AR093468A1 - Derivados de piridina - Google Patents
Derivados de piridinaInfo
- Publication number
- AR093468A1 AR093468A1 ARP130104172A ARP130104172A AR093468A1 AR 093468 A1 AR093468 A1 AR 093468A1 AR P130104172 A ARP130104172 A AR P130104172A AR P130104172 A ARP130104172 A AR P130104172A AR 093468 A1 AR093468 A1 AR 093468A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- atom
- halogen atom
- alkyl group
- ring
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heat Sensitive Colour Forming Recording (AREA)
- Beans For Foods Or Fodder (AREA)
Abstract
Útil para tratar o prevenir enfermedades en las cuales está implicado el URAT1, incluyendo gota, hiperuricemia, hipertensión, enfermedades renales tales como nefritis intersticial y demás, diabetes, arteriosclerosis, Síndrome de Lesch-Nyhan y demás. Reivindicación 1: Un derivado de piridina representado por la fórmula (1) o una sal farmacéuticamente aceptable del mismo o un solvato del mismo; en la cual: A representa un enlace simple, un átomo de oxígeno, un átomo de azufre, NH o CH₂; R¹ representa un átomo de nitrógeno o CH; uno de X¹ a X⁵ representa un átomo de nitrógeno y los cuatro restantes representan CR²; R² representan independientemente, en cada caso, un átomo de hidrógeno, un grupo alquilo C₁₋₆, un grupo alquenilo C₂₋₆, un grupo alquinilo C₂₋₆, un átomo de halógeno, un grupo trifluorometilo, un grupo difluorometilo, un grupo ciano, un grupo alquilcarbonilo C₂₋₇, un grupo alquilsulfonilo C₁₋₆, un grupo nitro, un grupo amino, un grupo dialquilamino C₁₋₆ que opcionalmente pueden formar un anillo, un grupo formilo, un grupo hidroxilo, un grupo alcoxi C₁₋₆ (que puede estar opcionalmente sustituido con uno o más de un grupo hidroxilo, un grupo fenilo, un grupo ciclohexilo y un átomo de halógeno), un grupo alquiltio C₁₋₆, un grupo fenilo (que puede estar opcionalmente sustituido con uno o más de un grupo alquilo C₁₋₆, un grupo alcoxi C₁₋₆ y un átomo de halógeno) o un grupo fenoxi (que puede estar opcionalmente sustituido con uno o más de un grupo alquilo C₁₋₆, un grupo alcoxi C₁₋₆ y un átomo de halógeno), con la salvedad de que cuando dos CR²s están adyacentes, los dos R²s se pueden unir opcionalmente para formar un anillo; R³ representa un átomo de hidrógeno, un grupo alquilo C₁₋₆ (que puede estar opcionalmente sustituido con uno o más de un grupo hidroxilo, un grupo amino, un grupo dialquilamino C₁₋₆ que opcionalmente pueden formar un anillo, un anillo de imidazol, un anillo de pirazol, un anillo de pirrolidina, un anillo de piperidina, un anillo de morfolina y un anillo de piperazina (que puede estar opcionalmente sustituido con uno o más de un grupo alquilo C₁₋₆ y un grupo alquilsulfonilo C₁₋₆)), un grupo alquenilo C₂₋₆, un grupo alquinilo C₂₋₆, un grupo alcoxi C₁₋₆ (que puede estar opcionalmente sustituido con uno o más de un grupo hidroxilo y un átomo de halógeno), un grupo alquilcarbonilo C₂₋₇, un grupo alquiltio C₁₋₆, un grupo alquilsulfinilo C₁₋₆, un átomo de halógeno, un grupo trifluorometilo, un grupo difluorometilo, un grupo ciano, un grupo fenilo (que puede estar opcionalmente sustituido con