ATE366110T1 - Verwendung von inhibitoren des renin-angiotensin systems - Google Patents

Verwendung von inhibitoren des renin-angiotensin systems

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Publication number
ATE366110T1
ATE366110T1 AT04021889T AT04021889T ATE366110T1 AT E366110 T1 ATE366110 T1 AT E366110T1 AT 04021889 T AT04021889 T AT 04021889T AT 04021889 T AT04021889 T AT 04021889T AT E366110 T1 ATE366110 T1 AT E366110T1
Authority
AT
Austria
Prior art keywords
renin
angiotensin system
system inhibitors
inhibitors
angiotensin
Prior art date
Application number
AT04021889T
Other languages
English (en)
Inventor
Hugh Edward Montgomery
John Francis Martin
Jorge Daniel Erusalimsky
Original Assignee
Ark Therapeutics Ltd
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26312447&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE366110(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9722026.3A external-priority patent/GB9722026D0/en
Priority claimed from GBGB9810855.8A external-priority patent/GB9810855D0/en
Application filed by Ark Therapeutics Ltd, Boehringer Ingelheim Int filed Critical Ark Therapeutics Ltd
Application granted granted Critical
Publication of ATE366110T1 publication Critical patent/ATE366110T1/de

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AT04021889T 1997-10-17 1998-10-19 Verwendung von inhibitoren des renin-angiotensin systems ATE366110T1 (de)

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GBGB9722026.3A GB9722026D0 (en) 1997-10-17 1997-10-17 Use of compounds
GBGB9810855.8A GB9810855D0 (en) 1998-05-20 1998-05-20 Use of compounds

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AT98947698T ATE294579T1 (de) 1997-10-17 1998-10-19 Verwendung von hemmern des renin-angiotensin systems zur behandlung von hypoxie oder verringertem stoffwechsel
AT04021889T ATE366110T1 (de) 1997-10-17 1998-10-19 Verwendung von inhibitoren des renin-angiotensin systems

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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101011390A (zh) 1999-01-26 2007-08-08 诺瓦提斯公司 血管紧张素ⅱ受体拮抗剂在治疗急性心肌梗塞中的应用
SE9903028D0 (sv) * 1999-08-27 1999-08-27 Astra Ab New use
CA2382549C (en) * 1999-08-30 2005-03-15 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events
AU2001246864B2 (en) * 2000-04-10 2006-07-27 Protein Express Co., Ltd. Hypotensors
WO2002099098A1 (en) * 2001-04-04 2002-12-12 American Diagnostica, Inc Method of preparation of stabilized thrombin-activatable fibrinolysis inhibitor (tafi) and methods of use thereof
GB0119460D0 (en) * 2001-08-09 2001-10-03 Ark Therapeutics Ltd The use of inhibitors of the renin-angiotensin system
AU2002364381A1 (en) * 2001-11-23 2003-06-10 Solvay Pharmaceuticals Gmbh Hypertonia treatment during the acute phase of a cerebrovascular accident
EP1382334A1 (de) * 2002-07-11 2004-01-21 Université de Picardie Jules Verne Verwendung von Angiotensin II AT1-Rezeptorblockern, allein oder in Kombination mit Thiazide oder Angiotensin II zur Behandlung von Schlaganfall
EP2204455A1 (de) 2002-08-29 2010-07-07 American Diagnostica, Inc. Diagnostischer Assay für den mit Thrombin aktivierbaren Fibrinolyse-Inhibitor (TAFI)
EP1600166A4 (de) * 2003-01-17 2008-02-27 Takeda Pharmaceutical Skelettmuskelschutzmittel
WO2005084648A1 (en) * 2004-02-27 2005-09-15 Ranbaxy Laboratories Limited Pharmaceutical compositions comprising candesartan cilexetil
DE602005025755D1 (de) 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
WO2006009325A1 (ja) * 2004-07-23 2006-01-26 Ono Pharmaceutical Co., Ltd. メタロプロテアーゼ阻害剤
EP1990049A3 (de) * 2005-03-21 2008-11-26 Vicus Therapeutics SPE 1, LLC Kombinationstherapie von Beta-Blockern und nicht steroidalen antiinflammatorischen Antiphlogistika/Antirheumatika (NSAR)
AR068814A1 (es) * 2007-08-29 2009-12-09 Orion Corp Composicion farmaceutica que comprende levosimendan y un inhibidor de la enzima conversina de la angiotensina (ace), y uso
EP2187892A1 (de) * 2007-09-17 2010-05-26 Bioneris AB Verfahren und mittel zur behandlung von kachexien
US10517839B2 (en) * 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
WO2012135597A2 (en) 2011-03-30 2012-10-04 The Johns Hopkins University Novel, protective, anti-inflammatory receptor and its use in preservation of mitochondrial function, wound healing and repair
KR20130074808A (ko) * 2011-12-16 2013-07-05 한올바이오파마주식회사 스타틴계 지질저하제에 의한 근육계 부작용의 치료 또는 예방을 위한 로사르탄을 포함하는 약제학적 조성물
EP2832357A1 (de) * 2013-07-29 2015-02-04 Charité - Universitätsmedizin Berlin Selektive AT2-Rezeptoragonisten zur Verwendung bei der Behandlung von Kachexie
US20160334389A1 (en) * 2014-01-14 2016-11-17 Won Cheol Choi Method for screening cancer prevention agent or anticancer agent using morphological characteristics of luterial
JP2016183174A (ja) * 2016-05-12 2016-10-20 ディフュージョン・ファーマシューティカルズ・エルエルシー 双極性トランスカロテノイド塩及びそれらの使用
EP3807898A1 (de) 2018-06-14 2021-04-21 AstraZeneca UK Limited Verfahren zur behandlung von bluthochdruck mit einer pharmazeutischen angiotensin-ii-rezeptorblockerzusammensetzung
DE202023100085U1 (de) 2023-01-09 2023-02-03 Sundararajan Gothandam Eine doppelte Blockade des Renin-Angiotensin-Systems zur Verringerung der frühen Veränderungen der diabetischen Retinopathie und Nephropathie

