AR095424A1 - 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina - Google Patents

7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina

Info

Publication number
AR095424A1
AR095424A1 ARP140100968A ARP140100968A AR095424A1 AR 095424 A1 AR095424 A1 AR 095424A1 AR P140100968 A ARP140100968 A AR P140100968A AR P140100968 A ARP140100968 A AR P140100968A AR 095424 A1 AR095424 A1 AR 095424A1
Authority
AR
Argentina
Prior art keywords
alkyl
pyrazolyl
pyridyl
halo
alkoxy
Prior art date
Application number
ARP140100968A
Other languages
English (en)
Spanish (es)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR095424A1 publication Critical patent/AR095424A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Neurology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
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  • Psychiatry (AREA)
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  • Obesity (AREA)
  • Endocrinology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Addiction (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ARP140100968A 2013-03-13 2014-03-13 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina AR095424A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361780428P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
AR095424A1 true AR095424A1 (es) 2015-10-14

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ARP140100968A AR095424A1 (es) 2013-03-13 2014-03-13 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina

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US (4) US9637496B2 (https=)
EP (1) EP2970313B1 (https=)
JP (1) JP6337082B2 (https=)
KR (1) KR102209432B1 (https=)
CN (1) CN105209468B (https=)
AR (1) AR095424A1 (https=)
AU (2) AU2014240388B2 (https=)
BR (1) BR112015022058A2 (https=)
CA (1) CA2905012C (https=)
CL (1) CL2015002616A1 (https=)
CR (1) CR20150434A (https=)
EA (1) EA028386B1 (https=)
ES (1) ES2659222T3 (https=)
IL (1) IL240929B (https=)
MX (1) MX360791B (https=)
NI (1) NI201500129A (https=)
PE (1) PE20151668A1 (https=)
PH (1) PH12015502030A1 (https=)
SG (1) SG11201507431UA (https=)
TW (1) TW201444849A (https=)
UA (1) UA116132C2 (https=)
UY (1) UY35408A (https=)
WO (1) WO2014159591A1 (https=)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
TW201444849A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途
TWI621618B (zh) 2013-03-13 2018-04-21 比利時商健生藥品公司 經取代２－氮雜雙環類及其作為食慾素受體調控劑之用途
TW201444821A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代之哌啶化合物及其作為食慾素受體調節劑之用途
WO2015131773A1 (zh) * 2014-03-06 2015-09-11 上海海雁医药科技有限公司 作为食欲素受体拮抗剂的哌啶衍生物
US9889327B2 (en) 2014-06-27 2018-02-13 Flexhead Industries, Inc. Adjustable bracket and hub for flexible hose support
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