uno o más de un grupo alquilo C₁₋₆, un grupo alcoxi C₁₋₆ y un átomo de halógeno), un grupo piridilo (que puede estar opcionalmente sustituido con uno o más de un grupo alquilo C₁₋₆, un grupo alcoxi C₁₋₆ y un átomo de halógeno), un grupo fenoxi (que puede estar opcionalmente sustituido con uno o más de un grupo alquilo C₁₋₆, un grupo alcoxi C₁₋₆ y un átomo de halógeno), un grupo carboxilo o -CO₂R⁵; R⁴ representa un grupo carboxilo, un grupo tetrazolilo, -CONHSO₂R⁵, -CO₂R⁵ o cualquiera de los sustituyentes del grupo de fórmulas (2) con la salvedad de que cuando R³ es un grupo alquilo C₁₋₆ sustituido con un grupo hidroxilo y cuando R⁴ es un grupo carboxilo, luego R³ y R⁴ se pueden fusionar opcionalmente para formar un anillo de lactona; R⁵ en R³ y R⁴ representan independientemente, en cada caso, un grupo alquilo C₁₋₆; Z representa cualquiera de los sustituyentes del grupo de fórmulas (3), en la cual: R⁶ y R⁷ representan independientemente, en cada caso, un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₆, un grupo trifluorometilo, un grupo trifluorometoxi o un grupo ciano, con la salvedad de que se excluye el caso en que R⁶ y R⁷ son simultáneamente átomos de hidrógeno; R⁸ representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₆ o un grupo trifluorometilo; R⁹ representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₆ o un grupo trifluorometilo; R¹⁰ representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₆ o un grupo trifluorometilo; R¹¹ y R¹² representan independientemente, en cada caso, un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₆ o un grupo trifluorometilo; R¹³ y R¹⁴ representan independientemente, en cada caso, un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₆ o un grupo trifluorometilo; R¹⁵ representa un átomo de hidrógeno, un átomo de halógeno, un grupo alquilo C₁₋₆ o un grupo trifluorometilo; Y representa un átomo de hidrógeno o un grupo alquilo C₁₋₆; y W representa un átomo de azufre, un átomo de oxígeno o NR¹⁶ (donde R¹⁶ representa un átomo de hidrógeno, un grupo alquilo C₁₋₆ o un grupo bencilo).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012250661 | 2012-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR093468A1 true AR093468A1 (es) | 2015-06-10 |
Family
ID=50731196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP130104172A AR093468A1 (es) | 2012-11-14 | 2013-11-13 | Derivados de piridina |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US9637469B2 (es) |
| EP (2) | EP3339302A1 (es) |
| JP (2) | JP5774238B2 (es) |
| KR (1) | KR20150082194A (es) |
| CN (2) | CN107721931A (es) |
| AR (1) | AR093468A1 (es) |
| AU (2) | AU2013345894B2 (es) |
| BR (1) | BR112015010977A2 (es) |
| CA (1) | CA2891408A1 (es) |
| CL (1) | CL2015001279A1 (es) |
| CY (1) | CY1120127T1 (es) |
| DK (1) | DK2944633T3 (es) |
| ES (1) | ES2662444T3 (es) |
| HK (1) | HK1211940A1 (es) |
| HR (1) | HRP20180451T1 (es) |
| HU (1) | HUE037736T2 (es) |
| IL (2) | IL238539A (es) |
| LT (1) | LT2944633T (es) |
| MA (1) | MA38078B1 (es) |
| ME (1) | ME03016B (es) |
| MX (1) | MX2015003672A (es) |
| NO (1) | NO2944633T3 (es) |
| NZ (1) | NZ708031A (es) |