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2655989B1 (fr) * 1989-12-20 1992-02-28 Adir Nouveaux derives d'amino-acides substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US5049553A (en) * 1990-01-04 1991-09-17 E. R. Squibb & Sons, Inc. Method for preventing or treating symptoms resulting from closed head injuries employing an ace inhibitor
GB2241890A (en) 1990-03-12 1991-09-18 Squibb & Sons Inc Preventing onset of or treating protein catabolism using an ace inhibitor
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
US5196444A (en) 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
CA2048699A1 (en) * 1990-09-04 1992-03-05 Abraham Sudilovsky Method for preventing or treating cerebro-vascular disease employing ceronapril
CA2052014A1 (en) 1990-10-19 1992-04-20 Henry Y. Pan Method for preventing diabetic complications employing a cholesterol lowering drug alone or in combination with an ace inhibitor
TW197945B (de) * 1990-11-27 1993-01-11 Hoechst Ag
FI905896A (fi) * 1990-11-29 1992-05-30 Valmet Paper Machinery Inc Formningsgapsarrangemang i en dubbelviraformare av en pappersmaskin.
GB9027199D0 (en) * 1990-12-14 1991-02-06 Smithkline Beecham Plc Medicaments
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
US5614519A (en) * 1991-02-06 1997-03-25 Karl Thomae Gmbh (1-(2,3 or 4-N-morpholinoalkyl)-imidazol-4-yl)-benizimidazol-1-yl-methyl]-biphenyls useful as angiotensin-II antagonists
GB9108811D0 (en) * 1991-04-24 1991-06-12 Erba Carlo Spa N-imidazolyl derivatives of substituted indole
AU3968193A (en) 1992-03-26 1993-10-21 Gensia, Inc. In vivo peptide therapy
US5972990A (en) * 1992-04-10 1999-10-26 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
US5374643A (en) 1992-09-11 1994-12-20 E. R. Squibb & Sons, Inc. Aryl urea (thiourea) and cyanoguanidine derivatives
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5824696A (en) * 1993-09-01 1998-10-20 Smithkline Beecham Corporation Medicaments
US5464854A (en) * 1993-11-11 1995-11-07 Depadova; Anathony S. Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S.
CA2140722A1 (en) * 1994-01-24 1995-07-25 Joseph A. Jakubowski Beta-carboline thromboxane synthase inhibitors
US5468757A (en) * 1994-01-31 1995-11-21 Eli Lilly And Company 6-azaindole thromboxane synthase inhibitors
US5550118A (en) * 1994-01-31 1996-08-27 Eli Lilly And Company Polyhydronorharman synthase inhibitors
DE4410997A1 (de) * 1994-03-30 1995-10-26 Isis Pharma Gmbh Pharmazeutische Zubereitungen und Arzneistoffe zur Prävention und Behandlung endothelialer Dysfunktionen
DE4420102A1 (de) 1994-06-09 1995-12-14 Asta Medica Ag Arzneimittelkombinationen aus alpha-Liponsäure und herz-kreislaufaktiven Substanzen
US5612359A (en) 1994-08-26 1997-03-18 Bristol-Myers Squibb Company Substituted biphenyl isoxazole sulfonamides
US5538991A (en) * 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5645839A (en) * 1995-06-07 1997-07-08 Trustees Of Boston University Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis
US5846990A (en) 1995-07-24 1998-12-08 Bristol-Myers Squibb Co. Substituted biphenyl isoxazole sulfonamides
TW356468B (en) * 1995-09-15 1999-04-21 Astra Pharma Prod Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same
CA2232663C (en) * 1995-10-06 2008-04-08 Novartis Ag At1-receptor antagonists for preventing and treating postischemic renal failure and for protecting ischemic kidneys
WO1997021436A1 (en) * 1995-12-12 1997-06-19 Merck & Co., Inc. New use for losartan
US6258032B1 (en) * 1997-01-29 2001-07-10 William M. Hammesfahr Method of diagnosis and treatment and related compositions and apparatus
US6420412B2 (en) 1996-03-29 2002-07-16 Smithkline Beecham Corporation Eprosartan dihydate and a process for its production and formulation
DE19614542A1 (de) 1996-04-12 1997-10-16 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung
DE19614533A1 (de) 1996-04-12 1997-10-16 Basf Ag Neue alpha-Hydroxysäurederivate, ihre Herstellung und Verwendung
US20040122096A1 (en) * 1996-06-03 2004-06-24 Hoechst Aktiengesellschaft Use of inhibitors of the cellular Na+/H+ exchanger (NHE) for preparing a medicament for normalizing serum lipids
DE19636046A1 (de) * 1996-09-05 1998-03-12 Basf Ag Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten
CN1230178A (zh) 1996-09-10 1999-09-29 麦地诺克斯公司 含聚二硫代氨基甲酸酯的大分子和其用于治疗和诊断应用的用途
US6008221A (en) 1996-11-06 1999-12-28 Bristol-Myers Squibb Company Method for treating Alzheimer's disease with folic acid
BR9714047A (pt) * 1996-12-18 2000-05-09 Basf Ag Derivados de ácido carboxìlico, uso dos mesmos, combinação destes com um ou mais compostos ativos, preparação de drogas para a administração oral e parenteral, e, antagonista de receptor de endotelina
EP0855392A3 (de) * 1997-01-22 2000-01-05 Hoechst Aktiengesellschaft Fünfgliedrige Heterocyclen mit Biphenylsulfonylsubstitution, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
TW536540B (en) 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
US6197505B1 (en) * 1997-04-04 2001-03-06 Pyrosequencing Ab Methods for assessing cardiovascular status and compositions for use thereof
US5916910A (en) 1997-06-04 1999-06-29 Medinox, Inc. Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore
CA2382549C (en) * 1999-08-30 2005-03-15 Aventis Pharma Deutschland Gmbh Use of inhibitors of the renin-angiotensin system in the prevention of cardiovascular events

