ATE159524T1 - Substituierte indole als angiotensin ii antagonisten - Google Patents
Substituierte indole als angiotensin ii antagonistenInfo
- Publication number
- ATE159524T1 ATE159524T1 AT93906123T AT93906123T ATE159524T1 AT E159524 T1 ATE159524 T1 AT E159524T1 AT 93906123 T AT93906123 T AT 93906123T AT 93906123 T AT93906123 T AT 93906123T AT E159524 T1 ATE159524 T1 AT E159524T1
- Authority
- AT
- Austria
- Prior art keywords
- lower alkyl
- hydrogen
- angiotensin
- antagonists
- halogen
- Prior art date
Links
- 229940123413 Angiotensin II antagonist Drugs 0.000 title 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- -1 1H-tetrazol-5-yl Chemical group 0.000 abstract 1
- 102000015427 Angiotensins Human genes 0.000 abstract 1
- 108010064733 Angiotensins Proteins 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/882,390 US5212195A (en) | 1992-05-13 | 1992-05-13 | Substituted indole antagonists derivatives which are angiotensin II |
| US08/004,869 US5380739A (en) | 1992-05-13 | 1993-02-04 | Substituted indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE159524T1 true ATE159524T1 (de) | 1997-11-15 |
Family
ID=26673598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93906123T ATE159524T1 (de) | 1992-05-13 | 1993-02-26 | Substituierte indole als angiotensin ii antagonisten |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0640080B1 (de) |
| JP (1) | JP3332234B2 (de) |
| CN (1) | CN1039714C (de) |
| AT (1) | ATE159524T1 (de) |
| AU (1) | AU672599B2 (de) |
| CA (1) | CA2135605A1 (de) |
| DE (1) | DE69314786T2 (de) |
| DK (1) | DK0640080T3 (de) |
| ES (1) | ES2110086T3 (de) |
| FI (1) | FI110512B (de) |
| GR (1) | GR3025118T3 (de) |
| HU (2) | HU221616B1 (de) |
| IL (1) | IL104869A (de) |
| MX (1) | MX9301088A (de) |
| NO (1) | NO308535B1 (de) |
| NZ (2) | NZ249729A (de) |
| WO (1) | WO1993023391A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569539B2 (en) | 1996-10-30 | 2003-05-27 | Tetra Level Holdings & Finance S.A. | Gas barrier packaging laminate method for production thereof and packaging containers |
| EA200000868A1 (ru) * | 1998-02-25 | 2001-04-23 | Дженетикс Инститьют, Инк. | Ингибиторы фосфолипаз |
| US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| AU1887401A (en) * | 1999-12-14 | 2001-06-25 | Nippon Shinyaku Co. Ltd. | Medicinal composition |
| ES2236332T3 (es) * | 2000-12-14 | 2005-07-16 | Clariant Gmbh | Procedimiento para la preparacion de acidos formil-fenil-boricos. |
| CZ2004423A3 (cs) * | 2001-09-28 | 2004-08-18 | Iharaáchemicaláindustryáco@Źáltd | Způsob výroby }@@nitrofenylB acetonitrilových derivátů a meziprodukt použitý pro tuto syntézu |
| US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
| US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
| US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
| US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
| US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
| US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
| US7129264B2 (en) * | 2003-04-16 | 2006-10-31 | Bristol-Myers Squibb Company | Biarylmethyl indolines and indoles as antithromboembolic agents |
| TW200718687A (en) | 2005-05-27 | 2007-05-16 | Wyeth Corp | Inhibitors of cytosolic phospholipase A2 |
| GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| CA2712854C (en) * | 2008-01-31 | 2016-02-23 | Sanofi-Aventis | Cyclic indole-3-carboxamides, their preparation and their use as pharmaceuticals |
| BRPI0906727A2 (pt) * | 2008-01-31 | 2015-08-04 | Sanofi Aventis | Azaindol-3-carboxamidas cíclicas, sua preparação e seu uso como produtos farmacêuticos |
| CN101940568B (zh) * | 2010-08-17 | 2012-11-14 | 合肥博太医药生物技术发展有限公司 | 吲哚-3-甲醇、二吲哚甲烷及其衍生物在制备治疗蒽环抗癌药引起的心脏衰竭药物中的应用 |
| CN107056781A (zh) * | 2017-05-18 | 2017-08-18 | 康化（上海）新药研发有限公司 | 一种(E)‑5‑甲基‑1H‑吡咯并[2,3‑b]吡啶‑3‑甲醛肟的合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2016710A1 (en) * | 1989-05-15 | 1990-11-15 | Prasun K. Chakravarty | Substituted benzimidazoles as angiotensin ii antagonists |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| US5124335A (en) * | 1991-01-30 | 1992-06-23 | Merck & Co., Inc. | Substituted pyrollo-fused 6 membered heterocycles as angiotensin ii antagonists |
-
1993
- 1993-02-26 ES ES93906123T patent/ES2110086T3/es not_active Expired - Lifetime
- 1993-02-26 HU HU9403238A patent/HU221616B1/hu not_active IP Right Cessation
- 1993-02-26 NZ NZ249729A patent/NZ249729A/en unknown
- 1993-02-26 NZ NZ299146A patent/NZ299146A/en unknown
- 1993-02-26 AU AU37274/93A patent/AU672599B2/en not_active Ceased
- 1993-02-26 MX MX9301088A patent/MX9301088A/es not_active IP Right Cessation
- 1993-02-26 IL IL104869A patent/IL104869A/xx not_active IP Right Cessation
- 1993-02-26 EP EP93906123A patent/EP0640080B1/de not_active Expired - Lifetime
- 1993-02-26 CA CA002135605A patent/CA2135605A1/en not_active Abandoned
- 1993-02-26 DK DK93906123.0T patent/DK0640080T3/da active
- 1993-02-26 DE DE69314786T patent/DE69314786T2/de not_active Expired - Fee Related
- 1993-02-26 AT AT93906123T patent/ATE159524T1/de not_active IP Right Cessation
- 1993-02-26 WO PCT/US1993/001533 patent/WO1993023391A1/en not_active Ceased
- 1993-02-26 CN CN93102401A patent/CN1039714C/zh not_active Expired - Fee Related
- 1993-02-26 JP JP52017993A patent/JP3332234B2/ja not_active Expired - Fee Related
-
1994
- 1994-11-11 FI FI945319A patent/FI110512B/fi active
- 1994-11-11 NO NO944311A patent/NO308535B1/no not_active IP Right Cessation
-
1995
- 1995-02-17 HU HU95P/P00076P patent/HU210709A9/hu unknown
-
1997
- 1997-10-23 GR GR970401901T patent/GR3025118T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL104869A (en) | 1997-11-20 |
| EP0640080A1 (de) | 1995-03-01 |
| FI945319A7 (fi) | 1994-11-11 |
| NO944311D0 (no) | 1994-11-11 |
| CN1039714C (zh) | 1998-09-09 |
| NO944311L (no) | 1994-11-14 |
| GR3025118T3 (en) | 1998-01-30 |
| NZ299146A (en) | 2000-06-23 |
| IL104869A0 (en) | 1993-06-10 |
| CA2135605A1 (en) | 1993-11-25 |
| ES2110086T3 (es) | 1998-02-01 |
| DK0640080T3 (da) | 1998-05-25 |
| CN1078469A (zh) | 1993-11-17 |
| EP0640080B1 (de) | 1997-10-22 |
| JPH07506826A (ja) | 1995-07-27 |
| DE69314786D1 (de) | 1997-11-27 |
| MX9301088A (es) | 1993-11-01 |
| HU210709A9 (en) | 1995-06-28 |
| AU672599B2 (en) | 1996-10-10 |
| NZ249729A (en) | 1996-12-20 |
| DE69314786T2 (de) | 1998-02-19 |
| NO308535B1 (no) | 2000-09-25 |
| WO1993023391A1 (en) | 1993-11-25 |
| JP3332234B2 (ja) | 2002-10-07 |
| AU3727493A (en) | 1993-12-13 |
| FI945319A0 (fi) | 1994-11-11 |
| FI110512B (fi) | 2003-02-14 |
| HUT68056A (en) | 1995-05-29 |
| HU221616B1 (hu) | 2002-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |