PE20151668A1 - 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina - Google Patents
7-azabiciclos sustituidos y su uso como moduladores del receptor de orexinaInfo
- Publication number
- PE20151668A1 PE20151668A1 PE2015001941A PE2015001941A PE20151668A1 PE 20151668 A1 PE20151668 A1 PE 20151668A1 PE 2015001941 A PE2015001941 A PE 2015001941A PE 2015001941 A PE2015001941 A PE 2015001941A PE 20151668 A1 PE20151668 A1 PE 20151668A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- compounds
- pyrazinyl
- pyridyl
- halo
- Prior art date
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract
La presente invencion se refiere a compuestos de Formula l, en donde el anillo A es fenilo, naftalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tiazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo, o indazolilo; R1 es H, alquilo, alcoxi hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazolilo, piridilo, pirimidinilo, pirazinilo, piridazinilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo, o dialquilamino; R2 es H, alquilo, alcoxi hidroxialquileno, o halo; Z es NH, N-alquilo, u O; R5 es piridilo, pirimidinilo, pirazinilo, piridazinilo, quinazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, imidazopirazinilo, triazolopirazinilo, opcionalmente sustituido con uno o dos sustituyentes independientemente seleccionados del grupo que consiste en alquilo, alcoxi, o halo; y n es 0 o 1 . Ademas, se describen metodos para preparar los compuestos de formula I. La invencion se relaciona, ademas, con composiciones farmaceuticas que comprenden compuestos de la formula I. Los metodos de uso de los compuestos de la invencion se encuentran, ademas, dentro del alcance de la invencion
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201361780428P | 2013-03-13 | 2013-03-13 |
Publications (1)
Publication Number | Publication Date |
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PE20151668A1 true PE20151668A1 (es) | 2015-11-12 |
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PE2015001941A PE20151668A1 (es) | 2013-03-13 | 2014-03-12 | 7-azabiciclos sustituidos y su uso como moduladores del receptor de orexina |
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US (4) | US9062078B2 (es) |
EP (1) | EP2970313B1 (es) |
JP (1) | JP6337082B2 (es) |
KR (1) | KR102209432B1 (es) |
CN (1) | CN105209468B (es) |
AR (1) | AR095424A1 (es) |
AU (2) | AU2014240388B2 (es) |
BR (1) | BR112015022058A2 (es) |
CA (1) | CA2905012C (es) |
CL (1) | CL2015002616A1 (es) |
CR (1) | CR20150434A (es) |
EA (1) | EA028386B1 (es) |
ES (1) | ES2659222T3 (es) |
HK (1) | HK1219726A1 (es) |
IL (1) | IL240929B (es) |
MX (1) | MX360791B (es) |
NI (1) | NI201500129A (es) |
PE (1) | PE20151668A1 (es) |
PH (1) | PH12015502030A1 (es) |
SG (1) | SG11201507431UA (es) |
TW (1) | TW201444849A (es) |
UA (1) | UA116132C2 (es) |
UY (1) | UY35408A (es) |
WO (1) | WO2014159591A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI621618B (zh) | 2013-03-13 | 2018-04-21 | 比利時商健生藥品公司 | 經取代2-氮雜雙環類及其作為食慾素受體調控劑之用途 |
TW201444821A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代之哌啶化合物及其作為食慾素受體調節劑之用途 |
TW201444849A (zh) | 2013-03-13 | 2014-12-01 | Janssen Pharmaceutica Nv | 經取代的7-氮雜雙環類及其作為食慾激素受體調節劑之用途 |
CA2941663C (en) * | 2014-03-06 | 2020-02-18 | Shanghai Haiyan Pharmaceutical Technology Co. Ltd | Piperidine derivatives as orexin receptor antagonist |
MX364612B (es) | 2014-06-27 | 2019-05-02 | Anvil Int Llc | Abrazadera ajustable y cubo para soporte de manguera flexible. |
GB201415569D0 (en) | 2014-09-03 | 2014-10-15 | C4X Discovery Ltd | Therapeutic Compounds |
BR112017004742B1 (pt) | 2014-09-11 | 2022-11-29 | Janssen Pharmaceutica Nv | 2-azabiciclos substituídos e seu uso como moduladores de receptor de orexina |
US10196383B2 (en) | 2015-07-17 | 2019-02-05 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
JP6772251B2 (ja) * | 2015-08-14 | 2020-10-21 | シャンハイ ハイヤン ファーマシューティカル テクノロジー カンパニー リミテッドShanghai Haiyan Pharmaceutical Technology Co., Ltd. | オレキシン受容体拮抗薬の化合物の結晶形およびその製造方法と使用 |
US10040796B2 (en) * | 2015-09-04 | 2018-08-07 | Janssen Pharmaceutica Nv | Therapeutic compounds for pain and synthesis thereof |
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