AU2014240388B2 - Substituted 7-azabicycles and their use as orexin receptor modulators - Google Patents
Substituted 7-azabicycles and their use as orexin receptor modulators Download PDFInfo
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- AU2014240388B2 AU2014240388B2 AU2014240388A AU2014240388A AU2014240388B2 AU 2014240388 B2 AU2014240388 B2 AU 2014240388B2 AU 2014240388 A AU2014240388 A AU 2014240388A AU 2014240388 A AU2014240388 A AU 2014240388A AU 2014240388 B2 AU2014240388 B2 AU 2014240388B2
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- Australia
- Prior art keywords
- methyl
- heptan
- methanone
- azabicyclo
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 CC(C)C(C)(CC(C)(C)C(C)C(CCC1C)*1C(C1C*(C*)(*C2)*2(C)CCCCC1)=C)N Chemical compound CC(C)C(C)(CC(C)(C)C(C)C(CCC1C)*1C(C1C*(C*)(*C2)*2(C)CCCCC1)=C)N 0.000 description 37
- RGGZSOVYGPLGNB-SNXNNQDSSA-N C/C=C(/C(/F)=C\C)\C1=NCCC=N1 Chemical compound C/C=C(/C(/F)=C\C)\C1=NCCC=N1 RGGZSOVYGPLGNB-SNXNNQDSSA-N 0.000 description 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N C1NCCNC1 Chemical compound C1NCCNC1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- HNEJZBPEYVIVBI-UHFFFAOYSA-N CC(C(C)=C)(c1cc(F)c(CCCC2NS(C)CC2)nc1)F Chemical compound CC(C(C)=C)(c1cc(F)c(CCCC2NS(C)CC2)nc1)F HNEJZBPEYVIVBI-UHFFFAOYSA-N 0.000 description 1
- PUQWHWTWRQNIFZ-UHFFFAOYSA-N CCC1CC2NC2C1 Chemical compound CCC1CC2NC2C1 PUQWHWTWRQNIFZ-UHFFFAOYSA-N 0.000 description 1
- CJYORBWCHKIGFV-UHFFFAOYSA-O CC[NH2+]c1ncccc1C(N1C2C(C)CC1CC2)=C1CC1 Chemical compound CC[NH2+]c1ncccc1C(N1C2C(C)CC1CC2)=C1CC1 CJYORBWCHKIGFV-UHFFFAOYSA-O 0.000 description 1
- SULPROUBGDBICU-UHFFFAOYSA-N COc(c(C(N(C(CC1)C2C3)C1C2[I](C1)C3C1c(nc1)ccc1Br)=C)ccc1)c1F Chemical compound COc(c(C(N(C(CC1)C2C3)C1C2[I](C1)C3C1c(nc1)ccc1Br)=C)ccc1)c1F SULPROUBGDBICU-UHFFFAOYSA-N 0.000 description 1
- ALHUXMDEZNLFTA-UHFFFAOYSA-N Cc1cnc(cccc2)c2n1 Chemical compound Cc1cnc(cccc2)c2n1 ALHUXMDEZNLFTA-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2018253525A AU2018253525A1 (en) | 2013-03-13 | 2018-10-24 | Substituted 7-azabicycles and their use as orexin receptor modulators |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361780428P | 2013-03-13 | 2013-03-13 | |
| US61/780,428 | 2013-03-13 | ||
| PCT/US2014/024322 WO2014159591A1 (en) | 2013-03-13 | 2014-03-12 | Substituted 7-azabicycles and their use as orexin receptor modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2018253525A Division AU2018253525A1 (en) | 2013-03-13 | 2018-10-24 | Substituted 7-azabicycles and their use as orexin receptor modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2014240388A1 AU2014240388A1 (en) | 2015-08-27 |
| AU2014240388B2 true AU2014240388B2 (en) | 2018-07-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2014240388A Active AU2014240388B2 (en) | 2013-03-13 | 2014-03-12 | Substituted 7-azabicycles and their use as orexin receptor modulators |
| AU2018253525A Abandoned AU2018253525A1 (en) | 2013-03-13 | 2018-10-24 | Substituted 7-azabicycles and their use as orexin receptor modulators |
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| Application Number | Title | Priority Date | Filing Date |
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| AU2018253525A Abandoned AU2018253525A1 (en) | 2013-03-13 | 2018-10-24 | Substituted 7-azabicycles and their use as orexin receptor modulators |
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| TWI621618B (zh) | 2013-03-13 | 2018-04-21 | 比利時商健生藥品公司 | 經取代2-氮雜雙環類及其作為食慾素受體調控劑之用途 |
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| WO2015131773A1 (zh) * | 2014-03-06 | 2015-09-11 | 上海海雁医药科技有限公司 | 作为食欲素受体拮抗剂的哌啶衍生物 |
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| AU2015314851B2 (en) * | 2014-09-11 | 2020-01-02 | Janssen Pharmaceutica Nv | Substituted 2-azabicycles and their use as orexin receptor modulators |
| WO2017012502A1 (en) | 2015-07-17 | 2017-01-26 | Sunshine Lake Pharma Co., Ltd. | Substituted quinazoline compounds and preparation and uses thereof |
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| GB201601703D0 (en) | 2016-01-29 | 2016-03-16 | C4X Discovery Ltd | Therapeutic compounds |
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| CN107573294A (zh) * | 2017-09-19 | 2018-01-12 | 四川大学 | 5‑甲基‑2‑(2h‑1,2,3‑三唑‑2‑基)苯甲酸的合成方法 |
| GB201906914D0 (en) | 2019-05-16 | 2019-07-03 | Ucl Business Plc | Substituted naphtahlene diimdes and their use |
| CN114286675A (zh) * | 2019-06-04 | 2022-04-05 | 海格生物科学有限责任公司 | 作为食欲肽拮抗剂的咪唑衍生物、组合物以及方法 |
| CN115379830A (zh) * | 2020-04-17 | 2022-11-22 | 上海海雁医药科技有限公司 | 固体药物制剂及其制备方法和用途 |
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| JP7591592B2 (ja) * | 2022-01-14 | 2024-11-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物を含有する医薬 |
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- 2014-03-12 WO PCT/US2014/024322 patent/WO2014159591A1/en not_active Ceased
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- 2014-03-12 AU AU2014240388A patent/AU2014240388B2/en active Active
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