Gas barrier packaging laminate method for production thereof and packaging containers |
| US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| JP2002504539A (ja) * | 1998-02-25 | 2002-02-12 | ジェネティックス・インスチチュート・インコーポレーテッド | ホスホリパーゼ酵素の阻害剤 |
| EP1243268A4 (en) * | 1999-12-14 | 2003-05-21 | Nippon Shinyaku Co Ltd | MEDICINAL COMPOSITION |
| WO2002048155A1 (de) * | 2000-12-14 | 2002-06-20 | Clariant Gmbh | Verfahren zur herstellung von formylphenylboronsäuren |
| EP1431278A4 (en) * | 2001-09-28 | 2006-01-25 | Ihara Chemical Ind Co | METHOD OF PREPARING (2-NITROPHENYL) ACETONITRILE DERIVATIVES AND INTERMEDIATES THEREFOR |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US7129264B2 (en) * | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
| GT200600228A (es) | 2005-05-27 | 2006-12-26 | Inhibidores de la fosfolipasa a2 citosolica | |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| RU2485102C2 (ru) * | 2008-01-31 | 2013-06-20 | Санофи-Авентис | Циклические индол-3-карбоксамиды, их получение и их применение в качестве лекарственных препаратов |
| MY153609A (en) * | 2008-01-31 | 2015-02-27 | Sanofi Aventis | Cyclic azaindole-3-carboxamides, their preparation and their use as pharmaceuticals |
| CN101940568B (zh) * | 2010-08-17 | 2012-11-14 | 合肥博太医药生物技术发展有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗蒽环抗癌药引起的心脏衰竭药物中的应用 |
| CN107056781A (zh) * | 2017-05-18 | 2017-08-18 | 康化（上海）新药研发有限公司 | 一种(E)‑5‑甲基‑1H‑吡咯并[2,3‑b]吡啶‑3‑甲醛肟的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0400835A1 (en) * | 1989-05-15 | 1990-12-05 | Merck & Co. Inc. | Substituted benzimidazoles as angiotensin II antagonists |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| US5124335A (en) * | 1991-01-30 | 1992-06-23 | Merck & Co., Inc. | Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists |
-
1993
- 1993-02-26 MX MX9301088A patent/MX9301088A/es not_active IP Right Cessation
- 1993-02-26 HU HU9403238A patent/HU221616B1/hu not_active IP Right Cessation
- 1993-02-26 ES ES93906123T patent/ES2110086T3/es not_active Expired - Lifetime
- 1993-02-26 NZ NZ299146A patent/NZ299146A/en unknown
- 1993-02-26 AT AT93906123T patent/ATE159524T1/de not_active IP Right Cessation
- 1993-02-26 CA CA002135605A patent/CA2135605A1/en not_active Abandoned
- 1993-02-26 EP EP93906123A patent/EP0640080B1/en not_active Expired - Lifetime
- 1993-02-26 WO PCT/US1993/001533 patent/WO1993023391A1/en active IP Right Grant
- 1993-02-26 JP JP52017993A patent/JP3332234B2/ja not_active Expired - Fee Related
- 1993-02-26 DE DE69314786T patent/DE69314786T2/de not_active Expired - Fee Related
- 1993-02-26 AU AU37274/93A patent/AU672599B2/en not_active Ceased
- 1993-02-26 IL IL104869A patent/IL104869A/xx not_active IP Right Cessation
- 1993-02-26 NZ NZ249729A patent/NZ249729A/en unknown
- 1993-02-26 CN CN93102401A patent/CN1039714C/zh not_active Expired - Fee Related
- 1993-02-26 DK DK93906123.0T patent/DK0640080T3/da active
-
1994
- 1994-11-11 NO NO944311A patent/NO308535B1/no not_active IP Right Cessation
- 1994-11-11 FI FI945319A patent/FI110512B/fi active
-
1995
- 1995-02-17 HU HU95P/P00076P patent/HU210709A9/hu unknown
-
1997
- 1997-10-23 GR GR970401901T patent/GR3025118T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT68056A (en) | 1995-05-29 |
| ES2110086T3 (es) | 1998-02-01 |
| NO944311L (no) | 1994-11-14 |
| HU221616B1 (hu) | 2002-12-28 |
| CN1039714C (zh) | 1998-09-09 |
| JP3332234B2 (ja) | 2002-10-07 |
| EP0640080A1 (en) | 1995-03-01 |
| IL104869A0 (en) | 1993-06-10 |
| EP0640080B1 (en) | 1997-10-22 |
| DK0640080T3 (da) | 1998-05-25 |
| AU672599B2 (en) | 1996-10-10 |
| NZ249729A (en) | 1996-12-20 |
| JPH07506826A (ja) | 1995-07-27 |
| FI110512B (fi) | 2003-02-14 |
| AU3727493A (en) | 1993-12-13 |
| CA2135605A1 (en) | 1993-11-25 |
| GR3025118T3 (en) | 1998-01-30 |
| IL104869A (en) | 1997-11-20 |
| NO944311D0 (no) | 1994-11-11 |
| MX9301088A (es) | 1993-11-01 |
| HU210709A9 (en) | 1995-06-28 |
| DE69314786T2 (de) | 1998-02-19 |
| NO308535B1 (no) | 2000-09-25 |
| DE69314786D1 (de) | 1997-11-27 |
| FI945319A0 (fi) | 1994-11-11 |
| ATE159524T1 (de) | 1997-11-15 |
| NZ299146A (en) | 2000-06-23 |
| CN1078469A (zh) | 1993-11-17 |
| WO1993023391A1 (en) | 1993-11-25 |
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