| PE (1) | PE20150974A1 (es) |
| PH (1) | PH12015501037A1 (es) |
| PL (1) | PL2944633T3 (es) |
| PT (1) | PT2944633T (es) |
| RS (1) | RS57090B1 (es) |
| RU (1) | RU2640588C2 (es) |
| SA (1) | SA515360431B1 (es) |
| SG (2) | SG10201705852PA (es) |
| SI (1) | SI2944633T1 (es) |
| TW (1) | TWI666205B (es) |
| UA (1) | UA117359C2 (es) |
| WO (1) | WO2014077285A1 (es) |
| ZA (1) | ZA201503322B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2016148736A (ru) * | 2014-05-13 | 2018-06-14 | Тейдзин Фарма Лимитед | Новые кристаллические полиморфы производного пиридина и способ их получения |
| AR100403A1 (es) * | 2014-05-13 | 2016-10-05 | Teijin Pharma Ltd | Derivados de pirazina |
| ES2775782T3 (es) * | 2016-03-15 | 2020-07-28 | Bayer Cropscience Ag | Sulfonilamidas sustituidas para combatir parásitos animales |
| CN107286156A (zh) * | 2016-04-05 | 2017-10-24 | 江苏新元素医药科技有限公司 | 新型urat1抑制剂及其在医药上的应用 |
| CN106008488B (zh) * | 2016-05-20 | 2018-10-30 | 广东东阳光药业有限公司 | 氰基吲哚类衍生物及其制备方法和用途 |
| NZ749427A (en) * | 2016-05-23 | 2019-11-29 | Cstone Pharmaceutical Suzhou Co Ltd | Thiophene, manufacturing method thereof, and pharmaceutical application of same |
| TW201822637A (zh) | 2016-11-07 | 2018-07-01 | 德商拜耳廠股份有限公司 | 用於控制動物害蟲的經取代磺醯胺類 |
| TW201837026A (zh) | 2017-01-10 | 2018-10-16 | 德商拜耳廠股份有限公司 | 作為除害劑之雜環衍生物（二） |
| KR102515694B1 (ko) | 2017-01-10 | 2023-03-29 | 바이엘 악티엔게젤샤프트 | 해충 방제제로서의 헤테로사이클 유도체 |
| CN108658879A (zh) * | 2017-03-29 | 2018-10-16 | 天津药物研究院有限公司 | 一种urat1抑制剂及其制备方法和用途 |
| CN109251184B (zh) * | 2017-07-13 | 2021-06-15 | 浙江海正药业股份有限公司 | 一种2-三氟甲基苯磺酰胺类衍生物的医药用途 |
| SI3762368T1 (sl) | 2018-03-08 | 2022-06-30 | Incyte Corporation | Aminopirazin diolne spojine kot zaviralci PI3K-y |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| TWI820231B (zh) | 2018-10-11 | 2023-11-01 | 德商拜耳廠股份有限公司 | 用於製備經取代咪唑衍生物之方法 |
| CN111943957B (zh) * | 2019-05-17 | 2023-01-06 | 中国医学科学院药物研究所 | 喹啉甲酰胺类化合物及其制备方法和用途 |
| US20220380318A1 (en) | 2019-11-07 | 2022-12-01 | Bayer Aktiengesellschaft | Substituted sulfonyl amides for controlling animal pests |
| BR112022026904A2 (pt) | 2020-07-02 | 2023-01-24 | Bayer Ag | Derivados de heterocicleno como agentes de controle de pragas |
| CN114315729B (zh) * | 2021-12-09 | 2024-01-26 | 大连理工大学 | 1-苄基-2，4-二芳基咪唑类化合物、合成方法及其在抗肿瘤上的应用 |
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| KR101294872B1 (ko) | 2008-09-04 | 2013-08-08 | 아디아 바이오사이언스즈 인크. | 요산 수치를 조절하기 위한 화합물, 조성물 및 이들의 사용 방법 |
| JP2010202575A (ja) * | 2009-03-03 | 2010-09-16 | Takeda Chem Ind Ltd | 複素環化合物 |
| CA2767112C (en) * | 2009-07-10 | 2018-06-19 | The General Hospital Corporation | Etomidate analogues that do not inhibit adrenocortical steroid synthesis |
| CN102035579B (zh) * | 2009-09-28 | 2014-09-03 | 夏普株式会社 | 信息反馈方法和用户设备 |
| AR081930A1 (es) * | 2010-06-16 | 2012-10-31 | Ardea Biosciences Inc | Compuestos de tioacetato |
| JP5485811B2 (ja) * | 2010-06-23 | 2014-05-07 | 株式会社ジャパンディスプレイ | 双方向シフトレジスタ、及びこれを用いた画像表示装置 |
| EA201390214A1 (ru) * | 2010-08-11 | 2013-07-30 | Милленниум Фармасьютикалз, Инк. | Гетероарилы и их применение |
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