CL2015002616A1 - 7-azabiciclos sustituidos y su uso como modulares del receptor de orexina. - Google Patents

7-azabiciclos sustituidos y su uso como modulares del receptor de orexina.

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Publication number
CL2015002616A1
CL2015002616A1 CL2015002616A CL2015002616A CL2015002616A1 CL 2015002616 A1 CL2015002616 A1 CL 2015002616A1 CL 2015002616 A CL2015002616 A CL 2015002616A CL 2015002616 A CL2015002616 A CL 2015002616A CL 2015002616 A1 CL2015002616 A1 CL 2015002616A1
Authority
CL
Chile
Prior art keywords
modulators
orexin receptor
substituted
azabicycles
substituted azabicycles
Prior art date
Application number
CL2015002616A
Other languages
English (en)
Inventor
Heather R Coate
Curt A Dvorak
Anne E Fitzgerald
Terry Pl Lebold
Cathy Preville
Brock T Shireman
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CL2015002616A1 publication Critical patent/CL2015002616A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

COMPUESTOS DERIVADOS DE 7-AZABICICLOS SUSTITUIDOS, MODULADORES DEL RECEPTRO DE OREXINA; COMPOSICION FARMACEUTICA; Y SU USO EN EL TRATAMIENTO DE UN TRASTORNO DE CICLO SUEÑO-VIGILIA, INSOMNIO, ANSIEDAD, FIBROMIALGIA, DEPRESION, ENF. PARKINSON, ENTRE. OTRAS
CL2015002616A 2013-03-13 2015-09-11 7-azabiciclos sustituidos y su uso como modulares del receptor de orexina. CL2015002616A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361780428P 2013-03-13 2013-03-13

Publications (1)

Publication Number Publication Date
CL2015002616A1 true CL2015002616A1 (es) 2016-03-28

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Application Number Title Priority Date Filing Date
CL2015002616A CL2015002616A1 (es) 2013-03-13 2015-09-11 7-azabiciclos sustituidos y su uso como modulares del receptor de orexina.

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US (4) US9062078B2 (es)
EP (1) EP2970313B1 (es)
JP (1) JP6337082B2 (es)
KR (1) KR102209432B1 (es)
CN (1) CN105209468B (es)
AR (1) AR095424A1 (es)
AU (2) AU2014240388B2 (es)
BR (1) BR112015022058A2 (es)
CA (1) CA2905012C (es)
CL (1) CL2015002616A1 (es)
CR (1) CR20150434A (es)
EA (1) EA028386B1 (es)
ES (1) ES2659222T3 (es)
HK (1) HK1219726A1 (es)
IL (1) IL240929B (es)
MX (1) MX360791B (es)
NI (1) NI201500129A (es)
PE (1) PE20151668A1 (es)
PH (1) PH12015502030A1 (es)
SG (1) SG11201507431UA (es)
TW (1) TW201444849A (es)
UA (1) UA116132C2 (es)
UY (1) UY35408A (es)
WO (1) WO2014159591A1 (es)

Families Citing this family (19)

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Publication number Priority date Publication date Assignee Title
TWI621618B (zh) 2013-03-13 2018-04-21 比利時商健生藥品公司 經取代２－氮雜雙環類及其作為食慾素受體調控劑之用途
TW201444821A (zh) 2013-03-13 2014-12-01 Janssen Pharmaceutica Nv 經取代之哌啶化合物及其作為食慾素受體調節劑之用途
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