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DE69830069D1 (de) 2005-06-09
JP2003521437A (ja) 2003-07-15
ES2238770T5 (es) 2012-01-17
HUP0003982A3 (en) 2002-01-28
DE69830069T3 (de) 2012-02-09
US20140045907A1 (en) 2014-02-13
HU0900792D0 (en) 2010-03-01
PT1498124E (pt) 2007-10-16
UY25972A1 (es) 2001-08-27
EP1498124B1 (de) 2007-07-04
EP1559424A3 (de) 2009-11-11
DK1023067T3 (da) 2005-09-05
US20120178784A1 (en) 2012-07-12
KR20010031179A (ko) 2001-04-16
DK1023067T4 (da) 2011-12-12
EP1023067B1 (de) 2005-05-04
WO1999020260A3 (en) 2000-03-09
US7071183B2 (en) 2006-07-04
DE69830069T2 (de) 2006-01-19
EP1498124A2 (de) 2005-01-19
US8604070B2 (en) 2013-12-10
KR20010031177A (ko) 2001-04-16
US20020187939A1 (en) 2002-12-12
UY25971A1 (es) 2000-12-29
PL193215B1 (pl) 2007-01-31
NO20001979L (no) 2000-06-13
CA2306216A1 (en) 1999-04-29
CN1279606A (zh) 2001-01-10
CA2677910C (en) 2011-03-15
CA2306216C (en) 2011-06-07
ATE294579T1 (de) 2005-05-15
EP1776954A3 (de) 2009-11-11
EP1776954A2 (de) 2007-04-25
PL340838A1 (en) 2001-02-26
KR20050085966A (ko) 2005-08-29
PL197164B1 (pl) 2008-03-31
NO326231B1 (no) 2008-10-20
US20090069348A1 (en) 2009-03-12
DE69838042D1 (de) 2007-08-16
US20050192327A1 (en) 2005-09-01
DK1498124T3 (da) 2007-11-05
ES2238770T3 (es) 2005-09-01
EP1023067A2 (de) 2000-08-02
AP2000001796A0 (en) 2000-06-30
AU9453398A (en) 1999-05-10
US8003679B2 (en) 2011-08-23
CY1106813T1 (el) 2012-05-23
EP1559424A2 (de) 2005-08-03
EP1023067B9 (de) 2005-08-17
ES2287617T3 (es) 2007-12-16
CA2677910A1 (en) 1999-04-29
US20050192326A1 (en) 2005-09-01
AP1300A (en) 2004-09-08
EP1023067B2 (de) 2011-08-24
DE69838042T2 (de) 2008-03-06
WO1999020260A2 (en) 1999-04-29
NO20001979D0 (no) 2000-04-14
HUP0003982A1 (hu) 2001-11-28
KR100572080B1 (ko) 2006-04-17
JP5187991B2 (ja) 2013-04-24
KR100523112B1 (ko) 2005-10-19
PT1023067E (pt) 2005-09-30
AU742506B2 (en) 2002-01-03
US20060217429A1 (en) 2006-09-28
CN1123342C (zh) 2003-10-08
US7998953B2 (en) 2011-08-16
EP1498124A3 (de) 2005-08-17

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